Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 11, 2007, Pages 2167-2172

  Takaai, Mari ^a   Suzuki, Hisaki ^a   Ishida, Kazuya ^a   Tahara, Katsutoshi ^a   Hashimoto, Yukiya ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Caco 2 cell; Intestinal absorption; Levofloxacin; LLC PK1 cell; Quinidine; Renal secretion

Indexed keywords

BISOPROLOL; CIMETIDINE; CLONIDINE; DIPHENHYDRAMINE; ERYTHROMYCIN; IMIPRAMINE; LEVOFLOXACIN; METOPROLOL; NICOTINE; PROCAINAMIDE; PROPRANOLOL; QUINIDINE; RIFAMPICIN; TETRYLAMMONIUM;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL LINE; CELL PH; CELL STRAIN CACO 2; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; MEMBRANE TRANSPORT; NONHUMAN; TRANSCYTOSIS; URINARY EXCRETION;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LLC-PK1 CELLS; METABOLIC CLEARANCE RATE; MODELS, THEORETICAL; OFLOXACIN; SWINE;

EID: 36048944069     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.2167     Document Type: Article

References (22)

1. Hidalgo I. J., Raub T. J., Borchardt R. T., Gastroenterology, 96, 736-749 (1989).
2. Englund G., Rorsman F., Ronnblom A., Karlbom U., Lazorova L., Grasjo J., Kindmark A., Artursson P., Eur. J. Pharm. Sci., 29, 269-277 (2006).
3. Hilgendorf C., Ahlin G., Seithel A., Artursson P., Ungell A. L., Karlsson J. E., Drug Metab. Dispos., 35, 1333-1340 (2007).
4. Artursson P., J. Pharm. Sci., 79, 476-482 (1990).
5. Artursson P., Karlsson J., Biochem. Biophys. Res. Commun., 175, 880-885 (1991).
6. Cavet M. E., West M., Simmons N. L., Br. J. Pharmacol., 118, 1389-1396 (1996).
7. Aiba T., Ishida K., Yoshinaga M., Okuno M., Hashimoto Y., Biol. Pharm. Bull., 28, 114-119 (2005).
8. Chiu Y. Y., Higaki K., Neudeck B. L., Barnett J. L., Welage L. S., Amidon G. L., Pharm. Res., 20, 749-756 (2003).
9. Watanabe K., Jinriki T., Sato J., Biol. Pharm. Bull., 29, 90-95 (2006).
10. Irie M., Terada T., Sawada K., Saito H., Inui K., J. Pharmacol. Exp. Ther., 298, 711-717 (2001).
11. Ishida K., Takaai M., Hashimoto Y., Biol. Pharm. Bull., 29, 522-526 (2006).
12. Tomita Y., Otsuki Y., Hashimoto Y., Inui K., Pharm. Res., 14, 1236-1240 (1997).
13. Ohtomo T., Saito H., Inotsume N., Yasuhara M., Inui K., J. Pharmacol. Exp. Ther., 276, 1143-1148 (1996).
14. Matsuo Y., Yano I., Ito T., Hashimoto Y., Inui K., J. Pharmacol. Exp. Ther., 287, 672-678 (1998).
15. Okuda M., Urakami Y., Saito H., Inui K., Biochim. Biophys. Acta, 1417, 224-231 (1999).
16. Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., Inui K., Biochem. Pharmacol., 74, 359-371 (2007).
17. Naruhashi K., Tamai I., Inoue N., Muraoka H., Sai Y., Suzuki N., Tsuji A., J. Pharm. Pharmacol., 53, 699-709 (2001).
18. Yamaguchi H., Yano I., Hashimoto Y., Inui K., J. Pharmacol. Exp. Ther., 295, 360-366 (2000).
19. Merino G., Alvarez A. I., Pulido M. M., Molina A. J., Schinkel A. H., Prieto J. G., Drug Metab. Dispos., 34, 690-695 (2006).
20. Xia C. Q., Liu N., Yang D., Miwa G., Gan L. S., Drug Metab. Dispos., 33, 637-643 (2005).
21. Maeda T., Takahashi K., Ohtsu N., Oguma T., Ohnishi T., Atsumi R., Tamai I., Mol. Pharm., 4, 85-94 (2007).
22. Mizuuchi H., Katsura T., Saito H., Hashimoto Y., Inui K., J. Pharmacol. Exp. Ther., 290, 388-392 (1999).