Desensitization of bladder sensory fibers by intravesical capsaicin or capsaicin analogs. A new strategy for treatment of urge incontinence in patients with spinal detrusor hyperreflexia or bladder hypersensitivity disorders

International Urogynecology Journal

Volumn 9, Issue 4, 1998, Pages 214-220

  Cruz, F ^a  

^a HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

Bladder hypersensitivity; Capsaicin; Detrusor hyperreflexia; Resiniferatoxin; Urge incontinence

Indexed keywords

CAPSAICIN; RESINIFERATOXIN;

BLADDER CAPACITY; BLADDER DISEASE; BLADDER FUNCTION; BLADDER IRRITATION; CLINICAL TRIAL; DESENSITIZATION; HUMAN; HYPERREFLEXIA; HYPERSENSITIVITY; INTRAVESICAL DRUG ADMINISTRATION; META ANALYSIS; MICTURITION; NOCICEPTION; NONMYELINATED NERVE; PELVIC NERVE; PRIORITY JOURNAL; REVIEW; SENSORY RECEPTOR; SENSORY STIMULATION; SPINAL REFLEX; SPINE DISEASE; URGE INCONTINENCE;

EID: 0031658963     PISSN: 09373462     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01901607     Document Type: Review

References (47)

1. Abrams P, Blaivas JG, Stanton SL, Anderson JT. Standardisation of terminology of lower urinary tract dysfunction. Scand J Urol Nephrol 1988;114(Suppl):5-19
2. Milsom I, Ekelund P, Molander U, Arvidsson L, Areskoug B. The influence of age, parity, oral contraception, hysterectomy and menopause on the prevalence of urinary incontinence in women. J Urol 1993;149:1459-1462
3. Wyman JF. The costs of urinary incontinence. Eur Urol 1997;32(Suppl 2):13-19
4. Ekelund P, Grimby AG, Milson I. Urinary incontinence - social and financial cost high. Br Med J 1993:306:1344
5. Hu T. Impact of urinary incontinence on health care costs. J Am Geriatr Soc 1990;38:292-295
6. Diokno AC. Epidemiology of female incontinence. In: Raz SW, ed. Female urology. Philadelphia: WB Saunders, 1996:73-79
7. Hampel C, Wienhold D, Benken N, Eggersmann C, Thuroff JW. Prevalence and natural history of female incontinence. Eur Urol 1997;32(Suppl 2):3-12
8. Stephenson TP, Mundy AR. The urge syndrome. In: Mundy AR, Stephenson TP, Wein AJ, eds. Urodynamics. Edinburgh: Churchill Livingstone, 1994:263-275
9. Heritz DM, Blaivas JG. Evaluation of urinary tract dysfunction. In: Raz SW, ed. Female urology. Philadelphia: WB Saunders, 1996:89-96
10. Szallasi A, Blumberg PM. Vanilloid receptors: new insights enhance potential as therapeutic target. Pain 1996;68:195-208
11. Walpole CSJ, Bevan S, Bovermann G. et al. The discovery of capsazeprine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin. J Med Chem 1994;37:1942-1954
12. Szallasi A, Blumberg PM. Specific binding of resiniferatoxin, an ultrapotent capsaicin analog by dorsal root ganglion membranes. Brain Res 1990;524:106-111
13. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-824
14. Bevan SJ, Docherty RJ. Cellular mechanisms of the action of capsaicin. In: Wood J, ed. Capsaicin in the study of pain. London: Academic Press, 1993:27-44
15. Szolcsányi J, Jancsó-Gabor A, Joo F. Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin. Naunyn Schmiedeberg's Arch 1975;287:157-161
16. McMahon SB, Lewin G, Bloom SR. The consequences of long-term topical capsaicin application in the rat. Pain 1991;44:301-310
17. de Groat WD. A neurologic basis for the overactive bladder. Urology 1997;50(Suppl 6A):36-52
18. Maggi CA, Barbanti G, Santicioli P et al. Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of the micturition reflex in humans. J Urol 1989;142:150-154
19. Blaivas JG. The neurophysiology of micturition: a clinical study of 550 patients. J Urol 1982;127:958-963
20. Fowler CA, Jewkes D, McDonald WI, Lynn B, de Groat WC, Intravesical capsaicin for neurogenic bladder dysfunction. Lancet 1992;339:1239
21. Fall M, Lindstrom S, Mazières L. A bladder cooling reflex in the cat. J Physiol (Lond) 1990;427:281-300
22. Geirsson G, Fall M, Sullivan L. Clinical and urodynamic effects of intravesical capsaicin treatment in patients with chronic traumatic spinal detrusor hyperreflexia. J Urol 1995;154:1825-1829
23. Habler HJ, Janig W, Koltzenburg M. Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol (Lond.) 1990;425:545-562
24. Cruz F, Avelino A, Lima D, Coimbra A. Activation of c-fos protooncogene in the spinal cord following noxious stimulation of the urinary bladder. Somatosens Motor Res 1994;11:319-325
25. Koltzenburg M. Stability and plasticity of nociceptor function and their relationship to provoked and ongoing pain. Semin Neurosci 1995;7:199-210
26. Andersson KE. The overactive bladder: pharmacologic basis of drug treatment. Urology 1997;50(Suppl 6A):74-84
27. Appell RA. Clinical efficacy and safety of tolterodine in the treatment of overactive bladder: a pooled analysis. Urology, 1997;50(Suppl 6A):90-96
28. Burnstock G. The changing face of autonomic neurotransmission. Acta Physiol Scand 1986;126:67-91
29. Levin RM, Ruggieri MR, Lee W, Wein AJ. Effect of chronic atropine administration on the rat urinary bladder. J Urol 1989;139:1347-1351
30. Mark SD, Webster GD. Detrusor hyperactivity. In: Raz SW, ed. Female urology. Philadelphia: WB Saunders, 1996;231-243
31. Zinner NR. The surgical principles associated with voiding dysfunction. Curr Opin Urol 1993;3:290-295
32. Fowler CA, Beck RO, Gerrard S, Betts CD, Fowler CG. Intravesical capsaicin for treatment of detrusor hyperreflexia. J Neurol Neurosurg Psychiatr 1994;57:169-173
33. Das AS, Chancellor MB, Watanabe T, Sedor J, Rivas DA. Intravesical capsaicin in neurologic impaired patients with detrusor hyperreflexia. J Spinal Cord Med 1996;19:190-193
34. Cruz F, Guimarães M, Silva C, Rio ME, Coimbra A, Reis M. Desensitization of bladder sensory fibers by intravesical capsaicin has long-lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction. J Urol 1997;157:585-589
35. De Ridder D, Chandiramani V, Dasgupta P, van Poppel H, Baert L, Fowler CJ. Intravesical capsaicin as a treatment for refractory detrusor hyperreflexia: a dual center study with long-term follow-up. J Urol 1997;158:2087-2092
36. Cruz F, Avelino A, Coimbra A. Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord. Pain 1996;64:553-557
37. Barbanti G, Maggi CA, Beneforti P, Baroldi P, Turini D. Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract. Br J Urol 1993;71:686-691
38. Lazzeri M, Beneforti P, Benaim G, Maggi CA, Lecci A, Turini D. Intravesical capsaicin for treatment of severe bladder pain: a randomized placebo controlled study. J Urol 1996;156:947-952
39. Craft RM, Porreca F. Tetracaine attenuates irritancy without attenuating desensitization produced by intravesical resiniferatoxin in the rat. Pain 1994;57:351-359
40. Avelino A, Cruz F, Coimbra A. Lidocaine prevents noxious excitation of bladder afferents induced by intravesical capsaicin without interfering with the ensuing sensory desensitization. An experimental study in the rat. J Urol 1998;159:567-570
41. Chandiramani VA, Peterson T, Duthie GS, Fowler CJ. Urodynamic changes during intravesical instillations of capsaicin. Br J Urol 1996;77:792-797
42. Dasgupta P, Chandiramani V, Parkinson MC, Beckett A, Fowler CJ. Treating the human bladder with capsaicin: is it safe? Eur Urol 1998;33:28-31
43. Cruz F, Avelino A, Coimbra A. Intravesical resiniferatoxin desensitizes bladder sensory fibers in a dose dependent manner. J Urol 1997;157(Suppl):79
44. Cruz F, Guimarães M, Silva C, Reis M. Intravesical resiniferatoxin, a capsaicin analog, represses bladder hyperreflexia without evoking significant acute discomfort. Lancet 1997; 350:640-641
45. Lazzeri M, Beneforti P, Turini D. Urodynamic effects of intravesical resiniferatoxin in humans: preliminary results in stable and unstable detrusor. J Urol 1997;158:2093-2096
46. Brading AF. A myogenic basis for the overactive bladder. Urology 1997;50(Suppl 6A):57-67
47. Steers WD, de Groat WC. Effect of bladder outlet obstruction on micturition reflex pathways in the rat. J Urol 1988;140:864-871