Effect of dopamine on intracellular sodium: A common pathway for pharmacological mechanism of action in bipolar illness

World Journal of Biological Psychiatry

Volumn 11, Issue 2 PART 2, 2010, Pages 181-187

  Roberts, Rona J ^a   Repass, Richard ^a   El Mallakh, Rif S ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Antipsychotics; Bipolar affective disorder; Dopamine D2 receptor occupancy; Psychopharmacology

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARBAMAZEPINE; CHLORPROMAZINE; CLOZAPINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; HALOPERIDOL; SODIUM ION; TRANSIENT RECEPTOR POTENTIAL CHANNEL M;

BIPOLAR DISORDER; CONCENTRATION RESPONSE; DRUG MECHANISM; HUMAN; MANIA; MEDICAL LITERATURE; NONHUMAN; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM CELL LEVEL; SODIUM TRANSPORT;

ANIMALS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; DOPAMINE; HUMANS; LITHIUM COMPOUNDS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SODIUM;

EID: 77950807141     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622970902718774     Document Type: Review

References (78)

1. Adir Y, Azzam ZS, Lecuona E, Leal S, Pesce L, Dumasius V, et al. 2004. Augmentation of endogenous dopamine production increases lung liquid clearance. Am J Respir Care Med 169:757-763.
2. Aizman O, Brismar H, Uhlen P, Zettergren E, Levey AI, Forssberg H, et al. 2002. Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nat Neurosci 3:226-230.
3. Ashgar M, Hussain T, Lokhandwala MF. 2001. Activation of dopamine D1-like receptor causes phosphorylation of alpha1-subunit of Na,K-ATPase in rat renal proximal tubules. Eur J Pharmacol 411:62-66.
4. Astrup J, Sorensen P, Sorensen H. 1981. Oxygen and glucose consumption related to Na-Ktransport in canine brain. Stroke 12:726-730.
5. Bearden CE, Thompson PM, Dalwani M, Hayashi KM, Lee AD, Nicoletti M, et al. 2007. Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol Psychiatry [Epub ahead of print].
6. Brismar H, Asghar M, Carey RM, Greengard P, Aperia A. 1998. Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane. Proc Natl Acad Sci USA 95: 5573-5578. (Pubitemid 28224136)
7. Buchsbaum MS, Wu J, DeLisi LE, Holcomb H, Kessler R, Johnson J, et al. 1986. Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness. J Affect Disord 10:137-152. (Pubitemid 16067656)
8. Calabrese JR, Keck PE Jr, Macfadden W, Minkwitz M, Ketter TA, Weisler RH, et al. 2005. A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. Am J Psychiatry 162:1351-1360. (Pubitemid 40905587)
9. Chang A, Li PP, Warsh JJ. 2003a. Altered cAMP-dependent protein kinase subunit immunolabeling in post-mortem brain from patients with bipolar affective disorder. J Neurochem 84:781-791. (Pubitemid 36176936)
10. Chang A, Li PP, Warsh JJ. 2003b. cAMP-Dependent protein kinase (PKA) subunit mRNA levels in postmortem brain from patients with bipolar affective disorder (BD). Brain Res Mol Brain Res 116:27-37. (Pubitemid 36993694)
11. Coppen A, Shaw DM, Malleson A, Costain R. 1966. Mineral metabolism in mania. Br Med J 1:71-75.
12. Dubovsky SL, Franks RD. 1983. Intracellular ions in affective disorders: A review and an hypothesis. Biol Psychiatry 18: 781-797. (Pubitemid 13073961)
13. Dubovsky SL, Christiano J, Daniell LC, Franks RD, Murphy J, Adler L, et al. 1989. Increased platelet intracellular calcium concentrations in patients with bipolar affective disorders. Arch Gen Psychiatry 46:632-638. (Pubitemid 19180343)
14. Dubovsky SL, Lee C, Christiano J, Murphy J. 1991. Lithium decreases platelet intracellular calcium concentration in bipolar patients. Lithium 2:167-174.
15. Dubovsky SL, Murphy J, Thomas M, Rademacher J. 1992. Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 149: 118-120.
16. Dubovsky SL, Thomas M, Hijazi A, Murphy J. 1994. Intracellular calcium signaling in peripheral cells of patients with bipolar affective disorder. Eur Arch Psychiatry Clin Neurosci 243: 229-234. (Pubitemid 24083875)
17. El-Mallakh RS, Huff MO. 2001. Mood stabilizers and ion regulation. Harv Rev Psychiatry 9:23-32.
18. El-Mallakh RS,Wyatt RJ. 1995. The Na,K-ATPase hypothesis for bipolar illness. Biol Psychiatry 37:235-244.
19. El-Mallakh RS, Harrison LT, Li R, Changaris DG, Levy RS. 1995. An animal model for mania: Preliminary results. Prog Neuro-Psychopharmacol Biol Psychiatry 19:955-962.
20. El-Mallakh RS, El-Masri MA, Huff MO, Li X-P, Decker S, Levy RS. 2003. Intracerebroventricular administration of ouabain to rats models human mania. Bipolar Disord 5:362-365. (Pubitemid 37361351)
21. El-Mallakh RS, Decker S, Morris M, Li Z-P, Huff MO, El-Masri MA, et al. 2006a. The effect of olanzapine and haloperidol in an animal's model of mania. Prog Neuro-Psychopharmacol Biol Psychiatry 30:1261-1264. (Pubitemid 44216066)
22. El-Mallakh RS, Stoddard M, Jortani SA, El-Masri MA, Sephton S, Valdes R Jr. 2006b. Aberrant regulation of endogenous ouabain-like factor in bipolar subjects. Presented at the annual Meeting of the American College of Neuropsychopharmacology, Miami, FL, December 2006.
23. Else PL, Mansfield K. 1997. Activation of sodium transport and intracellular sodium lowering by the neuroleptic drug chlorpromazine. Biochem Pharmacol 54:275-281. (Pubitemid 27357004)
24. Emamghoreishi M, Schlichter L, Li PP, Parikh S, Sen J, Kamble A, Warsh JJ. 1997. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder. Am J Psychiatry 154:976-982. (Pubitemid 27274541)
25. Fan S, Yazulla S. 2005. Reciprocal inhibition of voltage-gated potassium currents (IK(V)) by activation of cannabinoid CB1 and dopamine D1 receptors in ON bipolar cells of goldfish retina. Visual Neurosci 22:55-63. (Pubitemid 40675765)
26. Ferreira MP, DeLucia R, Aizenstein ML, Glezer AI, Scavone C. 1998. Fencamfamine modulates sodium, potassium-ATPase through cyclic AMP and cyclic AMP-dependent protein kinase in rat striatum. J Neural Transm 105:549-560. (Pubitemid 28454509)
27. Gao YL, Lei Z, Roisen F, Lu C, El-Mallakh RS. 2007. Effect of monensin and intracellular sodium concentration elevation of the bipolar candidate gene transient receptor potential protein melastatin subtype 2 (TRMP2). Presented at the 7th International Bipolar Meeting, Pittsburgh, PA, June 2007.
28. Gefvert O, Bergstrom M, Laangstroem B, Lundberg T, Lindstrom L, Yates R. 1998. Time course of central nervous dopamine-D2 and 5HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine in patients with schizophrenia. Psychopharmacology 135:119-126.
29. Gomes P, Soares-Da-Silva P. 2002. D2-like receptor medicated inhibition of Na-K-ATPase activity is dependent on the opening of Kchannels. Am J Physiol Renal Physiol 382:F114-F123.
30. Gomes P, Soares-Da-Silva P. 2004. Dopamine acutely decreases type 3 Na/H exchanges activity in renal OK cells through the activation of protein kinases A and C signaling cascades. Eur J Pharmacol 488:51-59. (Pubitemid 38388523)
31. Goodwin FK, Jamison KR. 1990. Manic depressive illness. New York, Oxford: Oxford University Press.
32. Grider G, El-Mallakh RS, Huff MO, Buss TJR, Miller J, Valdes R Jr. 1999. Endogenous digoxin-like immunoreactive factor (DLIF) serum concentrations are decreased in manic bipolar patients compared to normal controls. J Affect Disord 54: 261-267. (Pubitemid 29329434)
33. Guatteo E, Bengtson CP, Bernardi G, Mercuri NB. 2004. Voltage-gated calcium channels mediate intracellular calcium increase in weaver dopaminergic neurons during stimulation of D2 and GABAB receptors. J Neurophysiol 92:3368-3374. (Pubitemid 39506315)
34. Hu XT, Dong Y, Zhang XF, White FJ. 2005. Dopamine D2 receptor-activated Ca2- signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons. J Neurophysiol 93:1406-1417. (Pubitemid 40283729)
35. Hua LV, Green M, Wong A, Warsh JJ, Li PP. 2001. Tetraspan protein CD151: a common target of mood stabilizing drugs? Neuropsychopharmacology 25:729-736. (Pubitemid 32995955)
36. Huang X, Lei Z, El-Mallakh RS. 2007. Lithium normalizes elevated intracellular sodium. Bipolar Disord 9(3):298-300. (Pubitemid 46547123)
37. Jose PA, Eisner GM, Felder RA. 2000. Renal dopamine and sodium homeostasis. Curr Hypertens Rep 2:174-183.
38. Kim HS, Yumkham S, Choi JH, Kim E-K, Kim YS, Ryu SH, et al. 2006. Haloperidol induces calcium ion influx via L-type calcium channels in hippocampal HN33 cells and renders the neurons more susceptible to oxidative stress. Mol Cells 22: 51-57. (Pubitemid 44323045)
39. LaHoste GJ, Henry BL, Marshall JF. 2000. Dopamine D1 recptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J Neurosci 20:6666-6671.
40. Li R, El-Mallakh RS. 2004. Differential response of bipolar and normal control lymphoblastoid cell sodium pump to ethacrynic acid. J Affect Disord 80:11-17. (Pubitemid 38496524)
41. Looney SW, El-Mallakh RS. 1997. Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness. Depress Anxiety 5: 53-65. (Pubitemid 28079919)
42. Mah L, Zarate CA Jr, Singh J, Duan YF, Luckenbaugh DA, Manji HK, et al. 2007. Regional cerebral glucose metabolic abnormalities in bipolar II depression. Biol Psychiatry 61:765-775. (Pubitemid 46330241)
43. Manji HK, Chen G. 2002. PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers. Mol Psychiatry 7(Suppl 1):S46-56. (Pubitemid 34280648)
44. Manji HK, Lenox RH. 2000. Signaling: cellular insights into the pathophysiology of bipolar disorder. Biol Psychiatry 48: 518-530.
45. Manji HK, Moore GJ, Chen G. 2001. Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. Br J Psychiatry 41(Suppl):S107-119. (Pubitemid 32530338)
46. Manji HK, Quiroz JA, Payne JL, Singh J, Lopes BP, Viegas JS, et al. 2003. The underlying neurobiology of bipolar disorder. World Psychiatry 2:136-146.
47. Mazumder G, Mukherjee S, Sen PC. 1990. The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo. Mol Cell Biochem 95:13-20. (Pubitemid 20171468)
48. Naylor GJ, Smith AHW. 1981. Defective genetic control of sodium-pump density in manic depressive psychosis. Psychol Med 11:257-263.
49. Naylor GJ, McNamee HB, Moody JP. 1971. Changes in erythrocyte sodium and potassium on recovery from depressive illness. Br J Psychiatry 118:219-223.
50. Ogata N, Yoshii M, Narahashi T. 1990. Differential block of sodium and calcium channels by chlorpromazine in mouse neuroblastoma cells. J Physiol 420:165-183. (Pubitemid 20051213)
51. Ordieres MGL, De Lores Arnaiz GR. 2005. The inhibitory effect of neurotensin on synaptosomal membrane Na,K-ATPase is altered by antipsychotic administration. Regul Peptides 129:177-182.
52. Palotas A, Penke B, Palotas M, Kenderessy AS, Kemeny L, Kis E, et al. 2004. Haloperidol attenuates beta-amyloid-induced calcium imbalance in human fibroblasts. Skin Pharmacol Physiol 17:195-199. (Pubitemid 38969845)
53. Piper DC, Cooper DA, Upton N. 1996. The effect of antimanic drugs on the hyperlocomotor response to ICV administration of ouabain in the rat. Presented at the Annual Meeting of the European College of Neuropsychopharmacology. Amsterdam, The Netherlands.
54. Prokopenko RA, Mogilevich SE, Luik AI, Naydyenova IY, Batrak GN, Hawryluk BR, et al. 1995. Effects of haloperidol and chlorpromazine on smooth muscle contractility, platelet aggregation and neuronal calcium current. Gen Physiol Biophys 14:349-357.
55. Robbins TW, Sahakian BJ. 1980. Animal Models of mania. In: Bellmaker RH., Ban Prang HM, editors. Mania: An evolving concept. New York: Spectrum. pp 143-216.
56. Rose AM, Mellett BJ, Valdes R Jr, Kleinman JE, Hermann MM, Li R, El-Mallakh RS. 1998. Alpha2 isoform of the Na,KATPase is reduced in temporal cortex of bipolar individuals. Biol Psychiatry 44:892-897. (Pubitemid 28520227)
57. Rosso IM, Killgore WD, Clintron CM, Gruber SA, Tohen M, Yurgelun-Todd DA. 2007. Reduced amygdala volumes in firstepisode bipolar disorder and correlation with cerebral white matter. Biol Psychiatry 61:743-749. (Pubitemid 46330244)
58. Ruktanonchai DJ, El-Mallakh RS, Li R, Levy RS. 1998. Persistent hyperactivity following a single intracerebroventricular dose of ouabain. Physiol Behav 63:403-406. (Pubitemid 28055570)
59. Sah DW, Bean BP. 1994. Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists. Mol Pharmacol 45:84-92.
60. Santi CM, Cayabyab FS, Sutton KG, McRory JE, Mezeyova J, Manning KS, et al. 2002. Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci 15:396-403. (Pubitemid 34049077)
61. Shaw DM. 1966. Mineral metabolism, mania, and melancholia. Br Med J 2:262-267.
62. Shulman LM, Fox DA. 1996. Dopamine inhibits mammalian photoreceptor Na,K-ATPase activity via a selective effect on the alpha-3 isozyme. Proc Natl Acad Sci USA 93:8034-8039.
63. Sun W, Salvi RJ. 2001. Dopamine modulates sodium currents in cochlear spiral ganglion neurons. Neuroreport 12:803-807. (Pubitemid 32222721)
64. Surja AAS, Tamas RL, El-Mallakh RS. 2006. Antipsychotic medications in the treatment of bipolar disorder. Curr Drug Targets 7:1217-1224. (Pubitemid 44356018)
65. Tan CH, Javors MA, Seleshi E, Lowrimore PA, Bowden CL. 1990. Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. Life Sci 46:1175-1180. (Pubitemid 20169712)
66. Thase ME, Macfadden W, McCoy W, Chang W, Calabrese JR. 2006. Confirmation of the efficacy of quetiapine monotherapy in bipolar depression in a second double-blind, placebocontrolled study: the BOLDER II study. Presented at the American Psychiatric Association meeting, Toronto, Canada, May 2006. J Clin Psychopharmacol 26:600-609 (Erratum: J Clin Psychopharmacol 2007, 27:51).
67. Thiruvengadam AP, Chandrasekaran K, Regenold WT. 2007. Diagnostic blood test for bipolar disorder. J Affect Disord (Epub ahead of print).
68. Ueda K, Yagami T, Asakura K, Kawasaki K. 1997. Chlorpromazine reduces toxicity and Ca2- uptake induced by amyloid beta protein (25-35) in vitro. Brain Res 748:184-188.
69. Van Dyke RW, Scharschmidt BF. 1987. Effects of chlorpromazine on Na,K-ATPase pumping and solute transport in rat hepatocytes. Am J Physiol 253:G613-621.
70. Vieira-Coelho MA, Soares-Da-Silva P. 1981. Comparative study on sodium transport and Na,K-ATPase activity in Caco-2 and rat jejunal epithelial cells: Effects of dopamine. Life Sci 69:1969-1981.
71. Wakamori M, Kaneda M, Oyama Y, Akaike N. 1989. Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam, and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons. Brain Res 494:374-378.
72. Wasserman MJ, Corson TW, Sibony D, Cooke RG, Parikh SV, Pennefather PS, et al. 2004. Chronic lithium treatment attenuates intracellular calcium mobilization. Neuropsychopharmacology 29:759-769.
73. Wood AJ, Smith CE, Clarke EE, Cowen PJ, Aronson JK, Grahame-Smith DG. 1991. Altered in vitro adaptive responses of lymphocyte Na,K-ATPase in patients with manicdepressive psychosis. J Affect Disord 21:199-206.
74. Wu J, Dougherty JJ, Nichols RA. 2006. Dopamine receptor regulation of Ca2- levels in individual isolated nerve terminals from rat striatum: comparison of presynaptic D1-like and D2-like receptors. J Neurochem 98:481-494.
75. Yamaguchi I,Walk SF, Jose PA, Felder RA. 1996. Dopamine D2L receptors stimulate Na,K-ATPase activity in murine LTKcells. Mol Pharmacol 49:376-378.
76. Yoon IS, Li PP, Siu KP, Kennedy JL, Cooke RG, Parikh SV, Warsh JJ. 2001a. Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Mol Psychiatry 6:678-83.
77. Yoon IS, Li PP, Siu KP, Kennedy JL, Macciardi F, Cooke RG, et al. 2001b. Altered TRPC7 gene expression in bipolar-I disorder. Biol Psychiatry 50:620-626.
78. Xu C, Macciardi F, Li PP, Yoon IS, Cooke RG, Hughes B, et al. 2006. Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 50: 620-626.