Metabolism of pyridalyl in rats: Excretion, distribution, and biotransformation of dichloropropenyl-labeled pyridalyl

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 22, 2009, Pages 10845-10851

  Nagahori, Hirohisa ^a   Tomigahara, Yoshitaka ^a   Isobe, Naohiko ^a   Kaneko, Hideo ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Identification; Metabolism; MS; NMR; Pyridalyl; Rats

Indexed keywords

CARBON; DIAGNOSTIC AGENT; DIPHENYL ETHER DERIVATIVE; S 1812;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BREATH ANALYSIS; CHEMISTRY; FECES; FEMALE; HAIR; MALE; MASS SPECTROMETRY; MUSCLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SKIN; URINE;

ADIPOSE TISSUE; ANIMALS; BREATH TESTS; CARBON RADIOISOTOPES; FECES; FEMALE; HAIR; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MUSCLES; PHENYL ETHERS; RATS; SKIN; URINE;

RATTUS;

EID: 72449197515     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf9026469     Document Type: Article

References (15)

1. (1) Sakamoto, N.; Saito, S.; Hirose, T.; Suzuki, M.; Matsuo, S.; Izumi, K.; Nagatomi, T.; Ikegami, H.; Umeda, K.; Tsushima, K.; Matsuo, N. The discovery of pyridalyl: a novel insecticidal agent for controlling lepidopterous pests, Pest. Manage. Sci. 2004, 60, 25-34. (Pubitemid 38057135)
2. Isayama, S.; Saito, S.; Kuroda, K.; Umeda, K.; Kasamatsu, K. Pyridalyl, a novel insecticide: potency and insecticidal selectivity. Arch. Insect Biochem. Physiol. 2005, 58, 226-233.
3. Nagahori, H.; Saito, K.; Tomigahara, Y.; Isobe, N.; Kaneko, H. Metabolism, of pyridalyl in rats. Drug Metab. Dispos., in press.
4. Caster, W. O.; Poncelet, J.; Simon, A. B.; Armstrong, W. D. Tissue weight of rat: I., Normal values determined by dissection and chemical methods, Proc. Soc. Exp. Biol. Med. 1956, 91, 122-126.
5. 14C]dichloroacetate in male Sprague-Dawley rats. Drug Metab. Dispos. 1998, 26, 1134-1143.
6. Conn, E. E.; Stumpf, P. K. Outlines of Biochemistry, 4th ed.; John Wiley & Sons: New York, 1976.
7. Davidson, I. W. F.; Beliles, R. P. Consideration of the target organ, toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. Drug Metab. Rev. 1991, 23, 493-599.
8. Watabe, T.; Akamatsu, K. Oxidative cleavage of the ethylenic linkage of stilbene by rabbit liver microsomes. Biochem. Pharmacol. 1975, 24, 442-444.
9. Akhtar, M.; Corina, D.; Miller, S.; Shyadehi, A. Z.; Wright, J. N. Mechanism of the acyl-carbon cleavage and related reactions catalyzed by multifunctional P-450s: Studies on cytochlome P-450 17alpha. Biochemistry 1994, 33, 4410-4418.
10. (10) Umehara, K.; Kudo, S.; Hirano, Y.; Morita, S.; Uchida, M.; Odomi, M.; Miyamoto, G. Oxidative cleavage of the octyl side chain of l-(3,4-dichlorobenzyl)-5-octylbiguanide (OPB-2045) in rat and dog liver preparations. Drug Metab. Dispos. 2000, 28, 887-894. (Pubitemid 30612605)
11. Marnett, L. J. DNA Adducts of Alpha, Beta-Unsaturated Aldehydes and Dicarbonyl Compounds. In DNA Adducts: Identification and Biological Significance (IARC Scientific Publications No. 125); Hemminki, K., et al., Eds.; IARC: Lyon, France, 1994; pp 151-163.
12. Solomon, J. J. DNA Adducts of Lactones, Sulfones, Acylating Agents and Acrylic Compounds. In DNA Adducts: Identification and Biological Significance (IARC Scientific Publications No. 125); Hemminki, K., et al., Eds.; IARC: Lyon, France, 1994; pp 179-198.
13. (13) Ahmed, A. E.; Jacob, S.; Ghanayem, B. I. Comparative disposition of acrylonitrile and methacrylonitrile: Quantitative whole-body autoradiographic studies in rats. Fundam. Appl. Toxicol. 1996, 33, 49-59. (Pubitemid 126719891)
14. Meier, J. R.; Ringhand, H. P.; Coleman, W. E.; Munch, J. W.; Streicher, R. P.; Kaylor, W. H.; Schenck, K. M. Identification of mutagenic compounds formed during chlorination of humic acid. Mutal. Res. 1985, 157, 111-121.
15. (15) Robinson, M.; Bull, R. J.; Olson, G. R.; Stober, J. Carcinogenic activity associated with halogenated acetones and acroleins in the mouse skin assay. Mutat. Res. 1989, 48, 197-203. (Pubitemid 20009043)