Metabolism of 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether (pyridalyl) in rats after repeated oral administration and a simple physiologically based pharmacokinetic modeling in brown and white adipose tissues

Drug Metabolism and Disposition

Volumn 38, Issue 5, 2010, Pages 824-832

  Nagahori, Hirohisa ^a   Matsunaga, Haruyuki ^a   Tomigahara, Yoshitaka ^a   Isobe, Naohiko ^a   Kaneko, Hideo ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; INSECTICIDE; PYRIDALYL; UNCLASSIFIED DRUG;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; COMPARTMENT MODEL; DEALKYLATION; DEHALOGENATION; DISTRIBUTION VOLUME; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG METABOLISM; DRUG TISSUE LEVEL; FECES; FEMALE; KIDNEY PARENCHYMA; KINETICS; LIVER CLEARANCE; LUNG PARENCHYMA; LYMPH VESSEL; MALE; MEMBRANE PERMEABILITY; METABOLITE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RADIOACTIVITY; RAT; REPEATED DRUG DOSE; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; STEADY STATE; TREATMENT DURATION; URINE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMAL STRUCTURES; ANIMALS; COMPUTER SIMULATION; FECES; FEMALE; INSECTICIDES; LIVER; MALE; MODELS, BIOLOGICAL; PHARMACOKINETICS; PHENYL ETHERS; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; URINE;

RATTUS;

EID: 77950950881     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.031914     Document Type: Article

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