Reduced Amygdala Volumes in First-Episode Bipolar Disorder and Correlation with Cerebral White Matter

Biological Psychiatry

Volumn 61, Issue 6, 2007, Pages 743-749

  Rosso, Isabelle M ^a,b   Killgore, William D S ^a   Cintron, Christina M ^a   Gruber, Staci A ^a,b   Tohen, Mauricio ^c   Yurgelun Todd, Deborah A ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Amygdala; bipolar disorder; first episode; white matter

Indexed keywords

AMYGDALOID NUCLEUS; ANALYSIS OF VARIANCE; ARTICLE; BIPOLAR DISORDER; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GRAY MATTER; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; WHITE MATTER;

ADULT; AMYGDALA; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; FEMALE; HUMANS; MALE; MATCHED-PAIR ANALYSIS; NERVE FIBERS, MYELINATED; ORGAN SIZE; REFERENCE VALUES;

EID: 33847254850     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.07.035     Document Type: Article

References (77)

1. Addington J., and Addington D. Facial affect recognition and information processing in schizophrenia and bipolar disorder. Schizophr Res 32 (1998) 171-181
2. Adler C.M., Holland S.K., Schmithorst V., Wilke M., Weiss K.L., Pan H., et al. Abnormal frontal white matter tracts in bipolar disorder: A diffusion tensor imaging study. Bipolar Disord 6 (2004) 197-203
3. Adolphs R., Tranel D., and Damasio A.R. The human amygdala in social judgment. Nature 393 (1998) 470-474
4. Altshuler L.L. Bipolar disorder: Are repeated episodes associated with neuroanatomic and cognitive changes?. Biol Psychiatry 33 (1993) 563-565
5. Altshuler L.L., Bartzokis G., Grieder T., Curran J., Jimenez T., Leight K., et al. An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biol Psychiatry 48 (2000) 147-162
6. Altshuler L.L., Bartzokis G., Grieder T., Curran J., and Mintz J. Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: An MRI study demonstrating neuroanatomic specificity. Arch Gen Psychiatry 55 (1998) 663-664
7. Amaral D.G. The primate amygdala and the neurobiology of social behavior: Implications for understanding social anxiety. Biol Psychiatry 51 (2002) 11-17
8. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC
9. Anderson A.K., and Phelps E.A. Expression without recognition: Contributions of the human amygdala to emotional communication. Psychol Sci 11 (2000) 106-111
10. Anderson J.E., Wible C.G., McCarley R.W., Jakab M., Kasai K., and Shenton M.E. An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia. Schizophr Res 58 (2002) 123-134
11. Blumberg H.P., Fredericks C., Wang F., Kalmar J.H., Spencer L., Papademetris X., et al. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disord 7 (2005) 570-576
12. Blumberg H.P., Kaufman J., Martin A., Charney D.S., Krystal J.H., and Peterson B.S. Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder. Ann N Y Acad Sci 1021 (2004) 376-383
13. Blumberg H.P., Kaufman J., Martin A., Whiteman R., Zhang J.H., Gore J.C., et al. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry 60 (2003) 1201-1208
14. Bonilha L., Kobayashi E., Cendes F., and Li L.M. Effects of method and MRI slice thickness on entorhinal cortex volumetry. Neuroreport 14 (2003) 1291-1295
15. Bowley M.P., Drevets W.C., Ongur D., and Price J.L. Low glial numbers in the amygdala in major depressive disorder. Biol Psychiatry 52 (2002) 404-412
16. Brambilla P., Harenski K., Nicoletti M., Sassi R.B., Mallinger A.G., Frank E., et al. MRI investigation of temporal lobe structures in bipolar patients. J Psychiatr Res 37 (2003) 287-295
17. Brierley B., Shaw P., and David A.S. The human amygdala: A systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Res Brain Res Rev 39 (2002) 84-105
18. Chang K., Karchemskiy A., Barnea-Goraly N., Garrett A., Simeonova D.I., and Reiss A. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 44 (2005) 565-573
19. Chen B.K., Sassi R., Axelson D., Hatch J.P., Sanches M., Nicoletti M., et al. Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biol Psychiatry 56 (2004) 399-405
20. Cunningham M.G., Bhattacharyya S., and Benes F.M. Amygdalo-cortical sprouting continues into early adulthood: Implications for the development of normal and abnormal function during adolescence. J Comp Neurol 453 (2002) 116-130
21. Davidson R.J. Affective style and affective disorders: Perspectives from affective neuroscience. Cogn Emot 12 (1998) 307-320
22. De Bellis M.D., Casey B.J., Dahl R.E., Birmaher B., Williamson D.E., Thomas K.M., et al. A pilot study of amygdala volumes in pediatric generalized anxiety disorder. Biol Psychiatry 48 (2000) 51-57
23. De Bellis M.D., Hall J., Boring A.M., Frustaci K., and Moritz G. A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 50 (2001) 305-309
24. DelBello M.P., Zimmerman M.E., Mills N.P., Getz G.E., and Strakowski S.M. Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord 6 (2004) 43-52
25. Drevets W.C. Neuroimaging abnormalities in the amygdala in mood disorders. Ann N Y Acad Sci 985 (2003) 420-444
26. Faraone S.V., Glatt S.J., and Tsuang M.T. The genetics of pediatric-onset bipolar disorder. Biol Psychiatry 53 (2003) 970-977
27. Frazier J.A., Chiu S., Breeze J.L., Makris N., Lange N., Kennedy D.N., et al. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry 162 (2005) 1256-1265
28. Friston K.J., and Frith C.D. Schizophrenia: A disconnection syndrome?. Clin Neurosci 3 (1995) 89-97
29. Fudge J.L., Powers J.M., Haber S.N., and Caine E.D. Considering the role of the amygdala in psychotic illness: A clinicopathological correlation. J Neuropsychiatry Clin Neurosci 10 (1998) 383-394
30. Getz G.E., Shear P.K., and Strakowski S.M. Facial affect recognition deficits in bipolar disorder. J Int Neuropsychol Soc 9 (2003) 623-632
31. Gotlib I.H., Traill S.K., Montoya R.L., Joormann J., and Chang K. Attention and memory biases in the offspring of parents with bipolar disorder: Indications from a pilot study. J Child Psychol Psychiatry 46 (2005) 84-93
32. Hajek T., Carrey N., and Alda M. Neuroanatomical abnormalities as risk factors for bipolar disorder. Bipolar Disord 7 (2005) 393-403
33. Haldane M., and Frangou S. New insights help define the pathophysiology of bipolar affective disorder: Neuroimaging and neuropathology findings. Prog Neuropsychopharmacol Biol Psychiatry 28 (2004) 943-960
34. Hamidi M., Drevets W.C., and Price J.L. Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes. Biol Psychiatry 55 (2004) 563-569
35. Harmer C.J., Grayson L., and Goodwin G.M. Enhanced recognition of disgust in bipolar illness. Biol Psychiatry 51 (2002) 298-304
36. Haznedar M.M., Roversi F., Pallanti S., Baldini-Rossi N., Schnur D.B., Licalzi E.M., et al. Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol Psychiatry 57 (2005) 733-742
37. Hirayasu Y., Shenton M.E., Salisbury D.F., Dickey C.C., Fischer I.A., Mazzoni P., et al. Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry 155 (1998) 1384-1391
38. Kasai K., Shenton M.E., Salisbury D.F., Hirayasu Y., Lee C.U., Ciszewski A.A., et al. Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. Am J Psychiatry 160 (2003) 156-164
39. Kieseppa T., van Erp T.G., Haukka J., Partonen T., Cannon T.D., Poutanen V.P., et al. Reduced left hemispheric white matter volume in twins with bipolar I disorder. Biol Psychiatry 54 (2003) 896-905
40. Kikinis R., Shenton M.E., Gerig G., Martin J., Anderson M., Metcalf D., et al. Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging. J Magn Reson Imaging 2 (1992) 619-629
41. Lembke A., and Ketter T.A. Impaired recognition of facial emotion in mania. Am J Psychiatry 159 (2002) 302-304
42. Lennox B.R., Jacob R., Calder A.J., Lupson V., and Bullmore E.T. Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania. Psychol Med 34 (2004) 795-802
43. Lim K.O., Rosenbloom M.J., Faustman W.O., Sullivan E.V., and Pfefferbaum A. Cortical gray matter deficit in patients with bipolar disorder. Schizophr Res 40 (1999) 219-227
44. Loeber R.T., Cintron C.M., and Yurgelun-Todd D.A. Morphometry of individual cerebellar lobules in schizophrenia. Am J Psychiatry 158 (2001) 952-954
45. Lopez-Larson M.P., DelBello M.P., Zimmerman M.E., Schwiers M.L., and Strakowski S.M. Regional prefrontal gray and white matter abnormalities in bipolar disorder. Biol Psychiatry 52 (2002) 93-100
46. Malhi G.S., Lagopoulos J., Ward P.B., Kumari V., Mitchell P.B., Parker G.B., et al. Cognitive generation of affect in bipolar depression: An fMRI study. Eur J Neurosci 19 (2004) 741-754
47. McClure E.B., Pope K., Hoberman A.J., Pine D.S., and Leibenluft E. Facial expression recognition in adolescents with mood and anxiety disorders. Am J Psychiatry 160 (2003) 1172-1174
48. McDonald C., Bullmore E.T., Sham P.C., Chitnis X., Wickham H., Bramon E., et al. Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry 61 (2004) 974-984
49. Miller D.D., Andreasen N.C., O'Leary D.S., Rezai K., Watkins G.L., Ponto L.L., et al. Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography. Neuropsychopharmacology 17 (1997) 230-240
50. Miller D.H., Barkhof F., Frank J.A., Parker G.J., and Thompson A.J. Measurement of atrophy in multiple sclerosis: Pathological basis, methodological aspects and clinical relevance. Brain 125 (2002) 1676-1695
51. Mitra R., Jadhav S., McEwen B.S., Vyas A., and Chattarji S. Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala. Proc Natl Acad Sci U S A 102 (2005) 9371-9376
52. Pearlson G.D., Barta P.E., Powers R.E., Menon R.R., Richards S.S., Aylward E.H., et al. Ziskind-Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry 41 (1997) 1-14
53. Pedraza O., Bowers D., and Gilmore R. Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults. J Int Neuropsychol Soc 10 (2004) 664-678
54. Phan K.L., Wager T., Taylor S.F., and Liberzon I. Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 16 (2002) 331-348
55. Phillips M.L., Drevets W.C., Rauch S.L., and Lane R. Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biol Psychiatry 54 (2003) 504-514
56. Rajkowska G. Cell pathology in bipolar disorder. Bipolar Disord 4 (2002) 105-116
57. Rosso I.M., Cintron C.M., Steingard R.J., Renshaw P.F., Young A.D., and Yurgelun-Todd D.A. Amygdala and hippocampus volumes in pediatric major depression. Biol Psychiatry 57 (2005) 21-26
58. Sassi R.B., Nicoletti M., Brambilla P., Mallinger A.G., Frank E., Kupfer D.J., et al. Increased gray matter volume in lithium-treated bipolar disorder patients. Neurosci Lett 329 (2002) 243-245
59. Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., Wible C.G., et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med 327 (1992) 604-612
60. Soares J.C., and Mann J.J. The anatomy of mood disorders-review of structural neuroimaging studies. Biol Psychiatry 41 (1997) 86-106
61. Spitzer R.L. Structured Clinical Interview for DSM-III-R - Patient Version (SCID-P) (1988), New York State Psychiatric Institute, Biometrics Research, New York
62. Starkstein S.E., Boston J.D., and Robinson R.G. Mechanisms of mania after brain injury. 12 case reports and review of the literature. J Nerv Ment Dis 176 (1988) 87-100
63. Strakowski S.M., DelBello M.P., Sax K.W., Zimmerman M.E., Shear P.K., Hawkins J.M., et al. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry 56 (1999) 254-260
64. Strakowski S.M., Wilson D.R., Tohen M., Woods B.T., Douglass A.W., and Stoll A.L. Structural brain abnormalities in first-episode mania. Biol Psychiatry 33 (1993) 602-609
65. Swayze II V.W., Andreasen N.C., Alliger R.J., Yuh W.T., and Ehrhardt J.C. Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biol Psychiatry 31 (1992) 221-240
66. Szeszko P.R., MacMillan S., McMeniman M., Lorch E., Madden R., Ivey J., et al. Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: Preliminary findings. Neuropsychopharmacology 29 (2004) 826-832
67. Tkachev D., Mimmack M.L., Ryan M.M., Wayland M., Freeman T., Jones P.B., et al. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 362 (2003) 798-805
68. Tohen M., Stoll A.L., Strakowski S.M., Faedda G.L., Mayer P.V., Goodwin D.C., et al. The McLean First-Episode Psychosis Project: Six-month recovery and recurrence outcome. Schizophr Bull 18 (1992) 273-282
69. Tohen M., Strakowski S.M., Zarate Jr. C., Hennen J., Stoll A.L., Suppes T., et al. The McLean-Harvard First-Episode Project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis. Biol Psychiatry 48 (2000) 467-476
70. Tohen M., Zarate Jr. C.A., Hennen J., Khalsa H.M., Strakowski S.M., Gebre-Medhin P., et al. The McLean-Harvard First-Episode Mania Study: Prediction of recovery and first recurrence. Am J Psychiatry 160 (2003) 2099-2107
71. Vakili K., Pillay S.S., Lafer B., Fava M., Renshaw P.F., Bonello-Cintron C.M., et al. Hippocampal volume in primary unipolar major depression: A magnetic resonance imaging study. Biol Psychiatry 47 (2000) 1087-1090
72. Velakoulis D., Wood S.J., Wong M.T., McGorry P.D., Yung A., Phillips L., et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: A magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 63 (2006) 139-149
73. Vyas A., Bernal S., and Chattarji S. Effects of chronic stress on dendritic arborization in the central and extended amygdala. Brain Res 965 (2003) 290-294
74. Yuh W.T., Turgut Tala E., Afifi A.K., Sahinoglu K., Gao F., and Bergman R.A. MRI of Head and Neck Anatomy (1994), Churchill Livingstone, New York
75. Yurgelun-Todd D.A., Gruber S.A., Kanayama G., Killgore W.D., Baird A.A., and Young A.D. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disord 2 (2000) 237-248
76. Yurgelun-Todd D.A., Silveri M.M., Gruber S.A., Rohan M.L., and Pimentel P.J. White matter abnormalities observed in bipolar disorder: A diffusion tensor imaging study. Bipolor Disord (2006) (in press)
77. Zipursky R.B., Seeman M.V., Bury A., Langevin R., Wortzman G., and Katz R. Deficits in gray matter volume are present in schizophrenia but not bipolar disorder. Schizophr Res 26 (1997) 85-92