Synthesis and antiproliferative activity of oxazinocarbazole and N,N-bis(carbazolylmethyl)amine derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2567-2577

  Issa, Samar ^a   Walchshofer, Nadia ^a   Kassab, Issam ^b   Termoss, Hussein ^a   Chamat, Soulaima ^b   Geahchan, Aziz ^b   Bouaziz, Zouhair ^a  

^a UNIVERSITÉ LYON 1   (France)

^b LEBANESE UNIVERSITY   (Lebanon)

Author keywords

Antiproliferative activity; Hydroxycarbazole derivatives; Mannich reaction; N,N bis(carbazolylmethyl)amines; Oxazinocarbazoles

Indexed keywords

11 METHYL 2 PYRIDIN 2 YLMETHYL 1,2,3,11 TETRAHYDRO[2,4]OXAZINO[5,6 A]CARBAZOLE; 11 METHYL 7 (4 METHYLBENZYL) 6,7,8,11 TETRAHYDRO[7,9]OXAZINO[6,5 B]CARBAZOLE; 11 METHYL 7 (A METHYLBENZYL) 6,7,8,11 TETRAHYDRO[7,9]OXAZINO[6,5 B]CARBAZOLE; 11 METHYL 7 PYRIDIN 2 YLMETHYL 6,7,8,11 TETRAHYDRO[7,9]OXAZINO[6,5 B]CARBAZOLE; 2 BENZYL 11 METHYL 1,2,3,11 TETRAHYDRO[2,4]OXAZINO[5,6 A]CARBAZOLE; 3 ALLYL 7 ETHYL 2,3,4,7 TETRAHYDRO[1,3]OXAZINO[5,6 C]CARBAZOLE; 3 ALLYL 7 METHYL 2,3,4,7 TETRAHYDRO[1,3]OXAZINO[5,6 C]CARBAZOLE; 3 ALLYL 7 PRENYL 2,3,4,7 TETRAHYDRO[1,3]OXAZINO[5,6 C]CARBAZOLE; 3 BENZYL 7 PRENYL 2,3,4,7 TETRAHYDRO[1,3]OXAZINO[5,6 C]CARBAZOLE; 7 ALLYL 11 METHYL 6,7,8,11 TETRAHYDRO[7,9]OXAZINO[6,5 B]CARBAZOLE; ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG HYDROXYLATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MANNICH REACTION;

EID: 77950867152     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.045     Document Type: Article

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