Bone mass gain during puberty and adolescence: Deconstructing gender characteristics

Current Medicinal Chemistry

Volumn 17, Issue 5, 2010, Pages 453-466

  Perez Lopez F R ^a   Chedraui, P ^a   Cuadros Lopez J L ^a  

^a NONE

Author keywords

Adolescence; Bone mass; Exercise; Menstruation; Nutrition; Osteoporosis; Puberty

Indexed keywords

CALCIUM; GROWTH HORMONE; HYPOPHYSIS HORMONE; LEPTIN; MAGNESIUM; SEX HORMONE; SOMATOMEDIN C; VITAMIN D; VITAMIN K GROUP;

ADOLESCENT DEVELOPMENT; ALCOHOL CONSUMPTION; ANOREXIA NERVOSA; BONE DEVELOPMENT; BONE GROWTH; BONE MASS; DIET SUPPLEMENTATION; FOOD INTAKE; FRACTURE; HUMAN; LIFESTYLE MODIFICATION; MACRONUTRIENT; MENSTRUATION; NONHUMAN; NUTRITION; OSTEOPOROSIS; PHYSICAL ACTIVITY; PUBERTY; REVIEW; SEX DIFFERENCE; SMOKING;

ADOLESCENT; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; EXERCISE; FEMALE; GONADAL STEROID HORMONES; HUMANS; LIFE STYLE; MALE; NUTRITION ASSESSMENT; OSTEOPOROSIS; PUBERTY; SEX CHARACTERISTICS;

EID: 77950680949     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710790226138     Document Type: Review

References (175)

1. Recker, R.R.; Davies, K.M.; Hinders, S.M.; Heaney, R.P.; Stegman, M.R.; Kimmel, D.B. Bone gain in young adult women. JAMA 1992, 268, 2403-2408.
2. Henry, Y.M.; Fatayerji, D.; Eastell, R. Attainment of peak bone mass at the lumbar spine, femoral neck, and radius in men and women: relative contributions of bone size and volumetric bone mineral density. Osteoporos. Int. 2004, 15, 263-273. (Pubitemid 38543944)
3. Bailey, D.A.; Martin, A.D.; McKay, H.A.; Whiting, S.; Mirwald, R. Calcium accretion in girls and boys during puberty: a longitudinal analysis. J. Bone Miner. Res. 2000, 15, 2245-2250.
4. Bonjour, J.P.; Theinz, G.; Buchs, B.; Slosman, D.; Rizzoli, R. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J. Clin. Endocrinol. Metab. 1991, 73, 555-563. (Pubitemid 21921908)
5. Theintz, G.; Buchs, B.; Rizzoli, R.; Slosman, D.; Clavien, H.; Sizonenko, P.C.; Bonjour, J.P. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J. Clin. Endocrinol. Metab. 1992, 75, 1060-1065.
6. Kasperk, C.H.; Wakley, G.K.; Hierl, T.; Ziegler, R. Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J. Bone Miner. Res. 1997, 12, 464-471. (Pubitemid 27120484)
7. Loud, K.J.; Gordon, C.M. Adolescence: bone disease. In Nutrition in Pediatrics, 3rd ed; Walker, W.A.; Watkins, J.B.; Duggan, C. Eds.; BC Decker: Hamilton, Ontario, 2003; pp. 883-896.
8. Chan, J.L.; Mantzoros, C.S. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhea and anorexia nervosa. Lancet 2005, 366, 74-85.
9. Glastre, C.; Braillon, P.; David, L.; Cochat, P.; Meunier, P.J.; Delmas, PD. Measurement of bone mineral content of the lumbar spine by dual energy X-ray absorptiometry in normal children: correlations with growth parameters. J. Clin. Endocrinol. Metab. 1990, 70, 1330-1333. (Pubitemid 20159068)
10. Teegarden, D.; Proulx, W.R.; Martin, B.R.; Zhao, J.; McCabe, G.P.; Lyle, R.M.; Peacock, M.; Slemenda, C.; Johnston, C.C.; Weaver, C.M. Peak bone mass in young women. J. Bone Miner. Res. 1996, 10, 711-715.
11. Davies, J.H.; Evans, B.A.; Gregory, J.W. Bone mass acquisition in healthy children. Arch. Dis. Child. 2005, 90, 373-378.
12. Mølgaard, C.; Thomsen, B.L.; Michaelsen, K.F. Whole body bone mineral accretion in healthy children and adolescents. Arch. Dis. Child. 1999, 81, 10-15. (Pubitemid 29307449)
13. Horlick, M.; Wang, J.; Pierson, R.N.Jr.; Thornton, J.C. Prediction models for evaluation of total-body bone mass with dual-energy Xray absorptiometry among children and adolescents. Pediatrics 2004, 114, e337-45.
14. Proesmans, W.; Goos, G.; Emma, F.; Geusens, P.; Nijs, J.; Dequeker, J. Total body mineral mass measured with dual photon absorptiometry in healthy children. Eur. J. Pediatr. 1994, 153, 807-812. (Pubitemid 24314751)
15. Hernández-Prado, B.; Lazcano-Ponce, E.; Cruz-Valdez, A.; Díaz, R.; Tamayo, J.; Hernández-Avila, M. Validity of bone mineral density measurements in distal sites as an indicator of total bone mineral density in a group of pre-adolescent and adolescent women. Arch. Med. Res. 2002, 33, 33-39. (Pubitemid 34092268)
16. Moreira-Andrés, M.N.; Cañizo, F.J.; Papapietro, K.; Rejas, J.; Hawkins, F.G. Comparison between spinal and radial bone mineral density in children measured by X-ray absorptiometry. J. Pediatr. Endocrinol. Metab. 1995, 8, 35-41.
17. Tishya, A.; Wren, L.; Liu, X.; Pitukcheewanont, P.; Gilsanz, V.; and members of the bone mineral density in childhood study. Bone acquisition in healthy children and adolescents: Comparisons of dual-energy X-ray absorptiometry and computed tomography measures. J. Clin. Endocrinol. Metab. 2005, 90, 1925-1928.
18. Schoenau, E.; Neu, C.M.; Mokov, E.; Wassmer, G.; Manz, F. Influence of puberty on muscle area and cortical bone area of the forearm in boys and girls. J. Clin. Endocrinol. Metab. 2000, 85, 1095-1098. (Pubitemid 32269355)
19. Fewtrell, M.S. Bone densitometry in children assessed by dual x ray absorptiometry: uses and pitfalls. Arch. Dis. Child. 2003, 88, 795-798.
20. Tanner, J.M., Whitehouse, R.H. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch. Dis. Child. 1976; 51: 170-179.
21. Mora, S.; Prinster, C.; Proverbio, M.C.; Bellini, A.; de Poli, S.C.L.; Weber, G.; Abbiati G, Chiumello G. Primary markers of bone turnover in healthy children and adolescents: age-related changes and effect of puberty. Calcif. Tissue Int. 1998, 63, 369-374. (Pubitemid 28476324)
22. Mora, S.; Pitukcheewanont, P.; Kaufman, F.R.; Nelson, J.C.; Gilsanz, V. Biochemical markers of bone turnover and the volume and the density of bone in children at different stages of sexual development. J. Bone Miner. Res. 1999, 14, 1664-1671. (Pubitemid 29455814)
23. Young, D.; Hopper, J.L.; Nowson, C.A.; Green, R.M.; Sherwin, A.J.; Kaymakci, B.; Smid, M.; Guest, C.S.; Larkins, R.G.; Wark, J.D. Determinants of bone mass in 10- to 26-year-old females: a twin study. J. Bone Miner. Res. 1995, 10, 558-567.
24. Remer, T.; Boye, K.R.; Hartmann, M.; Neu, C.M.; Schoenau, E.; Manz, F.; Wudy, S.A. Adrenarche and bone modeling and remodeling at the proximal radius: weak androgens make stronger cortical bone in healthy children. J. Bone Miner. Res. 2003, 18, 1539-1546.
25. Güven, A.; Cinaz, P.; Ayvali, E. Are growth factors and leptin involved in the pathogenesis of premature adrenarche in girls? J. Pediatr. Endocrinol. Metab. 2005, 18, 785-791. (Pubitemid 41309342)
26. Martin, A.D.; Bailey, D.A.; McKay, H.A.; Whiting, S. Bone mineral and calcium accretion during puberty. Am. J. Clin. Nutr. 1997, 66, 611-615. (Pubitemid 27366785)
27. Moro, M.; van den Beld, A.W.; Kiratli, B.J.; Marcus, R.; Bachrach, L.K.; Carter, D.R. Body mass index is the primary determinant of midfemoral bone acquisition during adolescent growth. Bone 1996, 19, 519-526. (Pubitemid 126745132)
28. Forwood, M.R. Physical activity and bone development during childhood: insights from animal models. J. Appl. Physiol. 2008, 105, 334-341.
29. Van Coeverden, S.C.C.M.; Netelenbost, J.C.; de Ridder, C.M.; Roos, J.C.; Popp-Snijders, C.; Delemarre-van de Waal, H.A. Bone metabolism markers and bone mass in healthy pubertal boys and girls. Clin. Endocrinol. 2002, 57, 107-116.
30. Harel, Z.; Gold, M.; Cromer, B.; Bruner, A.; Stager, M.; Bachrach, L.; Wolter, K.; Reid, C.; Hertweck, P.; Nelson, A.; Nelson, D.; Coupey, S.; Johnson, C.; Burkman, R.; Bone, H. Bone mineral density in postmenarchal adolescent girls in the United States: Associated biopsychosocial variables and bone turnover markers. J. Adolescent. Health 2007, 40, 44-53. (Pubitemid 44918376)
31. Wang, Q.; Alén, M.; Nicholson, P.H.; Halleen, J.M.; Alatalo, S.L.; Ohlsson, C.; Suominen, H.; Cheng, S. Differential effects of sex hormones on peri- and endocortical bone surfaces in pubertal girls. J. Clin. Endocrinol. Metab. 2006, 91, 277-282. (Pubitemid 43069149)
32. Chevalley, T.; Bonjour, J.P.; Ferrari, S.; Rizzoli, R. The influence of pubertal timing on bone mass acquisition: A predetermined trajectory detectable five years before menarche. J. Clin. Endocrinol. Metab. 2009, 94, 3424-3431.
33. Yingling, V.R.; Xiang, Y.; Raphan, T.; Schaffler, M.B.; Koser, K.; Malique, R. The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis. Bone 2007, 40, 419-424. (Pubitemid 46054543)
34. Yingling, V.R. A delay in pubertal onset affects the covariation of body weight, estradiol, and bone size. Calcif. Tissue Int. 2009, 84, 286-296.
35. Bertelloni, S.; Baroncelli, G.I.; Sorrentino, M.C.; Perri, G.; Saggese, G. Effect of central precocious puberty and gonadotropinreleasing hormone analogue treatment on peak bone mass and final height in females. Eur. J. Pediatr. 1998, 157, 363-367. (Pubitemid 28225436)
36. Heger, S.; Partsch, C.J.; Sippell, W.G. Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J. Clin. Endocrinol. Metab. 1999, 84, 4583-4590.
37. Chiocca, E.; Dati, E.; Baroncelli, G.I.; Mora, S.; Parrini, D.; Erba, P.; Bertelloni, S. Body mass index and body composition in adolescents treated with gonadotropin-releasing hormone analogue triptorelin depot for central precocious puberty: data at near final height. Neuroendocrinology 2009, 89, 441-447.
38. Antoniazzi, F.; Bertoldo, F.; Zamboni, G.; Valentini, R.; Sirpresi, S.; Cavallo, L.; Adami, S.; Tatò, L. Bone mineral metabolism in girls with precocious puberty during gonadotrophin-releasing hormone agonist treatment. Eur. J. Endocrinol. 1995, 133, 412.
39. Kapteijns-van Kordelaar, S.; Noordam, K.; Otten, B.; van den Bergh, J. Quantitative calcaneal ultrasound parameters and bone mineral density at final height in girls treated with depot gonadotrophin- releasing hormone agonist for central precocious puberty or idiopathic short stature. Eur. J. Pediatr. 2003, 162, 776-780.
40. Antoniazzi, F.; Zamboni, G.; Bertoldo, F.; Lauriola, S.; Mengarda, F.; Pietrobelli, A.; Tatò, L. Bone mass at final height in precocious puberty after gonadotropin-releasing hormone agonist with and without calcium supplementation. J. Clin. Endocrinol. Metab. 2003, 88, 1096-1101. (Pubitemid 36337761)
41. DiVasta, A.M.; Laufer, M.R.; Gordon, C.M. Preservation of bone mineral density in adolescents treated with GnRH agonists and add-back therapy for endometriosis. J. Pediatr. Adolescent. Gynecol. 2006, 19, 136-137.
42. Giustina, A.; Mazziotti, G.; Canalis, E. Growth hormone, insulinlike growth factors, and the skeleton. Endocr. Rev. 2008, 29, 535-559.
43. Conover, C.A. Insulin-like growth factor-binding proteins and bone metabolism. Am. J. Physiol. Endocrinol. Metab. 2008, 294, E10-4.
44. Mohan, S.; Richman, C.; Guo, R.; Amaar, Y.; Donahue, L.R.; Wergedal, J.; Baylink, D.J. Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormonedependent and -independent mechanisms. Endocrinology 2003, 144, 929-936.
45. Mohan, S.; Baylink, D.J. Impaired skeletal growth in mice with haploinsufficiency of IGF-I: genetic evidence that differences in IGF-I expression could contribute to peak bone mineral density differences. J. Endocrinol. 2005, 185, 415-420.
46. Le Roith, D. Regulation of proliferation and apoptosis by the insulin-like growth factor I receptor. Growth Horm. IGF. Res. 2000, 10, S12-3. (Pubitemid 30641916)
47. Léger, J.; Mercat, I.; Alberti, C.; Chevenne, D.; Armoogum, P.; Tichet, J.; Czernichow, P. The relationship between the GH/IGF-I axis and serum markers of bone turnover metabolism in healthy children. Eur. J. Endocrinol. 2007, 157, 685-692. (Pubitemid 350187387)
48. Yao, W.; Zhong, J.; Yu, J.; Warner, T.; Bozic, T.; Ye, P.; D'Ercole, A.J.; Hock, J.M.; Lee, W.H. IGF-I improved bone mineral density and body composition of weaver mutant mice. Growth Horm. IGF. Res. 2008, 18, 517-525.
49. Cheung, C.C.; Thornton, J.E.; Kuijper, J.L.; Weigle, D.S.; Clifton, D.K.; Steiner, R.A. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 1997, 138, 855-858. (Pubitemid 27110945)
50. Moreno, L.A.; Mesana, M.I.; González-Gross, M.; Gil, C.M.; Fleta, J.; Wärnberg, J.; Ruiz, J.R.; Sarría, A.; Marcos, A.; Bueno, M.; AVENA Study Group. Anthropometric body fat composition reference values in Spanish adolescents. The AVENA Study. Eur. J. Clin. Nutr. 2006, 60, 191-196.
51. Cromer, B.A.; Binkovitz, L.; Ziegler, J.; Harvey, R.; Debanne, S.M. Reference values for bone mineral density in 12 to 18 year old girls categorized by weight, race, and age. Pediatr. Radiol. 2004, 34, 787-792.
52. Timpson, N.J.; Sayers, A.; Davey-Smith, G.; Tobias, J.H. How does body fat influence bone mass in childhood? A Mendelian randomization approach. J. Bone Miner. Res. 2009, 24, 522-533.
53. Young, D.; Hopper, J.L.; Macinnis, R.J.; Nowson, C.A.; Hoang, N.H.; Wark, J.D. Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8 to 26-year-old female twins. Osteoporos. Int. 2001, 12, 506-515.
54. Pietrobelli, A.; Faith, M.S.; Wang, J.; Brambilla, P.; Chiumello, G.; Heymsfield, S.B. Association of lean tissue and fat mass with bone mineral content in children and adolescents. Obes. Res. 2002, 10, 56-60.
55. Takeda, S.; Elefteriou, F.; Karsently, G. Common endocrine control of body weight, reproduction, and bone mass. Ann. Rev. Nutr. 2003, 23, 403-411.
56. Thomas, T. Leptin: a potential mediator for protective effects of fat mass on bone tissue. Joint Bone Spine 2003, 70, 18-21. (Pubitemid 36350408)
57. Santos, L.C.; Cintra, I.P.; Fisberg, M.; Martini, L.A. Effects of weight change on bone mass and metabolic parameters in obese adolescents. Eur. J. Clin. Nutr. Metab. 2009, 4, e47-52.
58. Sherar, L.B.; Baxter-Jones, A.D.; Mirwald, R.L. The relationship between body composition and onset of menarche. Ann. Hum. Biol. 2007; 34: 673-677.
59. Iwamoto, J.; Shimamura, C.; Takeda, T.; Abe, H.; Ichimura, S.; Sato, Y.; Toyama, Y. Effects of treadmill exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats. J. Bone Miner. Metab. 2004, 22, 26-31. (Pubitemid 38140039)
60. Morris, F.L.; Naughton, G.A.; Gibbs, J.L.; Carlson, J.S.; Wark, J.D. Prospective ten month exercise and bones of growing girls: positive effects on bone and lean mass. J. Bone Miner. Res. 1997, 12, 1453-1462.
61. Heinonen, A.; Sievanen, H.; Kannus, P.; Oja, P.; Pasanen, M.; Vuori, I. High-impact exercise and bones of growing girls: a 9-month controlled trial. Osteoporos. Int. 2000, 11, 1010-1017. (Pubitemid 32144592)
62. Hara, S.; Yanagi, H.; Amagai, H.; Endoh, K.; Tsuchiya, S.; Tomura, S. Effect of physical activity during teenage years, based on type of sport and duration of exercise, on bone mineral density of young, premenopausal Japanese women. Calcif. Tissue Int. 2001, 68, 23-30. (Pubitemid 33658479)
63. Burr, D.B.; Robling, A.G.; Turner, C.H. Effects of biomechanical stress on bones in animals. Bone 2002, 30, 781-786.
64. Kohrt, W.M.; Bloomfield, S.A.; Little, K.D.; Nelson, M.E.; Yingling, V.R. American College of Sports Medicine. American College of Sports Medicine Position Stand: physical activity and bone health. Med. Sci. Sports. Exerc. 2004, 36, 1985-1996.
65. Strong, W.B.; Malina, R.M.; Blimkie, C.J.R.; Daniels, S.R.; Dishman, R.K.; Gutin, B.; Hergenroeder, A.C.; Must, A.; Nixon, P.A.; Pivarnik, J.M.; Rowland, T.; Trost, S.; Trudeau, F. Evidence based physical activity for school-age youth. J. Pediatr. 2005, 146, 732-737. (Pubitemid 40840591)
66. Wang, M.-C., Crawford, P.B.; Hudes, M.; Van Loan, M.; Siemering, K.; Bachrach, L.K. Diet in midpuberty and sedentary activity in prepuberty predict peak bone mass. Am. J. Clin. Nutr. 2003, 77, 495-503.
67. Neville, C.E.; Murray, L.J.; Boreham, C.A.G.; Gallagher, A.M.; Twisk, J.; Robson, P.J.; Savage, J.M.; Kemper, H.C.; Ralston, S.H.; Smith G.D. Relationship between physical activity and bone mineral status in young adults: the Northern Ireland Young Hearts Project. Bone 2002, 30, 792-798. (Pubitemid 34468005)
68. Liu, L.; Maruno, R.; Mashimo, T.; Sanka, K.; Higuchi, T.; Hayashi, K.; Shirasaki, Y.; Mukai, N.; Saitoh, S.; Tokuyama, K. Effects of physical training on cortical bone at midtibia assessed by peripheral QCT. J. Appl. Physiol. 2003, 95, 219-224. (Pubitemid 36753804)
69. Rubin, C.T.; Lanyon, L.E. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. J. Orthop. Res. 1987, 5, 300-310.
70. Robling, A.G.; Hinant, F.M.; Burr, D.B.; Turner, C.H. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J. Bone Miner. Res. 2002, 17, 1545-1554.
71. Wang, Q.; Alén, M.; Nicholson, P.; Suominen, H.; Koistinen, A.; Kröger, H.; Cheng, S. Weight-bearing, muscle loading and bone mineral accrual in pubertal girls - a 2-year longitudinal study. Bone 2007, 40, 1196-1202. (Pubitemid 46550972)
72. Jackowski, S.A.; Faulkner, R.A.; Farthing, J.P.; Kontulainen, S.A.; Beck, T.J.; Baxter-Jones, A.D. Peak lean tissue mass accrual precedes changes in bone strength indices at the proximal femur during the pubertal growth spurt. Bone 2009, 44, 1186-1190.
73. Zouch, M.; Jaffre, C.; Thomas, T.; Frere, D.; Courteix, D.; Vico, L.; Alexandre, C. Long-term soccer practice increases bone mineral content gain in prepubescent boys. Joint Bone Spine 2008, 75, 41-49.
74. Nebigh, A.; Rebai, H.; Elloumi, M.; Bahlous, A.; Zouch, M.; Zaouali, M.; Alexandre, C.; Sellami, S.; Tabka, Z. Bone mineral density of young boy soccer players at different pubertal stages: relationships with hormonal concentration. Joint Bone Spine 2009, 76, 63-69.
75. Mackelvie, K.J.; McKay, H.A.; Khan, K.M.; Crocker, P.R. A school-based exercise intervention augments bone mineral accrual in early pubertal girls. J. Pediatr. 2001, 139, 501-508.
76. MacKelvie, K.J.; Petit, M.A.; Khan, K.M.; Beck, T.J.; McKay, H.A. Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. Bone 2004, 34, 755-764.
77. MacDonald, H.M.; Kontulainen, S.; Petit, M.; Khan, K.; McKay, H.A. Does a novel school-based physical activity model benefit femoral neck bone strength in pre- and early pubertal children? Osteoporos. Int. 2009, 19,1445-1456.
78. Moreno, L.A.; González-Gross, M.; Kersting, M.; Molnár, D.; de Henauw, S.; Beghin, L.; Sjöström, M.; Hagströmer, M.; Manios, Y.; Gilbert, C.C.; Ortega, F.B.; Dallongeville, J.; Arcella, D.; Wärnberg, J.; Hallberg, M.; Fredriksson, H.; Maes, L.; Widhalm, K.; Kafatos, A.G.; Marcos, A.; HELENA Study Group. Assessing, understanding and modifying nutritional status, eating habits and physical activity in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. Public Health Nutr. 2008, 11, 288-299. (Pubitemid 351214500)
79. US Institute of Medicine, Food and Nutrition Board. Dietary reference intakes: calcium, magnesium, phosphorus, vitamin D, and fluoride, National Academy Press: Washington, DC, 1997.
80. Cashman, K.D. Prebiotics and calcium bioavailability. Curr. Issues. Intest. Microbiol. 2003, 4, 21-32.
81. Fleming, K.H.; Heimbach, J.T. Consumption of calcium in the US: food sources and intake levels. J. Nutr. 1994, 124 (Suppl), 1426S - 30S.
82. Moshfegh, A.; Goldman, J.; Cleveland, L. What we eat in America, NHANES 2001-2002: Usual nutrient intakes from food compared to dietary reference intake, US Department of Agriculture, Agricultural Research Service: Washington, DC, 2005.
83. Wosje, K.S.; Specker, B.L. Role of calcium in bone health during childhood. Nutr. Rev. 2000, 58, 253-268.
84. Rockell, J.E.P.; Williams, S.M.; Taylor, R.W.; Grant, A.M.; Jones, I.E.; Goulding, A. Two-year changes in bone and body composition in young children with a history of prolonged milk avoidance. Osteoporos. Int. 2005, 16, 1016-1023. (Pubitemid 41226487)
85. Savaiano, D., McCabe, G.; VanLoan, M.; Blue, C.L.; Boushey, C.J. Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescents. Pediatrics 2007, 120, e669-77. (Pubitemid 47358281)
86. Specker, B.; Binkley, T. Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5-yearold children. J. Bone Miner. Res. 2003, 18, 885-892. (Pubitemid 37294972)
87. Kardinaal, A.F.; Ando, S.; Charles, P.; Charzewska, J.; Rotily, M.; Väänänen, K.; Van Erp-Baart, A.M.; Heikkinen, J.; Thomsen, J.; Maggiolini. M.; Deloraine, A.; Chabros, E.; Juvin, R.; Schaafsma, G. Dietary calcium and bone density in adolescent girls and young women in Europe. J. Bone Miner. Res. 1999, 14, 583-592. (Pubitemid 29153392)
88. Cheng, S.; Lyytikäinen, A.; Kröger, H.; Lamberg-Allardt, C.; Alén, M.; Koistinen, A.; Wang, Q.J.; Suuriniemi, M.; Suominen, H.; Mahonen, A.; Nicholson, P.H.; Ivaska, K.K.; Korpela, R.; Ohlsson, C.; Väänänen, K.H.; Tylavsky, F. Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial. Am. J. Clin. Nutr. 2005, 82, 1115-1126. (Pubitemid 43779773)
89. Miller, D.D. Calcium in the diet: food sources, recommended intakes and nutritional bioavailability. Adv. Food Nutr. Res. 1989, 33, 103-156.
90. Scholz-Ahrens, K.E.; Schrezenmeir, J. Effects of bioactive substances in milk on mineral and trace element metabolism with special reference to casein phosphopeptides. Br. J. Nutr. 2000, 84, S147-53. (Pubitemid 32106840)
91. Dibba, B.; Prentice, A.; Ceesay, M.; Stirling, D.M.; Cole, T.J.; Poskitt, E.M. Effect of calcium supplementation on bone mineral accretion in gambian children accustomed to a low-calcium diet. Am. J. Clin. Nutr. 2000, 71, 544-549.
92. Carpenter, T.O.; DeLucia, M.C.; Zhang, J.H.; Bejnerowicz, G.; Tartamella, L.; Dziura, J.; Petersen, K.F.; Befroy, D.; Cohen, D. A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. J. Clin. Endocrinol. Metab. 2006, 91, 4866-4872. (Pubitemid 44917320)
93. Holick, M.F. Vitamin D deficiency. N. Engl. J. Med. 2007, 357, 266-281.
94. Pérez-López, F.R. Vitamin D: the secosteroid hormone and human reproduction. Gynecol. Endocrinol. 2007, 23, 13-24.
95. Iwamoto, J.; Yeh, J.K.; Takeda, T.; Ichimura, S.; Sato, Y. Comparative effects of vitamin K and vitamin D supplementation on prevention of osteopenia in calcium-deficient young rats. Bone 2003, 33, 557-566. (Pubitemid 37222382)
96. Heaney, R.P. Vitamin D endocrine physiology. J. Bone Miner. Res. 2007, 22 (Suppl 2), 25-27.
97. Pérez-López, F.R. Vitamin D and its implications for musculoskeletal health in women: an update. Maturitas, 2007, 58, 117-137. (Pubitemid 47503630)
98. Docio, S.; Riancho, J.A.; Pérez, A.; Olmos, J.M.; Amado, J.A.; González-Macias, J. Seasonal deficiency of vitamin D in children: A potential target for osteoporosis-preventing strategies? J. Bone Miner. Res. 1998, 13, 544-548. (Pubitemid 28163005)
99. Guillemant, J.; Taupin, P.; Le, H.T.; Taright, N.; Allemandou, A.; Peres, G.; Guillemant, S. Vitamin D status during puberty in French healthy male adolescents. Osteoporos. Int. 1999, 10, 222-225. (Pubitemid 29458717)
100. Abrams, S.A.; Griffin, I.J.; Hawthorne, K.M.; Gunn, S.K.; Gundberg, C.M.; Carpenter, T.O. Relationships among vitamin D levels, parathyroid hormone and calcium absorption in young adolescents. J. Clin. Endocrinol. Metab. 2005, 90, 5576-5581.
101. Clemens, LH; Corcoran, A,M.; Ward, K.D.; McClanahan, B. The effect of calcium and vitamin D intake on the bone mineral density of youth and adolescents. J. Am. Diet. Assoc. 2005, 105 (Suppl 1), 67.
102. Outila, T.A.; Kärkkäinen, M.U.; Lamberg-Allardt, C.J. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am. J. Clin. Nutr. 2001, 74, 206-210. (Pubitemid 32702487)
103. Lehtonen-Veromaa, M.K.; Mottonen, T.T.; Nuotio, I.O.; Irjala, K.M.; Leino, A.E.; Viikari, J.S. Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: a 3-y prospective study. Am. J. Clin. Nutr. 2002, 76, 1446-1453.
104. Zittermannn, A.; Scheld, K.; Stehle, P. Seasonal variations in vitamin D status and calcium absorption do not influence bone turnover in young women. Eur. J. Clin. Nutr. 1998, 52, 501-506. (Pubitemid 28330395)
105. Kristinsson, J. O.; Valdimarsson, O.; Sigurdsson, G.; Franzson, L.; Olafsson, I.; Steingrimsdottir, L. Serum 25-hydroxyvitamin D levels and bone mineral density in 16-20-year-old girls: Lack of association. J. Intern. Med. 1998, 243, 381-388. (Pubitemid 28255483)
106. Oliveri, M. B.; Wittich, A.; Mautalen, C.; Chaperon, A.; Kizlansky, A. Peripheral bone mass is not affected by winter vitamin D deficiency in children and young adults from Ushuaia. Calcif. Tissue Int. 2000, 67, 220-224. (Pubitemid 30643859)
107. Looker, A.C.; Dawson-Hughes, B.; Calvo, M.S.; Gunter, E.W.; Sahyoun, N.R. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 2002, 30, 771-777.
108. Jones, G.; Dwyer, T.; Hynes, K.L.; Parameswaran, V.; Greenaway, T.M. Vitamin D insufficiency in adolescent males in southern Tasmania: prevalence, determinants, and relationship to bone turnover markers. Osteoporos. Int. 2005, 16, 636-641.
109. Foo, L.H.; Zhang, Q.; Zhu, K.; Ma, G.; Hu, X.; Greenfield, H.; Fraser, D.R. Low Vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls. J. Nutr. 2009, 139, 1002-1007.
110. Wagner, C.L.; Greer, F.R. American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008, 122, 1142-1152.
111. Huh, S.Y.; Gordon, C.M. Vitamin D deficiency in children and adolescents: epidemiology, impact and treatment. Rev. Endocr. Metab. Disord. 2008, 9, 161-170.
112. Ginde, A.A.; Liu, M.C.; Camargo, C.A. Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch. Intern. Med. 2009, 169, 626-632.
113. Kalkwarf, H.J.; Khoury, J.C.; Bean, J.; Elliot, J.G. Vitamin K, bone turnover, and bone mass in girls. Am. J. Clin. Nutr. 2004, 80, 1075-1080.
114. O'Connor, E.; Mølgaard, C.; Michaelsen, K.F.; Jakobsen, J.; Lamberg- Allardt, C.J.E.; Cashman, K.D. Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls. Br. J. Nutr. 2007, 97, 661-666. (Pubitemid 46470674)
115. van Summeren, M.J.; van Coeverden, S.C.; Schurgers, L.J.; Braam, L.A.; Noirt, F.; Uitrwaal, C.S.; Kuis, W.; Vermeer, C. Vitamin K status is associated with childhood bone mineral content. Br. J. Nutr. 2008, 100, 852-858.
116. Alexy, U.; Remer, T.; Manz, F.; Neu, C.M.; Schoenau E. Longterm protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. Am. J. Clin. Nutr. 2005, 82, 1107-1114. (Pubitemid 43779772)
117. New, S.; Robins, S.P.; Campbell, M.K.; Martin, J.C.; Garton, M.J.; Bolton-Smith, C.; Grubb, D.A.; Lee, S.J.; Reid, D.M. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am. J. Clin. Nutr. 2000, 71, 142-151.
118. Pérez-López, F.R.; Chedraui, P.; Haya, J.; Cuadros, J.L. Effects of the Mediterranean diet pattern on longevity and age prevalent morbid conditions. Maturitas. 2009, 64, 67-79.
119. Jones, G.; Riley, M.D.; Whiting, S. Association between urinary potassium, urinary sodium, current diet, and bone density in prepubertal children. Am. J. Clin Nutr. 2001, 73, 839-844. (Pubitemid 32239241)
120. Tylavsky FA, Holliday K, Danish R, Womack C, Norwood J, Carbone L. Fruit and vegetable intake is an independent predictor of bone size in early-pubertal children. Am. J. Clin. Nutr. 2004; 79: 311-317. (Pubitemid 41095986)
121. Canada's Food Guide to Healthy Eating. Health Canada; 1992. [Cited 13 August 2009]. Available from: http://www.hcsc. gc.ca/fn-an/food-guide-aliment/ review-examen/meetreunion/stake-meet-cfg-reunion-part-inter-gac-eng.php
122. Vatanparast, H.; Baxter-Jones, A.; Faulkner, R.A.; Bailey, D.A.; Whiting, S.J. Positive effects of vegetable and fruit consumption and calcium intake on bone mineral accrual in boys during growth from childhood to adolescence: the university of saskatchewan pediatric bone mineral accrual study. Am. J. Clin. Nutr. 2005, 82, 700-706.
123. Misra, M.; Aggarwal, A.; Miller, K.K.; Almazan, C.; Worley, M.; Soyka, L.A.; Herzog, D.B.; Klibanski, A. Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics 2004, 114, 1574-1583. (Pubitemid 41754920)
124. Winston, A.P.; Alwazeer, A.E.; Bankart, M.J. Screening for osteoporosis in anorexia nervosa: prevalence and predictors of reduced bone mineral density. Int. J. Eat. Disord. 2008, 41, 284-287.
125. Grinspoon, S.; Thomas, E.; Pitts, S.; Gross, E.; Mickley, D.; Miller, K.; Herzog, D.; Klibanski, A. Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa. Ann. Intern. Med. 2000, 133, 790-794.
126. Wiksten-Almströmer, M.; Hirschberg, A.L.; Hagenfeldt, K. Reduced bone mineral density in adult women diagnosed with menstrual disorders during adolescence. Acta Obstet. Gynecol. Scand. 2009, 88, 543-549.
127. Biller, B.M.K.; Saxe, V.; Herzog, D.B.; Rosenthal, D.I.; Holzman, S.; Klibanski, A. Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J. Clin. Endocrinol. Metab. 1989, 68, 548-554. (Pubitemid 19081427)
128. Misra M, Miller KK, Almazan C, Worley M, Herzog DB, Klibanski A. Hormonal determinants of regional body composition in adolescent girls with anorexia nervosa and controls. J. Clin. Endocrinol. Metab. 2005, 90, 2580-2587. (Pubitemid 40686294)
129. Misra M, Miller KK, Stewart V, Hunter E, Kuo K, Herzog DB, Klibanski A. Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents. J. Clin. Endocrinol. Metab. 2005, 90, 5082-5087. (Pubitemid 41262258)
130. Karlsson, M.K.; Weigall, S.J.; Duan, Y.; Seeman, E. Bone size and volumetric density in women with anorexia nervosa receiving estrogen replacement therapy and in women recovered from anorexia nervosa. J. Clin. Endocrinol. Metab. 2000, 85, 3177-3182.
131. Golden, N.H.; Lanzkowsky, L.; Schebendach, J.; Palestro, C.J.; Jacobson, M.S.; Shenker, I.R. The effect of estrogen-progestin treatment on bone mineral density in anorexia nervosa. J. Pediatr. Adolesc. Gynecol. 2002, 15, 135-143. (Pubitemid 34832457)
132. Legroux-Gérot, I.; Vignau, J.; Collier, F.; Cortet, B. Factors influencing changes in bone mineral density in patients with anorexia nervosa-related osteoporosis: the effect of hormone replacement therapy. Calcif. Tissue Int. 2008, 83, 315-323.
133. Gordon, C.M.; Grace, E.; Emans, S.J.; Feldman, H.A.; Goodman, E.; Becker, K.A.; Rosen. C.J.; Gundberg, C.M.; LeBoff, M.S. Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. J. Clin. Endocrinol. Metab. 2002, 87, 4935-4941. (Pubitemid 35316328)
134. Golden NH, Iglesias EA, Jacobson MS, Carey D, Meyer W, Schebendach J, Hertz S, Shenker IR. Alendronate for the treatment of osteopenia in anorexia nervosa: a randomized, double-blind, placebo-controlled trial. J. Clin. Endocrinol. Metab. 2005,90, 3179-3185. (Pubitemid 41014272)
135. Whiting, S.J.; Healey, A.; Psiuk, S.; Mirwald, R.; Kowalski, K:, Bailey, D.A. Relationship between carbonated and other low nutrient dense beverages and bone mineral content of adolescents. Nutr. Res. 2001, 21, 1107-1115.
136. McGartland, C.; Robson, P.J.; Murray, L.; Cran, G.; Savage, M.J.; Watkins, D.; Rooney, M.; Boreham, C. Carbonated soft drink consumption and bone mineral density in adolescence: the Northern Ireland Young Hearts project. J. Bone Miner. Res. 2003, 18, 1563-1569. (Pubitemid 37022913)
137. Ma, D.; Jones, G. Soft drink and milk consumption, physical activity, bone mass, and upper limb fractures in children: a populationbased case-control study. Calcif. Tissue. Int. 2004, 75, 286-291. (Pubitemid 40064229)
138. Bailey, D.A.; McKay, H.A.; Mirwald, R.L.; Crocker, P.E.; Faulkner, R.A. The University of Saskatchewan Bone Mineral Accrual Study: A six year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children. J. Bone Miner. Res. 1999, 14, 1672-1679.
139. Iuliano-Burns, S.; Whiting, S.J.; Faulkner, R.A.; Bailey, D.A. Levels, sources, and seasonality of dietary calcium intake in children and adolescents
140. Keller, K.L.; Kirzner, J.; Pietrobelli, A.; St-Onge, M.P.; Faith, M.S. Increased sweetened beverage intake is associated with reduced milk and calcium intake in 3- to 7-year-old children at multi-item laboratory lunches. J. Am. Diet. Assoc. 2009, 109, 497-501.
141. Libuda, L.; Alexy, U.; Remer, T.; Stehle, P.; Schoenau, E.; Kersting, M. Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy German children and adolescents. Am. J. Clin. Nutr. 2008, 88, 1670-1677.
142. Iwaniec, U.T.; Fung, Y.K.; Cullen, D.M.; Akhter, M.P.; Haven, M.C.; Schmid, M. Effects of nicotine on bone and calciotropic hormones in growing female rats. Calcif. Tissue Int. 2000, 67, 68-74. (Pubitemid 30460952)
143. Hapidin, H.; Othman, F.; Soelaiman, I.N.; Shuid, A.N.; Luke, D.A.; Mohamed, N. Negative effects of nicotine on bone-resorbing cytokines and bone histomorphometric parameters in male rats. J. Bone Miner. Metab. 2007, 25, 93-98. (Pubitemid 46328664)
144. Emanuele, M.A.; Wezeman, F.; Emanuele, N.V. Alcohol's effects on female reproductive function. Alcohol Res. Health 2002, 26, 274-281.
145. Duncan, C.S.; Blimkie, C.J.; Cowell, C.T.; Burke, S.T.; Briody, J.N.; Howman-Giles, R. Bone mineral density in adolescent female athletes: relationship to exercise type and muscle strength. Med. Sci. Sports Exerc. 2002, 34, 286-294. (Pubitemid 34132034)
146. Nichols, J.F.; Rauh, M.J.; Lawson, M.J.; Ji, M.; Barkai, H.S. Prevalence of the female athlete triad syndrome among high school athletes. Arch. Pediatr. Adolesc. Med. 2006, 160, 137-142. (Pubitemid 43213857)
147. Otis, C. Exercise-associated amenorrhea. Clin. Sports Med. 1992, 11, 351-362.
148. Loud, K.J.; Gordon, C.M.; Micheli, L.J.; Field, A.E. Correlates of stress fractures among preadolescent and adolescent girls. Pediatrics. 2005, 115, e399-406.
149. Bachrach, L.K.; Hastie, T.; Wang, M.C.; Narasimhan, B.; Marcus, R. Bone mineral acquisition in healthy Asian, Hispanic, Black, and Caucasian youth: A longitudinal study. J. Clin. Endocrinol. Metab. 1999, 84, 4702-4712.
150. Keen, A.; Drinkwater, B. Irreversible bone loss in former amenorrheic athletes. Osteoporos. Int. 1997, 7, 311-315. (Pubitemid 27346410)
151. Myburgh, K.H.; Bachrach, L.K.; Lewis, B.; Kent, K.; Marcus, R. Low bone mineral density at axial and appendicular sites in amenorrheic athletes. Med. Sci. Sports. Exerc. 1993, 25, 1197-1202. (Pubitemid 23326471)
152. Christo, K.; Prabhakaran, R.; Lamparello, B.; Cord, J.; Miller, K.K.; Goldstein, M.A.; Gupta, N.; Herzog, D.B.; Klibanski, A.; Misra, M. Bone metabolism in adolescent athletes with amenorrhea, athletes with eumenorrhea, and control subjects. Pediatrics 2008, 121, 1127-1136.
153. Ding, J.; Sheckter, C.; Drinkwater, B.; Soules, M.; Bremner, W. High serum cortisol levels in exercise-associated amenorrhea. Ann. Intern. Med. 1988, 108, 530-534.
154. Riggs, B. The mechanisms of estrogen regulation of bone resorption. J. Clin. Invest. 2000, 106, 1203-1204.
155. Loucks, A.B. The response of luteinizing hormone pulsatility to 5 days of low energy availability disappears by 14 years of gynecological age. J. Clin. Endocrinol. Metab. 2006, 91, 3158-3164.
156. Miller, K.K.; Grinspoon, S.; Gleysteen, S.; Grieco, K.A.; Ciampa, J.; Breu, J.; Herzog, D.B.; Klibanski, A. Preservation of neuroendocrine control of reproductive function despite severe undernutrition. J. Clin. Endocrinol. Metab. 2004, 89, 4434-4438. (Pubitemid 39244451)
157. Pikkarainen, E.; Lehtonen-Veromaa, M.; Möttönen, T.; Kautiainen, H.; Viikari, J. Estrogen-progestin contraceptive use during adolescence prevents bone mass acquisition: a 4-year follow-up study. Contraception 2008, 78, 226-231.
158. Cromer, B.A.; Bonny, A.E.; Stager, M.; Lazebnik, R.; Rome, E.; Ziegler, J.; Camlin-Shingler, K.; Secic, M. Bone mineral density in adolescent females using injectable or oral contraceptives: a 24- month prospective study. Fertil. Steril. 2008, 90, 2060-2067.
159. Karlsson, C.; Obrant, K.J.; Karlsson, M. Pregnancy and lactation confer reversible bone loss in humans. Osteoporos. Int. 2001, 12, 828-834.
160. Pearson, D.; Kaur, M.; San, P.; Lawson, N.; Baker, P.; Hosking, D. Recovery of pregnancy mediated bone loss during lactation. Bone 2004, 34, 570-578. (Pubitemid 38314922)
161. Goulding, A. Risk factors for fractures in normally active children and adolescents. Med. Sport Sci. 2007, 51, 102-120.
162. Duan, Y.; Wang, X.F.; Evans, A.; Seeman, E. Structural and biomechanical basis of racial and sex differences in vertebral fragility in Chinese and Caucasians. Bone 2005, 36, 987-998.
163. Zebaze, R.M.; Jones, A.; Knackstedt, M.; Maalouf, G.; Seeman, E. Construction of the femoral neck during growth determines its strength in old age. J. Bone Miner. Res. 2007, 22, 1055-1061. (Pubitemid 351339728)
164. Marshall, D.; Johnell, O.; Wedel, H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. Br. Med. J. 1996, 312, 1254-1259. (Pubitemid 26147662)
165. Oliver, H.; Jameson, K.A.; Sayer, A,A,; Cooper, C.; Dennison, E.M.; Hertfordshire Cohort Study Group. Growth in early life predicts bone strength in late adulthood: the Hertfordshire Cohort Study. Bone 2007, 41, 400-405.
166. Seeman, E.; Hopper, J.L.; Bach, L.A.; Cooper, M.E.; Parkinson, E.; McKay, J.; Jerums, G. Reduced bone mass in daughters of women with osteoporosis. N. Engl. J. Med. 1989, 320, 554-558. (Pubitemid 19070539)
167. Ferrari, S.; Rizzoli, R.; Slosman, D.; Bonjour, J.P. Familial resemblance for bone mineral mass is expressed before puberty. J. Clin. Endocrinol. Metab. 1998, 83, 358-361.
168. Ferrari, S.; Rizzoli, R.; Chevalley, T.; Slosman, D.; Eisman, J.A.; Bonjour, J.P. Vitamin-D-receptor-gene polymorphisms and change in lumbar-spine bone mineral density. Lancet 1995, 345, 423-424.
169. Sainz, J.; Van Tornout, J.M.; Sayre, J.; Kaufman, F.; Gilsanz, V. Association of collagen type 1 a1 gene polymorphism with bone density in early childhood. J. Clin. Endocrinol. Metab. 1999, 84, 853-855. (Pubitemid 29138207)
170. Steelman, J.; Zeitler, P. Osteoporosis in pediatrics. Pediatr. Rev. 2001, 22, 56-64.
171. McGuigan, F.E.; Murray, L.; Gallagher, A.; Davey-Smith, G.; Neville, C.E.; Van't Hof, R.; Boreham, C.; Ralston, S.H. Genetic and environmental determinants of peak bone mass in young men and women. J. Bone Miner. Res. 2002, 17, 1273-1279.
172. Gordon, C.M.; DePeter, K.C.; Feldman, H.A.; Grace, E.; Emans, S.J. Prevalence of vitamin D deficiency among healthy adolescents. Arch. Pediatr. Adolesc. Med. 2004, 158, 531-537.
173. DeBar, L.L.; Ritenbaugh, C.; Aickin, M.; Orwoll, E.; Elliot, D.; Dickerson, J.; Vuckovic, N.; Stevens, V.J.; Moe, E.; Irving, L.M. A health plan-based lifestyle intervention increases bone mineral density in adolescent girls. Arch. Pediatr. Adolesc. Med. 2006, 160, 1269-1276.
174. Petersen, A.C.; Leffert, N. Developmental issues influencing guidelines for adolescent health research: a review. J. Adolesc. Health 1995, 17, 298-305. (Pubitemid 26001399)
175. McKay, H.A.; Petit, M.A.; Schutz, R.W.; Prior, J.C.; Barr, S.I.; Khan, K.M. Augmented trochanteric bone mineral density after modified physical education classes: a randomized school-based exercise intervention study in prepubescent and early pubescent children. J. Pediatr. 2000, 136, 156-162.