Grape seed proanthocyanidins attenuate vascular smooth muscle cell proliferation via blocking phosphatidylinositol 3-kinase-dependent signaling pathways

Journal of Cellular Physiology

Volumn 223, Issue 3, 2010, Pages 713-726

  Wang, Lang ^a,b   Zhu, Li Hua ^a,b   Jiang, Hong ^a,b   Tang, Qi Zhu ^a,b   Yan, Ling ^a,b   Wang, Dong ^c   Liu, Chen ^d   Bian, Zhou Yan ^a,b   Li, Hongliang ^a,b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; GRAPE SEED PROANTHOCYANIDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; OXIDOREDUCTASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROANTHOCYANIDIN DERIVATIVE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P47; PROTEIN P67; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDINS; MITOGEN ACTIVATED PROTEIN KINASE; PROANTHOCYANIDIN; PROTEIN SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RESTENOSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS; VITACEAE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL PROLIFERATION; ENZYME ACTIVATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; GRAPE SEED EXTRACT; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE; NF-KAPPA B; PROANTHOCYANIDINS; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 77951219417     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22080     Document Type: Article

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