Predicting language outcome and recovery after stroke: The PLORAS system

Nature Reviews Neurology

Volumn 6, Issue 4, 2010, Pages 202-210

  Price, Cathy J ^a   Seghier, Mohamed L ^a   Leff, Alex P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

BRAIN REGION; CEREBROVASCULAR ACCIDENT; COGNITION; HUMAN; LANGUAGE ABILITY; LANGUAGE DISABILITY; LONGITUDINAL STUDY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PRIORITY JOURNAL; REVIEW; SPEECH ANALYSIS; SPEECH THERAPY; TREATMENT OUTCOME;

BRAIN; BRAIN MAPPING; COMPUTER SIMULATION; HUMANS; MODELS, NEUROLOGICAL; PROGNOSIS; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; SPEECH DISORDERS; STROKE;

EID: 77950858023     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2010.15     Document Type: Review

References (140)

1. Sanai, N., Mirzadeh, Z. &Berger, M. S. Functional outcome after language mapping for glioma resection. N. Engl. J. Med. 358, 18-27 (2008).
2. Caplan, D., Waters, G., Dede, G., Michaud, J. &Reddy, A. A study of syntactic processing in aphasia II: neurological aspects. Brain Lang. 101, 151-177 (2007).
3. Rijntjes, M. Mechanisms of recovery in stroke patients with hemiparesis or aphasia: new insights, old questions and the meaning of therapies. Curr. Opin. Neurol. 19, 76-83 (2006).
4. Lazar, R. M. &Antoniello, D. variability in recovery from aphasia. Curr. Neurol. Neurosci. Rep. 8, 497-502 (2008).
5. Crosson, B. et al. Functional MRI of language in aphasia: a review of the literature and the methodological challenges. Neuropsychol. Rev. 17, 157-177 (2007).
6. Marsh, e. B. &Hillis, A. e. Recovery from aphasia following brain injury: the role of reorganization. Prog. Brain Res. 157, 143-156 (2006).
7. Mesulam, M. et al. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann. Neurol. 63, 709-719 (2008).
8. Mesulam, M. M. Slowly progressive aphasia without generalized dementia. Ann. Neurol. 11, 592-598 (1982).
9. Hodges, J. R. &Patterson, K. Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol. 6, 1004-1014 (2007).
10. Bright, P., Moss, H. e., Stamatakis, e. A. &Tyler, L. K. Longitudinal studies of semantic dementia: the relationship between structural and functional changes over time. Neuropsychologia 46, 2177-2188 (2008).
11. Wilson, S. M. et al. Automated MRI-based classification of primary progressive aphasia variants. Neuroimage 47, 1558-1567 (2009).
12. Rosen, H. J. et al. Behavioral features in semantic dementia vs other forms of progressive aphasias. Neurology 67, 1752-1756 (2006).
13. Broca, P. Remarks on the seat of the faculty of articulated language, following an observation of aphemia (loss of speech) [French]. Bull. Soc. Anat. Paris 6, 330-357 (1861).
14. Dronkers, N. F., Plaisant, O., Iba-Zizen, M. T. &Cabanis, e. A. Paul Broca's historic cases: high resolution MR imaging of the brains of Leborgne and Lelong. Brain 130, 1432-1441 (2007).
15. Berker, e. A., Berker, A. H. &Smith, A. Translation of Broca's 1865 report. Localization of speech in the third left frontal convolution. Arch. Neurol. 43, 1065-1072 (1986).
16. Wernicke, C. Der Aphasiche Symptomenkomplex (Cohen and Weigert, Breslau, 1874).
17. Bogen, J. e. &Bogen, G. M. Wernicke's region- where is it? Ann. NY Acad. Sci. 280, 834-843 (1976).
18. Whitaker, H. A. &etlinger, S. C. Theodor Meynert's contribution to classical 19th century aphasia studies. Brain Lang. 45, 560-1471 (1993).
19. Thomson, A. D. et al. Wernicke's encephalopathy revisited. Translation of the case history section of the original manuscript by Carl Wernicke 'Lehrbuch der Gehirnkrankheiten fur Aerzte and Studirende' (1881) with a commentary. Alcohol Alcohol. 43, 174-179 (2008).
20. Keller, S. S., Crow, T., Foundas, A., Amunts, K. &Roberts, N. Broca's area: nomenclature, anatomy, typology and asymmetry. Brain Lang. 109, 29-48 (2009).
21. Naeser, M., Helm-estabrooks, N. &Haas, G. Relationship between lesion extent in Wernicke's area on computed tomographic scan and predicting recovery of comprehension in Wernicke's aphasia. Arch. Neurol. 44, 73-82 (1987).
22. Wise, R. J. et al. Separate neural subsystems within 'Wernicke's area'. Brain 124, 83-95 (2001).
23. Tyler, K. L. &Malessa, R. The Goltz-Ferrier debates and the triumph of cerebral localizationalist theory. Neurology 55, 1015-1024 (2000).
24. Mohr, J. P. et al. Broca aphasia: pathologic and clinical. Neurology 28, 311-324 (1978).
25. Marie, P. Aphasia revisited: the third left frontal convolution does not play any specific role in language function [French]. Brain Medicale 26, 241-247 (1906).
26. Fridriksson, J., Bonilha, L. &Rorden, C. Severe Broca's aphasia without Broca's area damage. Behav. Neurol. 18, 237-238 (2007).
27. Schmithorst, v. J., Holland, S. K. &Plante, e. Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study. Neuroimage 29, 254-266 (2006).
28. Schaffler, L., Luders, H. O., Dinner, D. S., Lesser, R. P. &Chelune, G. J. Comprehension deficits elicited by electrical stimulation of Broca's area. Brain 116, 695-715 (1993).
29. Davis, C. et al. Speech and language functions that require a functioning Broca's area. Brain Lang. 105, 50-58 (2008).
30. Rogalsky, C., Pitz, e., Hillis, A. e. &Hickok, G. Auditory word comprehension impairment in acute stroke: relative contribution of phonemic versus semantic factors. Brain Lang. 107, 167-169 (2008).
31. Blank, S. C., Scott, S. K., Murphy, K., Warburton, e. &Wise, R. J. S. Speech production: Wernicke, Broca and beyond. Brain 125, 1829-1838 (2002).
32. Kreisler, A. et al. The anatomy of aphasia revisited. Neurology 54, 1117-1123 (2000).
33. Willmes, K. &Poeck, K. To what extent can aphasic syndromes be localized? Brain 116, 1527-1540 (1993).
34. Signoret, J. L., Castaigne, P., Lhermitte, F., Abelanet, R. &Lavorel, P. Rediscovery of Leborgne's brain: anatomical description with CT scan. Brain Lang. 22, 303-319 (1984).
35. Rorden, C. &Karnath, H. O. Using human brain lesions to infer function: a relic from a past era in the fMRI age? Nat. Rev. Neurosci. 5, 813-819 (2004).
36. Rorden, C., Fridriksson, J. &Karnath, H. O. An evaluation of traditional and novel tools for lesion behavior mapping. Neuroimage 44, 1355-1362 (2009).
37. Awad, M., Warren, J. e., Scott, S. K., Turkheimer, F. e. &Wise, R. J. S. A common system for the comprehension and production of narrative speech. J. Neurosci. 27, 11455-11464 (2007).
38. Newhart, M., Ken, L., Kleinman, J. T., Heidler-Gary, J. &Hillis, A. e. Neural networks essential for naming and word comprehension. Cogn. Behav. Neurol. 20, 25-30 (2007).
39. Hillis, A. e. Aphasia: progress in the last quarter of a century. Neurology 69, 200-213 (2007).
40. Hillis, A. e. et al. Re-examining the brain regions crucial for orchestrating speech articulation. Brain 127, 1479-1487 (2004).
41. vigneau, M. et al. Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing. Neuroimage 30, 1414-1432 (2006).
42. Seghier, M. L., Lee, H. L., Schofield, T., ellis, C. L. &Price, C. J. Inter-subject variability in the use of two different neuronal networks for reading aloud familiar words. Neuroimage 42, 1226-1236 (2008).
43. Kherif, F., Josse, G., Seghier, M. L. &Price, C. J. The main sources of inter-subject variability in neuronal activation for reading aloud. J. Cogn. Neurosci. 21, 654-668 (2009).
44. Penfield, W. &Roberts, L. Speech and Brain- Mechanisms (Princeton University Press, Princeton, 1959).
45. Crosson, B. Subcortical functions in language: a working model. Brain Lang. 25, 257-292 (1985).
46. Kuljic-Obradovic, D. C. Subcortical aphasia: three different language disorder syndromes? Eur. J. Neurol. 10, 445-448 (2003).
47. Radanovic, M. &Scaff, M. Speech and language disturbances due to subcortical lesions. Brain Lang. 84, 337-352 (2003).
48. Alexander, M. P., Naeser, M. A. &Palumbo, C. L. Correlations of subcortical CT lesion sites and aphasia profiles. Brain 110, 961-991 (1987).
49. Kumral, e., evyapan, D. &Balkir, K. Acute caudate vascular lesions. Stroke 30, 100-108 (1999).
50. Ackermann, H., Mathiak, K. &Riecker, A. The contribution of the cerebellum to speech production and speech perception: clinical and functional imaging data. Cerebellum 6, 202-213 (2007).
51. Richter, S. et al. Cognitive functions in patients with MR-defined chronic focal cerebellar lesions. J. Neurol. 254, 1193-1203 (2007).
52. Hofmann, J., Kotz, S. A., Marschhauser, A., Yves von Cramon, D. &Friederici, A. D. Lesionsite affects grammatical gender assignment in German: perception and production data. Neuropsychologia 45, 954-965 (2007).
53. Amici, S. et al. Performance in specific language tasks correlates with regional volume changes in progressive aphasia. Cogn. Behav. Neurol. 20, 203-211 (2007).
54. Amici, S. et al. Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative disease. J. Neurosci. 27, 6282-6290 (2007).
55. Bates, e. et al. voxel-based lesion-symptom mapping. Nat. Neurosci. 6, 448-450 (2003).
56. Baldo, J. v., Schwartz, S., Wilkins, D. &Dronkers, N. F. Role of frontal versus temporal cortex in verbal fluency as revealed by voxelbased lesion symptom mapping. J. Int. Neuropsychol. Soc. 12, 896-900 (2006).
57. Baldo, J. v. &Dronkers, N. F. Neural correlates of arithmetic and language comprehension: a common substrate? Neuropsychologia 45, 229-235 (2007).
58. Borovsky, A., Saygin, A. P., Bates, e. &Dronkers, N. F. Lesion correlates of conversational speech production deficits. Neuropsychologia 45, 2525-2533 (2007).
59. Dronkers, N. F., Wilkins, D. P., van valin, R. D. J., Redfern, B. B. &Jaeger, J. J. Lesion analysis of the brain areas involved in language comprehension. Cognition 92, 145-177 (2004).
60. Dronkers, N. F. A new brain region for coordinating speech articulation. Nature 384, 159-161 (1996).
61. Kinkingnéhun, S. et al. A novel approach to clinical-radiological correlations: Anatomo- Clinical Overlapping Maps (AnaCOM): method and validation. Neuroimage 37, 1237-1249 (2007).
62. Saygin, A. P., Wilson, S. M., Dronkers, N. F. &Bates, e. Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates. Neuropsychologia 42, 1788 - 1804 (2004).
63. Specht, K. et al. Joint independent component analysis of structural and functional images reveals complex patterns of functional reorganisation in stroke aphasia. Neuroimage 47, 2057-2063 (2009).
64. Wilson, S. M. &Saygin, A. P. Grammaticality judgment in aphasia: deficits are not specific to syntactic structures, aphasic syndromes, or lesion sites. J. Cogn. Neurosci. 16, 238-252 (2004).
65. Broca, P. Localization of speech in the third left frontal convolution [French]. Bull. Soc. Anthropol. 6, 337-393 (1865).
66. Naeser, M. A. &Hayward, R. W. Lesion localization in aphasia with cranial computed tomography and the Boston Diagnostic Aphasia examination. Neurology 28, 545-551 (1978).
67. Naeser, M. A., Palumbo, C. L., Helm-estabrooks, N., Stiassny-eder, D. &Albert, M. L. Severe non-fluency in aphasia: role of the medial subcallosal fasciculus plus other white matter pathways in recovery of spontaneous language. Brain 112, 1-38 (1989).
68. Basso, A., Lecours, A. R., Moraschini, S. &vanier, M. Anatomoclinical correlations of the aphasias as defined through computerized tomography: exceptions. Brain Lang. 26, 201-229 (1985).
69. Murdoch, B. e., Afford, R. J., Ling, A. R. &Ganguley, B. Acute computerized tomographic scans: their value in the localization of lesions and as prognostic indicators in aphasia. J. Commun. Disord. 19, 311-345 (1986).
70. Kertesz, A., Harlock, W. &Coates, R. Computer tomographic localization, lesion size, and prognosis in aphasia and nonverbal impairment. Brain Lang. 8, 34-50 (1979).
71. Schiff, H. B., Alexander, M. P., Naeser, M. A. &Galaburda, A. M. Aphemia. Clinical-anatomic correlations. Arch. Neurol. 40, 720-727 (1983).
72. Alexander, M. P., Naeser, M. A. &Palumbo, C. L. Broca's area aphasias: aphasia after lesions including the frontal operculum. Neurology 40, 353-362 (1990).
73. Grodzinsky, Y. The neurology of syntax: language use without Broca's area. Behav. Brain Sci. 23, 1-21 (2000).
74. Godefroy, O. et al. Brain-behaviour relationships. Some models and related statistical procedures for the study of brain-damaged patients. Brain 121, 1545-1556 (1998).
75. Price, C. J. &Friston, K. J. Degeneracy and cognitive anatomy. Trends Cogn. Sci. 6, 416-421 (2002).
76. Ruppin, e. &Reggia, J. A. Patterns of functional damage in neural network models of associative memory. Neural Comput. 7, 1105-1127 (1995).
77. Chen, R., Hillis, A. e., Pawlak, M. &Herskovits, e. H. voxelwise Bayesian lesion- deficit analysis. Neuroimage 40, 1633-1642 (2008).
78. Herskovits, e. H. &Gerring, J. P. Application of a data-mining method based on Bayesian networks to lesion-deficit analysis. Neuroimage 19, 1664-1673 (2003).
79. Mummery, C. J. et al. A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory. Ann. Neurol. 47, 36-45 (2000).
80. Jefferies, e. &Lambon Ralph, M. A. Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison. Brain 129, 2132-2147 (2006).
81. Butler, C. R., Brambati, S. M., Miller, B. L. &Gorno-Tempini, M. The neural correlates of verbal and nonverbal semantic processing deficits in neurodegenerative disease. Cogn. Behav. Neurol. 22, 73-80 (2009).
82. Bates, e. et al. voxel-based lesion-symptom mapping. Nat. Neurosci. 6, 448-450 (2003).
83. Frank, R. J., Damasio, H. &Grabowski, T. J. Brainvox: an interactive, multimodal visualization and analysis system for neuroanatomical imaging. Neuroimage 5, 13-30 (1997).
84. Rorden, C. &Brett, M. Stereotaxic display of brain lesions. Behav. Neurol. 12, 191-200 (2000).
85. Rorden, C., Karnath, H. O. &Bonilha, L. Improving lesion-symptom mapping. J. Cogn. Neurosci. 19, 1081-1088 (2007).
86. Kimberg, D. Y., Coslett, H. B. &Schwartz, M. F. Power in voxel-based lesion-symptom mapping. J. Cogn. Neurosci. 19, 1067-1080 (2007).
87. Naeser, M. A. &Borod, J. C. Aphasia in lefthanders: lesion site, lesion side, and hemispheric asymmetries on CT. Neurology 36, 471-488 (1986).
88. Naugle, R. I. &Raymond, M. J. Neuropsychological sequelae of stroke as a function of handedness. Percept. Mot. Skills 73, 555-562 (1991).
89. Arnold, M. et al. Age-dependent differences in demographics, risk factors, co-morbidity, etiology, management, and clinical outcome of acute ischemic stroke. J. Neurol. 255, 1503-1507 (2008).
90. Basso, A., Bracchi, M., Capitani, e., Laiacona, M. &Zanobio, M. e. Age and evolution of language area functions. A study on adult stroke patients. Cortex 23, 475-483 (1987).
91. Thomalla, G. et al. Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke. Neuroimage 22, 1767-1774 (2004).
92. Young, M. P., Hilgetaq, C. C. &Scannell, J. W. On imputing function to structure from the behavioural effects of brain lesions. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355, 147-161 (2000).
93. Keinan, A., Kaufman, A., Sachs, N., Hilgetaq, C. C. &Ruppin, e. Fair localization of function via multi-lesion analysis. Neuroinformatics 2, 163-168 (2004).
94. Seghier, M. L., Ramlackhansingh, A., Crinion, J., Leff, A. &Price, C. J. Lesion identification using unified segmentation-normalisation models and fuzzy clustering. Neuroimage 41, 1253-1266 (2008).
95. Warburton, e., Price, C. J., Swinburn, K. &Wise, R. J. S. Mechanisms of recovery from aphasia: evidence from positron emission tomography studies. J. Neurol. Neurosurg. Psychiatry 66, 155-161 (1999).
96. Hillis, A. e. et al. Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke. Ann. Neurol. 50, 561-566 (2001).
97. Breier, J. I. et al. Spatiotemporal patterns of language-specific brain activity in patients with chronic aphasia after stroke using magnetoencephalography. Neuroimage 23, 1308-1316 (2004).
98. Meinzer, M. et al. Functional re-recruitment of dysfunctional brain areas predicts language recovery in chronic aphasia. Neuroimage 39, 2038-2046 (2008).
99. Saur, D. et al. Dynamics of language reorganization after stroke. Brain 129, 1371-1384 (2006).
100. Heiss, W. D. &Thiel, A. A proposed regional hierarchy in recovery of post-stroke aphasia. Brain Lang. 98, 118-123 (2006).
101. van der Zwan, A. &Hillen, B. Review of the variability of the territories of the major cerebral arteries. Stroke 22, 1078-1084 (1991).
102. Yang, Z. H., Zhao, X. Q., Wang, C. X., Chen, H. Y. &Zhang, Y. M. Neuroanatomic correlation of the post-stroke aphasias studied with imaging. Neurol. Res. 30, 356-360 (2008).
103. Meindl, J. D. Beyond Moore's law: the interconnect era. Comput. Sci. Eng. 5, 20-24 (2003).
104. Pozamantir, A., Lee, H., Chapman, J. &Prohovnik, I. Web-based multi-center data management system for clinical neuroscience research. J. Med. Syst. 34, 25-33 (2010).
105. Bandettini, P. A. What's new in neuroimaging methods? Ann. NY Acad. Sci. 1156, 260-293 (2009).
106. Crinion, J. et al. Spatial normalization of lesioned brains: performance evaluation and impact on fMRI analyses. Neuroimage 37, 866-875 (2007).
107. The Governing Council of the Organization for Human Brain Mapping. Neuroimaging databases. Science 292, 1673-1676 (2001).
108. Amari, S. et al. Neuroinformatics: the integration of shared databases and tools towards integrative neuroscience. J. Integr. Neurosci. 1, 117-128 (2002).
109. van Horn, J. D. &Toga, A. W. Is it time to re-prioritize neuroimaging databases and digital repositories? Neuroimage 47, 1720-1734 (2009).
110. National Data and Statistical Center. Traumatic Brain Injury Model Systems [online], http:// www.tbindsc.org/ (2010).
111. Mueller, S. G. et al. Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimers Dement. 1, 55-66 (2005).
112. evans, A. C. &Brain Development Cooperative Group. The NIH MRI study of normal brain development. Neuroimage 30, 184-202 (2006).
113. Price, C. J., Mummery, C. J., Moore, C. J., Frackowiak, R. S. &Friston, K. J. Delineating necessary and sufficient neural systems with functional imaging studies of neuropsychological patients. J. Cogn. Neurosci. 11, 371-382 (1999).
114. Price, C. J. &Friston, K. J. Functional imaging studies of neuropsychological patients: applications and limitations. Neurocase 8, 345-354 (2002).
115. Dick, F. et al. What is involved and what is necessary for complex linguistic and nonlinguistic auditory processing: evidence from functional magnetic resonance imaging and lesion data. J. Cogn. Neurosci. 19, 799-816 (2007).
116. vandenberghe, R. &Gillebert, C. R. Parcellation of parietal cortex: convergence between lesion- symptom mapping and mapping of the intact functioning brain. Behav. Brain Res. 199, 171-182 (2009).
117. Schnur, T. T. et al. Localizing interference during naming: convergent neuroimaging and neuropsychological evidence for the function of Broca's area. Proc. Natl Acad. Sci. USA 106, 322-327 (2009).
118. Molenberghs, P., Gillebert, C. R., Peeters, R. &vandenberghe, R. Convergence between lesion- symptom mapping and functional magnetic resonance imaging of spatially selective attention in the intact brain. J. Neurosci. 28, 3359-3373 (2008).
119. Rudrauf, D., Mehta, S. G. &Grabowski, T. J. Disconnection's renaissance takes shape: formal incorporation in group-level lesion studies. Cortex 44, 1048-1096 (2008).
120. Price, C. J. &Friston, K. J. Functional ontologies for cognition: the systematic definition of structure and function. Cogn. Neuropsychol. 22, 262-275 (2005).
121. Honey, C. J. &Sporns, O. Dynamical consequences of lesions in cortical networks. Hum. Brain Mapp. 29, 802-809 (2008).
122. Alstott, J., Breakspear, M., Hagmann, P., Cammoun, L. &Sporns, O. Modeling the impact of lesions in the human brain. PLoS Comput. Biol. 5, e1000408 (2009).
123. Hodges, J. R., Patterson, K., Oxbury, S. &Funnell, e. Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain 115, 1783 - 1806 (1992).
124. Basso, A. How intensive/prolonged should an intensive/prolonged treatment be? Aphasiology 19, 975-984 (2005).
125. Basso, A., Capitani, e. &vignolo, L. A. Influence of rehabilitation on language skills in aphasic patients. A controlled study. Arch. Neurol. 36, 190-196 (1979).
126. Bhogal, S. K., Teasell, R. &Speechley, M. Intensity of aphasia therapy, impact on recovery. Stroke 34, 987-993 (2003).
127. Hinckley, J. J. &Carr, T. H. Comparing the outcomes of intensive and non-intensive context-based aphasia treatment. Aphasiology 19, 965-974 (2005).
128. Holland, A. L., Fromm, D. S., DeRuyter, F. &Stein, M. Treatment efficacy: aphasia. J. Speech Lang. Hear. Res. 39, S27-S36 (1996).
129. Pulvermuller, F. &Berthier, M. L. Aphasia therapy on a neuroscience basis. Aphasiology 22, 563-599 (2008).
130. Raymer, A. M., Kohen, F. P. &Saffell, D. Computerised training for impairments of word comprehension and retrieval in aphasia. Aphasiology 20, 257-268 (2006).
131. Robey, R. R. A meta-analysis of clinical outcomes in the treatment of aphasia. J. Speech Lang. Hear. Res. 41, 172-187 (1998).
132. Cherney, L. R., Patterson, J. P., Raymer, A., Frymark, T. &Schooling, T. evidence-based systematic review: effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia. J. Speech Lang. Hear. Res. 51, 1282-1299 (2008).
133. Swinburn, K., Porter, G. &Howard, D. Comprehensive Aphasia Test (Psychology Press, London, 2004).
134. Moss, A. &Nicholas, M. Language rehabilitation in chronic aphasia and time postonset: a review of single-subject data. Stroke 37, 3043-3051 (2006).
135. Meinzer, M., elbert, T., Djundja, D., Taub, e. &Rockstroh, B. extending the constraint-induced movement therapy (CIMT) approach to cognitive functions: constraint-induced aphasia therapy (CIAT) of chronic aphasia. NeuroRehabilitation 22, 311-318 (2007).
136. Pulvermuller, F. et al. Constraint-induced therapy of chronic aphasia after stroke. Stroke 32, 1621-1626 (2001).
137. Berthier, M. L. et al. A randomized, placebocontrolled study of donepezil in poststroke aphasia. Neurology 67, 1687-1689 (2006).
138. Berthier, M. L. et al. Memantine and constraintinduced aphasia therapy in chronic poststroke aphasia. Ann. Neurol. 65, 577-585 (2009).
139. Seniow, J., Litwin, M., Litwin, T., Lesniak, M. &Czlonkowska, A. New approach to the rehabilitation of post-stroke focal cognitive syndrome: effect of levodopa combined with speech and language therapy on functional recovery from aphasia. J. Neurol. Sci. 283, 214-218 (2009).
140. Crinion, J. &Price, C. J. Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke. Brain 128, 2858-2871 (2005)