TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3β cascade is required for TNF-induced cell survival

Biochemical and Biophysical Research Communications

Volumn 371, Issue 1, 2008, Pages 118-121

  Yoon, Kwiyeom ^a   Jung, Eun Joo ^a   Lee, Soo Young ^a  

^a Ewha Womans University   (South Korea)

Author keywords

Akt; Cell survival; GSK3 ; PI3 kinase; TNF; TRAF6

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINASE B; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; ENZYME PHOSPHORYLATION; ENZYME REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; APOPTOSIS; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE 3; MICE; MICE, MUTANT STRAINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TNF RECEPTOR-ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTOR-ALPHA;

EID: 42949124032     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.007     Document Type: Article

References (28)

1. Arch R.H., Gedrich R.W., and Thompson C.B. Tumor necrosis factor receptor-associated factors (TRAFs)-a family of adapter proteins that regulates life and death. Genes Dev. 12 (1998) 2821-2830
2. Bradley J.R., and Pober J.S. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20 (2001) 6482-6491
3. Asagiri M., and Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 40 (2007) 251-264
4. Chung J.Y., Park Y.C., and Wu H. All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J. Cell Sci. 115 (2002) 679-688
5. Ichijo H., Nishida E., Irie K., ten Dijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., and Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275 (1997) 90-94
6. Regnier C.H., Song H.Y., Gao X., Goeddel D.V., Cao Z., and Rothe M. Identification and characterization of an IκB kinase. Cell 90 (1997) 373-383
7. Xu L.G., Li L.Y., and Shu H.B. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. 279 (2004) 17278-17282
8. Wu H., and Arron J.R. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays 25 (2003) 1096-1105
9. Akira S. Toll-like receptor signaling. J. Biol. Chem. 278 (2003) 38105-38108
10. Barton G.M., and Medzhitov R. Toll-like receptor signaling pathways. Science 300 (2003) 1524-1525
11. Yoon K., Jung E.J., Lee S.R., Kim J., Choi Y., and Lee S.Y. TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3β. Cell Death Differ. 15 (2008) 730-738
12. Todaro G.J., and Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17 (1963) 299-313
13. Oganesian A., Poot M., Daum G., Coats S.A., Wright M.B., Seifert R.A., and Bowen-Pope D.F. Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Proc. Natl. Acad. Sci. USA 13 (2003) 7563-7568
14. Rommel C., Bodine S.C., Clarke B.A., Rossman R., Nunez L., Stitt T.N., Yancopoulos G.D., and Glass D.J. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat. Cell Biol. 3 (2001) 1009-1013
15. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
16. Marte B.M. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22 (1997) 355-358
17. Datta S.R., Brunet A., and Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev. 13 (1999) 2905-2927
18. Song G., Ouyang G., and Bao S. The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med. 9 (2005) 59-71
19. Bao S., Ouyang G., Bai X., Huang Z., Ma C., Liu M., Shao R., Anderson R.M., Rich J.N., and Wang X.F. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell 5 (2004) 329-339
20. Gupta D., Syed N.A., Roesler W.J., and Khandelwal R.L. Effect of overexpression and nuclear translocation of constitutively active PKB-alpha on cellular survival and proliferation in HepG2 cells. J. Cell Biochem. 93 (2004) 513-525
21. Wendel H.G., De Stanchina E., Fridman J.S., Malina A., Ray S., Kogan S., Cordon-Cardo C., Pelletier J., and Lowe S.W. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428 (2004) 332-337
22. Shack S., Wang X.T., Kokkonen G.C., Gorospe M., Longo D.L., and Holbrook N.J. Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol. Cell Biol. 23 (2003) 2407-2414
23. Aki T., Mizukami Y., Oka Y., Yamaguichi K., Uemura K., Fujimiya T., and Yoshida K. Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia. Biochem. J. 358 (2001) 481-487
24. Aki T., Yamaguchi K., Fujimiya T., and Mizukami Y. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 3 (2003) 8529-8535
25. Lee S.B., Cho E.S., Yang H.S., Kim H., and Um H.D. Serum withdrawal kills U937 cells by inducing a positive mutual interaction between reactive oxygen species and phosphoinositide 3-kinase. Cell Signal. 17 (2005) 197-204
26. Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., and Woodgett J.R. Requirement for glycogen synthase kinase-3beta in cell survival and NF-κB activation. Nature 406 (2000) 86-90
27. Ougolkov A.V., Fernamdez-Zapico M.E., Savoy D.N., Urruitia R.A., and Billadeau D.D. Glycogen synthase kinase-3β participates in nuclear factor κB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res. 65 (2005) 2076-2081
28. King C.G., Kobayashi T., Cejas P.J., Kim T., Yoon K., Kim G.K., Chiffoleau E., Hickman S.P., Walsh P.T., Turka L.A., and Choi Y. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat. Med. 12 (2006) 1088-1092