Novel bis-phenanthridine derivatives with easily tunable linkers, study of their interactions with DNA and screening of antiproliferative activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2671-2676

  Dukši, Marko ^a,b   Baretić, Domagoj ^a   Čaplar, Vesna ^a   Piantanida, Ivo ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

DNA binding; Fluorescence; Phenanthridine; Solid phase synthesis

Indexed keywords

DOUBLE STRANDED DNA; MONOMER; PHENANTHRIDINE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; FLUORESCENCE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; PH; SOLID PHASE SYNTHESIS; SPECTROPHOTOMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NUCLEIC ACID DENATURATION; PHENANTHRIDINES; TRANSITION TEMPERATURE;

EID: 77950860147     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.017     Document Type: Article

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