Regulation of proliferation and apoptosis by the insulin-like growth factor I receptor

Growth Hormone and IGF Research

Volumn 10, Issue SUPPL. A, 2000, Pages

  Le Roith, D ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; RAS PROTEIN; SOMATOMEDIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

APOPTOSIS; BREAST CANCER; CELL CULTURE; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CONFERENCE PAPER; MONKEY; NONHUMAN; PRIORITY JOURNAL;

EID: 0033888983     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1096-6374(00)90005-4     Document Type: Conference Paper

References (6)

1. Growth hormone treatment induces mammary gland hyperplasia in aging primates
2. Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression
3. The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin-like growth factor-I (IGF) and enhanced IGF-I signaling
4. Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation
5. Insulin-like growth factor I inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways
6. Insulin-like growth factor-I inhibition of apoptosis is associated with increased expression of the bcl-x(L) gene product