Placental drug disposition and its clinical implications

Current Drug Metabolism

Volumn 9, Issue 2, 2008, Pages 106-121

  Weier, Naomi ^a   He, Shu Ming ^b   Li, Xiao Tian ^c   Wang, Lin Lin ^d,e   Zhou, Shu Feng ^d  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b Xiaolan People's Hospital   (China)

^c FUDAN UNIVERSITY   (China)

^d RMIT UNIVERSITY   (Australia)

^e PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cytochrome P450; Drug metabolism; Drug transporter; P glycoprotein; Placenta

Indexed keywords

ALCOHOL; AMINOSALICYLIC ACID DERIVATIVE; AMPHETAMINE DERIVATIVE; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; BETAMETHASONE; BREAST CANCER RESISTANCE PROTEIN; CEPHALOSPORIN DERIVATIVE; COCAINE; CORTICOSTEROID; CORTICOSTERONE; CYTOCHROME P450; DEXAMETHASONE; DICLOFENAC; FOLIC ACID ANTAGONIST; GANCICLOVIR; GLIBENCLAMIDE; GLUCOCORTICOID; GLYCOPROTEIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; PARACETAMOL; RITONAVIR; THALIDOMIDE; UNINDEXED DRUG; XENOBIOTIC AGENT;

ALCOHOL METABOLISM; ASTHMA; BLOOD PLACENTA BARRIER; DEPRESSION; DRUG CLEARANCE; DRUG DETOXIFICATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SAFETY; DRUG TRANSPORT; ENTERITIS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; FETOPLACENTAL UNIT; FETOTOXICITY; HUMAN; IMMUNOPATHOLOGY; MALIGNANT NEOPLASTIC DISEASE; MATERNAL HYPERTENSION; NONHUMAN; PLACENTA CIRCULATION; PLACENTA FUNCTION; PLACENTA WEIGHT; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; REVIEW; SINGLE DRUG DOSE; TERATOGENICITY;

ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; HUMANS; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; ORGANIC CATION TRANSPORT PROTEINS; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; PLACENTA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 41549105332     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008783571828     Document Type: Review

References (86)

1. Ganapathy, V.; Prasad, P. D.; Ganapathy, M. E and Leibach, F. H. (2000) J. Pharmacol. Exp. Ther., 294(2), 413-420.
2. Young, A. M.; Allen, C. E. and Audus, K. L. (2003) Adv. Drug Deliv. Rev., 55(1), 125-132.
3. Syme, M. R.; Paxton, J. W. and Keelan, J. A. (2004) Clin. Pharmacokinet., 43(8), 487-514.
4. Ganapathy, V. and Prasad, P. D. (2005) Toxicol. Appl. Pharmacol., 207(2 Suppl), 381-387.
5. van der Aa, E. M.; Peereboom-Stegeman, J. H.; Noordhock, J.; Gribnau, F. W. and Russel, F. G. (1998) Pharm. World Sci., 20(4), 139-148.
6. Gedeon, C. and Koren, G. (2006) Placenta, 27(8), 861-868.
7. Kekuda, R.; Prasad, P. D.; Wu, X.; Wang, H.; Fei, Y. J.; Leibach, F. H. and Ganapathy, V. (1998) J. Biol. Chem., 273(26), 15971-15979.
8. Myllynen, P.; Pasanen, and M.; Pelkonen, O. (2005) Placenta, 26(5), 361-371.
9. Pasanen, M. (1999) Adv. Drug Deliv. Rev., 38(1), 81-97.
10. Hakkola, J.; Pelkonen, O.; Pasanen, M. and Raunio, H. (1998) Crit. Rev. Toxicol., 28(1), 35-72.
11. Gedeon, C.; Behravan, J.; Koren, G. and Piquette-Miller, M. (2006) Placenta, 27(11-12), 1096-1102.
12. Collier, A. C.; Tingle, M. D.; Paxton, J. W.; Mitchell, M. D. and Keelan, J. A. (2002) Hum. Reprod., 17(10), 2564-2572.
13. Nebert, D. W.; Dalton, T. P.; Okey, A. B. and Gonzalez, F. J. (2004) J. Biol. Chem., 279(23), 23847-23850.
14. Nishimura, M.; Yaguti, H.; Yoshitsugu, H.; Naito, S. and Satoh, T. (2003) Yakugaku Zasshi., 123(5), 369-375.
15. Card, S. E.; Tompkins, S. F. and Brien, J. F. (1989) Biochem. Pharmacol., 38(15), 2535-2541.
16. Rasheed, A.; Hines, R. N. and McCarver-May, D. G. (1997) Toxicol. Appl. Pharmacol., 144(2), 396-400.
17. Hakkola, J.; Pasanen, M.; Pelkonen, O.; Hukkanen, J.; Evisalmi, S.; Anttila, S.; Rane, X.; Mantyla, M.; Purkunen, R.; Saarikoski, S.; Tooming, M. and Raunio, H. (1997) Carcinogenesis, 18(2), 391-397.
18. Bieche, I.; Narjoz, C.; Asselah, T.; Vacher, S.; Marcellin, P.; Lidereau, R.; Beaune, P. and de Waziers, I. (2007) Pharmacogenet Genomics, 17(9), 731-742.
19. Pasanen, M.; Taskinen, T.; Sotaniemi, E. A.; Kairaluoma, M. and Pelkonen, O. (1988) Pharmacol. Toxicol., 62(5), 311-317.
20. Avigdor, S.; Zakheim, D. and Barnea, E. R. (1992) Reprod. Toxicol., 6(4), 363-366.
21. Collier, A. C.; Ganley, N. A.; Tingle, M. D.; Blumenstein, M.; Marvin, K. W.; Paxton, J. W.; Mitchell, M. D. and Keelan, J. A. (2002) Biochem. Pharmacol., 63(3), 409-419.
22. Collier, A. C.; Keelan, J. A.; Van Zijl, P. E.; Paxton, J. W.; Mitchell, M. D. and Tingle, M. D. (2004) Drug Metab. Dispos., 32(8), 813-820.
23. Garland, M.; Abildskov, K. M.; Taylor, S.; Benzeroual, K.; Caspersen, C. S.; Arroyo, S. E.; Kiu, T. W.; Reznik, B.; Weldy, P.; Daniel, S. S. and Stark, R. I. (2006) Drug Metab. Dispos., 34(4), 636-646.
24. Collier, A. C.; Tingle, M. D.; Keelan, J. A.; Paxton, J. W. and Mitchell, M. D. (2000) Drug Metab. Dispos., 28(10), 1184-1186.
25. del Carmen Terrones Saldivar, M.; Juarez, F. J.; Viramontes, J. L.; Rodriguez Vazquez, M. L. and Posadas del Rio, F. A. (2004) Placenta, 25(4), 331-336.
26. Raijmakers, M. T.; Bruggeman, S. W.; Steegers, E. A. and Peters, W. H. (2002) Placenta, 23(6), 490-496.
27. Knapen, M. F.; Peters, W. H.; Mulder, T. P.; Merkus, H. M.; Jansen, J. B. and Steegers, E. A. (1999) Placenta, 20(7), 541-546.
28. Paakki, P.; Stockmann, H.; Kantola, M.; Wagner, P.; Lauper, U.; Huch, R.; Elovaara, E.; Kirkinen, P. and Pasanen, M. (2000) Environ. Health Perspect., 108(2), 141-145.
29. McRobie, D. J.; Glover, D. D. and Tracy, T. S. (1998) Drug Metab. Dispos., 26(4), 367-371.
30. Pacifici, G. M. and Rane, A. (1983) Dev. Pharmacol. Ther., 6(2), 83-93.
31. Pacifici, G. M.; Temellini, A.; Giuliani, L.; Rane, A.; Thomas, H. and Oesch, F. (1988) Arch. Toxicol., 62(4), 254-257.
32. Wixtrom, R. N.; Silva, M. H. and Hammock, B. D. (1988) Placenta, 9(5), 559-563.
33. Pasanen. and M.; Pelkonen, O. (1989) Drug Metab. Rev. 21(3), 427-461.
34. Tseng, L.; Lee, L. Y. and Mazella, J. (1985) J. Steroid Biochem., 22(5), 611-615.
35. Falany, C. N.; He, D.; Dumas, N.; Frost, A. R. and Falany, J. L. (2006) J. Steroid Biochem. Mol. Biol., 102(1-5), 214-221.
36. Pacifici, G. M. (2005) Early Hum. Dev., 81(7), 573-581.
37. He, D.; Meloche, C. A.; Dumas, N. A.; Frost, A. R. and Falany, C. N. (2004) Biochem. J., 379(Pt3), 533-540.
38. Stanley, E. L.; Hume, R.; Visser, T. J. and Coughtrie, M. W. (2001) J. Clin. Endocrinol. Metab., 86(12), 5944-5955.
39. Smelt, V. A.; Mardon, H. J. and Sim, E. (1998) Pharmacol. Toxicol., 83(4), 149-157.
40. Derewlany, L. O. and Koren, G. (1994) J. Lab. Clin. Med., 124(1), 134-141.
41. Derewlany, L. O.; Knie, B. and Koren, G. (1994) J. Pharmacol. Exp. Ther., 269(2), 761-765.
42. Derewlany, L. O.; Knie, B. and Koren, G. (1994) J. Pharmacol. Exp. Ther., 269(2), 756-760.
43. Smelt, V. A.; Upton, A.; Adjaye, J.; Payton, M. A.; Boukouvala, S.; Johnson, N.; Mardon, H. J.; Sim, E. (2000) Hum. Mol. Genet., 9(7), 1101-1107.
44. Mathias, A. A.; Hitti, J. and Unadkat, J. D. (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol., 289(4), R963-969.
45. Zhou, S. F. (2008) Xenobiotica, in press.
46. Smit, J. W.; Huisman, M. T.; van Tellingen, O.; Wiltshire, H. R. and Schinkel, A. H. (1999) J. Clin. Invest., 104(10), 1441-1447.
47. Ceckova-Novotna, M.; Pavek, P. and Staud, F. (2006) Reprod. Toxicol., 22(3), 400-410.
48. Sun, M.; Kingdom, J.; Baczyk, D.; Lye, S. J.; Matthews, S. G. and Gibb, W. (2006) Placenta, 27(6-7), 602-609.
49. St-Pierre, M. V.; Serrano, M. A.; Macias, R. I.; Dubs, U.; Hocchli, M.; Lauper, U.; Meier, P. J.and Marin, J. J. (2000) Am. J. Physiol. Regul. Integr. Comp. Physiol., 279(4), R1495-1503.
50. Staud, F.; Vackova, Z.; Pospechova, K.; Pavek, P.; Ceckova, M.; Libra, A.; Cygalova, L.; Nachtigal, P. and Fendrich, Z. (2006) J. Pharmacol. Exp. Ther., 319(1), 53-62.
51. Wang, H.; Zhou, L.; Gupta, A.; Vethanayagam, R. R.; Zhang, Y.; Unadkat, J. D. and Mao, Q. (2006) Am. J. Physiol. Endocrinol. Metab., 290(5), E798-807.
52. Sata, R.; Ohtani, H.; Tsujimoto, M.; Murakami, H.; Koyabu, N.; Nakamura, T.; Uchiumi, T.; Kuwano, M.; Nagata, H.; Tsukimori, K.; Nakano, H. and Sawada, Y. (2005) J. Pharmacol. Exp. Ther., 315(2), 888-895.
53. Bottalico, B.; Larsson, L; Brodszki, J.; Hernandez-Andrade, E.; Casslen, B.; Marsal, K. and Hansson, S. R. (2004) Placenta, 25(6), 518-529.
54. Wu, X.; Huang, W.; Prasad, P. D.; Seth, P.; Rajan, D. P.; Leibach, F. H.; Chen, J.; Conway, S. J. and Ganapathy, V. (1999) J. Pharmacol. Exp. Ther., 290(3), 1482-1492.
55. Leazer, T. M. and Klaassen, C. D. (2003) Drug Metab. Dispos., 31(2), 153-167.
56. St-Pierre, M. V.; Kullak-Ublick, G. A.; Hagenbuch, B. and Meier, P. J. (2001) J. Exp. Biol., 204(Pt 10), 1673-1686.
57. Antony, A, C. (2007) Am. J Clin. Nutr., 85(2), 598S-603S.
58. Yamashita, F.; Ohtani, H.; Koyabu, N.; Ushigone, F.; Satoh, H.; Murakami, H.; Uchiumi, T.; Nakamura, T,; Kuwano, M.; Tsujimoto, M. and Sawada, Y. (2006) J. Pharm. Pharmacol., 58(11), 1499-1505.
59. Cha, S. H.; Sekine, T.; Kusuhara, H.; Yu, E.; Kim, J. Y.; Kim, D. K.; Sugiyama, Y.; Kanai, Y. and Endou, H. (2000) J. Biol. Chem., 275(6), 4507-4512.
60. Parry, S. and Zhang, J. (2007) Am. J. Obstet. Gynecol., 196(5), 476 e471-476.
61. Schatz, M. (2001) Semin. Perinatol., 25(3), 145-152.
62. Emoto, A.; Ushigome, F.; Koyabu, N.; Kajiya, H.; Okabe, K.; Satoh, S.; Tsukimori, K.; Nakano, H.; Ohtani, H. and Sawada, Y. (2002) Am. J. Physiol. Cell Physiol., 282(5), C1064-1075.
63. Akande, V.; Garas, A. and Cahill, D. (2006) J Ob.stet. Gynaecol., 26(8), 785-787.
64. Setiawan, E.; Jackson, M. F.; MacDonald, J. F. and Matthews, S. G. (2007) J. Physiol., 581(Pt 3), 1033-1042.
65. Chan, K. K.; Huang, Y.; Tam, K. F.; Tse, K. Y. and Ngan, H. Y. (2006) Am J Obstet Gynecol., 195(5), 1282-1286.
66. Kalra, S.; Einarson, A. and Koren, G. (2005) Can. Fam. Physician., 51(1077-1078.
67. Kallen, B. (2004) Arch. Pediatr. Adolesc. Med., 158(4), 312-316.
68. Hendrick, V.; Smith, L. M.; Suri, R., Hwang, S.; Haynes, D. and Altshuler, L. (2003) Am J Obstet Gynecol., 188(3), 812-815.
69. Wisner, K. L.; Gelenberg, A. I.; Leonard, H.; Zarin, D. and Fiank, E. (1999) JAMA, 282(13), 1264-1269.
70. Oberlander, T. F.; Warburton, W.; Misri, S.; Aghajanian, J.; and Hertzman, C. (2006) Arch Gen Psychiatry. 62(8), 898-906.
71. Abalos, E.; Duley, L.; Steyn, D. W. and Henderson-Smart, D. J. (2007) Cochrane. Database Syst. Rev., 1, CD002252.
72. Snow, M. E. and Keiver, K. (2007) Bone, 41(2), 181-187.
73. Dennis, T.; Bendersky, M.; Ramsay, D. and Lewis, M. (2006) Dev. Psychol., 42(4), 688-697.
74. Bauer, C. R.; Langer, J. C.; Shankaran, S.; Bada, H. S.; Lester, B.; Wright, L. L.; Krause-Steinrauf, H.; Smeriglio, V. L.; Finnegan, L P.; Maza, P. L. and Vetter, J. (2005) Arch. Pediatr. Adolesc. Med., 159(9), 824-834.
75. Kennare, R.; Heard, A. and Chan, A. (2005) Aust. N. Z. J.Obstet. Gynaecol., 45(3), 22O-225.
76. Smith, L. M.; LaGasse, L. L.; Derauf, C.; Grant, P.; Shah, R.; Arria, A.; Huestis; M.; Haning, W.; Strauss, A.; Della Grotta, S.; Liu, J. and Lester, B. M. (2006) Pediatrics, 118(3), 1149-1156.
77. Lester, B. M.; Tronick, E. Z.; LaGasse, L.; Seife,r R.; Bauer, C. R.; Shankaran, S.; Bada, H. S.; Wright, L. L.; Smeriglio, V. L.; Lu, J.; Finnegan, L. P. and Maza, P. L. (2002) Pediatrics, 110(6), 1182-1192.
78. Miyata, M.; Tamura, E.; Motoki, K.; Nagata, K. and Yamazoe, Y. (2003) Drug Metab Dispos., 31(4), 469-475.
79. Mujagic, H.; Chabner, B. A. and Mujagic, Z. (2002) Croat. Med. J., 43(3), 274-285.
80. and Rajkumar, S. V. (2004) Mayo. Clin. Proc., 79(7), 899-903.
81. Ujhazy, E.; Maclh, M.; Dubovicky, M.; Navarova, J. and Brucknerova, I. (2005) Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub., 149(2), 209-212.
82. Stromland, K.; Philipson, E. and Andersson Gronlund, M. (2002) Teratology., 66(3), 115-121.
83. Hallene, K. L.; Oby, E.; Lee, B. J.; Santaguida, S.; Bassanini, S.; Cipolla, M.; Marchi, N.; Hossain, M.; Battaglia, G: and Janigro, D. (2006) Neuroscience, 142(1), 267-283.
84. Canton, R. F.; Scholten, D. E.; Marsh, G.; de Jong, P. C. and van den Berg, M. (2007) Toxicol. Appl. Pharmacol., [Epub ahead of print].
85. Mondragon, J.A.; Ocadiz-Delgado, R.;, Miranda, C.; Valencia, J.; Rosales, A. M.; Gariglio, P. and Romano, M. C. (2007) Theriogenology, 68(4), 646-653.
86. Mendelson, C. R. and Kamat, A. (2007) J. Steroid. Biochem. Mol. Biol., 106(1-5), 62-70.