Mtd/Bok takes a swing: Proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia

Cell Death and Differentiation

Volumn 17, Issue 5, 2010, Pages 846-859

  Ray, J E ^a,b,c   Garcia, J ^a   Jurisicova, A ^a,b,c   Caniggia, I ^a,b,c,d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cyclin E1; Matador; Preeclampsia; Proliferation; Trophoblast cell

Indexed keywords

CYCLIN E; CYCLIN E1; MATADOR PROTEIN; PROTEIN BCL 2; PROTEIN BCL 2 OVARIAN KILLER; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE PROGRESSION; CELL FRACTIONATION; CELL LINE; CELL PROLIFERATION; CELL STRAIN HEK293; CELL VIABILITY; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOFLUORESCENCE; MITOCHONDRION; NICK END LABELING; NUCLEOTIDE SEQUENCE; PLACENTA DEVELOPMENT; PLACENTA VILLUS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REPRODUCTION; RNA ANALYSIS; TROPHOBLAST; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN E; FEMALE; HUMANS; IN SITU NICK-END LABELING; ONCOGENE PROTEINS; PLACENTATION; PRE-ECLAMPSIA; PREGNANCY; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-BCL-2; TROPHOBLASTS;

EID: 77950866025     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.167     Document Type: Article

References (45)

1. Lea RG, Riley SC, Antipatis C, Hannah L, Ashworth CJ, Clark DA et al. Cytokines and the regulation of apoptosis in reproductive tissues: a review. Am J Reprod Immunol 1999; 42: 100-109.
2. Levy R, Nelson DM. To be, or not to be, that is the question. Apoptosis in human trophoblast. Placenta 2000; 21: 1-13.
3. Smith SC, Baker PN, Symonds EM. Placental apoptosis in normal human pregnancy. Am J Obstet Gynecol 1997; 177: 57-65.
4. Burton GJ, Jauniaux E, Watson AL. Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. Am J Obstet Gynecol 1999; 181: 718-724.
5. Jaffe R, Jauniaux E, Hustin J. Maternal circulation in the first-trimester human placenta-myth or reality? Am J Obstet Gynecol 1997; 176: 695-705.
6. Rodesch F, Simon P, Donner C, Jauniaux E. Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet Gynecol 1992; 80: 283-285.
7. Smith SC, Leung TN, To KF, Baker PN. Apoptosis is a rare event in first-trimester placental tissue. Am J Obstet Gynecol 2000; 183: 697-699.
8. Genbacev O, Zhou Y, Ludlow JW, Fisher SJ. Regulation of human placental development by oxygen tension. Science 1997; 277: 1669-1672.
9. Soleymanlou N, Jurisica I, Nevo O, Ietta F, Zhang X, Zamudio S et al. Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab 2005; 90: 4299-4308.
10. Heazell AE, Crocker IP. Live and let die-regulation of villous trophoblast apoptosis in normal and abnormal pregnancies. Placenta 2008; 29: 772-783.
11. Ray J, Jurisicova A, Caniggia I. IFPA trophoblast research award lecture: the dynamic role of Bcl-2 family members in trophoblast cell fate. Placenta 2008; 30 (Suppl A): S96-S100.
12. Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 1999; 274: 2225-2233.
13. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
14. Soleymanlou N, Wu Y, Wang JX, Todros T, Ietta F, Jurisicova A et al. A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. Cell Death Differ 2005; 12: 441-452.
15. Bonnefoy-Berard N, Aouacheria A, Verschelde C, Quemeneur L, Marcais A, Marvel J. Control of proliferation by Bcl-2 family members. Biochim Biophys Acta 2004; 1644: 159-168.
16. Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A et al. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat 2007; 10: 13-29.
17. Zinkel S, Gross A, Yang E. BCL2 family in DNA damage and cell cycle control. Cell Death Differ 2006; 13: 1351-1359.
18. Brady HJ, Gil-Gomez G, Kirberg J, Berns AJ. Bax alpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J 1996; 15: 6991-7001.
19. Fujise K, Zhang D, Liu J, Yeh ET. Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen. J Biol Chem 2000; 275: 39458-39465.
20. Jamil S, Sobouti R, Hojabrpour P, Raj M, Kast J, Duronio V. A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1. Biochem J 2005; 387 (Part 3): 659-667.
21. Knudson CM, Johnson GM, Lin Y, Korsmeyer SJ. Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res 2001; 61: 659-665.
22. Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJ. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective antiapoptotic Bcl-2 family members. Proc Natl Acad Sci USA 1997; 94: 12401-12406.
23. Hsu SY, Hsueh AJ. Tissue-specific Bcl-2 protein partners in apoptosis: an ovarian paradigm. Physiol Rev 2000; 80: 593-614.
24. Rodriguez JM, Glozak MA, Ma Y, Cress WD. Bok, Bcl-2-related ovarian killer, is cell cycle-regulated and sensitizes to stress-induced apoptosis. J Biol Chem 2006; 281: 22729-22735.
25. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American college of obstetricians and gynecologists. Int J Gynaecol Obstet 2002; 77: 67-75.
26. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet 2001; 357: 53-56.
27. Gerretsen G, Huisjes HJ, Elema JD. Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation. Br J Obstet Gynaecol 1981; 88: 876-881.
28. Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ. Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res 2002; 90: 1274-1281.
29. Soleymanlou N, Jurisicova A, Wu Y, Chijiiwa M, Ray JE, Detmar J et al. Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in Preeclampsia. Am J Pathol 2007; 171: 496-506.
30. Endl E, Gerdes J. The Ki-67 protein: fascinating forms and an unknown function. Exp Cell Res 2000; 257: 231-237.
31. Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 1991; 66: 1197-1206.
32. Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004; 18: 2699-2711.
33. Brown LM, Lacey HA, Baker PN, Crocker IP. E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia. Histochem Cell Biol 2005; 124: 499-506.
34. De Falco M, De Luca L, Acanfora F, Cavallotti I, Cottone G, Laforgia V et al. Alteration of the Bcl-2: Bax ratio in the placenta as pregnancy proceeds. Histochem J 2001; 33: 421-425.
35. Gao S, Fu W, Durrenberger M, De Geyter C, Zhang H. Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3. Cell Mol Life Sci 2005; 62: 1015-1024.
36. Inohara N, Ekhterae D, Garcia I, Carrio R, Merino J, Merry A et al. Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. J Biol Chem 1998; 273: 8705-8710.
37. Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 2000; 345 (Part 2): 271-278.
38. Antonsson B, Montessuit S, Sanchez B, Martinou JC. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem 2001; 276: 11615-11623.
39. Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, Ducret T et al. Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 2005; 16: 2424-2432.
40. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 1997; 139: 1281-1292.
41. Bartholomeusz G, Wu Y, Ali SM, Xia W, Kwong KY, Hortobagyi G et al. Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis. Mol Carcinog 2006; 45: 73-83.
42. Abuhamad AZ. ACOG Practice Bulletin, clinical management guidelines for obstetriciangynecologists. number 98, October 2008 (replaces Practice Bulletin number 58, December 2004). Ultrasonography in pregnancy. Obstet Gynecol 2008; 112: 951-961.
43. Hansen AR, Collins MH, Genest D, Heller D, Shen-Schwarz S, Banagon P et al. Very low birthweight placenta: clustering of morphologic characteristics. Pediatr Dev Pathol 2000; 3: 431-438.
44. Redline RW. Placental pathology: a systematic approach with clinical correlations. Placenta 2008; 29 (Suppl A): S86-S91.
45. Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M et al. Hypoxiainducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest 2000; 105: 577-587.