Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila

Journal of Neuroscience

Volumn 30, Issue 13, 2010, Pages 4562-4572

  Andrea Yao, C ^a   Carlson, John R ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT 30A; GUANOSINE TRIPHOSPHATE; PEPTIDE; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DROSOPHILA; GENETIC ANALYSIS; GENETIC TRANSDUCTION; MOSAICISM; NERVE CELL; NONHUMAN; OLFACTORY DISCRIMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE;

ANIMALS; CARBON DIOXIDE; CHEMORECEPTOR CELLS; DROSOPHILA; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GTP-BINDING PROTEIN GAMMA SUBUNITS; MUTATION; ODORS; OLFACTORY PATHWAYS; SMELL;

EID: 77950638294     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6357-09.2010     Document Type: Article

References (57)

1. Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ (1998) Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science 280:574-577.
2. Banerjee S, Joshi R, Venkiteswaran G, Agrawal N, Srikanth S, Alam F, Hasan G (2006) Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit. J Neurosci 26:8278-8288. (Pubitemid 44309841)
3. Benton R, Sachse S, Michnick SW, Vosshall LB (2006) Atypical membrane topology and heteromeric function of Drosopliila odorant receptors in vivo. PLoS Biol 4:e20. (Pubitemid 43275854)
4. Bourne HR, Sanders DA, McCormick F (1991) The GTPase superfamily: conserved structure and molecular mechanism. Nature 349:117-127.
5. Carlson JR (1996) Olfaction in Drosophila: from odor to behavior. Trends Genet 12:175-180.
6. 2 sensory systems. Science 319:1256-1260.
7. Clyne P, Grant A, O'Connell R, Carlson JR (1997) Odorant response of individual sensilla on the Drosophila antenna. Invert Neurosci 3:127-135.
8. Clyne PJ, Warr CG, Freeman MR, Lessing D, Kim J, Carlson JR (1999) A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron 22:327-338. (Pubitemid 29109666)
9. Clyne PJ, Warr CG, Carlson JR (2000) Candidate taste receptors in Drosophila. Science 287:1830-1834.
10. Couto A, Alenius M, Dickson BJ (2005) Molecular, anatomical, and functional organization of the Drosophila olfactory system. Curr Biol 15:1535-1547.
11. de Bruyne M, Foster K, Carlson JR (2001) Odor coding in the Drosopliila antenna. Neuron 30:537-552.
12. Dobritsa AA, van der Goes van Naters W, Warr CG, Steinbrecht RA, Carlson JR (2003) Integrating the molecular and cellular basis of odor coding in the Drosophila antenna. Neuron 37:827-841.
13. Elmore T, Smith DP (2001) Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. Insect Biochem Mol Biol 31:791-798.
14. Ferris J, Ge H, Liu L, Roman G (2006) G(o) signaling is required for Drosophila associative learning. Nat Neurosci 9:1036-1040.
15. Gilchrist A, Bunemann M, Li A, Hosey MM, Hamm HE (1999) A dominant-negative strategy for studying roles of G proteins in vivo. J Biol Chem 274:6610-6616. (Pubitemid 29111079)
16. Gilchrist A, Li A, Hamm HE (2002) G alpha COOH-terminal minigene vectors dissect heterotrimeric G protein signaling. Sci STKE 2002:PL1.
17. Grant AJ, Wigton BE, Aghajanian JG, O'Connell RJ (1995) Electrophysiological responses of receptor neurons in mosquito maxillary palp sensilla to carbon dioxide. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 177:389-396.
18. Hallem EA, Ho MG, Carlson JR (2004) The molecular basis of odor coding in the Drosophila antenna. Cell 117:965-979.
19. Hamm HE, Deretic D, Arendt A, Hargrave PA, Koenig B, Hofmann KP (1988) Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. Science 241:832-835.
20. Hiroi M, Tanimura T, Marion-Poll F (2008) Hedonic taste in Drosophila revealed by olfactory receptors expressed in taste neurons. PLoS One 3:e2610.
21. Hummel T, Vasconcelos ML, Clemens JC, Fishilevich Y, Vosshall LB, Zipursky SL (2003) Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron 37:221-231.
22. Ishimoto H, Takahashi K, Ueda R, Tanimura T (2005) G-protein gamma subunit 1 is required for sugar reception in Drosophila. EMBO J 24:3259-3265. (Pubitemid 41348700)
23. Jin S, Cornwall MC, Oprian DD (2003) Opsin activation as a cause of congenital night blindness. Nat Neurosci 6:731-735. (Pubitemid 36792888)
24. Jones WD, Cayirlioglu P, Kadow IG, Vosshall LB (2007) Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. Nature 445:86-90. (Pubitemid 46067306)
25. qα, phospholipase Cß, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction. J Neurosci 28:4745-4755.
26. Kalidas S, Smith DP (2002) Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron 33:177-184. (Pubitemid 34127751)
27. Katanaev VL, Tomlinson A (2006) Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc Natl Acad Sci U S A 103:6524-6529.
28. Katanaev VL, Ponzielli R, Semeriva M, Tomlinson A (2005) Trimeric G protein-dependent frizzled signaling in Drosophila. Cell 120:111-122.
29. 2 reception in Drosophila. Proc Natl Acad Sci U S A 104:3574-3578.
30. Larsson MC, Domingos AI, Jones WD, Chiappe ME, Amrein H, Vosshall LB (2004) Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron 43:703-714.
31. Lee T, Luo L (2001) Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci 24:251-254.
32. Lu T, Qiu YT, Wang G, Kwon JY, Rutzler M, Kwon HW, Pitts RJ, van Loon JJ, Takken W, Carlson JR, Zwiebel LJ (2007) Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae. Curr Biol 17:1533-1544.
33. Lundin C, Kail L, Kreher SA, Kapp K, Sonnhammer EL, Carlson JR, Heijne G, Nilsson I (2007) Membrane topology of the Drosophila OR83b odorant receptor. FEBS Lett 581:5601-5604.
34. McGuireSE, Le PT, Osborn AJ, Matsumoto K, Davis RL (2003) Spatiotemporal rescue of memory dysfunction in Drosophila. Science 302:1765-1768.
35. Miura N, Atsumi S, Tabunoki H, Sato R (2005) Expression and localization of three G protein alpha subunits, Go, Gq, and Gs, in adult antennae of the silkmoth (Bombyx mori). J Comp Neurol 485:143-152.
36. Nakagawa T, Vosshall LB (2009) Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system. Curr Opin Neuro biol 19:284-292.
37. Nakagawa. T, Sakurai T, Nishioka T, Touhara K (2005) Insect sex-pheromone signals mediated by specific combinations of olfactory receptors. Science 307:1638-1642. (Pubitemid 40354748)
38. Neuhaus EM, Gisselmann G, Zhang W, Dooley R, Stortkuhl K, Hatt H (2005) Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster. Nat Neurosci 8:15-17.
39. Olsen SR, Wilson RI (2008) Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature 452:956-960. (Pubitemid 351589620)
40. Rasenick MM, Watanabe M, Lazarevic MB, Hatta S, Hamm HE (1994) Synthetic peptides as probes for G protein function. Carboxyl-terminal G alpha s peptides mimic Gs and evoke high affinity agonist binding to beta-adrenergic receptors. J Biol Chem 269:21519-21525. (Pubitemid 24274783)
41. Ratnaparkhi A, Banerjee S, Hasan G (2002) Altered levels of Gq activity modulate axonal pathfinding in Drosophila. J Neurosci 22:4499-4508. (Pubitemid 37465666)
42. Robertson HM, Warr CG, Carlson JR (2003) Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proc Natl Acad Sci U S A 100 [Suppl 2]:14537-14542.
43. Root CM, Masuyama K, Green DS, Enell LE, Nassel DR, Lee CH, Wang JW (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59:311-321. (Pubitemid 352033691)
44. Rutzler M, Lu T, Zwiebel LJ (2006) Ga encoding gene family of the malaria vector mosquito Anopheles gambiae: expression analysis and immunolocalization of AGαq and AGαo in female antennae. J Comp Neurol 499:533-545.
45. Sato K, Pellegrino M, Nakagawa T, Nakagawa T, Vosshall LB, Touhara K (2008) Insect olfactory receptors are heteromeric ligand-gated ion channels. Nature 452:1002-1006. (Pubitemid 351589615)
46. Schulz S, Huber A, Schwab K, Paulsen R (1999) A novel Gγ isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. J Biol Chem 274:37605-37610.
47. Scott K, Becker A, Sun Y, Hardy R, Zuker C ( 1995) Gq[alpha] protein function in vivo: Genetic dissection of its role in photoreceptor cell physiology. Neuron 15:919-927.
48. Scott K, Brady R, Cravchik A, Morozov P, Rzhetsky A, Zuker C, Axel R (2001) A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell 104:661-673. (Pubitemid 32241017)
49. Shanbhag SR, Muller B, Steinbrecht RA (1999) Adas of olfactory organs of Drosophila melanogaster 1. Types, external organization, innervation and distribution of olfactory sensilla. lnt J Insect Morphol Embryol 28: 377-397.
50. Syed Z, Leal WS (2007) Maxillary palps are broad spectrum odorant detectors in Culex quinquefasciatus. Chem Senses 32:727-738.
51. Talluri S, Bhatt A, Smith DP ( 1995) Identification of a Drosophila G protein alpha subunit (dGq alpha-3) expressed in chemosensory cells and central neurons. Proc Natl Acad Sci U S A 92:11475-11479.
52. Ueno K, Kohatsu S, Clay C, Forte M, Isono K, Kidokoro Y (2006) Gsα is involved in sugar perception in Drosophila melanogaster. J Neurosci 26:6143-6152.
53. van der Goes van Naters W, Carlson JR (2006) Insects as chemosensors of humans and crops. Nature 444:302-307.
54. Vosshall LB, Amrein H, Morozov PS, Rzhetsky A, Axel R (1999) A spatial map of olfactory receptor expression in the Drosophila antenna. Cell 96:725-736.
55. Wetzel CH, Behrendt HJ, Gisselmann G, Stortkuhl KF, Hovemann B, Hatt H (2001 ) Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system. Proc Natl Acad Sci U S A 98:9377-9380.
56. Wicher D, Schafer R, Bauernfeind R, Stensmyr MC, Heller R, Heinemann SH, Hansson BS (2008) Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature 452:1007-1011.
57. Wolfgang WJ, Hoskote A, Roberts IJ, Jackson S, Forte M (2001) Genetic analysis of the Drosophila Gs(alpha) gene. Genetics 158:1189-1201.