Carrier-mediated uptake of LevoXoxacin by Befio cells, a human trophoblast cell line

Archives of Gynecology and Obstetrics

Volumn 281, Issue 5, 2010, Pages 833-838

  Polachek, Hana ^a,b   Holcberg, Gershon ^b   Rubin, Joseph Polachek Mazal ^a   Feinshtein, Valeria ^a   Sheiner, Eyal ^b   Ben Zvi, Zvi ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CIMETIDINE; CYCLOSPORIN A; GLYCOPROTEIN P INHIBITOR; LACTIC ACID; LEVOFLOXACIN; QUERCETIN; SALICYLIC ACID; VERAPAMIL;

ARTICLE; BEWO CELL; CELL LINE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; PLACENTAL TRANSFER; TROPHOBLAST;

ANTI-BACTERIAL AGENTS; CELL LINE, TUMOR; HUMANS; ION PUMPS; OFLOXACIN; TROPHOBLASTS;

EID: 77950627062     PISSN: 09320067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00404-009-1177-y     Document Type: Article

References (30)

1. Fish DN, Chow AT (1997) The clinical pharmacokinetics of levofloxacin. Clin Pharmacokinet 32:101-119
2. Mandel GL, Petri WA Jr (2006) The quinolones. In: Brunton LL, Lazo JS, Parker KL (eds) Goodman & Gilman's the pharmacolog-ical basis of therapeutics, 11th edn. McGraw-Hill, New York, pp 1119-1126
3. Audus KL (1999) Controlling drug delivery across the placenta. EurJPharmSci 8:161-165
4. Weier N, He SM, Li XT, Wang LL, Zhou SF (2008) Placental drug disposition and its clinical implications. Curr Drug Metab 9:106-121
5. Holcberg G, Tsadkin M, Sapir O, Huleihel M, Mazor M, Ben Zvi Z (2003) New aspects in placental drug transfer. Isr Med Assoc J 5(12): 873-876
6. Chandorkar GA, Ampasavate C, Stobaugh JF, Audus KL (1999) Peptide transport and metabolism across the placenta. Adv Drug Deliv Rev 38:59-67
7. Myren M, Mose T, Mathiesen L, Knudsen LE (2007) The human placenta-an alternative for studying foetal exposure. Toxicol In Vitro 21:1332-1340
8. Polachek H, Holcberg G, Sapir G, Tsadkin M, Polachek J, Katz M, Ben Zvi Z (2005) Transfer of CiproXoxacin, OXoxacin and LevoXoxacin across the perfused human placenta in vitro. Eur J Obstet Gynecol Reprod Biol 122:61-65
9. Pattilo RA, Gey GO, Delfs E, Mattingly RF (1968) Human hormone production in vitro. Science 159:1467-1469
10. Ringler GE, Strauss JF (1990) In vitro systems for the study of human placental endocrine function. Endocrinol Rev 11:105-123
11. Gips M, Barel S, Bridzy M, Soback S (1995) Detection of fluoro-quinolone residues in milk. In: Proceedings of the third IDF international Mastitis seminar
12. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
13. Young AM, Allen CE, Audus KL (2003) EZux transporters of the human placenta. Adv Drug Deliv Rev 55:125-132
14. Nakamura Y, Ikeda S, Furukawa T, Sumizawa T, Tani A, Akiy-ama S, Nagata Y (1997) Function of P-glycoprotein expressed in placenta and mole. Biochem Biophys Res Commun 235:849-853
15. Gil S, Saura R, Forestier F, Farinotti R (2005) P-glycoprotein expression of the human placenta during pregnancy. Placenta 26:268-270
16. Lankas GR, Wise LD, Cartwright ME, Pippert T, Umbenhauer DR (1998) Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. Reprod Toxicol 12:457-463
17. Utoguchi N, Chandorkar GA, Avery M, Audus KL (2000) Functional expression of P-glycoprotein in primary cultures of human cytotrophoblast and Befio cells. Reprod Toxicol 14:217-224
18. De Lange EC, Marchand S, Van Den Berg D, Van Der Sandt IC, De Boer AG, Delon A, Bouquet S, Couet W (2000) In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein eZux transporter on brain distribution of sparXoxacin. Eur J Pharm Sci 12:85-93
19. Yamaguchi H, Yano I, Hashimoto Y, Inui KI (2000) Secretory mechanisms of grepaXoxacin and levofloxacin in the human intestinal cell line Caco-2. J Pharmacol Exp Ther 295:360-366
20. Rabbaa L, Dautrey S, Colas-Linhart N (1996) Intestinal elimination of oXoxacin enantiomers in the rat: evidence of a carrier-mediated process. Antimicrob Agents Chemother 40:2126-2130
21. Ito T, Yano I, Tanaka K, Inuri KI (1997) Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther 282:955-960
22. Takaai M, Suzuki H, Ishida K, Tahara K, Hashimoto Y (2007) Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers. Biol Pharm Bull 30(11):2167-2172
23. Hagenbuch B, Meier PJ (2004) Organic anion transporting poly-peptides of the OATP/SLC21 family: phylogenetic classiWcation as OATP/SLCO superfamily, new nomenclature and molecular/ functional properties. Eur J Physiol 447:653-665
24. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H (2001) Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59:1277-1286 (Pubitemid 32385197)
25. Tahara H, Kusuhara H, Endou H, Koepsell H, Imaoka T, Fuse E, Sugiyama Y (2005) A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther 15:337-345
26. Balkovetz DF, Leibach FH, Mahesh VB, Ganapathy V (1988) A proton gradient is the driving force for uphill transport of lactate in human placental brush-border membrane vesicles. J Biol Chem 263:13823-13830
27. Carstensen MH, Leichtweiss HP, Schroder H (1983) Lactate carriers in the artificially perfused human term placenta. Placenta 4:165-174
28. Utoguchi N, Magnusson M, Audus KL (1999) Carrier-mediated transport of monocarboxylic acid in Befio cell monolayers as a model of the human trophoblast. J Pharma Sci 88:1288-1292
29. Ushigome F, Takanaga H, Matsuo H, Tsukimori K, Nakano H, Ohtani H, Sawada Y (2001) Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (Befio). Eur J Pharmacol 417:169-176
30. Alonso-Torre SR, Serrano MA, Alvarado F, Medina JM (1991) Carrier-mediated L-lactate transport in brush border membrane vesicles from rat placenta during late gestation. Biochem J 278:535-541