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Volumn 9, Issue , 2010, Pages

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; DEDICATOR OF CYTOKINESIS 2; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P110ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE P110BETA; PHOSPHATIDYLINOSITOL 3 KINASE P110DELTA; PHOSPHATIDYLINOSITOL 3 KINASE P110GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE P85ALPHA; PROTEIN TYROSINE KINASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; DOCK2 PROTEIN, HUMAN; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; FOCAL ADHESION KINASE 1; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PTK2 PROTEIN, HUMAN;

EID: 77951066411     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-85     Document Type: Article
Times cited : (54)

References (57)
  • 1
    • 43449127502 scopus 로고    scopus 로고
    • Prostate cancer
    • 10.1016/S0140-6736(08)60729-1, 18486743
    • Damber J-E, Aus G. Prostate cancer. Lancet 2008, 371:1710-1721. 10.1016/S0140-6736(08)60729-1, 18486743.
    • (2008) Lancet , vol.371 , pp. 1710-1721
    • Damber, J.-.E.1    Aus, G.2
  • 3
    • 33846689253 scopus 로고    scopus 로고
    • Prostate Cancer: A Practical Approach to Current Management of Recurrent Disease
    • 10.4065/82.2.243, 17290734
    • Walczak JR, Carducci MA. Prostate Cancer: A Practical Approach to Current Management of Recurrent Disease. Mayo Clin Proc 2007, 82:243-249. 10.4065/82.2.243, 17290734.
    • (2007) Mayo Clin Proc , vol.82 , pp. 243-249
    • Walczak, J.R.1    Carducci, M.A.2
  • 4
    • 0034659964 scopus 로고    scopus 로고
    • The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma
    • 10.1002/1097-0142(20000615)88:12+<2989::AID-CNCR14>3.0.CO;2-Q, 10898342
    • Carlin BI, Andriole GL. The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma. Cancer 2000, 88:2989-2994. 10.1002/1097-0142(20000615)88:12+<2989::AID-CNCR14>3.0.CO;2-Q, 10898342.
    • (2000) Cancer , vol.88 , pp. 2989-2994
    • Carlin, B.I.1    Andriole, G.L.2
  • 5
    • 0034859758 scopus 로고    scopus 로고
    • Mechanisms governing bone metastasis in prostate cancer
    • 10.1097/00042307-200109000-00006, 11493769
    • Cher ML. Mechanisms governing bone metastasis in prostate cancer. Current Opinion in Urology 2001, 11:483-488. 10.1097/00042307-200109000-00006, 11493769.
    • (2001) Current Opinion in Urology , vol.11 , pp. 483-488
    • Cher, M.L.1
  • 9
    • 34447264104 scopus 로고    scopus 로고
    • The role of tumor microenvironment in prostate cancer bone metastasis
    • 10.1002/jcb.21214, 17387734
    • Morrissey C, Vessella RL, Morrissey C, Vessella RL. The role of tumor microenvironment in prostate cancer bone metastasis. J Cell Biochem 2007, 101:873-886. 10.1002/jcb.21214, 17387734.
    • (2007) J Cell Biochem , vol.101 , pp. 873-886
    • Morrissey, C.1    Vessella, R.L.2    Morrissey, C.3    Vessella, R.L.4
  • 11
    • 5444236856 scopus 로고    scopus 로고
    • The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines
    • 10.1387/ijdb.041796go, 15349826
    • Opdenakker G, Van Damme J, Opdenakker G, Van Damme J. The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines. Int J Dev Biol 2004, 48:519-527. 10.1387/ijdb.041796go, 15349826.
    • (2004) Int J Dev Biol , vol.48 , pp. 519-527
    • Opdenakker, G.1    Van Damme, J.2    Opdenakker, G.3    Van Damme, J.4
  • 12
    • 10044284415 scopus 로고    scopus 로고
    • CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion
    • 10.1038/labinvest.3700181, 15467730
    • Singh S, Singh UP, Grizzle WE, Lillard JW. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest 2004, 84:1666-1676. 10.1038/labinvest.3700181, 15467730.
    • (2004) Lab Invest , vol.84 , pp. 1666-1676
    • Singh, S.1    Singh, U.P.2    Grizzle, W.E.3    Lillard, J.W.4
  • 13
    • 33748873913 scopus 로고    scopus 로고
    • Chemokines and cancer
    • 10.1002/ijc.22024, 16671092
    • Albert Z. Chemokines and cancer. Int J Cancer 2006, 119:2026-2029. 10.1002/ijc.22024, 16671092.
    • (2006) Int J Cancer , vol.119 , pp. 2026-2029
    • Albert, Z.1
  • 14
    • 0141793919 scopus 로고    scopus 로고
    • Chemokines: key players in cancer
    • 10.1185/030079903125002216, 14594528
    • Arya M, Patel HR, Williamson M, Patel HRH. Chemokines: key players in cancer. Curr Med Res Opin 2003, 19:557-564. 10.1185/030079903125002216, 14594528.
    • (2003) Curr Med Res Opin , vol.19 , pp. 557-564
    • Arya, M.1    Patel, H.R.2    Williamson, M.3    Patel, H.R.H.4
  • 15
    • 47749109823 scopus 로고    scopus 로고
    • The role of CXC chemokines and their receptors in cancer
    • 10.1016/j.canlet.2008.04.050, 18579287
    • Vandercappellen J, Van Damme J, Struyf S. The role of CXC chemokines and their receptors in cancer. Cancer Lett 2008, 267:226-244. 10.1016/j.canlet.2008.04.050, 18579287.
    • (2008) Cancer Lett , vol.267 , pp. 226-244
    • Vandercappellen, J.1    Van Damme, J.2    Struyf, S.3
  • 18
    • 67650429727 scopus 로고    scopus 로고
    • Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion
    • 10.1016/j.canlet.2009.03.022, 19375853
    • Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LWK, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett 2009, 283:29-35. 10.1016/j.canlet.2009.03.022, 19375853.
    • (2009) Cancer Lett , vol.283 , pp. 29-35
    • Singh, S.1    Singh, R.2    Sharma, P.K.3    Singh, U.P.4    Rai, S.N.5    Chung, L.W.K.6    Cooper, C.R.7    Novakovic, K.R.8    Grizzle, W.E.9    Lillard, J.W.10
  • 19
    • 0037211817 scopus 로고    scopus 로고
    • Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release
    • 10.1002/jcp.10188, 12447991
    • Lisignoli G, Toneguzzi S, Piacentini A, Cattini L, Lenti A, Tschon M, Cristino S, Grassi F, Facchini A, Lisignoli G, et al. Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release. J Cell Physiol 2003, 194:71-79. 10.1002/jcp.10188, 12447991.
    • (2003) J Cell Physiol , vol.194 , pp. 71-79
    • Lisignoli, G.1    Toneguzzi, S.2    Piacentini, A.3    Cattini, L.4    Lenti, A.5    Tschon, M.6    Cristino, S.7    Grassi, F.8    Facchini, A.9    Lisignoli, G.10
  • 20
    • 0035218756 scopus 로고    scopus 로고
    • In vitro models to study cellular differentiation and function in human prostate cancers
    • 10.1667/0033-7587(2001)155[0133:IVMTSC]2.0.CO;2, 11121225
    • Maitland NJ, Macintosh CA, Hall J, Sharrard M, Quinn G, Lang S. In vitro models to study cellular differentiation and function in human prostate cancers. Radiat Res 2001, 155:133-142. 10.1667/0033-7587(2001)155[0133:IVMTSC]2.0.CO;2, 11121225.
    • (2001) Radiat Res , vol.155 , pp. 133-142
    • Maitland, N.J.1    Macintosh, C.A.2    Hall, J.3    Sharrard, M.4    Quinn, G.5    Lang, S.6
  • 21
    • 0344626940 scopus 로고    scopus 로고
    • Phenotypic and genotypic characterization of commonly used human prostatic cell lines
    • 10.1046/j.1464-410x.2000.00606.x, 10792179
    • Mitchell S, Abel P, Ware M, Stamp G, Lalani E. Phenotypic and genotypic characterization of commonly used human prostatic cell lines. BJU Int 2000, 85:932-944. 10.1046/j.1464-410x.2000.00606.x, 10792179.
    • (2000) BJU Int , vol.85 , pp. 932-944
    • Mitchell, S.1    Abel, P.2    Ware, M.3    Stamp, G.4    Lalani, E.5
  • 22
    • 0036172306 scopus 로고    scopus 로고
    • Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases
    • 10.1046/j.1365-2567.2002.01345.x, 1782650, 11872087
    • Curnock AP, Logan MK, Ward SG. Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases. Immunology 2002, 105:125-136. 10.1046/j.1365-2567.2002.01345.x, 1782650, 11872087.
    • (2002) Immunology , vol.105 , pp. 125-136
    • Curnock, A.P.1    Logan, M.K.2    Ward, S.G.3
  • 23
    • 2142675597 scopus 로고    scopus 로고
    • Assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling: use of dominant negative mutants controlled by a tetracycline-regulated gene expression system
    • Curnock AP, Sotsios Y, Ward SG, Curnock AP, Sotsios Y, Ward SG. Assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling: use of dominant negative mutants controlled by a tetracycline-regulated gene expression system. Methods Mol Biol 2004, 239:211-222.
    • (2004) Methods Mol Biol , vol.239 , pp. 211-222
    • Curnock, A.P.1    Sotsios, Y.2    Ward, S.G.3    Curnock, A.P.4    Sotsios, Y.5    Ward, S.G.6
  • 25
    • 33746051169 scopus 로고    scopus 로고
    • Chemokines, chemokine receptors, and cancer metastasis
    • 10.1189/jlb.1105633, 16478915
    • Kakinuma T, Hwang ST, Kakinuma T, Hwang ST. Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 2006, 79:639-651. 10.1189/jlb.1105633, 16478915.
    • (2006) J Leukoc Biol , vol.79 , pp. 639-651
    • Kakinuma, T.1    Hwang, S.T.2    Kakinuma, T.3    Hwang, S.T.4
  • 26
    • 38949205852 scopus 로고    scopus 로고
    • Chemokines and cancer: migration, intracellular signaling and intercellular communication in the microenvironment
    • 10.1042/BJ20071493, 18177271
    • O'Hayre M, Salanga CL, Handel TM, Allen SJ, O'Hayre M, Salanga CL, Handel TM, Allen SJ. Chemokines and cancer: migration, intracellular signaling and intercellular communication in the microenvironment. Biochem J 2008, 409:635-649. 10.1042/BJ20071493, 18177271.
    • (2008) Biochem J , vol.409 , pp. 635-649
    • O'Hayre, M.1    Salanga, C.L.2    Handel, T.M.3    Allen, S.J.4    O'Hayre, M.5    Salanga, C.L.6    Handel, T.M.7    Allen, S.J.8
  • 27
    • 0033647242 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines
    • 10.1034/j.1600-065X.2000.17712.x, 11138779
    • Sotsios Y, Ward SG. Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines. Immunol Rev 2000, 177:217. 10.1034/j.1600-065X.2000.17712.x, 11138779.
    • (2000) Immunol Rev , vol.177 , pp. 217
    • Sotsios, Y.1    Ward, S.G.2
  • 29
    • 34948815127 scopus 로고    scopus 로고
    • PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
    • 10.1016/j.cellsig.2007.07.025, 2094004, 17826033
    • Fang J, Ding M, Yang L, Liu L-Z, Jiang B-H. PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. Cell Signal 2007, 19:2487-2497. 10.1016/j.cellsig.2007.07.025, 2094004, 17826033.
    • (2007) Cell Signal , vol.19 , pp. 2487-2497
    • Fang, J.1    Ding, M.2    Yang, L.3    Liu, L.-.Z.4    Jiang, B.-.H.5
  • 30
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • 10.1126/science.275.5308.1943, 9072974
    • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947. 10.1126/science.275.5308.1943, 9072974.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6    Puc, J.7    Miliaresis, C.8    Rodgers, L.9    McCombie, R.10
  • 31
    • 0141923861 scopus 로고    scopus 로고
    • DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1
    • 10.1182/blood-2003-01-0173, 12829596
    • Sanui T, Inayoshi A, Noda M, Iwata E, Stein JV, Sasazuki T, Y F. DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1. Blood 2003, 102:2948-2950. 10.1182/blood-2003-01-0173, 12829596.
    • (2003) Blood , vol.102 , pp. 2948-2950
    • Sanui, T.1    Inayoshi, A.2    Noda, M.3    Iwata, E.4    Stein, J.V.5    Sasazuki, T.6    Y, F.7
  • 32
    • 0034625002 scopus 로고    scopus 로고
    • Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells
    • 10.1073/pnas.97.10.5225, 25810, 10805781
    • Chung CY, Lee S, Briscoe C, Ellsworth C, Firtel RA. Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc Natl Acad Sci USA 2000, 97:5225-5230. 10.1073/pnas.97.10.5225, 25810, 10805781.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5225-5230
    • Chung, C.Y.1    Lee, S.2    Briscoe, C.3    Ellsworth, C.4    Firtel, R.A.5
  • 36
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-Src signaling in normal and cancer cells
    • 10.1016/j.ceb.2006.08.011, 16919435
    • Mitra SK, Schlaepfer DD, Mitra SK, Schlaepfer DD. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 2006, 18:516-523. 10.1016/j.ceb.2006.08.011, 16919435.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2    Mitra, S.K.3    Schlaepfer, D.D.4
  • 37
    • 7944236785 scopus 로고    scopus 로고
    • Src family kinases, key regulators of signal transduction
    • 10.1038/sj.onc.1208160, 15489908
    • Parsons S, Parsons J. Src family kinases, key regulators of signal transduction. Oncogene 2004, 23:7906-7909. 10.1038/sj.onc.1208160, 15489908.
    • (2004) Oncogene , vol.23 , pp. 7906-7909
    • Parsons, S.1    Parsons, J.2
  • 38
    • 5744253106 scopus 로고    scopus 로고
    • Receptor Tyrosine Kinases are Signaling Intermediates of G Protein-Coupled Receptors
    • Bentham Science Publishers Ltd
    • Piiper A, Zeuzem S. Receptor Tyrosine Kinases are Signaling Intermediates of G Protein-Coupled Receptors. In Curr Pharm Des 2004, 10:3539-3545. Bentham Science Publishers Ltd.
    • (2004) In Curr Pharm Des , vol.10 , pp. 3539-3545
    • Piiper, A.1    Zeuzem, S.2
  • 40
    • 0035920129 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
    • 10.1074/jbc.M100556200, 11337495
    • Cuevas BD, Lu Y, Mao M, Zhang J, LaPushin R, Siminovitch, Mills GB. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem 2001, 276:27455-61. 10.1074/jbc.M100556200, 11337495.
    • (2001) J Biol Chem , vol.276 , pp. 27455-27461
    • Cuevas, B.D.1    Lu, Y.2    Mao, M.3    Zhang, J.4    LaPushin, R.5    Siminovitch6    Mills, G.B.7
  • 41
    • 48949116158 scopus 로고    scopus 로고
    • ERK phosphorylation: spatial and temporal regulation by G protein-coupled receptors
    • 10.1016/j.biocel.2008.04.001, 18502166
    • May LT, Hill SJ, May LT, Hill SJ. ERK phosphorylation: spatial and temporal regulation by G protein-coupled receptors. Int J Biochem Cell Biol 2008, 40:2013-2017. 10.1016/j.biocel.2008.04.001, 18502166.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 2013-2017
    • May, L.T.1    Hill, S.J.2    May, L.T.3    Hill, S.J.4
  • 43
    • 34548183340 scopus 로고    scopus 로고
    • Bone marrow stromal cells promote growth and survival of prostate cancer cells
    • 10.1042/BST0350692, 17635126
    • Cross NA, Papageorgiou M, Eaton CL. Bone marrow stromal cells promote growth and survival of prostate cancer cells. Biochem Soc Trans 2007, 35:698-700. 10.1042/BST0350692, 17635126.
    • (2007) Biochem Soc Trans , vol.35 , pp. 698-700
    • Cross, N.A.1    Papageorgiou, M.2    Eaton, C.L.3
  • 44
    • 34547777444 scopus 로고    scopus 로고
    • The role of PTEN in prostate cancer cell tropism to the bone microenvironment
    • 10.1093/carcin/bgm050, 17347137
    • Wu Z, McRoberts KS, Theodorescu D. The role of PTEN in prostate cancer cell tropism to the bone microenvironment. Carcinogenesis 2007, 28:1393-1400. 10.1093/carcin/bgm050, 17347137.
    • (2007) Carcinogenesis , vol.28 , pp. 1393-1400
    • Wu, Z.1    McRoberts, K.S.2    Theodorescu, D.3
  • 45
    • 34250814224 scopus 로고    scopus 로고
    • Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression
    • 10.1186/1750-2187-2-2, 1808056, 17319972
    • New D, Wong Y. Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression. J Mol Signal 2007, 2:2. 10.1186/1750-2187-2-2, 1808056, 17319972.
    • (2007) J Mol Signal , vol.2 , pp. 2
    • New, D.1    Wong, Y.2
  • 47
    • 51649098950 scopus 로고    scopus 로고
    • The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML
    • 10.1038/leu.2008.158, 18548093
    • Kojima K, Shimanuki M, Shikami M, Samudio IJ, Ruvolo V, Corn P, Hanaoka N, Konopleva M, Andreeff M, Nakakuma H. The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML. Leukemia 2008, 22:1728-1736. 10.1038/leu.2008.158, 18548093.
    • (2008) Leukemia , vol.22 , pp. 1728-1736
    • Kojima, K.1    Shimanuki, M.2    Shikami, M.3    Samudio, I.J.4    Ruvolo, V.5    Corn, P.6    Hanaoka, N.7    Konopleva, M.8    Andreeff, M.9    Nakakuma, H.10
  • 48
    • 48649096069 scopus 로고    scopus 로고
    • Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity
    • 10.1158/0008-5472.CAN-08-0757, 18632646
    • Prevo R, Deutsch E, Sampson O, Diplexcito J, Cengel K, Harper J, O'Neill P, McKenna WG, Patel S, Bernhard EJ, et al. Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity. Cancer Res 2008, 68:5915-5923. 10.1158/0008-5472.CAN-08-0757, 18632646.
    • (2008) Cancer Res , vol.68 , pp. 5915-5923
    • Prevo, R.1    Deutsch, E.2    Sampson, O.3    Diplexcito, J.4    Cengel, K.5    Harper, J.6    O'Neill, P.7    McKenna, W.G.8    Patel, S.9    Bernhard, E.J.10
  • 50
    • 42249111545 scopus 로고    scopus 로고
    • Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation
    • Straub A, Wendel HP, Dietz K, Schiebold D, Peter K, Schoenwaelder SM, Ziemer G, Straub A, Wendel HP, Dietz K, et al. Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation. Thromb Haemost 2008, 99:609-615.
    • (2008) Thromb Haemost , vol.99 , pp. 609-615
    • Straub, A.1    Wendel, H.P.2    Dietz, K.3    Schiebold, D.4    Peter, K.5    Schoenwaelder, S.M.6    Ziemer, G.7    Straub, A.8    Wendel, H.P.9    Dietz, K.10
  • 51
    • 50149115138 scopus 로고    scopus 로고
    • Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors
    • 10.1016/j.abb.2008.06.024, 18647592
    • Zvelebil MJ, Waterfield MD, Shuttleworth SJ, Zvelebil MJ, Waterfield MD, Shuttleworth SJ. Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors. Arch Biochem Biophys 2008, 477:404-410. 10.1016/j.abb.2008.06.024, 18647592.
    • (2008) Arch Biochem Biophys , vol.477 , pp. 404-410
    • Zvelebil, M.J.1    Waterfield, M.D.2    Shuttleworth, S.J.3    Zvelebil, M.J.4    Waterfield, M.D.5    Shuttleworth, S.J.6
  • 52
    • 40549131271 scopus 로고    scopus 로고
    • Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes
    • 10.1161/CIRCULATIONAHA.107.720466, 18268153
    • Fougerat A, Gayral S, Gourdy P, Schambourg A, Ruckle T, Schwarz MK, Rommel C, Hirsch E, Arnal JF, Salles JP, et al. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation 2008, 117:1310-1317. 10.1161/CIRCULATIONAHA.107.720466, 18268153.
    • (2008) Circulation , vol.117 , pp. 1310-1317
    • Fougerat, A.1    Gayral, S.2    Gourdy, P.3    Schambourg, A.4    Ruckle, T.5    Schwarz, M.K.6    Rommel, C.7    Hirsch, E.8    Arnal, J.F.9    Salles, J.P.10
  • 54
    • 0032819983 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase in human prostate cancer
    • 10.1016/S0022-5347(05)68354-1, 10492251
    • Price DT, Della Rocca G, Guo C, Ballo MS, Schwinn DA, Luttrell LM. Activation of extracellular signal-regulated kinase in human prostate cancer. J Urol 1999, 162:1537-1542. 10.1016/S0022-5347(05)68354-1, 10492251.
    • (1999) J Urol , vol.162 , pp. 1537-1542
    • Price, D.T.1    Della Rocca, G.2    Guo, C.3    Ballo, M.S.4    Schwinn, D.A.5    Luttrell, L.M.6
  • 57
    • 33747429094 scopus 로고    scopus 로고
    • The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes
    • 10.1002/eji.200535004, 16821235
    • Durand CA, Westendorf J, Tse KW, Gold MR, Durand CA, Westendorf J, Tse KWK, Gold MR. The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. Eur J Immunol 2006, 36:2235-2249. 10.1002/eji.200535004, 16821235.
    • (2006) Eur J Immunol , vol.36 , pp. 2235-2249
    • Durand, C.A.1    Westendorf, J.2    Tse, K.W.3    Gold, M.R.4    Durand, C.A.5    Westendorf, J.6    Tse, K.W.K.7    Gold, M.R.8


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