Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin

Oncology Reports

Volumn 23, Issue 5, 2010, Pages 1369-1374

  Kim, Ju Young ^a   Park, Hyun Ki ^a   Yoon, Jin Sun ^a   Kim, Seo Ju ^a   Kim, Eun Shil ^a   Song, Sung Heon ^b   Choi, Jung Hye ^b   Kim, Byoung Kook ^a   Park, Byoung Bae ^b   Lee, Young Yiul ^a,b  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Acute myelogenous leukemia; Extracellular signal activated kinase 1 2; Human leukemia cells; Leptin; Signal transducer and activator of transcription 3

Indexed keywords

LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT3 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

CELL PROLIFERATION; FLAVONOIDS; HL-60 CELLS; HUMANS; K562 CELLS; LEPTIN; LEUKEMIA, MYELOID, ACUTE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTORS, LEPTIN; RECOMBINANT PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TYRPHOSTINS;

EID: 77950804780     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000773     Document Type: Article

References (28)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L and Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.
2. Campfield LA, Smith FJ, Guisez Y, Devos R and Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
3. Halaas JL, Gajiwala KS, Maffei M, et al: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995.
4. Friedman JM and Halaas JL: Leptin and the regulation of body weight in mammals. Nature 395: 763-770, 1998.
5. Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gbur J, Mikhail A, Platika D and Snodgrass HR: Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 2: 585-589, 1996. (Pubitemid 26151519)
6. Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR and Matthews W: A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 6: 1170-1180, 1996.
7. Bouloumie A, Drexler HC, Lafontan M and Busse R: Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 83: 1059-1066, 1998.
8. Loffreda S, Yang SQ, Lin HZ, et al: Leptin regulates proinflammatory immune responses. FASEB J 12: 57-65, 1998.
9. Janik JE, Curti BD, Considine RV, et al: Interleukin 1 alpha increases serum leptin concentrations in humans. J Clin Endocrinol Metab 82: 3084-3086, 1997.
10. Hoggard N, Hunter L, Trayhurn P, Williams LM and Mercer JG: Leptin and reproduction. Proc Nutr Soc 57: 421-427, 1998.
11. Kieffer TJ, Heller RS, Leech CA, Holz GG and Habener JF: Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 46: 1087-1093, 1997.
12. Tartaglia LA, Dembski M, Weng X, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271, 1995.
13. Gearing DP, Thut CJ, VandeBos T, et al: Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J 10: 2839-2848, 1991.
14. Hibi M, Murakami M, Saito M, Hirano T, Taga T and Kishimoto T: Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63: 1149-1157, 1990.
15. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI and Friedman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635, 1996.
16. Baumann H, Morella KK, White DW, et al: The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378, 1996.
17. Bjorbaek C, Uotani S, da Silva B and Flier JS: Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272: 32686-32695, 1997.
18. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH and Skoda RC: Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 93: 6231-6235, 1996.
19. Wang Y, Kuropatwinski KK, White DW, Hawley TS, Hawley RG, Tartaglia LA and Baumann H: Leptin receptor action in hepatic cells. J Biol Chem 272: 16216-16223, 1997.
20. Pai R, Lin C, Tran T and Tarnawski A: Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. Biochem Biophys Res Commun 331: 984-992, 2005.
21. Somasundar P, Frankenberry KA, Skinner H, et al: Prostate cancer cell proliferation is influenced by leptin. J Surg Res 118: 71-82, 2004.
22. Somasundar P, Yu AK, Vona-Davis L and McFadden DW: Differential effects of leptin on cancer in vitro. J Surg Res 113: 50-55, 2003.
23. Konopleva M, Mikhail A, Estrov Z, et al: Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 93: 1668-1676, 1999.
24. Hardwick JC, Van Den Brink GR, Offerhaus GJ, Van Deventer SJ and Peppelenbosch MP: Leptin is a growth factor for colonic epithelial cells. Gastroenterology 121: 79-90, 2001.
25. Meraz MA, White JM, Sheehan KC, et al: Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84: 431-442, 1996.
26. Ihle JN: Cytokine receptor signalling. Nature 377: 591-594, 1995.
27. Darnell JE Jr: Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci USA 93: 6221-6224, 1996.
28. Schindler C and Darnell JE Jr: Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64: 621-651, 1995.