Two new cytotoxic naphthoquinones from Mendoncia cowanii from the rainforest of Madagascar

Planta Medica

Volumn 72, Issue 6, 2006, Pages 564-566

  Williams, Russell B ^a   Norris, Andrew ^a   Miller, James S ^b   Razafitsalama, L Jeremie ^b   Andriantsiferana, Rabodo ^c   Rasamison, Vincent E ^c   Kingston, David C I ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b MISSOURI BOTANICAL GARDEN   (United States)

^c Centre National d'Application des Recherches Pharmaceutiques   (Madagascar)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; AVICEQUINONE D; AVICEQUINONE E; MENDONCIA COWANII EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAIN FOREST;

ANGIOSPERMS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MADAGASCAR; MEDICINE, TRADITIONAL; NAPHTHOQUINONES; OVARIAN NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANT STEMS; TREES;

MENDONCIA;

EID: 33744922964     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-931554     Document Type: Article

References (14)

1. Biodiversity, conservation and drug discovery in Madagascar. Part 19, this manuscript.
2. For part 18. Cao S, Radwan MM, Norris A, Miller JS, Ratovoson F, Mamisoa A et al. Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest J Nat Prod, 2006; 69: 284-6
3. Missouri Botanical Garden. Available at http://mobot.mobot.org/cgi-bin/ search_vast?ssdp = 01885737. Accessed in 2005.
4. Ito C, Katsuno S, Kondo Y, Tan HT-W, Furukawa H. Chemical constituents of Avicennia alba. Isolation and structural elucidation of new naphthaquinones and their analogs. Chem Pharm Bull 2000; 48: 339-43
5. Mock J, Murphy ST, Ritchie E, Taylor WC. Chemical studies of the Proteateae VI. Two naphthaquinones from Stenocarpus salignus. Aust J Chem 1973; 26: 1121-30
6. Thomson RH. Naturally occurring quinones; 2nd edition New York: Academic Press, 1971: p 49-57
7. Zhou H, Li X-M, Meinkoth J, Pittman RN. Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol 2000; 151: 483-94
8. Datta SR, Brunei A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999; 13: 2905-27
9. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-21
10. Tran H, Brunei A, Grenier JM, Datta SR, Fornace Jr. AJ, DiStefano PS et al. DNA repair pathway stimulated by the forkhead transcription factor FOX03a through the Gadd45 protein. Science 2002; 296: 530-4
11. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999; 96: 857-68
12. Williams RB, Norris A, Slebodnick C, Merola J, Miller JS, Andriantsiferana R et al. Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest. J Nat Prod 2005; 68: 1371-4
13. Ferreira VF, Pinto AV, Pinto MCFR, Silva MM. Selective reduction in pyranonaphthoquinone systems. J Chem Res Synop, 1987: 26
14. Louie KG, Behrens BC, Kinsella TJ, Hamilton TC, Grotzinger KR, McKoy WM et al. Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine. Cancer Res 1985; 45: 2110-5