Identification and characterization of the major allergen of green bean (Phaseolus vulgaris) as a non-specific lipid transfer protein (Pha v 3)

Molecular Immunology

Volumn 47, Issue 7-8, 2010, Pages 1561-1568

  Zoccatelli, Gianni ^a   Pokoj, Sven ^b   Foetisch, Kay ^b   Bartra, Joan ^c   Valero, Antonio ^c   del Mar San Miguel Moncin, Maria ^d   Vieths, Stefan ^b   Scheurer, Stephan ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b PAUL EHRLICH INSTITUT   (Germany)

^c UNIVERSITY OF BARCELONA   (Spain)

^d Pius Hospital de Valls   (Spain)

Author keywords

Food allergy; Green bean; Legume; Lipid transfer protein (LTP); Recombinant allergens

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; STEROL CARRIER PROTEIN 2;

ADULT; ALLERGIC REACTION; ANTIBODY DETECTION; ARTICLE; BASOPHIL; CIRCULAR DICHROISM; CLINICAL ARTICLE; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOOD ALLERGY; GREEN BEAN ALLERGY; HISTAMINE RELEASE; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; MALE; NUCLEOTIDE SEQUENCE; PHASEOLUS VULGARIS; PICHIA PASTORIS; PRICK TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROVOCATION TEST;

ADULT; AMINO ACID SEQUENCE; ANTIGENS, PLANT; BASOPHILS; CARRIER PROTEINS; CIRCULAR DICHROISM; CONSERVED SEQUENCE; DNA, COMPLEMENTARY; FEMALE; HISTAMINE; HISTAMINE RELEASE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; MALE; MOLECULAR SEQUENCE DATA; PHASEOLUS; PLANT PROTEINS; PRUNUS; SEQUENCE ALIGNMENT; YOUNG ADULT;

PHASEOLUS VULGARIS; PICHIA PASTORIS;

EID: 77950630253     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.01.009     Document Type: Article

References (28)

1. Asero R., Mistrello G., Roncarolo D., Amato S., Caldironi G., Barocci F., van Ree R. Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002, 57:900-906.
2. Asero R., Mistrello G., Roncarolo D., Amato S., Falagiani P. Why do lipid transfer protein-hypersensitive patients tolerate bean (and other legumes)?. Int. Arch. Allergy Immunol. 2005, 137:236-240.
3. Asero R., Mistrello G., Roncarolo D., Amato S., van R.R. String bean-induced anaphylaxis. Allergy 2001, 56:259-260.
4. Asero R., Mistrello G., Roncarolo D., de Vries S.C., Gautier M.F., Ciurana L.F., Verbeek E., Mohammadi T., Knul-Brettlova V., Akkerdaas J.H., Bulder I., Aalberse R.C., van Ree R. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int. Arch. Allergy Immunol. 2000, 122:20-32.
5. Bernhisel-Broadbent J., Sampson H.A. Cross-allergenicity in the legume botanical family in children with food hypersensitivity. J. Allergy Clin. Immunol. 1989, 83:435-440.
6. Bernhisel-Broadbent J., Taylor S., Sampson H.A. Cross-allergenicity in the legume botanical family in children with food hypersensitivity. II. Laboratory correlates. J. Allergy Clin. Immunol. 1989, 84:701-709.
7. Conti A., Fortunato D., Ortolani C., Giuffrida M.G., Pravettoni V., Napolitano L., Farioli L., Garoffo L.P., Trambaioli C., Pastorello E.A. Determination of the primary structure of two lipid transfer proteins from apricot (Prunus armeniaca). J. Chromatogr. B Biomed. Sci. Appl. 2001, 756:123-129.
8. Daroca P., Crespo J.F., Reano M., James J.M., Lopez-Rubio A., Rodriguez J. Asthma and rhinitis induced by exposure to raw green beans and chards. Ann. Allergy Asthma Immunol. 2000, 85:215-218.
9. Diaz-Perales A., Lombardero M., Sanchez-Monge R., Garcia-Selles F.J., Pernas M., Fernandez-Rivas M., Barber D., Salcedo G. Lipid-transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut and Rosaceae fruits, with different IgE-binding capacities. Clin. Exp. Allergy 2000, 30:1403-1410.
10. Douliez J.P., Michon T., Elmorjani K., Marion D. Structure, biological and technological functions of lipid transfer proteins and indolines, the major lipid binding proteins from cereal kernels. J. Cereal Sci. 2000, 32:1-20.
11. Dreborg S., Frew A. EAACI position paper-allergen standardization and skin tests. Allergy 1993, 48:49-54.
12. Fernandez-Rivas M., Bolhaar S., Gonzalez-Mancebo E., Asero R., van L.A., Bohle B., Ma Y., Ebner C., Rigby N., Sancho A.I., Miles S., Zuidmeer L., Knulst A., Breiteneder H., Mills C., Hoffmann-Sommergruber K., van R.R. Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J. Allergy Clin. Immunol. 2006, 118:481-488.
13. Foetisch K., Westphal S., Lauer I., Retzek M., Altmann F., Kolarich D., Scheurer S., Vieths S. Biological activity of IgE specific for cross-reactive carbohydrate determinants. J. Allergy Clin. Immunol. 2003, 111:889-896.
14. Gadermaier G., Harrer A., Girbl T., Palazzo P., Himly M., Vogel L., Briza P., Mari A., Ferreira F. Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen. Mol. Immunol. 2009, 46:1919-1924.
15. Garcia-Casado G., Pacios L.F., az-Perales A., Sanchez-Monge R., Lombardero M., Garcia-Selles F.J., Polo F., Barber D., Salcedo G. Identification of IgE-binding epitopes of the major peach allergen Pru p 3. J. Allergy Clin. Immunol. 2003, 112:599-605.
16. Ibanez M.D., Martinez M., Sanchez J.J., Fernandez-Caldas E. Legume cross-reactivity. Allergol. Immunopathol. (Madr.) 2003, 31:151-161.
17. Igea J.M., Fernandez M., Quirce S., de la Hoz B., Diez Gomez M.L. Green bean hypersensitivity: an occupational allergy in a homemaker. J. Allergy Clin. Immunol. 1994, 94:33-35.
18. Kader J.C. Lipid-transfer proteins in plants. Ann. Rev. Plant Physiol. Plant Mol. Biol. 1996, 47:627-654.
19. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
20. Lauer I., Alessandri S., Pokoj S., Reuter A., Conti A., Vieths S., Scheurer S. Expression and characterization of three important panallergens from hazelnut. Mol. Nutr. Food Res. 2008, 52(Suppl. 2):S262-S271.
21. Lauer I., Dueringer N., Pokoj S., Rehm S., Zoccatelli G., Reese G., Miguel-Moncin M.S., Cistero-Bahima A., Enrique E., Lidholm J., Vieths S., Scheurer S. The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut. Clin. Exp. Allergy 2009, 39:1427-1437.
22. Lauer I., Miguel-Moncin M.S., Abel T., Foetisch K., Hartz C., Fortunato D., Cistero-Bahima A., Vieths S., Scheurer S. Identification of a plane pollen lipid transfer protein (Pla a 3) and its immunological relation to the peach lipid-transfer protein, Pru p 3. Clin. Exp. Allergy 2007, 37:261-269.
23. Lombardero M., Garcia-Selles F.J., Polo F., Jimeno L., Chamorro M.J., Garcia-Casado G., Sanchez-Monge R., az-Perales A., Salcedo G., Barber D. Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens. Clin. Exp. Allergy 2004, 34:1415-1421.
24. Pastorello E.A., Farioli L., Pravettoni V., Ortolani C., Ispano M., Monza M., Baroglio C., Scibola E., Ansaloni R., Incorvaia C., Conti A. The major allergen of peach (Prunus persica) is a lipid transfer protein. J. Allergy Clin. Immunol. 1999, 103:520-526.
25. Pastorello E.A., Robino A.M. Clinical role of lipid transfer proteins in food allergy. Mol. Nutr. Food Res. 2004, 48:356-362.
26. Pravettoni V., Farioli L., Conti A., Scibilia J., Primavesi L., Piantanida M., Pastorello E. Severe allergic reactions to cooked green bean: the culprit protein is a lipid transfer protein. Allergy 2009, 64:1494.
27. Salcedo G., Sanchez-Monge R., Barber D., az-Perales A. Plant non-specific lipid transfer proteins: an interface between plant defence and human allergy. Biochim. Biophys. Acta 2007, 1771:781-791.
28. Scheurer S., Lauer I., Foetisch K., Moncin M.S.M., Retzek M., Hartz C., Enrique E., Lidholm J., Cistero-Bahima A., Vieths S. Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestion. J. Allergy Clin. Immunol. 2004, 114:900-907.