Construction of the femoral neck during growth determines its strength in old age

Journal of Bone and Mineral Research

Volumn 22, Issue 7, 2007, Pages 1055-1061

  Zebaze, Roger M D ^a   Jones, Anthony ^b   Knackstedt, Mark ^b   Maalouf, Ghassan ^c   Seeman, Ego ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c UNIVERSITY OF BALAMAND   (Lebanon)

Author keywords

Architecture; External size; Femoral neck; Mineralized bone mass; Volumetric density

Indexed keywords

ADAPTATION; ADULT; AGED; AGING; ARTICLE; BONE BOWING; BONE DENSITOMETRY; BONE DENSITY; BONE FRAGILITY; BONE GROWTH; BONE MASS; BONE REMODELING; BONE STRENGTH; COMPRESSIVE STRENGTH; CONFIDENCE INTERVAL; CORTICAL BONE; FEMALE; FEMUR NECK; FEMUR SHAFT; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; LEBANON; MICRO-COMPUTED TOMOGRAPHY; NORMAL HUMAN; OSTEOLYSIS; PELVIS; PERIOSTEUM; STRUCTURE ANALYSIS; TRABECULAR BONE; VARIANCE; VOLUMETRY; WEIGHT BEARING; BODY HEIGHT; BODY WEIGHT; COMPUTER ASSISTED TOMOGRAPHY; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; AGED, 80 AND OVER; AGING; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; FEMALE; FEMUR NECK; HUMANS; MIDDLE AGED; TOMOGRAPHY, X-RAY COMPUTED;

EID: 34548585426     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070329     Document Type: Article

References (16)

1. Currey JD 2002 The structure of bone tissue. In: Kelsey J (ed.) Bones. Structure and mechanics. Princeton University Press, NY, USA, pp. 1-26.
2. Bass S, Delmas PD, Pearce G, Hendrich E, Tabensky A, Seeman E 1999 The differing tempo of growth in bone size, mass, and density in girls is region-specific. J Clin Invest 104:795-804.
3. Martin B 1993 Aging and strength of bone as a structural material. Calcif Tissue Int 53(Suppl 1):S34-S39.
4. Zebaze RM, Jones A, Welsh F, Knackstedt M, Seeman E 2005 Femoral neck shape and the spatial distribution of its mineral mass varies with its size: Clinical and biomechanical implications. Bone 37:243-252.
5. Formica C, Loro M-L, Gilsanz V, Seeman E 1995 Inhomogeneity in body fat distribution may result in inaccuracy in the measurement of vertebral bone mass. J Bone Miner Res 10:1504-1511.
6. Tabensky AD, Williams J, DeLuca V, Briganti E, Seeman E 1996 Bone mass, areal, and volumetric bone density are equally accurate, sensitive, and specific surrogates of the breaking strength of the vertebral body: An in vitro study. J Bone Miner Res 11:1981-1988.
7. Sakellariou A, Sawkins T, Senden T, Limaye A 2004 X-ray tomography for mesoscale physics applications. Physica A (Amsterdam) 339:152-158.
8. Stromsoe K, Hoiseth A, Alho A, Kok WL 1995 Bending strength of the femur in relation to non-invasive bone mineral assessment. J Biomech 28:857-861.
9. Ruff CB, Hayes WC 1982 Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging. Science 217:945-948.
10. Seeman E, Delmas PD 2006 Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 354:2250-2261.
11. Seeman E 2003 Periosteal bone formation-a neglected determinant of bone strength. N Engl J Med 349:320-323.
12. Hui SL, Zhou L, Evans R, Slemenda CW, Peacock M, Weaver CM, McClintock C, Johnston CC Jr 1999 Rates of growth and loss of bone mineral in the spine and femoral neck in white females. Osteoporos Int 9:200-205.
13. Filardi S, Zebaze RM, Duan Y, Edmonds J, Beck T, Seeman E 2004 Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging. Osteoporos Int 15:103-107.
14. Seeman E, Duan Y, Fong C, Edmonds J 2001 Fracture site-specific deficits in bone size and volumetric density in men with spine or hip fractures. J Bone Miner Res 16:120-127.
15. Han Z-H, Palnitkar S, Rao DS, Nelson D, Parfitt AM 1996 Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Miner Res 11:1967-1975.
16. Rauch F 2005 Bone growth in length and width: The Yin and Yang of bone stability. J Musculoskelet Neuronal Interact 5:194-201.