New and bioactive natural products isolated from madagascar plants and marine organisms

Current Medicinal Chemistry

Volumn 17, Issue 12, 2010, Pages 1191-1219

  Hou, Y ^a   Harinantenaina, L ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Bioactivities; Biodiversity; Madagascar; Marine organisms; Natural products; Plants

Indexed keywords

19 EPI 3 OXOVOACRISTINE; 19 EPI VOACRISTINE HYDROXYINDOLENINE; 3 HYDROXYTABERNANTHINE; 4,7 DIMETHOXY 1 VINYL BETA CARBOLINE; 5 METHOXYMACULINE; 5,8 DIMETHOXYMACULINE; ALKALOID; ALPHA GLUCOSIDASE; BERBERINE; BURASAINE; COUMARIN DERIVATIVE; DEACETYLSTRYCHNOBRASILINE; DITERPENOID; FLAVONOID; INDUCIBLE NITRIC OXIDE SYNTHASE; KIRONDRINE; KOKUSAGININE; LIPOPOLYSACCHARIDE; MALAGASHANINE; MALAGASHINE; NATURAL PRODUCT; NORMACUSINE; SESQUITERPENOID; SKIMMIANINE; STRYCHNOBRASILINE; STRYCHNOFENDLERINE; TRITERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE; BIOLOGICAL PRODUCT;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; BIODIVERSITY; DRUG STRUCTURE; ENZYME INHIBITION; ETHNOBOTANY; ETHNOPHARMACOLOGY; HUMAN; IC 50; LIVERWORT; MADAGASCAR; MARINE SPECIES; NONHUMAN; PHYTOCHEMISTRY; TOXICITY TESTING; ANIMAL; CHEMISTRY; ISOLATION AND PURIFICATION; MARINE BIOLOGY; PLANT;

ANIMALS; BIOLOGICAL PRODUCTS; MADAGASCAR; MARINE BIOLOGY; PLANTS;

EID: 77950680444     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710790827834     Document Type: Article

References (91)

1. http://ridgwaydb.mobot.org/mobot/madagascar/default.asp
2. http://www.wildmadagascar.org/flora/
3. Johnson, I. S.; Armstrong, J. G.; Gorman, M.; Burnett, J. P. jr. The vinca alkaloids: a new class of oncolytic agents. Cancer Res. 1963, 23, 1390-1427.
4. Chaturvedula, V. S. P.; Shannon, S.; Schilling, J. K.; Kingston, D. G. I. New cytotoxic indole alkaloids from Tabernaemontana calcarea from the Madagascar rainforest. J. Nat. Prod. 2003, 66, 528-531 (Pubitemid 36531903)
5. Krebs, H. C.; Rakotoarimanga, J. V.; Rasoanaivo, P.; Frappier, F.; Martin, M.-T. Alkaloids of Perriera madagascariensis. J. Nat. Prod. 1997, 60, 1183-1185
6. Rasonavo, P.; Galeffi, G.; De Vicente, Y.; Nicoleti, M. Research on African medicinal plants. Part 26. Malagashine and malagashanine, two alkaloids of Strychnos mostueoides Leeuwenb. Rev. Latinoamer: Quimi 1991, 22, 32-34
7. Chaturvedula, V. S. P.; Schilling, J. K.; Miller, J. S.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D.G. I. New cytotoxic alkaloids from the wood of Vepris punctata from the Madagascar rainforest. J. Nat. Prod. 2003, 66, 532-534 (Pubitemid 36531904)
8. Chill, L.; Aknin, M.; Kashman. Y. Barrenazine A and B; two new cytotoxic alkaloids from an unidentified tunicate. Org. Lett. 2003, 5, 2433-2435 (Pubitemid 37140877)
9. Kluza, J.; Baldeyrou, B.; Colson, P.; Rasoanaivo, P.; Mambu, L.; Frappier, F.; Bailly, C. Cytotoxicity and DNA binding properties of the plant alkaloid burasaine. Eur. J. Pharm. Sci. 2003, 20, 383-391 (Pubitemid 37491432)
10. Goldshlager, G. K.; Aknin, M. E.; Gaydou, M.; Kashman, Y. Three new alkaloids from the marine tunicate Cystodytes violatinctus. J. Org. Chem. 1998, 63, 4601-4603 (Pubitemid 28342968)
11. Chin, Y.; Jones, W. P.; Waybright, T. J.; McCloud, T. G.; Rasoanaivo, P.; Cragg, G. M.; Cassady, J. M.; Kinghorn, A. D. Tropane aromatic ester alkaloids from a large-scale re-collection of Erythroxylum pervillei stem bark obtained in Madagascar. J. Nat. Prod. 2006, 69, 414-417
12. Silva, G. L.; Cui, B.; Chávez, D.; You, M.; Chai, H.; Rasoanaivo, P.; Lynn, S. M.; O'Neill, M. J.; Lewis, J. A.; Besterman, J. M.; Monks, A.; Farnsworth, N. R.; Cordell, G. A.; Pezzuto, J. M.; Kinghorn, A. D. Modulation of the multidrug??resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei. J. Nat. Prod. 2001, 64, 1514-1520 (Pubitemid 34051970)
13. Sorek, H.; Rudi, A.; Gueta, S.; Reyes, F.; Martin, M. J.; Aknin, M.; Gaydou, E.; Vacelet, J.; Kashman, Y. Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei. Tetrahedron 2006, 62, 8838-8843
14. Bensemhoun, J.; Bombarda, I.; Aknin, M.; Vacelet, J.; Gaydou, E. M. Ptilomycalin D, a polycyclic guanidine alkaloid from the marine sponge Monanchora dianchora. J. Nat. Prod. 2007, 70, 2033-2035
15. Mananjarasoa, E.; Ochi, H.; Harinantenaina, L.; Kasai, R.; Yamasaki, K. A new secoiridoid glucoside from a Malagasy medicinal plant, Cassinopsis chapieleri. Nat. Med. 2002, 56, 204-206 (Pubitemid 35416181)
16. Harinantenaina, L.; Kasai, R.; Rakotovao, M.; Yamasaki, K. New iridoid and phenethyl glycosides from Malagasy medicinal plant, Phyllarthron madagascariense. Nat. Med. 2001, 55, 187-192 (Pubitemid 32862031)
17. Harinantenaina, L.; Kida, S.; Asakawa, Y. Phytochemistry of three selected liverworts: Conocephalum conicum, Plagiochila barteri and P. terebrans. Arkivoc 2007, (vii) 1-8.
18. Chaturvedula,V. S. P.; Schilling, J. K.; Miller, J. S.; Andriantsiferana, R.; Rasamison, V. E.; Kingston. D. G. I. New cytotoxic terpenoids from the wood of Vepris punctata from the Madagascar rainforest. J. Nat. Prod. 2004, 67, 895-898
19. Salmoun, M.; Braekman, J. C.; Ranarivelo, Y.; Rasamoelisendra, R.; Ralambomanana, D.; Dewelle, J.; Darro, F.; Kiss, R. New calamenene sesquiterpenes from Tarenna madagascariensis. Nat. Prod. Res. Part A 2007, 21, 111-120
20. Harinantenaina, L.; Asakawa, Y. Chemical constituents of malagasy Liverworts. 6. A myltaylane caffeate with nitric oxide inhibitory activity from Bazzania nitida. J. Nat. Prod. 2007, 70, 856-858 (Pubitemid 46953614)
21. Rudi, A.; Lev-Ari Dayan, T.; Aknin, M.; Gaydou, E. M.; Kashman, Y. Several new isoprenoids from the soft coral Sinularia erecta. J. Nat. Prod. 1998, 61, 872-875 (Pubitemid 28354522)
22. Ramanandraibe, V.; Martin, M.; Rakotondramanana, D. L.; Mambu, L.; Ramanitrahasimbola, D.; Labaied, M.; Grellier, P.; Rasoanaivo, P.; Frappier, F. Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities. J. Nat. Prod. 2005, 68, 800-803 (Pubitemid 40825302)
23. Harinantenaina, L.; Takaoka, S. Cinnafragrins A-C, dimeric and trimeric drimane sesquiterpenoids from Cinnamosma fragrans, and structure revision of capsicodendrin. J. Nat. Prod. 2006, 69, 1193-1197
24. Harinantenaina, L.; Asakawa, Y.; De Clercq, E. Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa. J. Nat. Prod. 2007, 70, 277-282
25. Harinantenaina, L.; Matsunami, K.; Otsuka, H.; Kawahata, M.; Yamaguchi, K.; Asakawa, Y. Secondary metabolites of Cinnamosma madagascariensis and their α-glucosidase inhibitory properties. J. Nat. Prod. 2008, 71, 123-126 (Pubitemid 351236409)
26. Harinantenaina, L.; Asakawa, Y. Chemical constituents of Malagasy liverworts, Part II1): Mastigophoric acid methyl ester of biogenetic interest from Mastigophora diclados (Lepicoleaceae Subf. Mastigophoroideae). Chem. Pharm. Bull. 2004, 52, 1382-1384 (Pubitemid 41364467)
27. Harinantenaina, L.; Kurata, R.; Asakawa, Y. Chemical constituents of Malagasy liverworts, Part III: Sesquiterpenoids from Bazzania decrescens and Bazzania madagassa. Chem. Pharm. Bull. 2005, 53, 515-518 (Pubitemid 40740619)
28. Harinantenaina, L.; Kurata, R.; Takaoka, S.; Asakawa,Y. Chemical constituents of Malagasy liverworts: Cyclomyltaylanoids from Bazzania madagassa. Phytochemistry 2006, 67, 2616-2622
29. Williams, R. B.; Norris, A.; Slebodnick, C.; Merola, J.; Miller, J. S.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest. J. Nat. Prod. 2005, 68, 1371-1374 (Pubitemid 41499432)
30. Raharivelomanana, P.; Bianchini, J. P.; Ramanoelina, A. R. P.; Rasoharahona, J. R. E.; Chatel, F.; Faure, R. Structures of cadinane - and guaiane-type sesquiterpenoids from Enterospermum madagascariensis (Baill.) Homolle. Magn. Reson. Chem. 2005, 43, 1049-1052 (Pubitemid 41751895)
31. Krebs, H. C.; Duddeck, H.; Malik, S.; Beil, R.; Winfried, P.; Andrianarijaona, M. Chemical composition and antitumor activities from Givotia madagascariensis. Chemical composition and antitumor activities from Givotia madagascariensis. Z. Naturforsch. B. 2004, 59, 58-62.
32. Mambu, L.; Ramanandraibe, V.; Martin, M. T.; Blond, A.; Grellier, P.; Frappier, F. Constituents of Burasaia madagascarensis: a new clerodane-type diterpene. Planta Med. 2002, 68, 377-379 (Pubitemid 34494058)
33. Chaturvedula, V. S. P.; Hoch, J. M.; Kingston, D. G. I. Structure and stereochemistry of new cytotoxic clerodane diterpenoids from the bark of Casearia lucida from the Madagascar rainforest. J. Nat. Prod. 2002, 65, 100-107
34. Williams, R. B.; Norris, A.; Miller, J. S.; Birkinshaw, C.; Ratovoson, F.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. J. Nat. Prod. 2007, 70, 206-209
35. Harinantenaina, L.; Takahara, Y.; Nishizawa, T.; Kohchi, C. Soma, G.-I.; Asakawa, Y. Chemical constituents of malagasy liverworts, Part V: Prenyl bibenzyls and clerodane diterpenoids with nitric oxide inhibitory activity from Radula appressa and Thysananthus spathulistipus. Chem. Pharm. Bull. 2006, 54, 1046-1049
36. Harinantenaina, L.; Kasai, R.; Yamasaki, K. Ent-kaurane diterpenoid glycosides from the leaves of Cussonia racemosa, a Malagasy endemic plant. Chem. Pharm. Bull. 2002, 50, 268.
37. Harinantenaina, L.; Kasai, R.; Yamasaki, K. ent-Kaurane diterpenoid glycoside from a Malagasy endemic plant, Cussonia vantsilana. Phytochemistry 2002, 61, 367-372 (Pubitemid 35230791)
38. Harinantenaina, L.; Kasai, R.; Yamasaki, K. A new ent-Kaurane diterpenoid glycoside from the leaves of Cussonia bojeri, a Malagasy endemic Plant. Chem. Pharm. Bull. 2002, 50, 1122-1123 (Pubitemid 41702078)
39. Longeon, A.; Kondracki, M.-L. B.; Guyot, M. Two new cembrane diterpenes from a Madagascan soft coral of the genus Sarcophyton. Tetrahedron Lett. 2002, 43, 5937-5939 (Pubitemid 34874634)
40. Schaller, F.; Rahalison, L.; Islam, N.; Potterat, O.; Hostettmann, K.; Evans, H. S.; Mavi, S. A new potent antifungal "quinone methide" diterpene with a cassane skeleton from Bobgunnia madagascariensis. Helv. Chim. Acta 2000, 83, 407-413
41. Schaller, F.; Wolfender, J.; Hostettmann, K.; Mavi, S. New antifungal "quinone methide" diterpenes from Bobgunnia madagascariensis and study of their interconversion by LC/NMR. Helv. Chim. Acta, 2001, 84, 222-229
42. Hou,Y.; Cao, S.; Brodie, P.; Miller, J. S.; Birkinshaw, C.; Ratovoson, F.; Rakotondrajaona, R.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest. J. Nat. Prod. 2008, 71, 150-152.
43. Chaturvedula, V. S. P.; Norris, A.; Miller, J. S.; Ratovoson, F.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest. J. Nat. Prod. 2006, 69, 287-289
44. Wellsow, J.; Grayer, R. J.; Veitch, N. C.; Kokubun, T.; Lelli, R.; Kite, G. C.; Simmonds, M. S. J. Insect-antifeedant and antibacterial activity of diterpenoids from species of Plectranthus. Phytochemistry 2006, 67, 1818-1825 (Pubitemid 44247018)
45. Cao, S.; Guza, R. C.; Miller, J. S.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. J. Nat. Prod. 2004, 67, 986-989
46. Seo, Y.; Berger, J. M.; Hoch, J.; Neddermann, K. M.; Bursuker, I.; Mamber, S. W.; Kingston, D. G. I. A new triterpene saponin from Pittosporum viridiflorum from the Madagascar rainforest. J. Nat. Prod. 2002, 65, 65-68 (Pubitemid 34118816)
47. Chaturvedula,V. S. P.; Schilling, J. K.; Miller, J. S.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Two new triterpene esters from the twigs of Brachylaena ramiflora from the Madagascar rainforest. J. Nat. Prod. 2002, 65, 1222-1224
48. Harinantenaina, L.; Kasai, R.; Yamasaki, K. Cussosaponin A-E, triterpene saponins from the leaves of Cussonia racemosa, a Malagasy endemic plant. Chem. Pharm. Bull. 2002, 50, 1290-1293 (Pubitemid 41656853)
49. Deng, Y.; Manoelson, T.-R.; Snyder, J. K. Remangilone D, a new bisnoroleanane triterpene, and a new flavone from Physena madagascariensis. Z. Naturofrsch. B 2001, 56, 1079-1083 (Pubitemid 33362243)
50. Deng, Y.; Jiang, T.; Sheng, S.; Manoelson, T.-R.; Snyder, J. K. Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis. J. Nat. Prod. 1999, 62, 471-476
51. Antonov, A. S.; Kalinovsky, A. I.; Stonik, V. A. Ulososide B, and new unusual norlanostane-triterpene glycoside and its genuine aglycon from the Madagascar sponge Ulosa sp. Tetrahedron Lett. 1998, 39, 3807-3808
52. Achenbach, H.; Asunka, S. A.; Waibel, R.; Addae-Mensah, I.; Oppong, I. V. Dichapetalin A, a novel plant constituent from Dichapetalum madagascariense with potential antineoplastic activity. Nat. Prod. Lett. 1995, 7, 93-100.
53. Mensah, I. A.; Waibel, R. S.; Asunka, A.; Oppong, I. V.; Achenbach, H. The dichapetalins-a new class of triterpenoids. Phytochemistry 1996, 43, 649-656
54. Weckert, E.; Mattern, G.; Addae-Mensah, I.; Waibel, R.; Achenbach, H. The absolute configuration of dichapetalin A. Phytochemistry 1996, 43, 657-660
55. Dijoux, M. G.; Lavaud, C.; Massiot, G.; Le Men-Olivier, L.; Sheeley, D. M. A saponin from leaves of Aphloia madagascariensis. Phytochemistry 1993, 34, 497-499
56. Ponomarenko, L. P.; Kalinovsky, A. I.; Stonik, V. A. New scalarane- based sesterterpenes from the sponge Phyllospongia madagascarensis. J. Nat. Prod. 2004, 67, 1507-1510
57. Thiem, D. A.; Sneden, A. T.; Khan, S. I.; Tekwani, B. L. Bisnortriterpenes from Salacia madagascariensis. J. Nat. Prod. 2005, 68, 251-254
58. Cao, S.; Norris, A.; Miller, J. S.; Ratovoson, F.; Razafitsalama, J.; Andriantsiferana, R.; Rasamison, V. E.; Ten Dyke, K.; Suh, T.; Kingston, D. G. I. Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest. J. Nat. Prod. 2007, 70, 361-366
59. Deng, Y.; Manoelson, T.-R.; Snyder, J. K. Remangilone D, a new bisnoroleanane triterpene, and a new flavone from Physena madagascariensis. Z. Naturofrsch. B 2001, 56, 1079-1083 (Pubitemid 33362243)
60. Cao, S.; Schilling, J. K.; Miller, J. S.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Cytotoxic compounds from Mundulea chapelieri from the Madagascar rainforest. J. Nat. Prod. 2004, 67, 454-456 (Pubitemid 38405714)
61. Cao, S.; Norris, A.; Miller, J. S.; Ratovoson, F.; Birkinshaw, C.; Andriantsiferana, R.; Rasamison, V. E.; Rakotonandrasana, S.; Kingston, D. G. I. Biodiversity conservation and drug discovery in madagascar, part 22: cytotoxic compounds of Physena madagascariensis from the Madagascar rain forest. Nat. Prod. Res. Part A 2006, 20, 1157-1163
62. Murphy, B. T.; Cao, S.; Norris, A.; Miller, J. S.; Ratovoson, F.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Cytotoxic flavanones of Schizolaena hystrix from the Madagascar rainforest. J. Nat. Prod. 2005, 68, 417-419 (Pubitemid 40545482)
63. Koorbanally, N. A.; Randrianarivelojosia, M.; Mulholland, D. A.; Ufford, L. Q. V.; Berg, A. J. J. V. D. Bioactive constituents of Cedrelopsis microfoliata. J. Nat. Prod. 2002, 65, 1349-1352
64. Chaturvedula, V. S. P.; Schilling, J. K.; Kingston, D. G. I. New cytotoxic coumarins and prenylated benzophenone derivatives from the bark of Ochrocarpos punctatus from the Madagascar rainforest. J. Nat. Prod. 2002, 65, 965-972
65. Rudi, A.; Chill, L.; Aknin, M.; Kashman, Y. Didmolamide A and B, two new cyclic hexapeptides from the marine ascidian Didemnum molle. J. Nat. Prod. 2003, 66, 575-577
66. Nogle, L. M.; Gerwick, W. H. Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscule. J. Nat. Prod. 2002, 65, 21-24
67. Rudi, A.; Afanii, R.; Gravalos, L. G.; Aknin, M.; Gaydou, E.; Vacelet, J.; Kashman, Y. Three new cyclic peroxides from the marine sponge Plakortis aff simplex. J. Nat. Prod. 2003, 66, 682-685 (Pubitemid 36617896)
68. Kanchanapoom, T.; Kasai, R.; Ohtani, K.; Andriantsiferana, M.; Yamasaki, K. Pregnane and pregnane glycosides from the Malagasy plant, Cynanchum aphyllum. Chem. Pharm. Bull. 2002, 50, 1031-1034 (Pubitemid 41702060)
69. Chaturvedula, V. S. P.; Schilling, J. K.; Miller, J. S.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. New cytotoxic bis 5-alkylresorcinol derivatives from the leaves of Oncostemon bojerianum from the Madagascar rainforest. J. Nat. Prod. 2002, 65, 1627-1632
70. Long, L.; Lee, S. K.; Chai, H.-B.; Rasoanaivo, P.; Gao, Q.; Navarro, H.; Wall, M.; Wani, M. C.; Farnsworth, N. R.; Cordell, G. A.; Pezzuto, J. M.; Kinghom, A. D. Novel bioactive phenanthrene derivatives from Domohinea perrieri. Tetrahedron 1997, 53, 15663-15670
71. Rasoanaivo, P.; Galeffi, C.; Multari, G.; Nicoletti, M.; Capolongo, L. Research on african medicinal plants. XXXI. Kalanchoside, a cytotoxic bufadienolidic glycoside from Kalanchoe tomentosa Baker. Gazz. Chim. Ital. 1993, 123, 533-541
72. Coombes, P. H; Mulholland, D. A; Randrianarivelojosia, M. Quivisianthone, an evodulone limonoid from the Madagascan Meliaceae Quivisia papinae. Phytochemistry 2004, 65, 377-380
73. Segraves, N. L.; Crews, P. A Madagascar sponge Batzella sp. as a source of alkylated iminosugars. J. Nat. Prod. 2005, 68, 118-121 (Pubitemid 40175945)
74. Coombes, P. H.; Naidoo, D.; Mulholland, D. A.; Randrianarivelojosia, M. Quassinoids from the leaves of the Madagascan Simaroubaceae Samadera madagascariensis. Phytochemistry 2005, 66, 2734-2739 (Pubitemid 41727659)
75. Cao, S.; Radwan, M. M.; Norris, A.; Miller, J. S.; Ratovoson, F.; Mamisoa, A.; Andriantsiferana, R.; Rasamison, V. E.; Rakotonandrasana, S.; Kingston, D. G. I. Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest. J. Nat. Prod. 2006, 69, 284-286
76. Williams, R. B.; Norris, A.; Miller, J. S.; Razafitsalama, L. J.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Two new cytotoxic naphthoquinones from Mendoncia cowanii from the rainforest of Madagascar. Planta Med. 2006, 72, 564-566
77. Sorek, H.; Rudi, A.; Aknin, M.; Gaydou, E.; Kashman, Y. Itampolins A and B, new brominated tyrosine derivatives from the sponge Iotrochota purpurea. Tetrahedron Lett. 2006, 47, 7237-7239
78. Murphy, B. T.; Cao, S.; Norris, A.; Miller, J. S.; Ratovoson, F.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Cytotoxic compounds of Schizolaena hystrix from the Madagascar rainforest. Planta Med. 2006, 72, 1235-1238 (Pubitemid 44759235)
79. Cao, S.; Ranarivelo, L.; Ratsimbason, M.; Randrianasolo, S.; Ratovoson, F.; Andrianjafy, M.; Kingston, D. G. I. Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the madagascar rain forest. Planta Med. 2006, 72, 1438-1440
80. Cao, S.; Brodie, P. J.; Miller, J. S.; Randrianaivo, R.; Ratovoson, F.; Birkinshaw, C.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest. J. Nat. Prod. 2007, 70, 679-681 (Pubitemid 46797881)
81. Yoder, B. J.; Cao, S.; Norris, A.; Miller, J. S.; Ratovoson, F.; Razafitsalama, J.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. J. Nat. Prod. 2007, 70, 342-346
82. Cao, S.; Brodie, P. J.; Miller, J. S.; Ratovoson, F.; Birkinshaw, C.; Randrianasolo, S.; Rakotobe, E.; Rasamison, V. E.; Kingston, D. G. I. Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest. J. Nat. Prod. 2007, 70, 686-688
83. Cao, S.; Brodie, P. J.; Miller, J. S.; Ratovoson, F.; Callmander, M. W.; Randrianasolo, S.; Rakotobe, E.; Rasamison, V. E.; Suh, E. M.; Ten Dyke, K.; Kingston, D. G. I. Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest. J. Nat. Prod. 2007, 70, 1064-1067 (Pubitemid 47056131)
84. Hou, Y; Cao, S.; Brodie, P. J.; Callmander, M.; Ratovoson, F.; Randrianaivo, R.; Rakotobe, E.; Rasamison, V. E.; Rakotonandrasana, S.; TenDyke, K.; Suh, E. M.; Kingston, D. G. I. Antiproliferative cardenolide glycosides of Elaeodendron alluaudianum from the Madagascar rainforest. Bioorg. Med. Chem. 2009, 17, 2215-2218
85. Bishara, A.; Rudi, A.; Aknin, M.; Neumann, D.; Ben-Califa, N.; Kashman, Y. Salarins A and B and tulearin A: new cytotoxic sponge-derived macrolides. Org. Lett. 2008, 10, 153-156
86. Murphy, B. T.; Brodie, P.; Slebodnick, C.; Miller, J. S.; Birkinshaw, C.; Randrianjanaka, L. M.; Andriantsiferana, R.; Rasamison, V. E.; Ten Dyke, K.; Suh, E. M.; Kingston, D. G. I. Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest. J. Nat. Prod. 2008, 71, 325-329
87. Leet, J. E.; Liu, X.; Drexler, D. M.; Cantone, J. L.; Huang, S.; Mamber, S. W.; Fairchild, C. R.; Hussain, R.; Newman, D. J.; Kingston, D. G. I. Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest. J. Nat. Prod. 2008, 71, 460-463
88. Bishara, A.; Rudi, A.; Aknin, M.; Neumann, D.; Ben-Califa, N.; Kashman, Y. Taumycins A and B, two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp. Org. Lett. 2008, 10, 4307-4309
89. Poza, J. J.; Fernandez, R.; Reyes, F.; Rodriguez, J.; Jimenez, C. Isolation, biological significance, synthesis, and cytotoxic evaluation of new natural parathiosteroids A-C and analogues from the soft coral Paragorgia sp. J. Org. Chem. 2008, 73, 7978-7984
90. Murphy, B. T.; Cao, S.; Brodie, P.; Maharavo, J.; Andriamanantoanina, H.; Ravelonandro, P.; Kingston, D. G. I. Antiproliferative bistramides from Trididemnum cyclops from Madagascar. J. Nat. Prod. 2009, 72, 1338-1340
91. Hou, Y.; Cao, S.; Brodie, P. J.; Callmander, M.; Ratovoson, F.; Rakotobe, E.; Rasamison, V. E.; Ratsimbason, M.; Alumasa, J. N.; Roepe, P. D.; Kingston, D. G. I. Antiproliferative and antimalarial anthraquinones of Scutia myrtina from Madagascar forest. Bioorg. Med. Chem., 2009, 17, 2871-2876