High-throughput screening strategy for photogenotoxic potential of pharmaceutical substances using fluorescent intercalating dye

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 5, 2010, Pages 781-786

  Seto, Yoshiki ^a   Ochi, Masanori ^a   Onoue, Satomi ^a   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Assay validation; Photogenotoxicity; Plasmid DNA; Reactive oxygen species; Thiazole orange

Indexed keywords

ACETAZOLAMIDE; AMITRIPTYLINE; CARBAMAZEPINE; CHLORPROMAZINE; CLOMIPRAMINE; DIAZEPAM; DICLOFENAC; DOXYCYCLINE; FLUORESCENT DYE; FLUOROURACIL; FLUTAMIDE; FUROSEMIDE; IMIPRAMINE; INDOMETACIN; INTERCALATING AGENT; KETOPROFEN; METHOTREXATE; METHOXSALEN; NALIDIXIC ACID; NAPROXEN; NITRAZEPAM; NITROFURANTOIN; OMEPRAZOLE; OXYTETRACYCLINE; PIROXICAM; PROMETHAZINE; QUININE; REACTIVE OXYGEN METABOLITE; TOLBUTAMIDE; UNINDEXED DRUG;

ACCURACY; AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; FLUORESCENCE; GENOTOXICITY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; PHOTODYNAMICS; PHOTOTOXICITY; PRIORITY JOURNAL; REPRODUCIBILITY;

DNA; FLUORESCENT DYES; LIGHT; MUTAGENICITY TESTS; PHARMACEUTICAL PREPARATIONS; REACTIVE OXYGEN SPECIES; REPRODUCIBILITY OF RESULTS;

EID: 77950867820     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.02.029     Document Type: Article

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