Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4204-4206

  Das, Bhaskar C ^a   Madhukumar, Ankanahlli V ^a   Anguiano, Jaime ^a   Mani, Sridhar ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Hypoxia agent; Hypoxia inducing factor (HIF) alpha; Oxazine; PET agent

Indexed keywords

2H BENZO[B][1,4]OXAZINE DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXAZINE DERIVATIVE; PROTEIN P21; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOXIA;

ANOXIA; ANTINEOPLASTIC AGENTS; BENZOXAZINES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NEOPLASMS; OXAZINES; POLYMERASE CHAIN REACTION; POSITRON-EMISSION TOMOGRAPHY; TETRAZOLIUM SALTS; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67649949954     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.110     Document Type: Article

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