DNA methylation profiles of MGMT, DAPK1, hMLH1, CDH1, SHP1, and HIC1 in B-cell lymphomas

Korean Journal of Pathology

Volumn 43, Issue 5, 2009, Pages 420-427

  Kim, Sung Sun ^a   Choi, Young Hyo ^a   Han, Chang Woo ^a   Choi, Yoo Duk ^a   Park, Youngkyu ^a   Lee, Je Jung ^a   Kim, Hyeoung Joon ^a,b   Lee, Il Kwon ^a,b   Lee, Ji Shin ^a   Juhng, Sang Woo ^a   Choi, Chan ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Research Institute of Medical Sciences   (South Korea)

Author keywords

B lymphocytes; Lymphoma; Methylation

Indexed keywords

EID: 77951198049     PISSN: 17381843     EISSN: None     Source Type: Journal    
DOI: 10.4132/KoreanJPathol.2009.43.5.420     Document Type: Article

References (30)

1. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415-28.
2. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 2001; 10: 687-92.
3. Costello JF, Fruhwald MC, Smiraglia DJ, et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet 2000; 24: 132-8.
4. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001; 61: 3225-9.
5. Baur AS, Shaw P, Burri N, Delacretaz F, Bosman FT, Chaubert P. Frequent methylation silencing of p15 (INK4b) (MTS2) and p16 (INK4a) (MTS1) in B-cell and T-cell lymphomas. Blood 1999; 94: 1773-81.
6. Chim CS, Wong KY, Loong F, Srivastava G. SOCS1 and SHP1 hypermethylation in mantle cell lymphoma and follicular lymphoma: implications for epigenetic activation of the Jak/STAT pathway. Leukemia 2004; 18: 356-8.
7. Esteller M, Gaidano G, Goodman SN, et al. Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J Natl Cancer Inst 2002; 94: 26-32.
8. Rossi D, Gaidano G, Gloghini A, et al. Frequent aberrant promoter hypermethylation of O6-methylguanine-DNA methyltransferase and death-associated protein kinase genes in immunodeficiencyrelated lymphomas. Br J Haematol 2003; 123: 475-8.
9. Katzenellenbogen RA, Baylin SB, Herman JG. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood 1999; 93: 4347-53.
10. Menigatti M, Truninger K, Gebbers JO, Marbet U, Marra G, Schar P. Nomal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. Oncogene 2009; 28: 899-909.
11. Cohen O, Feinstein E, Kimchi A. DAP-kinase is a Ca2+/calmodulindependent, cytoskeletal-associated protein kinase, with cell deathinducing functions that depend on its catalytic activity. EMBO J 1997; 16: 998-1008.
12. Kissil JL, Feinstein E, Cohen O, et al. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene. Oncogene 1997; 15: 403-7.
13. Inbal B, Cohen O, Polak-Charcon S, et al. DAP-kinase links the control of apoptosis to metastasis. Nature 1997; 390: 180-4.
14. Sanchez-Beato M, Sanchez-Aguilera A, Piris MA. Cell cycle deregulation in B-cell lymphomas. Blood 2003; 101: 1220-35.
15. Siu LL, Chan JK, Wong KF, Choy C, Kwong YL. Aberrant promoter CpG methylation as a molecular marker for disease monitoring in natural killer cell lymphomas. Br J Haematol 2003; 122: 70-7.
16. Chu LC, Eberhart CG, Grossman SA, Herman JG. Epigenetic silencing of multiple genes in primary CNS lymphoma. Int J Cancer 2006; 119: 2487-91.
17. Scarisbrick JJ, Mitchell TJ, Calonje E, Orchard G, Russell-Jones R, Whittaker SJ. Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides. J Invest Dermatol 2003; 121: 894-901.
18. Tang X, Khuri FR, Lee JJ, et al. Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. J Natl Cancer Inst 2000; 92: 1511-6.
19. Ogama Y, Ouchida M, Yoshino T, et al. Prevalent hypermethylation of the CDH13 gene promoter in malignant B cell lymphomas. Int J Oncol 2004; 25: 685-91.
20. Delibrias CC, Floettmann JE, Rowe M, Fearon DT. Down regulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. J Exp Med 1997; 186: 1575-83.
21. Kossev PM, Raghunath PN, Bagg A, Schuster S, Tomaszewski JE, Wasik MA. SHP-1 expression by malignant small B-cell lymphomas reflects the maturation stage of their normal B-cell counterparts. Am J Surg Pathol 2001; 25: 949-55.
22. Oka T, Yoshino T, Hayashi K, et al. Reduction of hematopoietic cellspecific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias: combination analysis with cDNA expression array and tissue microarray. Am J Pathol 2001; 159: 1495-505.
23. Koyama M, Oka T, Ouchida M, et al. Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylation. Lab Invest 2003; 83: 1849-58.
24. Wales MM, Biel MA, El Deiry W, et al. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med 1995; 1: 570-7.
25. Issa JP, Zehnbauer BA, Kaufmann SH, Biel MA, Baylin SB. HIC1 hypermethylation is a late event in hematopoietic neoplasms. Cancer Res 1997; 57: 1678-81.
26. Zhou W, Jiang Z, Li X, et al. EMP3 overexpression in primary breast carcinomas is not associated with epigenetic aberrations. J Korean Med Sci 2009; 24: 97-103.
27. Lenz G, Hutter G, Hiddemann W, Dreyling M. Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia. Ann Hematol 2004; 83: 628-33.
28. Park SJ, Rashid SJ, Lee JH, Kim SG, Hamilton SR, Wu TT. Frequent CpG island methylation in serrated adenomas of the colorectum. Am J Pathol 2003; 162: 815-22.
29. Oka T, Ouchida M, Koyama M, et al. Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res 2002; 62: 6390-4.
30. Ekmekci CG, Gutierrez MI, Siraj AK, Ozbek U, Bhatia K. Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia. Am J Hematol 2004; 77: 233-40.