Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 8022-8030

  Dennison, Jennifer B ^a   Ayres, Mary L ^a   Kaluarachchi, Kumar ^a   Plunkett, William ^a   Gandhi, Varsha ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE KINASE; ADENYLATE; ATP SYNTHASE; CHRONIC LYMPHOCYTIC LEUKEMIAS; ENERGY METABOLISM; FUMARATES; IN-PHASE; INTRACELLULAR ACCUMULATION; INTRACELLULAR METABOLISM; LYMPHOMA CELLS; MANTLE CELLS; METABOLIC PATHWAYS; METFORMINS; MONOPHOSPHATES; MULTIPLE CELLS; OLIGOMYCIN; SECONDARY METABOLITES; SUCCINYLATION;

BIOMOLECULES; CELL CULTURE; METABOLITES;

METABOLISM;

8 CHLOROADENOSINE; 8 CHLOROADENOSINE MONOPHOSPHATE; 8 CHLOROADENOSINE TRIPHOSPHATE; CITRIC ACID; FUMARIC ACID; METFORMIN; NUCLEOSIDE DERIVATIVE; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PURINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; 2 CHLOROADENOSINE; 8 BROMO CYCLIC AMP; 8 CHLORO CYCLIC ADENOSINE MONOPHOSPHATE; 8-CHLORO-CYCLIC ADENOSINE MONOPHOSPHATE; 8-CHLOROADENOSINE; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; FUMARIC ACID DERIVATIVE; PURINE DERIVATIVE; SUCCINIC ACID; UNCOUPLING PROTEIN;

ARTICLE; CELL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENERGY METABOLISM; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MANTLE CELL LYMPHOMA; METABOLITE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; PURINE METABOLISM; STEADY STATE; CHEMISTRY; CITRIC ACID CYCLE; DOSE RESPONSE; DRUG EFFECT; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

2-CHLOROADENOSINE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CITRIC ACID CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; FUMARATES; HUMANS; HYPOGLYCEMIC AGENTS; LYMPHOMA, MANTLE-CELL; METFORMIN; OLIGOMYCINS; PURINES; SUCCINIC ACID; UNCOUPLING AGENTS;

EID: 77950905193     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.085803     Document Type: Article

References (32)

1. Dennison, J. B., Balakrishnan, K., and Gandhi, V. (2009) Br. J. Haematol. 147, 297-307
2. Stellrecht, C. M., Rodriguez, C. O., Jr., Ayres, M., and Gandhi, V. (2003) Cancer Res. 63, 7968-7974
3. Gandhi, V., Chen, W., Ayres, M., Rhie, J. K., Madden, T. L., and Newman, R. A. (2002) Cancer Chemother. Pharmacol. 50, 85-94
4. Balakrishnan, K., Stellrecht, C. M., Genini, D., Ayres, M., Wierda, W. G., Keating, M. J., Leoni, L. M., and Gandhi, V. (2005) Blood 105, 4455-4462
5. Gandhi, V., Ayres, M., Halgren, R. G., Krett, N. L., Newman, R. A., and Rosen, S. T. (2001) Cancer Res. 61, 5474-5479
6. Stellrecht, C. M., Phillip, C. J., Cervantes-Gomez, F., and Gandhi, V. (2007) Cancer Res. 67, 9913-9920
7. Ghias, K., Ma, C., Gandhi, V., Platanias, L. C., Krett, N. L., and Rosen, S. T. (2005) Mol. Cancer Ther. 4, 569-577
8. Krett, N. L., Davies, K. M., Ayres, M., Ma, C., Nabhan, C., Gandhi, V., and Rosen, S. T. (2004) Mol. Cancer Ther. 3, 1411-1420
9. Chen, L. S., and Sheppard, T. L. (2004) J. Biol. Chem. 279, 40405-40411
10. Chen, L. S., Nowak, B. J., Ayres, M. L., Krett, N. L., Rosen, S. T., Zhang, S., and Gandhi, V. (2009) Biochem. Pharmacol. 78, 583-591
11. Rodriguez, C. O., Jr., Plunkett, W., Paff, M. T., Du, M., Nowak, B., Ramakrishna, P., Keating, M. J., and Gandhi, V. (2000) J. Chromatogr. B. Biomed. Sci. App. 745, 421-430
12. de Korte, D., Haverkort, W. A., Roos, D., and van Gennip, A. H. (1985) Clin. Chim. Acta 148, 185-196
13. Silverstein, R. M., Bassler, G., and Morrill, T. (2005) Spectrometric Identification of Organic Compounds, 7th Ed., John Wiley and Sons, New York
14. Carter, C. E., and Cohen, L. H. (1956) J. Biol. Chem. 222, 17-30
15. Van den Bergh, F., Vincent, M. F., Jaeken, J., and Van den Berghe, G. (1991) Anal. Biochem. 193, 287-291
16. Van den Berghe, G., Vincent, M. F., and Jaeken, J. (1997) J. Inherit. Metab. Dis. 20, 193-202
17. Zeman, J., Krijt, J., Stratilová, L., Hansíková, H., Wenchich, L., Kmoch, S., Chrastina, P., and Houstek, J. (2000) J. Inherit. Metab. Dis. 23, 371-374
18. Tortora, G., Ciardiello, F., Pepe, S., Tagliaferri, P., Ruggiero, A., Bianco, C., Guarrasi, R., Miki, K., and Bianco, A. R. (1995) Clin. Cancer Res. 1, 377-384
19. El-Mir, M. Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., and Leverve, X. (2000) J. Biol. Chem. 275, 223-228
20. Bosi, E. (2009) Diabetes, Obesity, Metabol. 11, 3-8
21. Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M. C., Hortobagyi, G. N., and Gonzalez-Angulo, A. M. (2009) J. Clin. Oncol. 27, 3297-3302
22. Bennett, L. L., Chang, C. H., Allan, P. W., Adamson, D. J., Rose, L. M., Brockman, R. W., Secrist, J. A., Shortnacy, A., and Montgomery, J. A. (1985) Nucleosides Nucleotides Nucleic Acids 4, 107-116
23. Isaacs, J. S., Jung, Y. J., Mole, D. R., Lee, S., Torres-Cabala, C., Chung, Y. L., Merino, M., Trepel, J., Zbar, B., Toro, J., Ratcliffe, P. J., Linehan, W. M., and Neckers, L. (2005) Cancer Cell 8, 143-153
24. Koivunen, P., Hirsilä, M., Remes, A. M., Hassinen, I. E., Kivirikko, K. I., and Myllyharju, J. (2007) J. Biol. Chem. 282, 4524-4532
25. Stellrecht, C., Ayres, M., Arya, R., and Gandhi, V. (2009) Breast Cancer Res. Treat, Epub ahead of print
26. Sudarshan, S., Sourbier, C., Kong, H. S., Block, K., Romero, V. A., Yang, Y., Galindo, C., Mollapour, M., Scroggins, B., Goode, N., Lee, M. J., Gourlay, C. W., Trepel, J., Linehan, W. M., and Neckers, L. (2009) Mol. Cell Biol. 29, 4080-4090
27. Liu, R., Li, Z., Bai, S., Zhang, H., Tang, M., Lei, Y., Chen, L., Liang, S., Zhao, Y. L., Wei, Y., and Huang, C. (2009) Mol. Cell Proteomics 8, 70-85
28. Tomlinson, I. P., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomäki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V., and Aaltonen, L. A. (2002) Nat. Genet. 30, 406-410
29. Carvajal-Carmona, L. G., Alam, N. A., Pollard, P. J., Jones, A. M., Barclay, E., Wortham, N., Pignatelli, M., Freeman, A., Pomplun, S., Ellis, I., Poulsom, R., El-Bahrawy, M. A., Berney, D. M., and Tomlinson, I. P. M. (2006) J. Clin. Endocrinol. Metab. 91, 3071-3075
30. King, A., Selak, M. A., and Gottlieb, E. (2006) Oncogene 25, 4675-4682
31. Vander Heiden, M. G., Cantley, L. C., and Thompson, C. B. (2009) Science 324, 1029-1033
32. Xie, H., Valera, V. A., Merino, M. J., Amato, A. M., Signoretti, S., Linehan, W. M., Sukhatme, V. P., and Seth, P. (2009) Mol. Cancer Ther. 8, 626-635