Nanoparticle inhalation impairs coronary microvascular reactivity via a local reactive oxygen species-dependent mechanism

Cardiovascular Toxicology

Volumn 10, Issue 1, 2010, Pages 27-36

  Leblanc, A J ^a,b   Moseley, A M ^c   Chen, B T ^c   Frazer, D ^b,c   Castranova, V ^c   Nurkiewicz, T R ^a,b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Arteriole; Coronary; Inhalation; Microcirculation; Nanoparticle; Reactive oxygen species; Titanium dioxide; Vasodilation

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; ARACHIDONIC ACID; CATALASE; HYDROETHIDINE; INDOMETACIN; N(G) METHYLARGININE; NANOPARTICLE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN; PROSTANOID; REACTIVE OXYGEN METABOLITE; TEMPONE; TITANIUM DIOXIDE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL REACTIVITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY DILATATION; ENDOTHELIAL DYSFUNCTION; FLUORESCENCE ANALYSIS; LUNG DEPOSIT; MALE; MICROCIRCULATION; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INHALATION; ANIMALS; ARACHIDONIC ACID; ARTERIOLES; BODY WEIGHT; CAPILLARIES; CORONARY CIRCULATION; CORONARY VESSELS; HEART; MALE; NANOPARTICLES; NITRIC OXIDE; ORGAN SIZE; OXIDATIVE STRESS; PROSTAGLANDINS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THROMBOXANES; TITANIUM; VASOCONSTRICTION; VASODILATION;

RATTUS;

EID: 77951126792     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-009-9060-4     Document Type: Article

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