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Volumn 10, Issue 3, 2010, Pages 353-359

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

Author keywords

Apoptosis; M30 Apoptosense ELISA; M65 ELISA; Necrosis; Pharmacodynamic marker

Indexed keywords

BIOLOGICAL MARKER; CYTOKERATIN; CYTOKERATIN 18; MONOCLONAL ANTIBODY;

EID: 77950621989     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.10.14     Document Type: Review
Times cited : (47)

References (53)
  • 1
    • 0001388221 scopus 로고
    • Hormones and cancer
    • Tannock IF, Hill RP (Eds). Pergamon Press, NY, USA
    • Sutherland DJ. Hormones and cancer. In: The Basic Science of Oncology. Tannock IF, Hill RP (Eds). Pergamon Press, NY, USA 204-222 (1987).
    • (1987) The Basic Science of Oncology , pp. 204-222
    • Sutherland, D.J.1
  • 2
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344(11), 783-792 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 3
    • 0036717347 scopus 로고    scopus 로고
    • Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human annexin v in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis
    • Belhocine T, Steinmetz N, Hustinx R et al. Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis. Clin. Cancer Res. 8(9), 2766-2774 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , Issue.9 , pp. 2766-2774
    • Belhocine, T.1    Steinmetz, N.2    Hustinx, R.3
  • 5
    • 0014566175 scopus 로고
    • The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system
    • Thomson DM, Krupey J, Freedman SO et al. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc. Natl Acad. Sci. USA 64(1), 161-167 (1969).
    • (1969) Proc. Natl Acad. Sci. USA , vol.64 , Issue.1 , pp. 161-167
    • Thomson, D.M.1    Krupey, J.2    Freedman, S.O.3
  • 6
    • 0344011553 scopus 로고    scopus 로고
    • PSA markers in prostate cancer detection
    • Gretzer MB, Partin AW. PSA markers in prostate cancer detection. Urol. Clin. North Am. 30 (4), 677-686 (2003).
    • (2003) Urol. Clin. North Am. , vol.30 , Issue.4 , pp. 677-686
    • Gretzer, M.B.1    Partin, A.W.2
  • 7
    • 0029837662 scopus 로고    scopus 로고
    • Dynamic use of tumor markers, rationale-clinical applications and pitfalls
    • Gion M, Mione R, Barioli P et al. Dynamic use of tumor markers, rationale-clinical applications and pitfalls. Anticancer Res. 16(4B), 2279-2284 (1996).
    • (1996) Anticancer Res. , vol.16 , Issue.4 B , pp. 2279-2284
    • Gion, M.1    Mione, R.2    Barioli, P.3
  • 8
    • 0035889639 scopus 로고    scopus 로고
    • On the release and half-life of S100B protein in the peripheral blood of melanoma patients
    • Ghanem G, Loir B, Morandini R et al. On the release and half-life of S100B protein in the peripheral blood of melanoma patients. Int. J. Cancer 94(4), 586-590 (2001).
    • (2001) Int. J. Cancer , vol.94 , Issue.4 , pp. 586-590
    • Ghanem, G.1    Loir, B.2    Morandini, R.3
  • 9
    • 0032409035 scopus 로고    scopus 로고
    • CA 125 production and release by ovarian cancer cells in vitro
    • Beck EP, Moldenhauer A, Merkle E et al. CA 125 production and release by ovarian cancer cells in vitro. Int. J. Biol. Markers 13(4), 200-206 (1998).
    • (1998) Int. J. Biol. Markers , vol.13 , Issue.4 , pp. 200-206
    • Beck, E.P.1    Moldenhauer, A.2    Merkle, E.3
  • 10
    • 0035221326 scopus 로고    scopus 로고
    • The versatility of cytokeratins as tumor markers
    • Stigbrand T. The versatility of cytokeratins as tumor markers. Tumour Biol. 22(1), 1-3 (2001).
    • (2001) Tumour Biol. , vol.22 , Issue.1 , pp. 1-3
    • Stigbrand, T.1
  • 11
    • 34548494871 scopus 로고    scopus 로고
    • Cytokeratin markers come of age
    • Linder S. Cytokeratin markers come of age. Tumour Biol. 28(4), 189-195 (2007).
    • (2007) Tumour Biol. , vol.28 , Issue.4 , pp. 189-195
    • Linder, S.1
  • 12
    • 0035163803 scopus 로고    scopus 로고
    • Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure
    • Cocco RE, Ucker DS. Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure. Mol. Biol. Cell 12(4), 919-930 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , Issue.4 , pp. 919-930
    • Cocco, R.E.1    Ucker, D.S.2
  • 13
    • 1542313978 scopus 로고    scopus 로고
    • Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production
    • Brouckaert G, Kalai M, Krysko DV et al. Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production. Mol. Biol. Cell 15(3), 1089-1100 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , Issue.3 , pp. 1089-1100
    • Brouckaert, G.1    Kalai, M.2    Krysko, D.V.3
  • 14
    • 0031918742 scopus 로고    scopus 로고
    • The mitochondrial death/life regulator in apoptosis and necrosis
    • DOI 10.1146/annurev.physiol.60.1.619
    • Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60, 619-642 (1998). (Pubitemid 28157889)
    • (1998) Annual Review of Physiology , vol.60 , pp. 619-642
    • Kroemer, G.1    Dallaporta, B.2    Resche-Rigon, M.3
  • 15
    • 0034687663 scopus 로고    scopus 로고
    • Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood
    • Chang YS, di Tomaso E, McDonald DM et al. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc. Natl Acad. Sci. USA 97(26), 14608-14613 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.26 , pp. 14608-14613
    • Chang, Y.S.1    Di Tomaso, E.2    McDonald, D.M.3
  • 16
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
    • Liotta L, Kleinerman J, Saidel G. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res. 34, 997-1004 (1974).
    • (1974) Cancer Res. , vol.34 , pp. 997-1004
    • Liotta, L.1    Kleinerman, J.2    Saidel, G.3
  • 17
    • 0032750852 scopus 로고    scopus 로고
    • Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity
    • Swartz MA, Kristensen CA, Melder RJ et al. Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity. Br. J. Cancer 81(5), 756-759 (1999).
    • (1999) Br. J. Cancer , vol.81 , Issue.5 , pp. 756-759
    • Swartz, M.A.1    Kristensen, C.A.2    Melder, R.J.3
  • 18
    • 8144220008 scopus 로고    scopus 로고
    • Apoptosis of circulating tumor cells in prostate cancer patients
    • Larson CJ, Moreno JG, Piento KJ et al. Apoptosis of circulating tumor cells in prostate cancer patients. Cytometry A 62(1), 46-53 (2004).
    • (2004) Cytometry A , vol.62 , Issue.1 , pp. 46-53
    • Larson, C.J.1    Moreno, J.G.2    Piento, K.J.3
  • 19
    • 4344576754 scopus 로고    scopus 로고
    • Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker
    • Linder S, Havelka AM, Ueno T et al. Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker. Cancer Lett. 214(1), 1-9 (2004).
    • (2004) Cancer Lett. , vol.214 , Issue.1 , pp. 1-9
    • Linder, S.1    Havelka, A.M.2    Ueno, T.3
  • 20
    • 68449100184 scopus 로고    scopus 로고
    • Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy
    • Hou JM, Greystok A, Lancashire L et al. Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy. Am. J. Pathol. 175(2), 808-816 (2009).
    • (2009) Am. J. Pathol. , vol.175 , Issue.2 , pp. 808-816
    • Hou, J.M.1    Greystok, A.2    Lancashire, L.3
  • 21
    • 0026305235 scopus 로고
    • Molecular diversity of cytokeratins: Significance for cell and tumor differentiation
    • Moll R. Molecular diversity of cytokeratins: significance for cell and tumor differentiation. Acta Histochemica. Suppl. 41, 117-127 (1991).
    • (1991) Acta Histochemica. Suppl. , vol.41 , pp. 117-127
    • Moll, R.1
  • 22
    • 0017917113 scopus 로고
    • Tissue polypeptide antigen (TPA): Biology, biochemistry, improved assay methodology, clinical significance in cancer and other conditions, and future outlook
    • Björklund B. Tissue polypeptide antigen (TPA): Biology, biochemistry, improved assay methodology, clinical significance in cancer and other conditions, and future outlook. Antibiot. Chemother. 22, 16-31 (1978).
    • (1978) Antibiot. Chemother , vol.22 , pp. 16-31
    • Björklund, B.1
  • 23
    • 0021525316 scopus 로고
    • Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: Re- evaluation of a human tumor marker
    • Weber K, Osborne M, Moll R et al. Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: re- evaluation of a human tumor marker. EMBO J. 3(11), 2707-2714 (1984).
    • (1984) EMBO J. , vol.3 , Issue.11 , pp. 2707-2714
    • Weber, K.1    Osborne, M.2    Moll, R.3
  • 24
    • 10244279220 scopus 로고    scopus 로고
    • Molecular characterization of a tissue-polypeptide-specific-antigen epitope and its relationship to human cytokeratin 18
    • Rydlander L, Ziegler E, Bergman T et al. Molecular characterization of a tissue-polypeptide-specific-antigen epitope and its relationship to human cytokeratin 18. Eur. J. Biochem. 241(2), 309-314 (1996).
    • (1996) Eur. J. Biochem. , vol.241 , Issue.2 , pp. 309-314
    • Rydlander, L.1    Ziegler, E.2    Bergman, T.3
  • 26
    • 0027244147 scopus 로고
    • A significant soluble keratin fraction in 'simple' epithelial cells. Lack of an apparent phosphorylation and glycosylation role in keratin solubility
    • Chou CF, Riopel CL, Rott LS et al. A significant soluble keratin fraction in 'simple' epithelial cells. Lack of an apparent phosphorylation and glycosylation role in keratin solubility. J. Cell Sci. 105(Pt 2), 433-444 (1993).
    • (1993) J. Cell Sci. , vol.105 , Issue.PART 2 , pp. 433-444
    • Chou, C.F.1    Riopel, C.L.2    Rott, L.S.3
  • 27
    • 0029976567 scopus 로고    scopus 로고
    • Human colorectal carcinomas specifically accumulate Mr 42,000 ubiquitin-conjugated cytokeratin 8 fragments
    • Nishibori H, Matsuno Y, Iwaya M et al. Human colorectal carcinomas specifically accumulate Mr 42,000 ubiquitin-conjugated cytokeratin 8 fragments. Cancer Res. 56(12), 2752-2757 (1996).
    • (1996) Cancer Res. , vol.56 , Issue.12 , pp. 2752-2757
    • Nishibori, H.1    Matsuno, Y.2    Iwaya, M.3
  • 28
    • 0033994455 scopus 로고    scopus 로고
    • Identification of gel-separated tumor marker proteins by mass spectrometry
    • Bergman AC, Benjamin T, Alaiya A et al. Identification of gel-separated tumor marker proteins by mass spectrometry. Electrophoresis 21(3), 679-686 (2000).
    • (2000) Electrophoresis , vol.21 , Issue.3 , pp. 679-686
    • Bergman, A.C.1    Benjamin, T.2    Alaiya, A.3
  • 29
    • 65449160047 scopus 로고    scopus 로고
    • Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker
    • Olofsson MH, Cummings J, Fayad W et al. Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker. Cancer Biomark. 5(3), 117-125 (2009).
    • (2009) Cancer Biomark. , vol.5 , Issue.3 , pp. 117-125
    • Olofsson, M.H.1    Cummings, J.2    Fayad, W.3
  • 30
    • 0028304290 scopus 로고
    • Cytokeratins and tissue polypeptide antigen
    • Sundström BE, Stigbrand TI. Cytokeratins and tissue polypeptide antigen. Int. J. Biol. Markers 9(2), 102-108 (1994).
    • (1994) Int. J. Biol. Markers , vol.9 , Issue.2 , pp. 102-108
    • Sundström, B.E.1    Stigbrand, T.I.2
  • 31
    • 34548558675 scopus 로고    scopus 로고
    • Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: Long term antigen stability in cancer patient plasma
    • Cummings J, Ranson M, Butt F et al. Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma. Cancer Chemother. Pharmacol. 60(6), 921-924 (2007).
    • (2007) Cancer Chemother. Pharmacol. , vol.60 , Issue.6 , pp. 921-924
    • Cummings, J.1    Ranson, M.2    Butt, F.3
  • 32
    • 0030770449 scopus 로고    scopus 로고
    • Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
    • Caulin C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J. Cell Biol. 138(6), 1379-1394 (1997).
    • (1997) J. Cell Biol. , vol.138 , Issue.6 , pp. 1379-1394
    • Caulin, C.1    Salvesen, G.S.2    Oshima, R.G.3
  • 33
    • 0031455379 scopus 로고    scopus 로고
    • Apoptosis generates stable fragments of human type i keratins
    • Ku NO, Liao J, Omary MB. Apoptosis generates stable fragments of human type I keratins. J. Biol. Chem. 272(52), 33197-33203 (1997).
    • (1997) J. Biol. Chem. , vol.272 , Issue.52 , pp. 33197-33203
    • Ku, N.O.1    Liao, J.2    Omary, M.B.3
  • 34
    • 0345040854 scopus 로고    scopus 로고
    • Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis
    • Leers MP, Kölgen W, Björklund V et al. Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis. J. Pathol. 187(5), 567-572 (1999).
    • (1999) J. Pathol. , vol.187 , Issue.5 , pp. 567-572
    • Leers, M.P.1    Kölgen, W.2    Björklund, V.3
  • 35
    • 12144290503 scopus 로고    scopus 로고
    • Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18
    • Kramer G, Erdal H, Mertens HJ et al. Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res. 64(5), 1751-1756 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.5 , pp. 1751-1756
    • Kramer, G.1    Erdal, H.2    Mertens, H.J.3
  • 36
    • 0036021196 scopus 로고    scopus 로고
    • A novel high-through-put assay for screening of pro-apoptotic drugs
    • Hägg M, Biven K, Ueno T et al. A novel high-through-put assay for screening of pro-apoptotic drugs. Invest. New Drugs 20(3), 253-259 (2002).
    • (2002) Invest. New Drugs , vol.20 , Issue.3 , pp. 253-259
    • Hägg, M.1    Biven, K.2    Ueno, T.3
  • 37
    • 0346035003 scopus 로고    scopus 로고
    • Measurement of an apoptosis product in the sera of breast cancer patients
    • Ueno T, Toi M, Bivén K et al. Measurement of an apoptosis product in the sera of breast cancer patients. Eur. J. Cancer 39, 769-774 (2003).
    • (2003) Eur. J. Cancer , vol.39 , pp. 769-774
    • Ueno, T.1    Toi, M.2    Bivén, K.3
  • 38
    • 33751538939 scopus 로고    scopus 로고
    • Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: A prospective pilot study
    • Demiray M, Ulukaya EE, Arslan M et al. Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: a prospective pilot study. Cancer Invest. 24(7), 669-676 (2006).
    • (2006) Cancer Invest. , vol.24 , Issue.7 , pp. 669-676
    • Demiray, M.1    Ulukaya, E.E.2    Arslan, M.3
  • 39
    • 64749109611 scopus 로고    scopus 로고
    • Circulating cell death products predict clinical outcome of colorectal cancer patients
    • Koelink PJ, Lamers CB, Hommes DW et al. Circulating cell death products predict clinical outcome of colorectal cancer patients. BMC Cancer 9, 88 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 88
    • Koelink, P.J.1    Lamers, C.B.2    Hommes, D.W.3
  • 40
    • 68149170221 scopus 로고    scopus 로고
    • Caspase-cleaved cytokeratin 18 fragment (M30) as marker of postoperative residual tumor load in colon cancer patients
    • Ausch C, Buxhofer-Ausch V, Olszewski U et al. Caspase-cleaved cytokeratin 18 fragment (M30) as marker of postoperative residual tumor load in colon cancer patients. Eur. J. Surg. Oncol. 35(11), 1164-1168 (2009).
    • (2009) Eur. J. Surg. Oncol. , vol.35 , Issue.11 , pp. 1164-1168
    • Ausch, C.1    Buxhofer-Ausch, V.2    Olszewski, U.3
  • 41
    • 34247642617 scopus 로고    scopus 로고
    • The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival
    • Ulukaya E, Yilmaztepe A, Akgoz S et al. The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival. Lung Cancer 56(3), 399-404 (2007).
    • (2007) Lung Cancer , vol.56 , Issue.3 , pp. 399-404
    • Ulukaya, E.1    Yilmaztepe, A.2    Akgoz, S.3
  • 42
    • 33745247388 scopus 로고    scopus 로고
    • Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles
    • Kramer G, Schwarz S, Hagg M et al. Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles. Br. J. Cancer 94(11), 1592-1598 (2006).
    • (2006) Br. J. Cancer , vol.94 , Issue.11 , pp. 1592-1598
    • Kramer, G.1    Schwarz, S.2    Hagg, M.3
  • 43
    • 54249157397 scopus 로고    scopus 로고
    • Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer
    • de Haas EC, di Pietro A, Simpson KL et al. Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer. Neoplasia 10(10), 1041-1048 (2008).
    • (2008) Neoplasia , vol.10 , Issue.10 , pp. 1041-1048
    • De Haas, E.C.1    Di Pietro, A.2    Simpson, K.L.3
  • 44
    • 63549125876 scopus 로고    scopus 로고
    • Elevated serum levels of M30 and M65 in patients with locally advanced head and neck tumors
    • Ozturk B, Coskun U, Sancak B et al. Elevated serum levels of M30 and M65 in patients with locally advanced head and neck tumors. Int. Immunopharmacol. 9(5), 645-648 (2009).
    • (2009) Int. Immunopharmacol. , vol.9 , Issue.5 , pp. 645-648
    • Ozturk, B.1    Coskun, U.2    Sancak, B.3
  • 45
    • 76349103498 scopus 로고    scopus 로고
    • Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer
    • Dive C, Smith RA, Garner E et al. Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. Br. J. Cancer 102(3), 577-582 (2010).
    • (2010) Br. J. Cancer , vol.102 , Issue.3 , pp. 577-582
    • Dive, C.1    Smith, R.A.2    Garner, E.3
  • 46
    • 68149159205 scopus 로고    scopus 로고
    • Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response
    • Scott LC, Evans TR, Cassidy J et al. Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response. Br. J. Cancer 101(3), 410-417 (2009).
    • (2009) Br. J. Cancer , vol.101 , Issue.3 , pp. 410-417
    • Scott, L.C.1    Evans, T.R.2    Cassidy, J.3
  • 47
    • 34250643551 scopus 로고    scopus 로고
    • Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy
    • Olofsson MH, Ueno T, Pan Y et al. Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy. Clin. Cancer Res. 13(11), 3198-3206 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.11 , pp. 3198-3206
    • Olofsson, M.H.1    Ueno, T.2    Pan, Y.3
  • 49
    • 58149340163 scopus 로고    scopus 로고
    • Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer
    • Micha D, Cummings J, Shoemaker A et al. Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer. Clin. Cancer Res. 14(22), 7304-7310 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.22 , pp. 7304-7310
    • Micha, D.1    Cummings, J.2    Shoemaker, A.3
  • 51
    • 0344393783 scopus 로고    scopus 로고
    • Alterations in the apoptotic machinery and their potential role in anticancer drug resistance
    • DOI 10.1038/sj.onc.1206945, Drug Resistance
    • Kaufmann SH, Vaux DL. Alterations in the apoptotic machinery and their potential role in anticancer drug resistance. Oncogene 22(47), 7414-7430 (2003). (Pubitemid 37487167)
    • (2003) Oncogene , vol.22 , Issue.REV. ISS. 6 , pp. 7414-7430
    • Kaufmann, S.H.1    Vaux, D.L.2
  • 52
    • 29944438881 scopus 로고    scopus 로고
    • Necrotic death as a cell fate
    • Zong WX, Thompson CB. Necrotic death as a cell fate. Genes Dev. 20(1), 1-15 (2006).
    • (2006) Genes Dev. , vol.20 , Issue.1 , pp. 1-15
    • Zong, W.X.1    Thompson, C.B.2
  • 53
    • 33845465718 scopus 로고    scopus 로고
    • Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA
    • DOI 10.1002/ijc.22132
    • Berndtsson M, Hagg M, Panaretakis T et al. Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA. Int. J. Cancer 120(1), 175-180 (2007). (Pubitemid 44901933)
    • (2007) International Journal of Cancer , vol.120 , Issue.1 , pp. 175-180
    • Berndtsson, M.1    Hagg, M.2    Panaretakis, T.3    Havelka, A.M.4    Shoshan, M.C.5    Linder, S.6


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