-
1
-
-
0000664911
-
Diagnosis, and Therapy Consensus Statement 2000
-
Osteoporosis Prevention
-
Osteoporosis Prevention, Diagnosis, and Therapy Consensus Statement 2000. JAMA. 2001;285:785-795.
-
(2001)
JAMA
, vol.285
, pp. 785-795
-
-
-
2
-
-
33744992495
-
Osteoporosis
-
Sambrook P, Cooper C. Osteoporosis. Lancet. 2006;367:2010-2018.
-
(2006)
Lancet
, vol.367
, pp. 2010-2018
-
-
Sambrook, P.1
Cooper, C.2
-
3
-
-
31944443249
-
Osteoporosis: A still increasing prevalence
-
Reginster JY, Burlet N. Osteoporosis: a still increasing prevalence. Bone. 2006;38:S4-S9.
-
(2006)
Bone
, vol.38
-
-
Reginster, J.Y.1
Burlet, N.2
-
4
-
-
0037129560
-
Epidemiology and outcomes of osteoporotic fractures
-
Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359:1761-1767.
-
(2002)
Lancet
, vol.359
, pp. 1761-1767
-
-
Cummings, S.R.1
Melton, L.J.2
-
5
-
-
33750209491
-
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
-
Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17:1726-1733.
-
(2006)
Osteoporos Int
, vol.17
, pp. 1726-1733
-
-
Johnell, O.1
Kanis, J.A.2
-
6
-
-
0029976494
-
Osteoporosis. Frequency, consequences, and risk factors
-
Ross PD. Osteoporosis. Frequency, consequences, and risk factors. Arch Intern Med. 1996;156:1399-1411.
-
(1996)
Arch Intern Med
, vol.156
, pp. 1399-1411
-
-
Ross, P.D.1
-
8
-
-
31044432767
-
Pathogenesis of osteoporosis: Concepts, conflicts and prospects
-
Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts and prospects. J Clin Invest. 2005;115:3318-3325.
-
(2005)
J Clin Invest
, vol.115
, pp. 3318-3325
-
-
Raisz, L.G.1
-
9
-
-
0019159483
-
Prevention of spinal osteoporosis in oophorectomised women
-
Lindsay R, Hart DM, Forrest C, Baird C. Prevention of spinal osteoporosis in oophorectomised women. Lancet. 1980;2(8205): 1151-1154.
-
(1980)
Lancet
, vol.2
, Issue.8205
, pp. 1151-1154
-
-
Lindsay, R.1
Hart, D.M.2
Forrest, C.3
Baird, C.4
-
10
-
-
0027529964
-
Bone density at various sites for prediction of hip fractures
-
Cummings SR, Black DM, Nevitt MC, et al. Bone density at various sites for prediction of hip fractures. Lancet. 1993;341:72-75.
-
(1993)
Lancet
, vol.341
, pp. 72-75
-
-
Cummings, S.R.1
Black, D.M.2
Nevitt, M.C.3
-
12
-
-
33646889773
-
Bone quality-the material and structural basis of bone strength and fragility
-
Seeman E, Delmas PD. Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354:2250-2261.
-
(2006)
N Engl J Med
, vol.354
, pp. 2250-2261
-
-
Seeman, E.1
Delmas, P.D.2
-
13
-
-
56349142989
-
Bone remodeling: Its local regulation and the emergence of bone fragility
-
Martin TJ, Seeman E. Bone remodeling: its local regulation and the emergence of bone fragility. Best Pract Res Clin Endo Endocrinol Metab. 2008;22:701-722.
-
(2008)
Best Pract Res Clin Endo Endocrinol Metab
, vol.22
, pp. 701-722
-
-
Martin, T.J.1
Seeman, E.2
-
14
-
-
84967614664
-
Sex steroids and the construction and conservation of the adult skeleton
-
Riggs BL, Khosla S, Melton LJ III. Sex steroids and the construction and conservation of the adult skeleton. Endo Rev. 2002;23:279-302.
-
(2002)
Endo Rev
, vol.23
, pp. 279-302
-
-
Riggs, B.L.1
Khosla, S.2
Melton III, L.J.3
-
15
-
-
13444256417
-
Mechanisms of sex steroid effects on bone
-
Syed F, Khosla S. Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun. 2005;328:688-696.
-
(2005)
Biochem Biophys Res Commun
, vol.328
, pp. 688-696
-
-
Syed, F.1
Khosla, S.2
-
16
-
-
77951161728
-
Mechanisms of estrogen action in bone
-
In: Bilezikian JP, Raisz LG, Martin TJ, editors, 3rd ed. USA: Elsevier Inc
-
Pacifici R. Mechanisms of estrogen action in bone. In: Bilezikian JP, Raisz LG, Martin TJ, editors. Principles of Bone Biology, 3rd ed. USA: Elsevier Inc; 2008. pp. 921-933.
-
(2008)
Principles of Bone Biology
, pp. 921-933
-
-
Pacifici, R.1
-
17
-
-
0029907556
-
Effects of hormone therapy on bone mineral density-results from the postmenopausal estrogen/ progestin interventions (PEPI) trial
-
Bush TL, Wells HB, James MK, et al. Effects of hormone therapy on bone mineral density-results from the postmenopausal estrogen/ progestin interventions (PEPI) trial. JAMA. 1996;276:1389-1396.
-
(1996)
JAMA
, vol.276
, pp. 1389-1396
-
-
Bush, T.L.1
Wells, H.B.2
James, M.K.3
-
18
-
-
34047237367
-
Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
-
Rossouw JE, Prentice RL, Manson JE, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA. 2007;297:1465-1477.
-
(2007)
JAMA
, vol.297
, pp. 1465-1477
-
-
Rossouw, J.E.1
Prentice, R.L.2
Manson, J.E.3
-
19
-
-
38049021024
-
The role of hormone therapy and calcium plus vitamin D for reduction of bone loss and risk for fractures: Lessons learned from the Women's Health Initiative
-
Jackson RD, Shidham S. The role of hormone therapy and calcium plus vitamin D for reduction of bone loss and risk for fractures: lessons learned from the Women's Health Initiative. Current Osteoporosis Reports. 2007;5(4):153-159.
-
(2007)
Current Osteoporosis Reports
, vol.5
, Issue.4
, pp. 153-159
-
-
Jackson, R.D.1
Shidham, S.2
-
20
-
-
0034687825
-
A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease
-
Grodstein F, Manson JE, Colditz GA, et al. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med. 2000;133:933-941.
-
(2000)
Ann Intern Med
, vol.133
, pp. 933-941
-
-
Grodstein, F.1
Manson, J.E.2
Colditz, G.A.3
-
21
-
-
0042093742
-
Women's Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease
-
Manson JE, Hsia J, Johnson KC, et al. Women's Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003;349:523-534.
-
(2003)
N Engl J Med
, vol.349
, pp. 523-534
-
-
Manson, J.E.1
Hsia, J.2
Johnson, K.C.3
-
22
-
-
77957126077
-
Effects of estrogen or estrogen/ progestin regimens on heart disease risk factors in postmenopausal women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
-
The Writing Group for the PEPI Trial
-
The Writing Group for the PEPI Trial. Effects of estrogen or estrogen/ progestin regimens on heart disease risk factors in postmenopausal women: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA. 1995;273:199-208.
-
(1995)
JAMA
, vol.273
, pp. 199-208
-
-
-
23
-
-
0642303149
-
Breast cancer and hormonal replacement therapy
-
Vassilopoulou-Sellin R. Breast cancer and hormonal replacement therapy. Ann N Y Acad Sci. 2003;997:341-350.
-
(2003)
Ann N Y Acad Sci
, vol.997
, pp. 341-350
-
-
Vassilopoulou-Sellin, R.1
-
24
-
-
51449124264
-
Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American menopause society
-
The North American Menopause Society
-
The North American Menopause Society. Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American menopause society. Menopause. 2008;15(4):584-602.
-
(2008)
Menopause
, vol.15
, Issue.4
, pp. 584-602
-
-
-
25
-
-
0035027169
-
Therapeutic potential of oestrogen receptor ligands in development for osteoporosis
-
Cho CH, Nuttall ME. Therapeutic potential of oestrogen receptor ligands in development for osteoporosis. Expert Opin Emerg Drugs. 2001;6:137-154.
-
(2001)
Expert Opin Emerg Drugs
, vol.6
, pp. 137-154
-
-
Cho, C.H.1
Nuttall, M.E.2
-
26
-
-
0024214940
-
Chemosuppression of breast cancer with tamoxifen-laboratory evidence and future clinical investigations
-
Jordan VC. Chemosuppression of breast cancer with tamoxifen-laboratory evidence and future clinical investigations. Cancer Investigation. 1988;6:589-595.
-
(1988)
Cancer Investigation
, vol.6
, pp. 589-595
-
-
Jordan, V.C.1
-
27
-
-
0025338591
-
Development of antiestrogens and their use in breast cancer (Eighth Cain Memorial award lecture)
-
Lerner LJ, Jordan VC. Development of antiestrogens and their use in breast cancer (Eighth Cain Memorial award lecture). Cancer Res. 1990;50:4177-4189.
-
(1990)
Cancer Res
, vol.50
, pp. 4177-4189
-
-
Lerner, L.J.1
Jordan, V.C.2
-
28
-
-
0002041213
-
SERM Drugs for the prevention of osteoporosis
-
Avioli LV. SERM Drugs for the prevention of osteoporosis. Trends Endocrinol Metab. 1999;10:317-319.
-
(1999)
Trends Endocrinol Metab
, vol.10
, pp. 317-319
-
-
Avioli, L.V.1
-
29
-
-
0037434618
-
Selective Estrogen-Receptor Modulators-Mechanisms of Action and Application to Clinical Practice
-
Riggs L, Hartmann LC. Selective Estrogen-Receptor Modulators-Mechanisms of Action and Application to Clinical Practice. N Engl J Med. 2003;348:618-629.
-
(2003)
N Engl J Med
, vol.348
, pp. 618-629
-
-
Riggs, L.1
Hartmann, L.C.2
-
30
-
-
0030667676
-
Molecular basis of agonism and antagonism in the oestrogen receptor
-
Brzozowski AM, Pike AC, Dauter Z, et al. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature. 1997;389:753-758.
-
(1997)
Nature
, vol.389
, pp. 753-758
-
-
Brzozowski, A.M.1
Pike, A.C.2
Dauter, Z.3
-
31
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau AK, Barstad D, Loria PM, et al. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell. 1998;95:927-937.
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
-
32
-
-
2642544810
-
Estrogen receptor (ER) modulators each induce distinct conformational changes in ERa and ERb
-
Paige LA, Christensen DJ, Grøn H, et al. Estrogen receptor (ER) modulators each induce distinct conformational changes in ERa and ERb. Proc Natl Acad Sci U S A. 1999;96:3999-4004.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3999-4004
-
-
Paige, L.A.1
Christensen, D.J.2
Grøn, H.3
-
33
-
-
13944279890
-
Oestrogen receptors and selective oestrogen receptor modulators: Molecular and cellular pharmacology
-
Nilsson S, Koehler KF. Oestrogen receptors and selective oestrogen receptor modulators: molecular and cellular pharmacology. Basic Clin Pharmacol Toxicol. 2005;96:15-25.
-
(2005)
Basic Clin Pharmacol Toxicol
, vol.96
, pp. 15-25
-
-
Nilsson, S.1
Koehler, K.F.2
-
34
-
-
34249055240
-
Selective estrogen receptor modulators for postmenopausal osteoporosis: Current state of development
-
Gennari L, Merlotti D, Valleggi F, Martini G, Nuti R. Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development. Drugs Aging. 2007;24:361-379.
-
(2007)
Drugs Aging
, vol.24
, pp. 361-379
-
-
Gennari, L.1
Merlotti, D.2
Valleggi, F.3
Martini, G.4
Nuti, R.5
-
35
-
-
61549094100
-
Bazedoxifene for the prevention of postmenopausal osteoporosis
-
Gennari L, Merlotti D, De Paola V, Martini G, Nuti R. Bazedoxifene for the prevention of postmenopausal osteoporosis. Ther Clin Risk Manag. 2008a;4(6):1229-1242.
-
(2008)
Ther Clin Risk Manag
, vol.4
, Issue.6
, pp. 1229-1242
-
-
Gennari, L.1
Merlotti, D.2
de Paola, V.3
Martini, G.4
Nuti, R.5
-
36
-
-
0030664688
-
Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women
-
Delmas PD, Bjarnason NH, Mitlak BH, et al. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med. 1997;337:1641-1647.
-
(1997)
N Engl J Med
, vol.337
, pp. 1641-1647
-
-
Delmas, P.D.1
Bjarnason, N.H.2
Mitlak, B.H.3
-
37
-
-
0031755910
-
Treatment of established postmenopausal osteoporosis with raloxifene: A randomized trial
-
Lufkin EG, Whitaker MD, Nickelsen T, et al. Treatment of established postmenopausal osteoporosis with raloxifene: a randomized trial. J Bone Miner Res. 1998;13:1747-1754.
-
(1998)
J Bone Miner Res
, vol.13
, pp. 1747-1754
-
-
Lufkin, E.G.1
Whitaker, M.D.2
Nickelsen, T.3
-
38
-
-
0033581212
-
Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators
-
Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA. 1999;282(7):637-645.
-
(1999)
JAMA
, vol.282
, Issue.7
, pp. 637-645
-
-
Ettinger, B.1
Black, D.M.2
Mitlak, B.H.3
-
39
-
-
0023547257
-
Effects of anti-estrogens on bone in castrated and intact female rats
-
Jordan VC, Phelps E, Lindgren JU. Effects of anti-estrogens on bone in castrated and intact female rats. Breast Cancer Res Treat. 1987;10:31-35.
-
(1987)
Breast Cancer Res Treat
, vol.10
, pp. 31-35
-
-
Jordan, V.C.1
Phelps, E.2
Lindgren, J.U.3
-
40
-
-
0028033883
-
Effect of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years
-
Love RR, Barden HS, Mazess RB, et al. Effect of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years. Arch Intern Med. 1994;154:2585-2588.
-
(1994)
Arch Intern Med
, vol.154
, pp. 2585-2588
-
-
Love, R.R.1
Barden, H.S.2
Mazess, R.B.3
-
41
-
-
0034455674
-
A comparison of the effects of raloxifene and estrogen on bone in postmenopausal women
-
Prestwood KM, Gunness M, Muchmore DB, et al. A comparison of the effects of raloxifene and estrogen on bone in postmenopausal women. J Clin Endocrinol Metab. 2000;85:2197-2202.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 2197-2202
-
-
Prestwood, K.M.1
Gunness, M.2
Muchmore, D.B.3
-
42
-
-
0344445501
-
Effects of raloxifene, hormone replacement therapy, and placebo on bone turnover in postmenopausal women
-
Weinstein RS, Parfitt AM, Marcus R, et al. Effects of raloxifene, hormone replacement therapy, and placebo on bone turnover in postmenopausal women. Osteoporos Int. 2003;14:814-822.
-
(2003)
Osteoporos Int
, vol.14
, pp. 814-822
-
-
Weinstein, R.S.1
Parfitt, A.M.2
Marcus, R.3
-
44
-
-
67649595194
-
Ospemifene use in postmenopausal women
-
Gennari L, Merlotti D, Valleggi F, Nuti R. Ospemifene use in postmenopausal women. Expert Opin Investig Drugs. 2009;18(6):839-849.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, Issue.6
, pp. 839-849
-
-
Gennari, L.1
Merlotti, D.2
Valleggi, F.3
Nuti, R.4
-
45
-
-
0032581614
-
Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene
-
Rosati RL, Da Silva Jardine P, Cameron KO. Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene. J Med Chem. 1998;41:2928-2931.
-
(1998)
J Med Chem
, vol.41
, pp. 2928-2931
-
-
Rosati, R.L.1
Da Silva Jardine, P.2
Cameron, K.O.3
-
46
-
-
0001236520
-
Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models
-
Ke HZ, Paralkar VM, Grasser WA. Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models. Endocrinology. 1998;139:2068-2076.
-
(1998)
Endocrinology
, vol.139
, pp. 2068-2076
-
-
Ke, H.Z.1
Paralkar, V.M.2
Grasser, W.A.3
-
47
-
-
33748201643
-
Lasofoxifene: A third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis
-
Gennari L, Merlotti D, Martini G, Nuti R. Lasofoxifene: a third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis. Expert Opin Investig Drugs. 2006a;15: 1091-1103.
-
(2006)
Expert Opin Investig Drugs
, vol.15
, pp. 1091-1103
-
-
Gennari, L.1
Merlotti, D.2
Martini, G.3
Nuti, R.4
-
49
-
-
33746261241
-
Lasofoxifene: A new type of selective estrogen receptor modulator for the treatment of osteoporosis
-
Gennari L. Lasofoxifene: a new type of selective estrogen receptor modulator for the treatment of osteoporosis. Drugs Today (Barc). 2006b;42:355-367.
-
(2006)
Drugs Today (Barc)
, vol.42
, pp. 355-367
-
-
Gennari, L.1
-
50
-
-
27544445005
-
Effect of Food on the Pharmacokinetics of Lasofoxifene, in Healthy Postmenopausal Women
-
Abstract SU487
-
Moller R, Fisher J, Taylor A, et al. Effect of Food on the Pharmacokinetics of Lasofoxifene, in Healthy Postmenopausal Women. J Bone Miner Res. 2004;19:Abstract SU487.
-
(2004)
J Bone Miner Res
, pp. 19
-
-
Moller, R.1
Fisher, J.2
Taylor, A.3
-
51
-
-
27544514718
-
A Single-Dose Pharmacokinetic Study of Lasofoxifene in Japanese and Caucasian Postmenopausal Women
-
Abstract M469
-
Gardner M, Nishizawa Y, Wei G, et al. A Single-Dose Pharmacokinetic Study of Lasofoxifene in Japanese and Caucasian Postmenopausal Women. J Bone Miner Res. 2004;19:Abstract M469.
-
(2004)
J Bone Miner Res
, pp. 19
-
-
Gardner, M.1
Nishizawa, Y.2
Wei, G.3
-
52
-
-
29644446214
-
Clinical pharmacology of multiple doses of lasofoxifene in postmenopausal women
-
Gardner M, Taylor A, Wei G, et al. Clinical pharmacology of multiple doses of lasofoxifene in postmenopausal women. J Clin Pharmacol. 2006;46:52-58.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 52-58
-
-
Gardner, M.1
Taylor, A.2
Wei, G.3
-
53
-
-
33745286232
-
Clinical pharmacology of lasofoxifene in Japanese and white postmenopausal women
-
Fountaine RJ, Nishizawa Y, Wei G, Dogolo L, Calcagni A, Gardner MJ. Clinical pharmacology of lasofoxifene in Japanese and white postmenopausal women. J Clin Pharmacol. 2006;46:693-699.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 693-699
-
-
Fountaine, R.J.1
Nishizawa, Y.2
Wei, G.3
Dogolo, L.4
Calcagni, A.5
Gardner, M.J.6
-
54
-
-
0022312813
-
D-1,2-Dyaril-3,4-dihydronaphthalenes: Photofluorogenic ligands for the estrogen receptor
-
Katzenellenbogen JA. D-1,2-Dyaril-3,4-dihydronaphthalenes: photofluorogenic ligands for the estrogen receptor. J Steroid Biochem. 1985;23:929-937.
-
(1985)
J Steroid Biochem
, vol.23
, pp. 929-937
-
-
Katzenellenbogen, J.A.1
-
55
-
-
29644443552
-
In vivo and in vitro metabolites of a next-generation selective estrogen receptor modulator, lasofoxifene, in humans
-
Jhonson KA, Gardner MJ, Prakash C. In vivo and in vitro metabolites of a next-generation selective estrogen receptor modulator, lasofoxifene, in humans. Drug Metab Rev. 2004;36:246.
-
(2004)
Drug Metab Rev
, vol.36
, pp. 246
-
-
Jhonson, K.A.1
Gardner, M.J.2
Prakash, C.3
-
56
-
-
27844504738
-
Effect of lasofoxifene on the pharmacokinetics of digoxin in healthy postmenopausal women
-
Roman D, Bramson C, Ouellet D, et al. Effect of lasofoxifene on the pharmacokinetics of digoxin in healthy postmenopausal women. J Clin Pharmacol. 2005;45:1407-1412.
-
(2005)
J Clin Pharmacol
, vol.45
, pp. 1407-1412
-
-
Roman, D.1
Bramson, C.2
Ouellet, D.3
-
57
-
-
32344443131
-
Effects of Steady-State Lasofoxifene on CYP2D6- and CYP2E1-Mediated Metabolism
-
Moller RA, Fisher JM, Taylor AE, et al. Effects of Steady-State Lasofoxifene on CYP2D6- and CYP2E1-Mediated Metabolism. Ann Pharmacother. 2006;40:32-37.
-
(2006)
Ann Pharmacother
, vol.40
, pp. 32-37
-
-
Moller, R.A.1
Fisher, J.M.2
Taylor, A.E.3
-
58
-
-
29644437590
-
A single-dose pharmacokinetic study of lasofoxifene in healthy volunteers and subjects with mild and moderate hepatic impairment
-
Bramson C, Ouellet D, Roman D, et al. A single-dose pharmacokinetic study of lasofoxifene in healthy volunteers and subjects with mild and moderate hepatic impairment. J Clin Pharmacol. 2006;46:29-36.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 29-36
-
-
Bramson, C.1
Ouellet, D.2
Roman, D.3
-
59
-
-
33646920045
-
Effects of lasofoxifene on the pharmacokinetics and pharmacodynamics of single-dose warfarin
-
Ouellet D, Bramson C, Carvajal-Gonzalez S, Roman D, Randinitis E, Remmers A, et al. Effects of lasofoxifene on the pharmacokinetics and pharmacodynamics of single-dose warfarin. Br J Clin Pharmacol. 2006;61:741-745.
-
(2006)
Br J Clin Pharmacol
, vol.61
, pp. 741-745
-
-
Ouellet, D.1
Bramson, C.2
Carvajal-Gonzalez, S.3
Roman, D.4
Randinitis, E.5
Remmers, A.6
-
60
-
-
33746257434
-
Effects of different dose regimens of lasofoxifene (CP-336,156) in preventing bone loss in ovariectomized rats
-
Ke HZ, Qi H, Chidsey-Frink KL, et al. Effects of different dose regimens of lasofoxifene (CP-336,156) in preventing bone loss in ovariectomized rats. J Bone Miner Res. 2000a;15:S1-S310.
-
(2000)
J Bone Miner Res
, vol.15
-
-
Ke, H.Z.1
Qi, H.2
Chidsey-Frink, K.L.3
-
61
-
-
1642489155
-
Long-term treatment of lasofoxifene preserves bone mass and bone strength and does not adversely affect the uterus in ovariectomized rats
-
Ke HZ, Foley GL, Simmons HA, Shen V, Thompson DD. Long-term treatment of lasofoxifene preserves bone mass and bone strength and does not adversely affect the uterus in ovariectomized rats. Endocrinology. 2004;145:1996-2005.
-
(2004)
Endocrinology
, vol.145
, pp. 1996-2005
-
-
Ke, H.Z.1
Foley, G.L.2
Simmons, H.A.3
Shen, V.4
Thompson, D.D.5
-
62
-
-
0034457008
-
Lasofoxifene (CP-336-156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat
-
Ke HZ, Qi H, Crawford DT, et al. Lasofoxifene (CP-336-156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat. Endocrinology. 2000b; 141:1338-1344.
-
(2000)
Endocrinology
, vol.141
, pp. 1338-1344
-
-
Ke, H.Z.1
Qi, H.2
Crawford, D.T.3
-
63
-
-
0035082747
-
Lasofoxifene (CP-336-156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats
-
Ke HZ, Oi H, Chidsey-Frink KL, et al. Lasofoxifene (CP-336-156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats. J Bone Miner Res. 2001;16:765-773.
-
(2001)
J Bone Miner Res
, vol.16
, pp. 765-773
-
-
Ke, H.Z.1
Oi, H.2
Chidsey-Frink, K.L.3
-
64
-
-
14844308652
-
Comparison of the effects of bazedoxifene, raloxifene, lasofoxifene and risedronate, co-treatment on h-PTH-induced reversal of established osteopenia in ovariectomized rats
-
Kharode YP, Green PD, Marzolf JT, et al. Comparison of the effects of bazedoxifene, raloxifene, lasofoxifene and risedronate, co-treatment on h-PTH-induced reversal of established osteopenia in ovariectomized rats. J Bone Miner Res. 2003;18:S273.
-
(2003)
J Bone Miner Res
, vol.18
-
-
Kharode, Y.P.1
Green, P.D.2
Marzolf, J.T.3
-
65
-
-
0035893734
-
LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-nitroso-N-methylurea-induced rat mammary tumor model
-
Cohen LA, Pittman B, Wang CX, et al. LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-nitroso-N-methylurea-induced rat mammary tumor model. Cancer Res. 2001;61:8683-8688.
-
(2001)
Cancer Res
, vol.61
, pp. 8683-8688
-
-
Cohen, L.A.1
Pittman, B.2
Wang, C.X.3
-
66
-
-
77951184874
-
Lasofoxifene: The evidence of its therapeutic value in osteoporosis
-
Gennari L, Merlotti D, De Paola V, Nuti R. Lasofoxifene: the evidence of its therapeutic value in osteoporosis. Core Evidence. 2009;4:113-129.
-
(2009)
Core Evidence
, vol.4
, pp. 113-129
-
-
Gennari, L.1
Merlotti, D.2
de Paola, V.3
Nuti, R.4
-
68
-
-
33746218233
-
Lasofoxifene Phase 2 and Phase 3 Clinical Trial Design and Strategy
-
Abstract M384
-
Lee A, Radecki D, Wolter K, et al. Lasofoxifene Phase 2 and Phase 3 Clinical Trial Design and Strategy. J Bone Miner Res. 2005;20:Abstract M384.
-
(2005)
J Bone Miner Res
, pp. 20
-
-
Lee, A.1
Radecki, D.2
Wolter, K.3
-
69
-
-
33645377680
-
Lasofoxifene phase 2 dose response analysis in postmenopausal women
-
Abstract M385
-
Day W, Martel J, Lee A. Lasofoxifene phase 2 dose response analysis in postmenopausal women. J Bone Miner Res. 2005;20:Abstract M385.
-
(2005)
J Bone Miner Res
, pp. 20
-
-
Day, W.1
Martel, J.2
Lee, A.3
-
70
-
-
17144396489
-
Lasofoxifene, a Next Generation SERM, is Effective in Preventing Loss of BMD and Reducing LDL-C in Postmenopausal Women
-
Abstract SA426
-
Moffett AH, Ettinger M, Bolognese M, et al. Lasofoxifene, a Next Generation SERM, is Effective in Preventing Loss of BMD and Reducing LDL-C in Postmenopausal Women. J Bone Miner Res. 2004;19: Abstract SA426.
-
(2004)
J Bone Miner Res
, pp. 19
-
-
Moffett, A.H.1
Ettinger, M.2
Bolognese, M.3
-
71
-
-
27544495693
-
Lasofoxifene, a selective estrogen receptor modulator, improves objective measures of vaginal atrophy
-
Portman DJ, Moffett AH, Bachman GA, West C, Symons J. Lasofoxifene, a selective estrogen receptor modulator, improves objective measures of vaginal atrophy. Obstetrics and Gynecology. 2004;103:25S-26S.
-
(2004)
Obstetrics and Gynecology
, vol.103
-
-
Portman, D.J.1
Moffett, A.H.2
Bachman, G.A.3
West, C.4
Symons, J.5
-
72
-
-
77951179411
-
Lasofoxifene: A next generation selective estrogen receptor modulator (SERM) in the prevention of bone loss in postmenopausal women
-
June 16-19; New Orleans, LA
-
Ettinger M, Schwartz E, Emkey R, et al. Lasofoxifene: a next generation selective estrogen receptor modulator (SERM) in the prevention of bone loss in postmenopausal women. 86th Annual Meeting of the Endocrine Society; 2004 June 16-19; New Orleans, LA.
-
(2004)
86th Annual Meeting of The Endocrine Society
-
-
Ettinger, M.1
Schwartz, E.2
Emkey, R.3
-
73
-
-
0003906060
-
-
Lingand pharmaceutical Internetional Inc., Available from
-
Lingand pharmaceutical Internetional Inc., Annual Report 2000. Available from http//investors.ligand.com.
-
Annual Report 2000
-
-
-
74
-
-
17144379874
-
Comparison of the extraskeletal effects of lasofoxifene and raloxifene
-
Abstract SA423
-
McClung M, Portman D, Emkey R, et al. Comparison of the extraskeletal effects of lasofoxifene and raloxifene. J Bone Miner Res. 2004;19: Abstract SA423.
-
(2004)
J Bone Miner Res
, pp. 19
-
-
McClung, M.1
Portman, D.2
Emkey, R.3
-
75
-
-
33745253921
-
Prevention of bone loss in postmenopausal women treated with lasofoxifene compared with raloxifene
-
McClung MR, Siris E, Cummings S, et al. Prevention of bone loss in postmenopausal women treated with lasofoxifene compared with raloxifene. Menopause. 2006;13:377-386.
-
(2006)
Menopause
, vol.13
, pp. 377-386
-
-
McClung, M.R.1
Siris, E.2
Cummings, S.3
-
76
-
-
33748189110
-
Lasofoxifene Increased BMD of the Spine and Hip and Decreased Bone Turnover Markers in Postmenopausal Women with Low or Normal BMD
-
Abstract F429
-
McClung M, Siris E, Cummings S, et al. Lasofoxifene Increased BMD of the Spine and Hip and Decreased Bone Turnover Markers in Postmenopausal Women with Low or Normal BMD. J Bone Miner Res. 2005;20:Abstract F429.
-
(2005)
J Bone Miner Res
, pp. 20
-
-
McClung, M.1
Siris, E.2
Cummings, S.3
-
77
-
-
33645361883
-
Extraskeletal Effects of Lasofoxifene on Postmenopausal Women
-
Abstract SA428
-
Davidson M, Moffett A, Welty F, et al. Extraskeletal Effects of Lasofoxifene on Postmenopausal Women. J Bone Miner Res. 2005;20: Abstract SA428.
-
(2005)
J Bone Miner Res
, pp. 20
-
-
Davidson, M.1
Moffett, A.2
Welty, F.3
-
78
-
-
67149139468
-
The Effects of Lasofoxifene on Bone Turnover Markers: The PEARL Trial
-
Abstract 1287
-
Eastell R, Reid DM, Vukicevic S, et al. The Effects of Lasofoxifene on Bone Turnover Markers: the PEARL Trial. J Bone Miner Res. 2008;23: Abstract 1287.
-
(2008)
J Bone Miner Res
, pp. 23
-
-
Eastell, R.1
Reid, D.M.2
Vukicevic, S.3
-
79
-
-
68949128124
-
A randomized double blinded controlled trial of individual response in biochemical markers of bone turnover to lasofoxifene therapy
-
Abstract M507
-
Glover SJ, Rogers A, Gossiel F, Eastell R. A randomized double blinded controlled trial of individual response in biochemical markers of bone turnover to lasofoxifene therapy. J Bone Miner Res. 2008;23: Abstract M507.
-
(2008)
J Bone Miner Res
, pp. 23
-
-
Glover, S.J.1
Rogers, A.2
Gossiel, F.3
Eastell, R.4
-
80
-
-
67149136308
-
The effects of lasofoxifene on fractures and breast cancer: 3-year results from the PEARL Trial
-
Abstract 1288
-
Cummings SR, Eastell R, Ensrud K, et al. The effects of lasofoxifene on fractures and breast cancer: 3-year results from the PEARL Trial. J Bone Miner Res. 2008;23:Abstract 1288.
-
(2008)
J Bone Miner Res
, pp. 23
-
-
Cummings, S.R.1
Eastell, R.2
Ensrud, K.3
-
82
-
-
33044494094
-
A systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosis
-
Stevenson N, Jones ML, De Nigris E, Brewer N, Davis S, Oakley J. A systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosis. Health Technol Assess. 2005; 9:1-160.
-
(2005)
Health Technol Assess
, vol.9
, pp. 1-160
-
-
Stevenson, N.1
Jones, M.L.2
de Nigris, E.3
Brewer, N.4
Davis, S.5
Oakley, J.6
|