Expression and characterization of a constitutively active STAT6 from Tetraodon

Fish and Shellfish Immunology

Volumn 28, Issue 5-6, 2010, Pages 819-828

  Sung, Shu Chiun ^a   Cheng, Chia Hsiung ^a,b   Chou, Chih Ming ^c   Chu, Cheng Ying ^a   Chen, Gen Der ^a   Hwang, Pung Pung ^d   Huang, Fore Lien ^b   Huang, Chang Jen ^a  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

DNA binding; Interleukin 4; Pufferfish; Reporter assay; STAT6

Indexed keywords

CYPRINIDAE; MAMMALIA; TETRAODON; TETRAODON NIGROVIRIDIS; TETRAODONTIDAE;

EID: 77951099550     PISSN: 10504648     EISSN: 10959947     Source Type: Journal    
DOI: 10.1016/j.fsi.2010.01.015     Document Type: Article

References (73)

1. Ihle J.N., and Kerr I.M. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 11 (1995) 69-74
2. Rawlings J.S., Rosler K.M., and Harrison D.A. The JAK/STAT signaling pathway. J Cell Sci 117 (2004) 1281-1283
3. Schindler U., Wu P., Rothe M., Brasseur M., and McKnight S.L. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2 (1995) 689-697
4. Watanabe S., and Arai K. Roles of the JAK-STAT system in signal transduction via cytokine receptors. Curr Opin Genet Dev 6 (1996) 587-596
5. Darnell Jr. J.E. STATs and gene regulation. Science 277 (1997) 1630-1635
6. de Prati A.C., Ciampa A.R., Cavalieri E., Zaffini R., Darra E., Menegazzi M., et al. STAT1 as a new molecular target of anti-inflammatory treatment. Curr Med Chem 12 (2005) 1819-1828
7. Durbin J.E., Hackenmiller R., Simon M.C., and Levy D.E. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84 (1996) 443-450
8. Catlett-Falcone R., Landowski T.H., Oshiro M.M., Turkson J., Levitzki A., Savino R., et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10 (1999) 105-115
9. Fukada T., Hibi M., Yamanaka Y., Takahashi-Tezuka M., Fujitani Y., Yamaguchi T., et al. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5 (1996) 449-460
10. Hodge D.R., Hurt E.M., and Farrar W.L. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41 (2005) 2502-2512
11. Akira S. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17 (1999) 138-146
12. Barash I. Stat5 in the mammary gland: controlling normal development and cancer. J Cell Physiol 209 (2006) 305-313
13. Bunting K.D. STAT5 signaling in normal and pathologic hematopoiesis. Front Biosci 12 (2007) 2807-2820
14. Frank D.A. STAT signaling in the pathogenesis and treatment of cancer. Mol Med 5 (1999) 432-456
15. Hebenstreit D., Wirnsberger G., Horejs-Hoeck J., and Duschl A. Signaling mechanisms, interaction partners, and target genes of STAT6. Cytokine Growth Factor Rev 17 (2006) 173-188
16. Leonard W.J., and O'Shea J.J. Jaks and STATs: biological implications. Annu Rev Immunol 16 (1998) 293-322
17. Watford W.T., Hissong B.D., Bream J.H., Kanno Y., Muul L., and O'Shea J.J. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev 202 (2004) 139-156
18. Hou J., Schindler U., Henzel W.J., Ho T.C., Brasseur M., and McKnight S.L. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265 (1994) 1701-1706
19. Quelle F.W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S.M., et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol 15 (1995) 3336-3343
20. Paul W.E. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77 (1991) 1859-1870
21. Seder R.A., and Paul W.E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12 (1994) 635-673
22. Coffman R.L., Lebman D.A., and Rothman P. Mechanism and regulation of immunoglobulin isotype switching. Adv Immunol 54 (1993) 229-270
23. Takeda K., Tanaka T., Shi W., Matsumoto M., Minami M., Kashiwamura S., et al. Essential role of Stat6 in IL-4 signalling. Nature 380 (1996) 627-630
24. Lin J.X., Migone T.S., Tsang M., Friedmann M., Weatherbee J.A., Zhou L., et al. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2 (1995) 331-339
25. Ryan J.J., McReynolds L.J., Keegan A., Wang L.H., Garfein E., Rothman P., et al. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 4 (1996) 123-132
26. Kammer W., Lischke A., Moriggl R., Groner B., Ziemiecki A., Gurniak C.B., et al. Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling. J Biol Chem 271 (1996) 23634-23637
27. Kotanides H., and Reich N.C. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262 (1993) 1265-1267
28. Rothman P., Li S.C., Gorham B., Glimcher L., Alt F., and Boothby M. Identification of a conserved lipopolysaccharide-plus-interleukin-4- responsive element located at the promoter of germ line epsilon transcripts. Mol Cell Biol 11 (1991) 5551-5561
29. Lundgren M., Larsson C., Femino A., Xu M., Stavnezer J., and Severinson E. Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. J Immunol 153 (1994) 2983-2995
30. Mikita T., Campbell D., Wu P., Williamson K., and Schindler U. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol Cell Biol 16 (1996) 5811-5820
31. Lu B., Reichel M., Fisher D.A., Smith J.F., and Rothman P. Identification of a STAT6 domain required for IL-4-induced activation of transcription. J Immunol 159 (1997) 1255-1264
32. Leu J.H., Chang M.S., Yao C.W., Chou C.K., Chen S.T., and Huang C.J. Genomic organization and characterization of the promoter region of the round-spotted pufferfish (Tetraodon fluviatilis) JAK1 kinase gene. Biochim Biophys Acta 1395 (1998) 50-56
33. Leu J.H., Yan S.J., Lee T.F., Chou C.M., Chen S.T., Hwang P.P., et al. Complete genomic organization and promoter analysis of the round- spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes. DNA Cell Biol 19 (2000) 431-446
34. Sung S.C., Fan T.J., Chou C.M., Leu J.H., Hsu Y.L., Chen S.T., et al. Genomic structure, expression and characterization of a STAT5 homologue from pufferfish (Tetraodon fluviatilis). Eur J Biochem 270 (2003) 239-252
35. Conway G., Margoliath A., Wong-Madden S., Roberts R.J., and Gilbert W. Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos. Proc Natl Acad Sci U S A 94 (1997) 3082-3087
36. Oates A.C., Brownlie A., Pratt S.J., Irvine D.V., Liao E.C., Paw B.H., et al. Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis. Blood 94 (1999) 2622-2636
37. Oates A.C., Wollberg P., Pratt S.J., Paw B.H., Johnson S.L., Ho R.K., et al. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Dev Dyn 215 (1999) 352-370
38. Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., et al. Expression, characterization, and genomic structure of carp JAK1 kinase gene. DNA Cell Biol 15 (1996) 827-844
39. Yin Z., and Kwang J. Molecular cloning of a carp Jak3 from activated leukocytes. Vet Immunol Immunopathol 74 (2000) 225-236
40. Zhang Y., and Gui J. Molecular characterization and IFN signal pathway analysis of Carassius auratus CaSTAT1 identified from the cultured cells in response to virus infection. Dev Comp Immunol 28 (2004) 211-227
41. Park E.M., Kang J.H., Seo J.S., Kim G., Chung J., and Choi T.J. Molecular cloning and expression analysis of the STAT1 gene from olive flounder, Paralichthys olivaceus. BMC Immunol 9 (2008) 31
42. Guo C.J., Zhang Y.F., Yang L.S., Yang X.B., Wu Y.Y., Liu D., et al. The JAK and STAT family members of the mandarin fish Siniperca chuatsi: molecular cloning, tissues distribution and immunobiological activity. Fish Shellfish Immunol 27 (2009) 349-359
43. Corripio-Miyar Y., Zou J., Richmond H., and Secombes C.J. Identification of interleukin-22 in gadoids and examination of its expression level in vaccinated fish. Mol Immunol 46 (2009) 2098-2106
44. Diaz-Rosales P., Bird S., Wang T.H., Fujiki K., Davidson W.S., Zou J., et al. Rainbow trout interleukin-2: cloning, expression and bioactivity analysis. Fish Shellfish Immunol 27 (2009) 414-422
45. Igawa D., Sakai M., and Savan R. An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Mol Immunol 43 (2006) 999-1009
46. Iliev D.B., Castellana B., Mackenzie S., Planas J.V., and Goetz F.W. Cloning and expression analysis of an IL-6 homolog in rainbow trout (Oncorhynchus mykiss). Mol Immunol 44 (2007) 1803-1807
47. Inoue Y., Kamota S., Ito K., Yoshiura Y., Ototake M., Moritomo T., et al. Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) interleukin-10 cDNAs. Fish Shellfish Immunol 18 (2005) 335-344
48. Laing K.J., Zou J.J., Wang T., Bols N., Hirono I., Aoki T., et al. Identification and analysis of an interleukin 8-like molecule in rainbow trout Oncorhynchus mykiss. Dev Comp Immunol 26 (2002) 433-444
49. Li J.H., Shao J.Z., Xiang L.X., and Wen Y. Cloning, characterization and expression analysis of pufferfish interleukin-4 cDNA: the first evidence of Th2-type cytokine in fish. Mol Immunol 44 (2007) 2078-2086
50. Wang T, Diaz-Rosales P, Martin SA, Secombes CJ. Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family. Dev Comp Immunol 2009;in press.
51. Wang T., Holland J.W., Bols N., and Secombes C.J. Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss. FEBS J 272 (2005) 1136-1147
52. Wang T., Holland J.W., Carrington A., Zou J., and Secombes C.J. Molecular and functional characterization of IL-15 in rainbow trout Oncorhynchus mykiss: a potent inducer of IFN-gamma expression in spleen leukocytes. J Immunol 179 (2007) 1475-1488
53. Zou J., Bird S., Truckle J., Bols N., Horne M., and Secombes C. Identification and expression analysis of an IL-18 homologue and its alternatively spliced form in rainbow trout (Oncorhynchus mykiss). Eur J Biochem 271 (2004) 1913-1923
54. Zou J., Carrington A., Collet B., Dijkstra J.M., Yoshiura Y., Bols N., et al. Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fish. J Immunol 175 (2005) 2484-2494
55. Jaillon O., Aury J.M., Brunet F., Petit J.L., Stange-Thomann N., Mauceli E., et al. Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature 431 (2004) 946-957
56. Wang T., and Secombes C.J. Cloning and expression of a putative common cytokine receptor gamma chain (gammaC) gene in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol 11 (2001) 233-244
57. Evans D.L., Leary III J.H., and Jaso-Friedmann L. An antigen receptor (NCCRP-1) on nonspecific cytotoxic cells is a phosphoprotein associated with the JAK-STAT activation pathway. Cell Signal 11 (1999) 287-292
58. Jaso-Friedmann L., Leary III J.H., and Evans D.L. The non-specific cytotoxic cell receptor (NCCRP-1): molecular organization and signaling properties. Dev Comp Immunol 25 (2001) 701-711
59. Jaso-Friedmann L., Peterson D.S., Gonzalez D.S., and Evans D.L. The antigen receptor (NCCRP-1) on catfish and zebrafish nonspecific cytotoxic cells belongs to a new gene family characterized by an F-box-associated domain. J Mol Evol 54 (2002) 386-395
60. Gouilleux F., Wakao H., Mundt M., and Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J 13 (1994) 4361-4369
61. Harris M.B., Chang C.C., Berton M.T., Danial N.N., Zhang J., Kuehner D., et al. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol 19 (1999) 7264-7275
62. Ariyoshi K., Nosaka T., Yamada K., Onishi M., Oka Y., Miyajima A., et al. Constitutive activation of STAT5 by a point mutation in the SH2 domain. J Biol Chem 275 (2000) 24407-24413
63. Chang M.S., Chang G.D., Leu J.H., Huang F.L., Chou C.K., Huang C.J., et al. Expression, characterization, and genomic structure of carp JAK1 kinase gene. DNA Cell Biol 15 (1996) 827-844
64. Schmitt-Ney M., Doppler W., Ball R.K., and Groner B. Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor. Mol Cell Biol 11 (1991) 3745-3755
65. Shuai K., Horvath C.M., Huang L.H., Qureshi S.A., Cowburn D., and Darnell Jr. J.E. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76 (1994) 821-828
66. Moriggl R., Berchtold S., Friedrich K., Standke G.J., Kammer W., Heim M., et al. Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Mol Cell Biol 17 (1997) 3663-3678
67. Copeland N.G., Gilbert D.J., Schindler C., Zhong Z., Wen Z., Darnell Jr. J.E., et al. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 29 (1995) 225-228
68. Becker S., Groner B., and Muller C.W. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394 (1998) 145-151
69. Chen X., Vinkemeier U., Zhao Y., Jeruzalmi D., Darnell Jr. J.E., and Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93 (1998) 827-839
70. Ghosh G., van Duyne G., Ghosh S., and Sigler P.B. Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature 373 (1995) 303-310
71. Schjerven H., Brandtzaeg P., and Johansen F.E. Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response. J Immunol 165 (2000) 3898-3906
72. Mikita T., Daniel C., Wu P., and Schindler U. Mutational analysis of the STAT6 SH2 domain. J Biol Chem 273 (1998) 17634-17642
73. Zhang T., Kee W.H., Seow K.T., Fung W., and Cao X. The coiled-coil domain of Stat3 is essential for its SH2 domain- mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6. Mol Cell Biol 20 (2000) 7132-7139