G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 12823-12830

  Chen, Xiaoqing ^a   Zhu, Huiling ^a   Yuan, Man ^a   Fu, Jie ^b   Zhou, Yuqing ^a   Ma, Lan ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC RESPONSE; DNA DAMAGES; G-PROTEIN-COUPLED RECEPTOR KINASE; GENOME STABILITY; GENOTOXIC DAMAGE; IN-VIVO; INDUCED APOPTOSIS; NEGATIVE REGULATORS; OSTEOSARCOMA CELLS; TUMOR SUPPRESSORS;

GENES; PROTEINS; SIGNAL TRANSDUCTION;

CELL DEATH;

DNA; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; PROTEIN P53; THREONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SUBSTRATE; GENE SILENCING; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VIVO STUDY; IRRADIATION; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DNA DAMAGE; G-PROTEIN-COUPLED RECEPTOR KINASE 5; GAMMA RAYS; HUMANS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 77951219148     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.094243     Document Type: Article

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