Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells

Journal of Biological Chemistry

Volumn 285, Issue 10, 2010, Pages 7028-7034

  Röhrl, Johann ^a   Yang, De ^b   Oppenheim, Joost J ^b   Hehlgans, Thomas ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; ANTI-MICROBIAL ACTIVITY; BIOLOGICAL ACTIVITIES; CHEMOKINE LIGANDS; CHEMOKINE RECEPTORS; CHEMOTACTIC ACTIVITY; DEFENSINS; EPITHELIAL CELLS; EXPRESSION SYSTEM; FLUORESCENCE-ACTIVATED CELL SORTERS; FUSION PROTEINS; GRAM-POSITIVE BACTERIUM; HUMAN ORTHOLOGUE; HUMAN PERIPHERAL BLOOD; INNATE IMMUNE RESPONSE; ISOLATED MOUSE; MICROBICIDAL EFFECT; PERITONEAL CELLS; RECEPTOR INTERACTION; SPECIFIC BINDING; SPECIFIC INTERACTION;

BACTERIA; BIOACTIVITY; BIOCHEMISTRY; CELLS; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGY;

PROTEINS;

BETA DEFENSIN 2; BETA DEFENSIN 4; CHEMOKINE RECEPTOR CCR6; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; DROSOPHILA; FLUORESCENCE ACTIVATED CELL SORTING; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SOLUBILITY;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BETA-DEFENSINS; CELL LINE; CHEMOKINE CCL20; CHEMOTAXIS; ESCHERICHIA COLI; HUMANS; IMMUNOGLOBULINS; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; RECEPTORS, CCR6; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

NEGIBACTERIA; POSIBACTERIA;

EID: 77951221301     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.091090     Document Type: Article

References (25)

1. Lehrer, R. I., and Ganz, T. (2002) Curr. Opin. Immunol. 14, 96-102
2. Jia, H. P., Wowk, S. A., Schutte, B. C., Lee, S. K., Vivado, A., Tack, B. F., Bevins, C. L., and McCray, P. B., Jr. (2000) J. Biol. Chem. 275, 33314-33320
3. Rivas-Santiago, B., Sada, E., Tsutsumi, V., Aguilar-Leon, D., Contreras, J. L., and Hernandez-Pando, R. (2006) J. Infect. Dis. 194, 697-701
4. Chong, K. T., Thangavel, R. R., and Tang, X. (2008) Virology 380, 136-143
5. Joly, S., Organ, C. C., Johnson, G. K., McCray, P. B., Jr., and Guthmiller, J. M. (2005) Mol. Immunol. 42, 1073-1084
6. Harder, J., Bartels, J., Christophers, E., and Schroder, J. M. (2001) J. Biol. Chem. 276, 5707-5713
7. Harder, J., Meyer-Hoffert, U., Wehkamp, K., Schwichtenberg, L., and Schröder, J. M. (2004) J. Invest Dermatol. 123, 522-529
8. Harder, J., and Schröder, J. M. (2005) Chem. Immunol. Allergy 86, 22-41
9. Fang, X. M., Shu, Q., Chen, Q. X., Book, M., Sahl, H. G., Hoeft, A., and Stuber, F. (2003) Eur. J. Clin. Invest. 33, 82-87
10. Tsutsumi-Ishii, Y., and Nagaoka, I. (2003) J. Immunol. 170, 4226-4236
11. Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M., and Oppenheim, J. J. (1999) Science 286, 525-528
12. Yang, D., Biragyn, A., Kwak, L. W., and Oppenheim, J. J. (2002) Trends Immunol. 23, 291-296
13. Biragyn, A., Surenhu, M., Yang, D., Ruffini, P. A., Haines, B. A., Klyushnenkova, E., Oppenheim, J. J., and Kwak, L. W. (2001) J. Immunol. 167, 6644-6653
14. Conejo-Garcia, J. R., Benencia, F., Courreges, M. C., Kang, E., Mohamed- Hadley, A., Buckanovich, R. J., Holtz, D. O., Jenkins, A., Na, H., Zhang, L., Wagner, D. S., Katsaros, D., Caroll, R., and Coukos, G. (2004) Nat. Med. 10, 950-958
15. Soruri, A., Grigat, J., Forssmann, U., Riggert, J., and Zwirner, J. (2007) Eur. J. Immunol. 37, 2474-2486
16. Taylor, K., Clarke, D. J., McCullough, B., Chin, W., Seo, E., Yang, D., Oppenheim, J., Uhrin, D., Govan, J. R., Campopiano, D. J., MacMillan, D., Barran, P., and Dorin, J. R. (2008) J. Biol. Chem. 283, 6631-6639
17. Hinrichsen, K., Podschun, R., Schubert, S., Schröder, J. M., Harder, J., and Proksch, E. (2008) Antimicrob. Agents Chemother. 52, 1876-1879
18. Ishimoto, H., Mukae, H., Date, Y., Shimbara, T., Mondal, M. S., Ashitani, J., Hiratsuka, T., Kubo, S., Kohno, S., and Nakazato, M. (2006) Eur. Respir. J. 27, 253-260
19. Röhrl, J., Yang, D., Oppenheim, J. J., and Hehlgans, T. (2008) J. Biol. Chem. 283, 5414-5419
20. Piers, K. L., Brown, M. H., and Hancock, R. E. (1993) Gene 134, 7-13
21. Pazgier, M., Hoover, D. M., Yang, D., Lu, W., and Lubkowski, J. (2006) Cell. Mol. Life Sci. 63, 1294-1313
22. Yin, C., Dang, H. N., Gazor, F., and Huang, G. T. (2006) Int. J. Antimicrob. Agents 28, 352-360
23. Vargues, T., Morrison, G. J., Seo, E. S., Clarke, D. J., Fielder, H. L., Bennani, J., Pathania, U., Kilanowski, F., Dorin, J. R., Govan, J. R., Mackay, C. L., Uhrín, D., and Campopiano, D. J. (2009) Protein Pept. Lett. 16, 668-676
24. Yang, D., Chen, Q., Chertov, O., and Oppenheim, J. J. (2000) J. Leukoc. Biol. 68, 9-14
25. Wu, Z., Hoover, D. M., Yang, D., Boulègue, C., Santamaria, F., Oppenheim, J. J., Lubkowski, J., and Lu, W. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8880-8885