Similar and different effects of capsaicin and resiniferatoxin on substance P release and transient receptor potential vanilloid type 1 expression of cultured rat dorsal root ganglion neurons

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 32, Issue 1, 2010, Pages 3-11

  Yang, X ^a   Gong, H ^a   Liu, Z ^a   Liu, H ^b   Wang, H ^a   Li, Zhenzhong ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; PREPROTACHYKININ; RESINIFERATOXIN; SUBSTANCE P; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; EMBRYO; NERVE CELL; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL GANGLION; WISTAR RAT;

ANIMALS; CAPSAICIN; CELLS, CULTURED; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; NEURONS; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RNA, MESSENGER; SENSORY SYSTEM AGENTS; SUBSTANCE P; TACHYKININS; TIME FACTORS; TRPV CATION CHANNELS;

EID: 77950874125     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2010.32.1.1444424     Document Type: Article

References (44)

1. Chen, T.Y., Corcos, J., Camel, M., Ponsot, Y., Tu le, M. Prospective, randomized, double-blind study of safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC). Int Urogynecol J Pelvic Floor Dysfunct 2005, 16(4): 293-297
2. Karai, L., Brown, D.C., Mannes, A.J. et al. Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control. J Clin Invest 2004, 113(9): 1344-1352
3. Hussain, I.F., Fowler, C.J. Use of intravesical capsaicin for urge urinary incontinence and irritative voiding syndromes. Curr Opin Urol 1998, 8(4): 293-296
4. Reitz, A., Schurch, B. Intravesical therapy options for neurogenic detrusor overactivity. Spinal Cord 2004, 42(5): 267-272
5. Cruz, F. Mechanisms involved in new therapies for overactive bladder. Urology 2004, 63(3 Suppl 1): 65-73.
6. Evans, R.J. Intravesical therapy for overactive bladder. Curr Urol Rep 2005, 6(6): 429-433
7. Hingtgen, C.M., Waite, K.J., Vasko, M.R. Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3′,5′-cyclic monophosphate transduction cascade. J Neurosci 1995, 15(7 Pt 2): 5411-5419
8. Yang, X., Liu, Z., Wang, L. et al. Exogenous galanin regulates capsaicinevoked substance P release from primary cultured dorsal root ganglion neurons. Neuro Endocrinol Lett 2008, 29(6): 911-916
9. Caterina, M.J., Schumacher, M.A., Tominaga, M. et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997, 389(6653): 816-824
10. Winston, J., Toma, H., Shenoy, M., Pasricha, P.J. Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons. Pain 2001, 89(2-3): 181-186
11. Wang, Y., Szabo, T., Welter, J.D. et al. High affinity antagonists of the vanilloid receptor. Mol Pharmacol 2002, 62(4): 947-956
12. Jeftinija, S., Liu, F., Jeftinija, K., Urban, L. Effect of capsaicin and resiniferatoxin on peptidergic neurons in cultured dorsal root ganglion. Regul Pept 1992, 39(2-3): 123-135
13. Szallasi, A., Farkas-Szallasi, T., Tucker, J.B. et al. Effects of systemic resiniferatoxin treatment on substance P mRNA in rat dorsal root ganglia and substance P receptor mRNA in the spinal dorsal horn. Brain Res 1999, 815(2): 177-184
14. Chen, S.R., Pan, H.L. Loss of TRPV1-expressing sensory neurons reduces spinal mu opioid receptors but paradoxically potentiates opioid analgesia. J Neurophysiol 2006, 95(5): 3086-3096
15. Farkas-Szallasi, T., Bennett, G.J., Blumberg, P.M. et al. Vanilloid receptor loss is independent of the messenger plasticity that follows systemic resiniferatoxin administration. Brain Res 1996, 719(1-2): 213-218
16. Winter, J., Dray, A., Wood, J.N., Yeats, J.C., Bevan, S. Cellular mechanism of action of resiniferatoxin: A potent sensory neuron excitotoxin. Brain Res 1990, 520(1-2): 131-140
17. Craft, R.M., Cohen, S.M., Porreca, F. Long-lasting desensitization of bladder afferents following intravesical resiniferatoxin and capsaicin in the rat. Pain 1995, 61(2): 317-323
18. Fowler, C.J. Intravesical treatment of overactive bladder. Urology 2000, 55 (5A, Suppl.): 60-64
19. Lazzeri, M., Beneforti, P., Turini, D. Urodynamic effects of intravesical resiniferatoxin in humans: Preliminary results in stable and unstable detrusor. J Urol 1997, 158(6): 2093-2096
20. Xu, X.J., Farkas-Szallasi, T., Lundberg, J.M. et al. Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: Behavioral, electrophysiological and in situ hybridization studies. Brain Res 1997, 752: 52-60.
21. Cruz, F. Desensitization of bladder sensory fibers by intravesical capsaicin or capsaicin analogs. A new strategy for treatment of urge incontinence in patients with spinal detrusor hyperreflexia or bladder hypersensitivity disorders. Int Urogynecol J Pelvic Floor Dysfunct 1998, 9(4): 214-220
22. Fowler, C.J. Bladder afferents and their role in the overactive bladder. Urology 2002, 59 (5, Suppl. 1): 37-42.
23. Abdulla, F.A., Stebbing, M.J., Smith, P.A. Effects of substance P on excitability and ionic currents of normal and axotomized rat dorsal root ganglion neurons. Eur J Neurosci 2001, 13(3): 545-552
24. Tominaga, M., Tominaga, T. Structure and function of TRPV1. Pflugers Arch 2005, 451(1): 143-150
25. Tang, H.B., Inoue, A., Iwasa, M., Hide, I., Nakata, Y. Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. J Neurochem 2006, 97(5): 1412-1418
26. Mowa, C.N., Usip, S., Storey-Workley, M., Amann, R., Papka, R. Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis. Peptides 2003, 24(5): 761-771
27. Hong, C.H., Kim, J.H., Noh, J.Y. et al. Sensory neuronal change after intravesical electrical stimulation in spinalized rat. Yonsei Med J 2002, 43(5): 652-656
28. Liu, Z., Zhang, F., Liu, H. et al. Co-administration of nerve growth factor and butyrate regulates vanilloid receptor 1 and substance P levels in cultures of rat dorsal root ganglion neurons. Acta Physiol Hung 2009, 96(2): 231-241
29. Ribeiro-da-Silva, A., Hökfelt, T. Neuroanatomical localisation of substance P in the CNS and sensory neurons. Neuropeptides 2000, 34(5): 256-271
30. Pang, X., Marchand, J., Sant, G.R., Kream, R.M., Theoharides, T.C. Increased number of substance P positive nerve fibres in interstitial cystitis. Br J Urol 1995, 75(6): 744-750
31. Xing, Y., Liu, Z., Wang, L.H. et al. Butyrate sensitizes the release of substance P and calcitonin gene-related peptide evoked by capsaicin from primary cultured rat dorsal root ganglion neurons. Neuro Endocrinol Lett 2006, 27(6): 695-701.
32. Avelino, A., Cruz, C., Nagy, I., Cruz, F. Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 2002, 109(4): 787-798
33. Hwang, S.J., Oh, J.M., Valtschanoff, J.G. Expression of the vanilloid receptor TRPV1 in rat dorsal root ganglion neurons supports different roles of the receptor in visceral and cutaneous afferents. Brain Res 2005, 1047(2): 261-266
34. Anelino, A., Cruz, F., Coimbra, A. Intravesical resiniferatoxin desensitizes rat bladder sensory fibres without causing intense noxious excitation. A cfos study. Eur J Pharmacol 1999, 378(1): 17-22.
35. Jakab, G., Szallasi, A., Agoston, D. The calcitonin gene-related peptide (CGRP) phenotype is expressed early and up-regulated by resiniferatoxin (RTX) in mouse sensory neurons. Brain Res Dev Brain Res 1994, 80(1-2): 290-294
36. Craft, R.M., Carlisi, V.J., Mattia, A., Herman, R.M., Porreca, F. Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat. Pain 1993, 55(2): 205-215
37. Calixto, J.B., Kassuya, C.A., André, E., Ferreira, J. Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions. Pharmacol Ther 2005, 106(2): 179-208.
38. Helliwell, R.J., McLatchie, L.M., Clarke, M. et al. Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia. Neurosci Lett 1998, 250(3): 177-180
39. Cruz, F. Vanilloid receptor and detrusor instability. Urology 2002, 59(5, Suppl. A): 51-60.
40. Apostolidis, A., Brady, C.M., Yiangou, Y., Davis, J., Fowler, C.J., Anand, P. Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin. Urology 2005, 65(2): 400-405
41. Brady, C.M., Apostolidis, A.N., Harper, M. et al. Parallel changes in bladder suburothelial vanilloid receptor TRPV1 and pan-neuronal marker PGP9.5 immunoreactivity in patients with neurogenic detrusor overactivity after intravesical resiniferatoxin treatment. BJU Int 2004, 93(6): 770-776
42. Caudle, R.M., Karai, L., Mena, N. et al. Resiniferatoxin-induced loss of plasma membrane in vanilloid receptor expressing cells. Neurotoxicology 2003, 24(6): 895-908.
43. Raisinghani, M., Pabbidi, R.M., Premkumar, L.S. Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin. J Physiol 2005, 567(Pt 3): 771-786
44. Neubert, J.K., Karai, L., Jun, J.H. et al. Peripherally induced resiniferatoxin analgesia. Pain 2003, 104(1-2): 219-228