Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling

Toxicological Sciences

Volumn 110, Issue 1, 2009, Pages 191-203

  Nurkiewicz, Timothy R ^a,c   Porter, Dale W ^a,b   Hubbs, Ann F ^b   Stone, Samuel ^b   Chen, Bean T ^b   Frazer, David G ^a,b   Boegehold, Matthew A ^a   Castranova, Vincent ^b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Arteriole; Endothelium; Inhalation; Nanoparticle; Nitric oxide; Systemic microcirculation

Indexed keywords

CALCIMYCIN; MYELOPEROXIDASE; NANOPARTICLE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; REACTIVE OXYGEN METABOLITE; SCAVENGER; TITANIUM DIOXIDE;

AEROSOL; ANIMAL EXPERIMENT; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; IONTOPHORESIS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; RAT; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; CALCIMYCIN; CAPILLARIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; INHALATION EXPOSURE; LUNG; MALE; NANOPARTICLES; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROPRUSSIDE; OXIDATIVE STRESS; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TITANIUM; TYROSINE; VASODILATION;

RATTUS;

EID: 67649236667     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp051     Document Type: Article

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