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Volumn 31, Issue 3, 2010, Pages 504-511

IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress

Author keywords

[No Author keywords available]

Indexed keywords

IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MESSENGER RNA; VIMENTIN; COPPER; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN;

EID: 77950909565     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp313     Document Type: Article
Times cited : (24)

References (48)
  • 1
    • 20044396925 scopus 로고    scopus 로고
    • Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma
    • Obama,K. et al. (2005) Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma. Hepatology, 41, 1339-1348.
    • (2005) Hepatology , vol.41 , pp. 1339-1348
    • Obama, K.1
  • 2
    • 47849114741 scopus 로고    scopus 로고
    • Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: detection by oligonucleotide microarray and real-time PCR analysis
    • Hass,H.G. et al. (2008) Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: detection by oligonucleotide microarray and real-time PCR analysis. World J. Gastroenterol., 14, 2501-2510.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 2501-2510
    • Hass, H.G.1
  • 3
    • 41349085813 scopus 로고    scopus 로고
    • Translational microarray systems for outcome prediction of hepatocellular carcinoma
    • Iizuka,N. et al. (2008) Translational microarray systems for outcome prediction of hepatocellular carcinoma. Cancer Sci., 99, 659-665.
    • (2008) Cancer Sci. , vol.99 , pp. 659-665
    • Iizuka, N.1
  • 4
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi,P.A. et al. (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer, 6, 674-687.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1
  • 5
    • 47149112544 scopus 로고    scopus 로고
    • Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment
    • Blechacz,B. et al. (2008) Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology, 48, 308-321.
    • (2008) Hepatology , vol.48 , pp. 308-321
    • Blechacz, B.1
  • 6
    • 52949153589 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma: a malignancy of increasing importance
    • Hammill,C.W. et al. (2008) Intrahepatic cholangiocarcinoma: a malignancy of increasing importance. J. Am. Coll. Surg., 207, 594-603.
    • (2008) J. Am. Coll. Surg. , vol.207 , pp. 594-603
    • Hammill, C.W.1
  • 7
    • 41449093701 scopus 로고    scopus 로고
    • Hepatocarcinoma in viral and metabolic liver disease
    • Rosenthal,P. (2008) Hepatocarcinoma in viral and metabolic liver disease. J. Pediatr. Gastroenterol. Nutr., 46, 370-375.
    • (2008) J. Pediatr. Gastroenterol. Nutr. , vol.46 , pp. 370-375
    • Rosenthal, P.1
  • 8
    • 0035266345 scopus 로고    scopus 로고
    • Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression
    • Okabe,H. et al. (2001) Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res., 61, 2129-2137.
    • (2001) Cancer Res. , vol.61 , pp. 2129-2137
    • Okabe, H.1
  • 9
    • 0037099610 scopus 로고    scopus 로고
    • Comparison of gene expression profiles between hepatitis B virusand hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method
    • Iizuka,N. et al. (2002) Comparison of gene expression profiles between hepatitis B virusand hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res., 62, 3939-3944.
    • (2002) Cancer Res. , vol.62 , pp. 3939-3944
    • Iizuka, N.1
  • 10
    • 0029782304 scopus 로고    scopus 로고
    • Oxidative stress during viral infection: a review
    • Schwarz,K.B. (1996) Oxidative stress during viral infection: a review. Free Radic. Biol. Med., 21, 641-649.
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 641-649
    • Schwarz, K.B.1
  • 11
    • 0036484856 scopus 로고    scopus 로고
    • Chronic inflammation and cancer
    • 229 (discussion 230-232)
    • Shacter,E. et al. (2002) Chronic inflammation and cancer. Oncology, 16, 217-226, 229; (discussion 230-232).
    • (2002) Oncology , vol.16 , pp. 217-226
    • Shacter, E.1
  • 12
    • 0035824070 scopus 로고    scopus 로고
    • Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma
    • Marrogi,A.J. et al. (2001) Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma. J. Natl Cancer Inst., 93, 1652-1655.
    • (2001) J. Natl Cancer Inst. , vol.93 , pp. 1652-1655
    • Marrogi, A.J.1
  • 13
    • 3042591085 scopus 로고    scopus 로고
    • Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
    • Kurz,D.J. et al. (2004) Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J. Cell Sci., 117, 2417-2426.
    • (2004) J. Cell Sci. , vol.117 , pp. 2417-2426
    • Kurz, D.J.1
  • 14
    • 0028001088 scopus 로고
    • The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene
    • Wu,J. et al. (1994) The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat. Genet., 7, 541-545.
    • (1994) Nat. Genet. , vol.7 , pp. 541-545
    • Wu, J.1
  • 15
    • 0023740231 scopus 로고
    • High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis
    • Masuda,R. et al. (1988) High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis. Jpn. J. Cancer Res., 79, 828-835.
    • (1988) Jpn. J. Cancer Res. , vol.79 , pp. 828-835
    • Masuda, R.1
  • 16
    • 85045533444 scopus 로고    scopus 로고
    • Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride
    • Sone,K. et al. (1996) Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride. Hepatology, 23, 764-770.
    • (1996) Hepatology , vol.23 , pp. 764-770
    • Sone, K.1
  • 17
    • 0031914712 scopus 로고    scopus 로고
    • Identification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: increased levels following bile duct ligation and during the development of cholangiocarcinoma
    • Meerson,N.R. et al. (1998) Identification of B10, an alkaline phosphodiesterase of the apical plasma membrane of hepatocytes and biliary cells, in rat serum: increased levels following bile duct ligation and during the development of cholangiocarcinoma. Hepatology, 27, 563-568.
    • (1998) Hepatology , vol.27 , pp. 563-568
    • Meerson, N.R.1
  • 18
    • 0034656849 scopus 로고    scopus 로고
    • Reactive oxygen species, cell signaling, and cell injury
    • Hensley,K. et al. (2000) Reactive oxygen species, cell signaling, and cell injury. Free Radic. Biol. Med., 28, 1456-1462.
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 1456-1462
    • Hensley, K.1
  • 19
    • 0028798434 scopus 로고
    • Oxidative mechanisms in the toxicity of metal ions
    • Stohs,S.J. et al. (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med., 18, 321-336.
    • (1995) Free Radic. Biol. Med. , vol.18 , pp. 321-336
    • Stohs, S.J.1
  • 21
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: a software environment for integrated models of biomolecular interaction networks
    • Shannon,P. et al. (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res., 13, 2498-2504.
    • (2003) Genome Res. , vol.13 , pp. 2498-2504
    • Shannon, P.1
  • 22
    • 0043093686 scopus 로고    scopus 로고
    • IQGAP proteins are integral components of cytoskeletal regulation
    • Briggs,M.W. et al. (2003) IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep., 4, 571-574.
    • (2003) EMBO Rep. , vol.4 , pp. 571-574
    • Briggs, M.W.1
  • 23
    • 0038787005 scopus 로고    scopus 로고
    • IQGAPs: integrators of the cytoskeleton, cell adhesion machinery, and signaling networks
    • Mateer,S.C. (2003) IQGAPs: integrators of the cytoskeleton, cell adhesion machinery, and signaling networks. Cell Motil. Cytoskeleton, 55, 147-155.
    • (2003) Cell Motil. Cytoskeleton , vol.55 , pp. 147-155
    • Mateer, S.C.1
  • 24
    • 21044443326 scopus 로고    scopus 로고
    • IQGAP1: a key regulator of adhesion and migration
    • Noritake,J. et al. (2005) IQGAP1: a key regulator of adhesion and migration. J. Cell Sci., 118, 2085-2092.
    • (2005) J. Cell Sci. , vol.118 , pp. 2085-2092
    • Noritake, J.1
  • 25
    • 33646726750 scopus 로고    scopus 로고
    • IQGAP1 in cellular signaling: bridging the GAP
    • Brown,M.D. (2006) IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol., 16, 242-249.
    • (2006) Trends Cell Biol. , vol.16 , pp. 242-249
    • Brown, M.D.1
  • 26
    • 0032493903 scopus 로고    scopus 로고
    • Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherinmediated cell-cell adhesion
    • Kuroda,S. et al. (1998) Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherinmediated cell-cell adhesion. Science, 281, 832-835.
    • (1998) Science , vol.281 , pp. 832-835
    • Kuroda, S.1
  • 27
    • 38149036613 scopus 로고    scopus 로고
    • IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells
    • Jadeski,L. et al. (2008) IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J. Biol. Chem., 283, 1008-1017.
    • (2008) J. Biol. Chem. , vol.283 , pp. 1008-1017
    • Jadeski, L.1
  • 28
    • 42549116142 scopus 로고    scopus 로고
    • Combined analysis of Rac1, IQGAP1 Tiam1 and E-cadherin expression in gastric cancer
    • Walch,A. et al. (2008) Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod. Pathol., 21, 544-552.
    • (2008) Mod. Pathol. , vol.21 , pp. 544-552
    • Walch, A.1
  • 29
    • 4043148481 scopus 로고    scopus 로고
    • IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation
    • Yamaoka-Tojo,M. et al. (2004) IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ. Res., 95, 276-283.
    • (2004) Circ. Res. , vol.95 , pp. 276-283
    • Yamaoka-Tojo, M.1
  • 30
    • 57349159403 scopus 로고    scopus 로고
    • IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis
    • (1-11)
    • Meyer,R.D. et al. (2008) IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PLoS ONE, 3, e3848; (1-11).
    • (2008) PLoS ONE , vol.3
    • Meyer, R.D.1
  • 31
    • 0035111088 scopus 로고    scopus 로고
    • IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A
    • Sugimoto,N. et al. (2001) IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A. J. Hum. Genet., 46, 21-25.
    • (2001) J. Hum. Genet. , vol.46 , pp. 21-25
    • Sugimoto, N.1
  • 32
    • 0035869652 scopus 로고    scopus 로고
    • Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers
    • Takemoto,H. et al. (2001) Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers. Int. J. Cancer, 91, 783-788.
    • (2001) Int. J. Cancer , vol.91 , pp. 783-788
    • Takemoto, H.1
  • 33
    • 3042858956 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization
    • Sun,W. et al. (2004) Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. Cancer Lett., 212, 83-93.
    • (2004) Cancer Lett. , vol.212 , pp. 83-93
    • Sun, W.1
  • 34
    • 0037039718 scopus 로고    scopus 로고
    • Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts
    • Nabeshima,K. et al. (2002) Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. Cancer Lett., 176, 101-109.
    • (2002) Cancer Lett. , vol.176 , pp. 101-109
    • Nabeshima, K.1
  • 35
    • 33749251431 scopus 로고    scopus 로고
    • Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas
    • Dong,P. et al. (2006) Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas. Cancer Lett., 243, 120-127.
    • (2006) Cancer Lett. , vol.243 , pp. 120-127
    • Dong, P.1
  • 36
    • 33749455736 scopus 로고    scopus 로고
    • IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme
    • Balenci,L. et al. (2006) IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme. Cancer Res., 66, 9074-9082.
    • (2006) Cancer Res. , vol.66 , pp. 9074-9082
    • Balenci, L.1
  • 37
    • 39749108409 scopus 로고    scopus 로고
    • Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent
    • Schmidt,V.A. et al. (2008) Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Mol. Cell. Biol., 28, 1489-1502.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 1489-1502
    • Schmidt, V.A.1
  • 38
    • 33747365847 scopus 로고    scopus 로고
    • Regulation of vimentin by SIP1 in human epithelial breast tumor cells
    • Bindels,S. et al. (2006) Regulation of vimentin by SIP1 in human epithelial breast tumor cells. Oncogene, 25, 4975-4985.
    • (2006) Oncogene , vol.25 , pp. 4975-4985
    • Bindels, S.1
  • 39
    • 54049148253 scopus 로고    scopus 로고
    • Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility
    • Paccione,R.J. et al. (2008) Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Mol. Cancer Ther., 7, 2894-2903.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2894-2903
    • Paccione, R.J.1
  • 40
    • 34250901825 scopus 로고    scopus 로고
    • Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion
    • McInroy,L. et al. (2007) Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion. Biochem. Biophys. Res. Commun., 360, 109-114.
    • (2007) Biochem. Biophys. Res. Commun. , vol.360 , pp. 109-114
    • McInroy, L.1
  • 41
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery,J.P. (2002) Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer, 2, 442-454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 42
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber,M.A. et al. (2005) Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol., 17, 548-558.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 548-558
    • Huber, M.A.1
  • 43
    • 51349133312 scopus 로고    scopus 로고
    • Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    • Nitta,T. et al. (2008) Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology, 48, 909-919.
    • (2008) Hepatology , vol.48 , pp. 909-919
    • Nitta, T.1
  • 44
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • Kaimori,A. et al. (2007) Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J. Biol. Chem., 282, 22089-22101.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22089-22101
    • Kaimori, A.1
  • 45
    • 27144509163 scopus 로고    scopus 로고
    • A network-based analysis of systemic inflammation in humans
    • Calvano,S.E. et al. (2005) A network-based analysis of systemic inflammation in humans. Nature, 437, 1032-1037.
    • (2005) Nature , vol.437 , pp. 1032-1037
    • Calvano, S.E.1
  • 46
    • 34447628843 scopus 로고    scopus 로고
    • Pathway mapping tools for analysis of high content data
    • Ekins,S. et al. (2007) Pathway mapping tools for analysis of high content data. Methods Mol. Biol., 356, 319-350.
    • (2007) Methods Mol. Biol. , vol.356 , pp. 319-350
    • Ekins, S.1
  • 47
    • 0035042776 scopus 로고    scopus 로고
    • A literature network of human genes for highthroughput analysis of gene expression
    • Jenssen,T.K. et al. (2001) A literature network of human genes for highthroughput analysis of gene expression. Nat. Genet., 28, 21-28.
    • (2001) Nat. Genet. , vol.28 , pp. 21-28
    • Jenssen, T.K.1
  • 48
    • 27744523967 scopus 로고    scopus 로고
    • The next generation of literature analysis: integration of genomic analysis into text mining
    • Scherf,M. et al. (2005) The next generation of literature analysis: integration of genomic analysis into text mining. Brief. Bioinform., 6, 287-297.
    • (2005) Brief. Bioinform. , vol.6 , pp. 287-297
    • Scherf, M.1


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