Modulation of EGF receptor activity by changes in the GM3 content in a human epidermoid carcinoma cell line, A431

Experimental Cell Research

Volumn 256, Issue 1, 2000, Pages 74-82

  Meuillet, Emmanuelle J ^a   Mania Farnell, Barbara ^a,b   George, David ^a   Inokuchi, Jin Ichi ^c   Bremer, Eric G ^a,d  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b PURDUE UNIVERSITY CALUMET   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cancer; EGF receptor; Ganglioside; Proliferation; Tyrosine kinase; D PDMP

Indexed keywords

CERAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; GANGLIOSIDE GM3;

ARTICLE; AUTOPHOSPHORYLATION; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM; SQUAMOUS CELL CARCINOMA;

EID: 0034630507     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4509     Document Type: Article

References (28)

1. Hakomori S. I. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv. Cancer Res. 52:1989;257-331.
2. Fredman P., Von Holst H., Collins V. P., Dellheden B., Svennerholm L. Expression of ganglioside GD3 and 3′-isoLM1 in autopsy brains from patients with malignant tumors. J. Neurochem. 60:1993;99-105.
3. Tokuyama S., Moriya S., Taniguchi S.-I., Yasui A., Miyazari J.-I., Orikasa S., Miyagi T. Supression of pulmonary metastasis in murine B16 melanoma cells by transfection of a sialidase cDNA. Int. J. Cancer. 73:1997;410-415.
4. Hakomori S. I. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res. 56:1996;5309-5318.
5. Bremer E. G., Schlessinger J., Hakomori S. I. Ganglioside-mediated modulation of cell growth: Specific effects of GM3 on tyrosine phosphorylation of the epidermal factor receptor. J. Biol. Chem. 261:1986;2334-2440.
6. Bremer E. G., Hakomori S.-I. GM3 ganglioside induces hamster fibroblast growth factor inhibition in chemically-defined medium: Ganglioside may regulate growth factor receptor function. Biochem. Biophys. Res. Commun. 106:1982;711-728.
7. Bremer E. G., Hakomori S., Bowen-Pope D. G., Raines E., Ross R. Ganglioside-mediated modulation of cell growth, growth binding factor and receptor phosphorylation. J. Biol. Chem. 259:1984;6818-6825.
8. Yates A. J., Brocklin J. V., Saqr H. E., Guan Z., Stokes B. T., O'Dorisio M. S. Mechanism through which gangliosides inhibit PDGF-stimulated mitogenesis in intact swiss 3T3 cells: Receptor tyrosine phosphorylation, intracellular calcium, and receptor binding. Exp Cell Res. 204:1993;38-45.
9. Mutoh T., Tokuda A., Miyadai T., Hamagauchi M., Fujuki N. Ganglioside GM1 binds to the Trk protein and regulates receptor function. Proc. Natl. Acad. Sci. USA. 92:1995;5087-5091.
10. Meuillet E., Cremel G., Dreyfus H., Hicks D. Differential modulation of basic fibroblast and epidermal growth factor receptor activation by ganglioside GM3 in cultured retinal muller glial. Glia. 17:1996;206-216.
11. Meuillet, E., Kroes, R., Yamamoto, H., George, D., Mania-Farnell, B., Rebbaa, A., Warner, T., Ferrari, J., Moskal, J. R., and Bremer, E. G.Sialidase gene transfection activates Epidermal growth factor receptor in epidermoid carcinoma cells line (A431). Cancer Res.59, 234-240.
12. Barbour S., Edidin M., Feldong-Habermann B., Taylor-Norton J., Radin N., Fenderson B. Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells. J. Cell. Physiol. 150:1992;610-619.
13. Radin N. S., Shayman J. A., Inokuchi J.-I. Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances. Adv. Lipid Res. 26:1993;183-203.
14. Uemura K., Sujgiyama E., Tamai C., Hra A., Taketomi T., Radin N. S. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J. Biochem. 108:1990;525-530.
15. Folch-Pi J., Lees M., Sloane-Stanley G. H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:1957;497-509.
16. Wakshull E. M., Wharton W. Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulates RNA synthesis but not mitogenesis. Proc. Natl. Acad. Sci. USA. 82:1985;8513-8517.
17. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding. Anal. Biochem. 72:1976;248-254.
18. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of the bacterial phage. Nature. 227:1970;680-685.
19. Kawamoto T., Sato J. D., Polikoff A., Sato G., Medelsohn J. Growth stimulation of A431 cells by epidermal growth factor: Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. J. Biol. Chem. 80:1983;1337-1341.
20. Chinkers M., McKanna J. A., Cohen S. Rapid rounding of human epidermoid carcinoma cells A-431 induced by epidermal growth factor. J. Cell Biol. 88:1981;422-429.
21. Rebbaa H., Hurh J., Yamamoto H., Kersey D. S., Bremer E. G. Ganglioside GM3 inhibition of EGF receptor mediated signal transduction. Glycobiology. 6:1996;399-406.
22. Suarez-Pestana E., Greiser U., Sanchez B., Fernandez L. E., Lage A., Perez R., Bohmer F. D. Growth inhibition of human lung adenocarcinoma cells by antibodies against the epidermal growth factor receptor and by ganglioside GM3: Involvement of receptor-directed tyrosine phosphatase(s). Br. J. Cancer. 75:1997;213-220.
23. Goldkorn T., Dressler K., Muindi J., Radin N. S., Mendelsohn J., Menaldino D., Liotta D., Kolesick R. N. Ceramide stimulated epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. J. Biol. Chem. 266:1991;16092-16097.
24. Couet J., Sargiacomo M., Lisanti M. P. Interactions of a receptor tyrosine kinase, EGFR, with caveolins. J. Biol. Chem. 272:1997;302429-330438.
25. Parton R. G. Caveolae and caveolin. Curr. Opin. Cell Biol. 8:1996;542-548.
26. Anderson R. G. The caveolae membrane system. Annu. Rev. Biochem. 67:1998;199-225.
27. Furuichi T., Anderson R. G. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J. Biol. Chem. 273:1998;21099-21104.
28. Pike L. J., Miller J. M. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273:1998;22298-22304.