Drotrecogin alfa (activated) may attenuate severe sepsis-associated encephalopathy in clinical septic shock

Critical Care

Volumn 14, Issue 2, 2010, Pages

  Spapen, Herbert ^a   Nguyen, Duc N ^a   Troubleyn, Joris ^a   Huyghens, Luc ^a   Schiettecatte, Johan ^a  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DROTRECOGIN; PROTEIN S100B; ANTIINFECTIVE AGENT; PROTEIN C; RECOMBINANT PROTEIN;

AGED; ARTICLE; BRAIN DISEASE; BRAIN LEVEL; CONTINUOUS INFUSION; DRUG EFFECT; FEMALE; GLASGOW COMA SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESUSCITATION; SEDATION; SEPSIS; SEPTIC SHOCK; BELGIUM; CLINICAL TRIAL; MIDDLE AGED;

AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS; BELGIUM; BRAIN DISEASES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN C; RECOMBINANT PROTEINS; SHOCK, SEPTIC;

EID: 77950681329     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc8947     Document Type: Article

References (29)

1. Sharshar T, Annane D, de la Grandmaison GL, Brouland JP, Hopkinson NS, Françoise G. The neuropathology of septic shock. Brain Pathol 2004, 14:21-33.
2. Levi M, Poll T. Recombinant human activated protein C: current insights into its mechanism of action. Crit Care 2007, 11:S3. 10.1186/cc6154, 2230607, 18269690.
3. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709. 10.1056/NEJM200103083441001, 11236773.
4. Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, Johnson G, Bernard GR. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 2003, 31:834-840. 10.1097/01.CCM.0000051515.56179.E1, 12626993.
5. Nguyen DN, Spapen H, Su F, Schiettecatte J, Shi L, Hachimi-Idrissi S, Huyghens L. Elevated serum levels of S-100β protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock. Crit Care Med 2006, 34:1967-1974. 10.1097/01.CCM.0000217218.51381.49, 16607230.
6. Eidelman LA, Putterman D, Putterman C, Sprung CL. The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. JAMA 1996, 275:470-473. 10.1001/jama.275.6.470, 8627969.
7. Sharshar T, Carlier R, Bernard F, Guidoux C, Brouland JF, Nardi O, de la Grandmaison GL, Aboab J, Gray F, Menon D, Annane D. Brain lesions in septic shock: a magnetic resonance imaging study. Intensive Care Med 2007, 33:798-806. 10.1007/s00134-007-0598-y, 17377766.
8. Bozza FA, Garteiser P, Oliveira MF, Doblas S, Cranford R, Saunders D, Jones I, Towner RA, Castro-Faria-Neto HC. Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab 2010, 30:440-448. 10.1038/jcbfm.2009.215, 19844239.
9. Sharshar T, Gray F, de la Grandmaison GL, Hopkinson NS, Ross E, Dorandeu A, Orlikowski D, Raphael JC, Gajdos P, Annane D. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003, 362:1799-1805. 10.1016/S0140-6736(03)14899-4, 14654318.
10. Piazza O, Russo E, Cotena S, Esposito G, Tufano R. Elevated S100B levels do not correlate with the severity of encephalopathy during sepsis. Br J Anaesth 2007, 99:518-521. 10.1093/bja/aem201, 17650519.
11. Zauner C, Gendo A, Kramer L, Funk GC, Bauer E, Schenk P, Ratheiser K, Madl C. Impaired subcortical and cortical sensory evoked potential pathways in septic patients. Crit Care Med 2002, 30:1136-1139. 10.1097/00003246-200205000-00030, 12006815.
12. Pleines VE, Morganti-Kossmann MC, Rancan M, Joller N, Trentz O, Kossmann T. S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J Neurotrauma 2001, 18:491-498. 10.1089/089771501300227297, 11393252.
13. Herrmann M, Vos P, Wunderlich MT, de Bruijn CH, Lamers KJ. Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100β and glial fibrillary acidic protein. Stroke 2000, 31:2670-2677.
14. Georgiadis D, Berger A, Kowatschev E, Lautenschläger C, Börner A, Lindner A, Schulte-Mattler W, Zerkowski HR, Zierz S, Deufel T. Predictive value of S-100β and neuron-specific enolase serum levels for adverse neurologic outcome after cardiac surgery. J Thorac Cardiovasc Surg 2000, 119:138-147. 10.1016/S0022-5223(00)70229-7, 10612773.
15. Hamed SA, Hamed EA, Abdella MM. Septic encephalopathy: relationship to serum and cerebrospinal fluid levels ofadhesion molecules, lipid peroxides and S-100B protein. Neuropediatrics 2009, 40:66-72. 10.1055/s-0029-1231054, 19809934.
16. Piazza O, Cotena S, De Robertis E, Caranci F, Tufano R. Sepsis associated encephalopathy studied by MRI and cerebral spinal fluid S100B measurement. Neurochem Res 2009, 34:1289-1292. 10.1007/s11064-008-9907-2, 19132530.
17. Bruno A, Kent TA, Coull BM, Shankar RR, Saha C, Becker KJ, Kissela BM, Williams LS. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke 2008, 39:384-389. 10.1161/STROKEAHA.107.493544, 18096840.
18. Bilotta F, Caramia R, Cernak I, Paoloni FP, Doronzio A, Cuzzone V, Santoro A, Rosa G. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care 2008, 9:159-166. 10.1007/s12028-008-9084-9, 18373223.
19. Duning T, Heuvel I, Dickmann A, Volkert T, Wempe C, Reinholz J, Lohmann H, Freise H, Ellger B. Hypoglycemia aggravates critical illness induced neurocognitive dysfunction. Diabetes Care 2010, 33:639-644. 10.2337/dc09-1740, 20032274.
20. Fitch MT, Beek D. Drug Insight: steroids in CNS infectious diseases-new indications for an old therapy. Nat Clin Pract Neurol 2008, 4:97-104. 10.1038/ncpneuro0713, 18256681.
21. Cronin L, Cook DJ, Carlet J, Heyland DK, King D, Lansang MA, Fisher CJ. Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med 1995, 23:1430-1439. 10.1097/00003246-199508000-00019, 7634816.
22. Slotman GJ, Fisher CJ, Bone RC, Clemmer TP, Metz CA. Detrimental effects of high-dose methylprednisolone sodium succinate on serum concentrations of hepatic and renal function indicators in severe sepsis and septic shock. The Methylprednisolone Severe Sepsis Study Group. Crit Care Med 1993, 21:191-195.
23. Mussack T, Briegel J, Schelling G, Biberthaler P, Jochum M. Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock. Clin Chem Lab Med 2005, 43:259-268. 10.1515/CCLM.2005.044, 15843228.
24. O'Brien LA, Gupta A, Grinnell BW. Activated protein C and sepsis. Front Biosci 2006, 11:676-698. 10.2741/1827, 16146761.
25. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlocovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest 2009, 119:3437-3449. 2769191, 19841542.
26. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation 2001, 103:1799-1805.
27. Yesilirmak DC, Kumral A, Baskin H, Ergur BU, Aykan S, Genc S, Genc K, Yilmaz O, Tugyan K, Giray O, Duman N, Ozkan H. Activated protein C reduces endotoxin-induced white matter injury in the developing rat brain. Brain Research 2007, 1164:14-23. 10.1016/j.brainres.2007.04.083, 17644074.
28. Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 2003, 9:338-342. 10.1038/nm826, 12563316.
29. Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 2003, 101:4797-4801. 10.1182/blood-2002-12-3680, 12586611.