C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells

Journal of Bone and Mineral Research

Volumn 12, Issue 5, 1997, Pages 778-785

  Martínez, Maria Eugenia ^a   García Ocaña, Adolfo ^b   Sánchez, Maravillas ^a   Medina, Sonia ^a   Del Campo, Teresa ^a   Valin, Alvaro ^b   Sanchez Cabezudo, Maria Jesus ^a   Esbrit, Pedro ^b  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b Metabolic Research Unit   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; CALCITRIOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; PARATHYROID HORMONE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; DNA SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERCALCEMIA; OSTEOBLAST; PARATHYROID HORMONE BLOOD LEVEL; PROTEIN ANALYSIS;

EID: 1842299921     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.5.778     Document Type: Article

References (49)

1. Martin TJ, Suva LJ 1989 Parathyroid hormone-related protein in hypercalcaemia of malignancy. Clin Endocrinol 31:631-647.
2. Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF 1996 Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev 76:127-173.
3. Abou-Samra A-B, Jüppner H, Force T, Freeman MW, Kong X-F, Schipani E, Ureña P, Richards J, Bonventre JV, Potts JT, Jr, Kronenberg HM, Segre GV 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide for rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736.
4. Wu S, Pirola CJ, Green J, Yamaguchi DT, Okano K, Jueppner H, Forrester JS, Fagin JA, Clemens TL 1993 Effects of N-terminal, midregion, and C-terminal parathyroid hormone-related peptides on adenosine 3′,5′-monophosphate and cyto plasmic free calcium in rat aortic smooth muscle cells and UMR-106 osteoblast-like cells. Endocrinology 133:2437-2444.
5. Verheijen MHG, Defize LHK 1995 Parathyroid hormone inhibits mitogen-activated protein kinase activity in osteosarcoma cells via a protein kinase A-dependent pathway. Endocrinology 136:3331-3337.
6. Centrella M, Canalis E, McCarthy TL, Stewart AF, Orloff JJ, Insogna KL 1989 Parathyroid hormone-related protein modulates the effect of transforming growth factor-β on deoxyribonucleic acid and collagen synthesis in fetal rat bone cells. Endocrinology 125:199-208.
7. Kano J, Sugimoto T, Fukase M, Fujita T 1991 The activation of cAMP-dependent protein kinase is directly linked to the inhibition of osteoblast proliferation (UMR-106) by parathyroid hormone-related protein. Biochem Biophys Res Commun 179:97-101.
8. Sugimoto T, Kano J, Yamaguchi T, Fukase M, Chihara K 1993 Role of calcium/protein kinase C in the regulation of DNA synthesis by parathyroid hormone-related peptide in osteoblastic osteosarcoma cells. Horm Metabol Res 25:608-611.
9. Murray TM, Rao LG, Muzaffar SA, Ly H 1989 Human parathyroid hormone carboxyterminal peptide (53-84) stimulates alkaline phosphatase activity in dexamethasone-treated rat osteosarcoma cells in vitro. Endocrinology 124:1097-1099.
10. Kano J, Sugimoto T, Fukase M, Chihara K 1994 Direct involvement of cAMP-dependent protein kinase in the regulation of alkaline phosphatase activity by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic UMR-106 cells. Biochem Biophys Res Commun 199:271-276.
11. Sabatini M, Lesur C, Pacherie M, Pastoureau P, Kucharczyk N, Fauchère J-L, Bonnet J 1996 Effects of parathyroid hormone and agonists of the adenylyl cyclase and protein kinase C pathways on bone cell proliferation. Bone 18:59-65.
12. Yamato H, Nagai Y, Inoue D, Ohnishi Y, Ueyama Y, Ohno H, Matsumoto T, Ogata E, Ikeda K 1995 In vivo evidence for progressive activation of parathyroid hormone-related peptide gene transcription with tumor growth and stimulation of osteoblastic bone formation at an early stage of humoral hypercalcemia of cancer. J Bone Miner Res 10:36-44.
13. Canalis E, McCarthy TL, Centrella M 1990 Differential effects of continuous and transient treatment with parathyroid hormone-related peptide (PTHrp) on bone collagen synthesis. Endocrinology 126:1806-1812.
14. Drake MT, Baldassare JJ, McConkey ChL, Gonzalez EA, Martin KJ 1994 Parathyroid hormone increases the expression of receptors for epidermal growth factor in UMR 106-01 cells. Endocrinology 134:1733-1737.
15. Canalis E, Centrella M, Burch W, McCarthy TL 1989 Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60-65.
16. Yang KH, dePapp AE, Soifer NE, Dreyer BE, Wu TL, Porter SE, Bellantoni M, Burtis WJ, Insogna KL, Broadus AE, Philbrick WM, Stewart AF 1994 Parathyroid hormone-related protein: Evidence for isoform- and tissue-specific posttranslational processing. Biochemistry 33:7460-7469.
17. Burtis WJ 1992 Parathyroid hormone-related protein: Structure, function, and measurement. Clin Chem 38:2171-2183.
18. Fenton AJ, Martin TJ, Nicholson GC 1993 Long-term culture of disaggregated rat osteoclasts: Inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP (107-139). J Cell Physiol 155:1-7.
19. Fenton AJ, Kemp BE, Kent GN, Moseley JM, Zheng M-H, Rowe DJ, Britto JM, Martin TJ, Nicholson GC 1991 A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts. Endocrinology 129:1762-1768.
20. Fenton AJ, Martin TJ, Nicholson GC 1994 Carboxyl-terminal parathyroid hormone-related protein inhibits bone resorption by isolated chicken osteoclasts. J Bone Miner Res 9:515-519.
21. Murrills RJ, Stein LS, Dempster DW 1995 Lack of significant effect of carboxyl-terminal parathyroid hormone-related peptide fragments on isolated rat and chick osteoclasts. Calcif Tissue Int 57:47-51.
22. Kaji H, Sugimoto T, Kanatani M, Fukase M, Chihara K 1995 Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation. Endocrinology 136:842-848.
23. Zheng MH, McCaughan HB, Papadimitriou JM, Nicholson GC, Wood DJ 1994 Tartrate-resistant acid phosphatase activity in rat cultured osteoclasts is inhibited by a carboxyl terminal peptide (osteostatin) from parathyroid hormone-related protein. J Cell Biochem 54:145-153.
24. Seitz PK, Zhang R-W, Simmons DJ, Cooper CW 1995 Effect of C-terminal parathyroid hormone-related peptide on osteoblasts. Miner Electrolyte Metab 21:180-183.
25. Gagnon L, Jouishomme H, Whitfield J, Durkin JP, MacLean S, Neugebauer W, Willick G, Rixon RH, Chakravarthy B 1993 Protein kinase C-activating domains of parathyroid hormone-related protein. J Bone Miner Res 8:497-503,
26. 3, PTH and glucocorticoids. Metab Bone Dis 5:229-234.
27. Partridge NC, Kemp BE, Livesey SA, Martin TJ 1982 Activity ratio measurements reflect intracellular activation of adenosine 3′,5′-monophosphate-dependent protein kinase in osteoblasts. Endocrinology 111:178-183.
28. Bradford M 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
29. Price PA, Parthemore JG, Deftos LJ 1980 New biochemical marker for bone metabolism. J Clin Invest 66:878-883.
30. Krane SM, Muñoz AJ, Harris ED 1970 Urinary polypeptides related to collagen synthesis. J Clin Invest 49:716-729.
31. Melkko J, Niemi S, Risteli L, Risteli J 1990 Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen. Clin Chem 36:1328-1332.
32. Risteli J, Niemi S, Trivedi P, Mäentausta O, Mowat AP, Risteli L 1988 Rapid equilibrium radioimmunoassay for the amino-terminal propeptide of human type III procollagen. Clin Chem 34:715-718.
33. Whitfield JF, Isaacs RJ, Jouishomme H, MacLean S, Chakravarthy BR, Morley P, Barisoni D, Regalia E, Armato U 1996 C-terminal fragment of parathyroid hormone-related protein, PTHrP-(107-111), stimulates membrane-associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes. J Cell Physiol 166:1-11.
34. McKee RL, Goldman ME, Caulfield MP, DeHaven PA, Levy JJ, Nutt RF, Rosenblatt M 1988 The 7-34-fragment of human hypercalcemia factor is a partial agonist/antagonist for parathyroid hormone-stimulated cAMP production. Endocrinology 122:3008-3010.
35. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inone T, Naito K, Toshioka T, Hidaka H 1990 Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthetized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-((p-bromocinnamyl)amino)-ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265:5267-5272.
36. Kobayashi E, Nakano H, Morimoto M, Tamaoki T 1989 Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553.
37. Walsh CA, Birch MA, Fraser WD, Robinson J, Lawton R, Dorgan J, Klenerman L, Gallagher JA 1994 Primary cultures of human bone-derived cells produce parathyroid hormone-related protein: A study of 40 patients of varying age and pathology. Bone Miner 27:43-50.
38. Walsh CA, Birch MA, Fraser WD, Lawton R, Dorgan J, Walsh S, Sansom D, Beresford JN, Gallagher JA 1995 Expression and secretion of parathyroid hormone-related protein by human bone-derived cells in vitro: Effects of glucocorticoids. J Bone Miner Res 10:17-25.
39. Guenther HL, Hofstetter W, Moseley JM, Gillispie MT, Suda N, Martin TJ 1995 Evidence for the synthesis of parathyroid hormone-related protein (PTHrP) by nontransformed clonal rat osteoblastic cells in vitro. Bone 16:341-347.
40. Suda N, Gillespie MT, Traianedes K, Zhou H, Ho PWM, Hards DK, Allan EH, Martin TJ, Moseley JM 1996 Expression of parathyroid hormone-related protein in cells of osteoblast lineage. J Cell Physiol 166:94-104.
41. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VLJ, Kronenberg HM, Mulligan RC 1994 Lethal skeletal dysplasia from targeted disruption of the parathyroid hormonerelated peptide gene. Genes Dev 8:277-289.
42. Kano J, Sugimoto T, Kanatani M, Kuroki Y, Tsukamoto T, Fukase M, Chihara K 1994 Second messenger signaling of c-fos gene induction by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: Its role in osteoblast proliferation and osteoclast-like cell formation. J Cell Physiol 161:358-366.
43. 2 in different types of osteoblastic cells. Bone Miner 26:141-154.
44. Li X, Drucker DJ 1993 Growth factor-like properties of parathyroid hormone-related peptide in transfected rodent lines, Cancer Res 53:2980-2986.
45. Chen J, Singh K, Mukherjee BB, Sodek J 1993 Developmental expression of osteopontin (OPN) mRNA in rat tissues: Evidence for a role for OPN in bone formation and resorption. Matrix 13:113-123.
46. Hanafin NM, Persons KS, Holick MF 1995 Increased PKC activity in cultured human keratinocytes and fibroblasts after treatment with 1 alpha, 25-dihydroxyvitamin D3. J Cell Biochem 57:362-370.
47. 2+-independent isoforms of protein kinase C in rat colonocytes. J Clin Invest 95:2215-2221.
48. 3 metabolites in chondrocyte cultures. J Cell Physiol 157:271-278.
49. Whitfield JF, Isaacs RJ, Chakravarthy BR, Durkin JP, Morley P, Neugebauer W, Williams RE, Willick G, Rixon RH 1994 C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), and the N-terminal PTHrP-(1-40) fragment stimulate membrane-associated protein kinase C activity in rat spleen lymphocytes. J Cell Physiol 158:518-522.