Intercalation of imidazoacridinones to DNA and its relevance to cytotoxic and antitumor activity

Biochemical Pharmacology

Volumn 63, Issue 9, 2002, Pages 1653-1662

  Dzi, Jaroslaw ^a   Slusarski, Bartlomiej ^a   Konitz, Antoni ^a,b   Skladanowski, Andrzej ^a   Konopa, Jerzy ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF GDA SK   (Poland)

Author keywords

C 1311; Crystal structure; DNA intercalation; Imidazoacridinones; Structure activity relationship

Indexed keywords

ANTINEOPLASTIC AGENT; C 1176; C 1212; C 1263; C 1266; C 1310; C 1330; C 1371; C 1415; C 1419; C 1492; C 1554; C 1558; DNA TOPOISOMERASE; IMIDACRINE; IMIDAZOACRIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA SYNTHESIS; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

AMINOACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA, NEOPLASM; HUMANS; INTERCALATING AGENTS; LEUKEMIA L1210; MICE; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; RNA; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ATOMIC; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0036569639     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00916-4     Document Type: Article

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