The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer

Chemosphere

Volumn 79, Issue 7, 2010, Pages 686-697

  Gasull, Magda ^a,b   Porta, Miquel ^a,b,c   Pumarega, José ^a,b   Vioque, Jesús ^b,d   de Basea, Magda Bosch ^a,b   Puigdomènech, Elisa ^a,b,c   Morales, Eva ^a,b,e   Grimalt, Joan O ^f   Malats, Núria ^g  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^e CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^f DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^g Structural Biology and Biocomputing Programme   (Spain)

Author keywords

Dairy products; Exocrine pancreatic cancer; Milk; Organochlorine compounds; Persistent organic pollutants (POPs); Ras genes

Indexed keywords

CHEMICAL CONTAMINATION; CHLORINE COMPOUNDS; DAIRIES; DAIRY PRODUCTS; DISEASES; GAS CHROMATOGRAPHY; NUTRITION; POLYCHLORINATED BIPHENYLS;

ELECTRON CAPTURE DETECTION; HIGH-RESOLUTION GAS CHROMATOGRAPHIES; HOSPITAL ADMISSIONS; MILK; ORGANOCHLORINE COMPOUNDS; PANCREATIC CANCERS; PERSISTENT ORGANIC POLLUTANTS; SERUM CONCENTRATION;

ORGANIC POLLUTANTS;

CHLORPHENOTANE; K RAS PROTEIN; OMEGA 6 FATTY ACID; ORGANOCHLORINE DERIVATIVE; POLYCHLORINATED BIPHENYL; POLYUNSATURATED FATTY ACID;

CANCER; DDT; DIET; FOOD INTAKE; MILK; ORGANIC POLLUTANT; ORGANOCHLORINE; PCB; SERUM;

ARTICLE; CLINICAL TRIAL; DAIRY PRODUCT; DIETARY INTAKE; ELECTRON CAPTURE DETECTION; FOOD INTAKE; GAS CHROMATOGRAPHY; GENE FREQUENCY; GENE MUTATION; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MEAT; MILK; MUTATIONAL ANALYSIS; PANCREAS CANCER;

EID: 77950630226     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2010.03.011     Document Type: Article

References (88)

1. Agudo A., Goñi F., Etxeandia A., Vives A., Millán E., López R., Amiano P., et al. Polychlorinated biphenyls in Spanish adults: determinants of serum concentrations. Environ. Res. 2009, 109:620-628.
2. Alcock R., Bashkin V., Bisson M., Brecher R.W., van Bree L., Chrast R., et al. Joint WHO/Convention Task Force on the Health Aspects of Air Pollution. Health Risks of Persistent Organic Pollutants from Long-range Transboundary Air Pollution 2003, World Health Organization, Regional Office for Europe, Copenhaguen, (accessed 24.12.09).
3. Alguacil J., Porta M., Malats N., Kauppinen T., Kogevinas M., Benavides F.G., et al. Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer. Carcinogenesis 2002, 23:101-106.
4. Apostoli P., Magoni M., Bergonzi R., Carasi S., Indelicato A., Scarcella C., et al. Assessment of reference values for polychlorinated biphenyl concentration in human blood. Chemosphere 2005, 61:413-421.
5. Arrebola J.P., Martin-Olmedo P., Fernandez M.F., Sanchez-Cantalejo E., Jimenez-Rios J.A., Torne P., et al. Predictors of concentrations of hexachlorobenzene in human adipose tissue: a multivariate analysis by gender in Southern Spain. Environ. Int. 2009, 35:27-32.
6. Badia-Vila M., Ociepa M., Mateo R., Guitart R. Comparison of residue levels of persistent organochlorine compounds in butter from Spain and from other European countries. J. Environ. Sci. Health B 2000, 35:201-210.
7. Bautista D., Obrador A., Moreno V., Cabeza E., Canet R., Benito E., et al. Ki-ras mutation modifies the protective effect of dietary monounsaturated fat and calcium on sporadic colorectal cancer. Cancer Epidemiol. Biomarkers Prev. 1997, 6:57-61.
8. Bocio A., Domingo JL. Daily intake of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDD/PCDFs) in foodstuffs consumed in Tarragona, Spain: a review of recent studies (2001-2003) on human PCDD/PCDF exposure through the diet. Environ. Res. 2005, 97:1-9.
9. Brink M., Weijenberg M.P., de Goeij A.F., Roemen G.M., Lentjes M.H., de Bruine A.P., et al. Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. Brit. J. Cancer 2005, 92:1310-1320.
10. Brink M., Weijenberg M.P., de Goeij A.F., Roemen G.M., Lentjes M.H., de Bruine A.P., et al. Dietary folate intake and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. Int. J. Cancer 2005, 114:824-830.
11. Campoy C., Olea-Serrano F., Jiménez M., Bayés R., Cañabate F., Rosales M.J., et al. Diet and organochlorine contaminants in women of reproductive age under 40years old. Early Hum. Dev. 2001, 65:S173-S182.
12. Costabeber I., Emanuelli T. Influence of alimentary habits, age and occupation on polychlorinated biphenyl levels in adipose tissue. Food Chem. Toxicol. 2003, 41:73-80.
13. Crous-Bou, M., 2009. Clinical and environmental influences on the prevalence of mutations in the K-ras oncogene in patients with pancreatic ductal adenocarcinoma [Doctoral dissertation; Director: M. Porta]. Universitat Autònoma de Barcelona, Barcelona. 181 p (in Catalan and English). and from . http://www.tesisenxarxa.net/TDX-0121110-085153/.
14. Crous-Bou M., Porta M., López T., Jariod M., Malats N., Alguacil J., et al. Lifetime history of tobacco consumption and K-ras mutations in exocrine pancreatic cancer. Pancreas 2007, 35:135-141.
15. Crous-Bou M., Porta M., López T., Jariod M., Malats N., Morales E., et al. Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma. Environ. Mol. Mutagen 2009, 50:421-430.
16. Crous-Bou M., Porta M., Morales E., López T., Carrato A., Puigdomènech E., et al. Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study. Cancer Causes Control 2009, 20:591-599.
17. Darnerud P.O., Atuma S., Aune M., Bjerselius R., Glynn A., Grawe K.P., et al. Dietary intake estimations of organohalogen contaminants (dioxins, PCB, PBDE and chlorinated pesticides, e.g. DDT) based on Swedish market basket data. Food Chem. Toxicol. 2006, 44:1597-1606.
18. Den Hond E., Govarts E., Bruckers L., Schoeters G. Determinants of polychlorinated aromatic hydrocarbons in serum in three age classes - methodological implications for human biomonitoring. Environ. Res. 2009, 109:495-502.
19. Department of Health and Human Services, 2009. Fourth National Report on Human Exposure to Environmental Chemicals. Centers for Disease Control and Prevention, Atlanta. (accessed 8.01.10). http://www.cdc.gov/exposurereport/index.html.
20. DeVoto E., Kohlmeier L., Heeschen W. Some dietary predictors of plasma organochlorine concentrations in an elderly German population. Arch. Environ. Health 1998, 53:147-155.
21. Diamanti-Kandarakis E., Bourguignon J.P., Giudice L.C., Hauser R., Prins G.S., Soto A.M., et al. Endocrine-disrupting chemicals: an endocrine society scientific statement. Endocrine Rev. 2009, 30:293-342.
22. Ekbom A., Hunter D. Pancreatic cancer. Textbook of Cancer Epidemiology 2002, 233-247. Oxford University Press, New York. H.O. Adami, D. Hunter, D. Trichopoulos (Eds.).
23. Fattore E., Fanelli R., Dellatte E., Turrini A., di Domenico A. Assessment of the dietary exposure to non-dioxin-like PCBs of the Italian general population. Chemosphere 2008, 73:S278-283.
24. Fryzek J.P., Garabrant D.H., Schenk M., Kinnard M., Greenson J.K., Sarkar F.H. The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations. Int. J. Gastrointest. Cancer 2006, 37:139-145.
25. Fukushima S., Kinoshita A., Puatanachokchai R., Kushida M., Wanibuchi H., Morimura K. Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis 2005, 26:1835-1845.
26. Gavaldà L., Porta M., Malats N., Pinol J.L., Fernandez E., Maguire A., et al. Agreement between information supplied by the patient and a family member on medical history, consumption of tobacco, alcohol and coffee and diet in cancer of the exocrine pancreas and extrahepatic biliary tract. Gac. Sanit. 1995, 9:334-342.
27. Glynn A.W., Granath F., Aune M., Atuma S., Darnerud P.O., Bjerselius R., et al. Organochlorines in Swedish women: determinants of serum concentrations. Environ. Health Perspect. 2003, 111:349-355.
28. Glynn A., Aune M., Darnerud P.O., Cnattingius S., Bjerselius R., Becker W., et al. Determinants of serum concentrations of organochlorine compounds in Swedish pregnant women: a cross-sectional study. Environ. Health 2007, 6:2.
29. Hesketh R. The Oncogene Handbook 1994, Academic Press, San Diego, CA, p. 383.
30. Hoppin J.A., Tolbert P.E., Holly E.A., Brock J.W., Korrick S.A., Altshul L.M., et al. Pancreatic cancer and serum organochlorine levels. Cancer Epidemiol. Biomark. Prev. 2000, 9:199-205.
31. Howsam M., Grimalt J.O., Guinó E., Navarro M., Martí-Rague J., Peinado M.A., et al. Organochlorine exposure and colorectal cancer risk. Environ. Health Perspect. 2004, 112:1460-1466.
32. Institute of Medicine Dioxins and Dioxin-like Compounds in the Food Supply. Strategies to Decrease Exposure 2003, The National Academies Press, Washington, DC.
33. Jakszyn P., Goñi F., Etxeandia A., Vives A., Millán E., López R., et al. Serum levels of organochlorine pesticides in healthy adults from five regions of Spain. Chemosphere 2009, 76:1518-1524.
34. Kalantzi O.I., Alcock R.E., Johnston P.A., Santillo D., Stringer R.L., Thomas G.O., et al. The global distribution of PCBs and organochlorine pesticides in butter. Environ. Sci. Technol. 2001, 35:1013-1018.
35. Kampman E., Voskuil D.W., van Kraats A.A., Balder H.F., van Muijen G.N., Goldbohm R.A., et al. Animal products and K-ras codon 12 and 13 mutations in colon carcinomas. Carcinogenesis 2000, 21:307-309.
36. Khasawneh J., Schulz M.D., Walch A., Rozman J., Hrabe de Angelis M., Klingenspor M., et al. Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion. Proc. Natl. Acad. Sci. USA 2009, 106:3354-3359.
37. Kleinbaum D.G., Kupper L.L., Muller K.E., Nizam A. Applied Regression Analysis and Other Multivariable Methods 2008, Duxbury, Belmont, CA. fourth ed.
38. Laden F., Neas L.M., Spiegelman D., Hankinson S.E., Willett W.C., Ireland K., et al. Predictors of plasma concentrations of DDE and PCBs in a group of US women. Environ. Health Perspect. 1999, 107:75-81.
39. Laso N., Mas S., Lafuente M., Casterad X., Trias M., Ballesta A., et al. Decrease in specific micronutrient intake in colorectal cancer patients with tumors presenting Ki-ras mutation. Anticancer Res. 2004, 24:2011-2020.
40. Lee D.H., Jacobs D.R., Porta M. Hypothesis: a unifying mechanism for nutrition and chemicals as lifelong modulators of global DNA hypomethylation. Environ. Health Perspect. 2009, 117:1799-1802.
41. Lee D.H., Jacobs D.R. Inconsistent epidemiological findings on fish consumption may be indirect evidence of harmful contaminants in fish. J. Epidemiol. Community Health 2010, 64:190-192.
42. Li D., Jiao L., Porta M. Epidemiology. Pancreatic Cancer 2005, 103-117. Jones & Bartlett, Boston. D.D. Hoff, D.B. Evans, R.H. Hruban (Eds.).
43. Luch A. Nature and nurture - lessons from chemical carcinogenesis. Nat. Rev. Cancer 2005, 5:113-125.
44. Malumbres M., Barbacid M. RAS oncogenes: the first 30years. Nat. Rev. Cancer 2003, 3:459-465.
45. Martí-Cid R., Llobet J.M., Castell V., Domingo J.L. Human dietary exposure to hexachlorobenzene in Catalonia, Spain. J. Food Prot. 2008, 71:2148-2152.
46. Martinez M.E., Maltzman T., Marshall J.R., Einspahr J., Reid M.E., Sampliner R., et al. Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas. Cancer Res. 1999, 59:5181-5185.
47. McGlynn K.A., Abnet C.C., Zhang M., Sun X.D., Fan J.H., O'Brien T.R., et al. Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer. J. Natl. Cancer Inst. 2006, 98:1005-1010.
48. Mendez M.A., Vioque J., Porta M., Morales E., Lopez T., Malats N., et al. Estimating dietary intakes from a brief questionnaire: a simulation study of reliability in a molecular epidemiologic study of pancreatic and biliary diseases. Eur. J. Epidemiol. 2006, 21:417-426.
49. Morales E., Porta M., Vioque J., López T., Mendez M.A., Pumarega J.A., et al. Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer. J. Epidemiol. Community Health 2007, 61:641-649.
50. Moysich K.B., Ambrosone C.B., Mendola P., Kostyniak P.J., Greizerstein H.B., Vena J.E., et al. Exposures associated with serum organochlorine levels among postmenopausal women from western New York State. Am. J. Ind. Med. 2002, 41:102-110.
51. National Research Council, Committee on Human Biomonitoring for Environmental Toxicants, 2006. Human Biomonitoring for Environmental Chemicals. The National Academies Press, Washington, DC. . http://www.nap.edu/catalog/11700.html.
52. Paris-Pombo A., Aronson K.J., Woolcott C.G., King W.D. Dietary predictors of concentrations of polychlorinated biphenyls in breast adipose tissue of women living in Ontario, Canada. Arch. Environ. Health 2003, 58:48-54.
53. Patandin S., Dagnelie P.C., Mulder P.G., Op de Coul E., van der Veen J.E., Weisglas-Kuperus N., et al. Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler, and long-term exposure. Environ. Health Perspect. 1999, 107:45-51.
54. Perelló G., Martí-Cid R., Castell V., Llobet J.M., Domingo J.L. Concentrations of polybrominated diphenyl ethers, hexachlorobenzene and polycyclic aromatic hydrocarbons in various foodstuffs before and after cooking. Food Chem. Toxicol. 2009, 47:709-715.
55. A Dictionary of Epidemiology 2008, Oxford University Press, New York, pp. 33, 129-130, 152. fifth ed. M. Porta (Ed.).
56. Porta M., Álvarez-Dardet C. Epidemiology: bridges over (and across) roaring levels [Editorial]. J. Epidemiol. Community Health 1998, 52:605.
57. Porta M., Malats N., Jariod M., Grimalt J.O., Rifà J., Carrato A., et al. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. Lancet 1999, 354:2125-2129.
58. Porta M., Costafreda S., Malats N., Guarner L., Soler M., Gubern J.M., et al. Validity of the hospital discharge diagnosis in epidemiologic studies of biliopancreatic pathology. PANKRAS II Study Group. Eur. J. Epidemiol. 2000, 16:533-541.
59. Porta M., Malats N., Alguacil J., Ruiz L., Jariod M., Carrato A., et al. Coffee, pancreatic cancer, and K-ras mutations: updating the research agenda. J. Epidemiol. Community Health 2000, 54:656-659.
60. Porta M., Ayude D., Alguacil J., Jariod M. Exploring environmental causes of altered ras effects: fragmentation plus integration?. Mol. Carcinog. 2003, 36:45-52.
61. Porta M., Vioque J., Ayude D., Alguacil J., Jariod M., Ruiz L., et al. Coffee drinking: the rationale for treating it as a potential effect modifier of carcinogenic exposures. Eur. J. Epidemiol. 2003, 18:289-298.
62. Porta M., Pumarega J., Ferrer-Armengou O., López T., Alguacil J., Malats N., et al. Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study. Eur. J. Epidemiol. 2007, 22:577-588.
63. Porta M., Puigdomènech E., Ballester F., Selva J., Ribas-Fitó N., Llop S., et al. Monitoring concentrations of persistent organic pollutants in the general population: the international experience. Environ. Int. 2008, 34:546-561.
64. Porta M., Ferrer-Armengou O., Pumarega J., López T., Crous-Bou M., Alguacil A., et al. Exocrine pancreatic cancer clinical factors were related to timing of blood extraction and influenced serum concentrations of lipids. J. Clin. Epidemiol. 2008, 61:695-704.
65. Porta M., Pumarega J., López T., Jariod M., Marco E., Grimalt J.O. Influence of tumor stage, symptoms and time of blood draw on serum concentrations of organochlorine compounds in exocrine pancreatic cancer. Cancer Causes Control 2009, 20:1893-1906.
66. Porta M., Crous-Bou M., Wark P.A., Vineis P., Real F.X., Malats N., et al. Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes. Mutat. Res. Rev. 2009, 682:83-93.
67. Porta M., Jariod M., López T., Pumarega J., Puigdomènech E., Marco E., et al. Correcting serum concentrations of organochlorine compounds by lipids: alternatives to the organochlorine/total lipids ratio. Environ. Int. 2009, 35:1080-1085.
68. Porta M., López T., Pumarega J., Jariod M., Crous-Bou M., Marco E., et al. In pancreatic ductal adenocarcinoma blood concentrations of some organochlorine compounds and coffee intake are independently associated with KRAS mutations. Mutagenesis 2009, 24:513-521.
69. Raimondi S., Maisonneuve P., Lowenfels A.B. Epidemiology of pancreatic cancer: an overview. Nat. Rev. Gastroenterol. Hepatol. 2009, 6:699-708.
70. Ribas-Fitó N., Torrent M., Carrizo D., Júlvez J., Grimalt J.O., Sunyer J. Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4years of age. Environ. Health Perspect. 2007, 115:447-450.
71. Rivas A., Cerrillo I., Granada A., Mariscal-Arcas M., Olea-Serrano F. Pesticide exposure of two age groups of women and its relationship with their diet. Sci. Total Environ. 2007, 382:14-21.
72. Rosenbaum P.R. The case-only odds ratio as a causal parameter. Biometrics 2004, 60:233-240.
73. Modern Epidemiology 2008, Lippincott Willian & Wilkins, Philadelphia. third ed. K.J. Rothman, S. Greenland, T.L. Lash (Eds.).
74. Sanz-Gallardo M.I., Guallar E., van 'T Veer P., Longnecker M.P., Strain J.J., Martin B.C., et al. Determinants of p,p′-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. Arch. Environ. Health 1999, 54:277-283.
75. Sarcinelli P.N., Pereira A.C., Mesquita S.A., Oliveira-Silva J.J., Meyer A., Menezes M.A., et al. Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro. Environ. Res. 2003, 91:143-150.
76. Schaeffer D.J., Dellinger J.A., Needham L.L., Hansen L.G. Serum PCB profiles in Native Americans from Wisconsin based on region, diet, age, and gender: implications for epidemiology studies. Sci. Total Environ. 2006, 357:74-87.
77. Schafer K.S., Kegley S.E. Persistent toxic chemicals in the US food supply. J. Epidemiol. Community Health 2002, 56:813-817.
78. Schaum J., Schuda L., Wu C., Sears R., Ferrario J., Andrews K. A national survey of persistent, bioaccumulative, and toxic (PBT) pollutants in the United States milk supply. J. Expo. Anal. Environ. Epidemiol. 2003, 13:177-186.
79. Schildkraut J.M., Demark-Wahnefried W., DeVoto E., Hughes C., Laseter J.L., Newman B. Environmental contaminants and body fat distribution. Cancer Epidemiol. Biomark. Prev. 1999, 8:179-183.
80. Slattery M.L., Curtin K., Anderson K., Ma K.N., Edwards S., Leppert M., et al. Associations between dietary intake and Ki-ras mutations in colon tumors: a population-based study. Cancer Res. 2000, 60:6935-6941.
81. Soliman A.S., Bondy M., Webb C.R., Schottenfeld D., Bonner J., El-Ghawalby N., et al. Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients. Int. J. Cancer 2006, 119:1455-1461.
82. Sukata T., Uwagawa S., Ozaki K., Ogawa M., Nishikawa T., Iwai S., et al. Detailed low-dose study of 1,1-b is(p-chlorophenyl)-2,2,2-trichloroethane carcinogenesis suggests the possibility of a hormetic effect. Int. J. Cancer 2002, 99:112-118.
83. Sunyer J., Torrent M., Muñoz-Ortiz L., Ribas-Fitó N., Carrizo D., Grimalt J., et al. Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children. Environ. Health Perspect. 2005, 113:1787-1790.
84. Tabb M.M., Blumberg B. New modes of action for endocrine-disrupting chemicals. Mol. Endocrinol. 2006, 20:475-482.
85. Thiébaut A.C., Jiao L., Silverman D.T., Cross A.J., Thompson F.E., Subar A.F., et al. Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study. J. Natl. Cancer Inst. 2009, 101:1001-1011.
86. United Nations Environment Programme Regionally based assessment of persistent toxic substances. Global Report 2003 2003, UNEP Chemicals, Châtelaine, Switzerland, (accessed 24.12.09).
87. Vaclavik E., Tjonneland A., Stripp C., Overvad K., Philippe Weber J., Raaschou-Nielsen O. Organochlorines in Danish women: predictors of adipose tissue concentrations. Environ. Res. 2006, 100:362-370.
88. Wark P.A., Van der Kuil W., Ploemacher J., Van Muijen G.N., Mulder C.J., Weijenberg M.P., et al. Diet, lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas. Int. J. Cancer 2006, 119:398-405.