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Volumn 7, Issue 3, 2008, Pages 455-463

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Author keywords

[No Author keywords available]

Indexed keywords

ADZ 1152; ANTIGEN; AURORA KINASE INHIBITOR; AZD 1152; M30 ANTIGEN; M65 ANTIGEN; PYRAZOLE DERIVATIVE; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 41649101581     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-2136     Document Type: Article
Times cited : (56)

References (44)
  • 1
    • 0141642224 scopus 로고    scopus 로고
    • Medicine. The NIH roadmap
    • Zerhouni E. Medicine. The NIH roadmap. Science 2003;302:63-72.
    • (2003) Science , vol.302 , pp. 63-72
    • Zerhouni, E.1
  • 2
    • 33947596504 scopus 로고    scopus 로고
    • Why is cancer drug discovery so difficult?
    • Kamb A, Wee S, Lengauer C. Why is cancer drug discovery so difficult? Nat Rev Drug Discov 2007;6:115-20.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 115-120
    • Kamb, A.1    Wee, S.2    Lengauer, C.3
  • 3
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 2004;3:711-5.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 4
    • 33845974419 scopus 로고    scopus 로고
    • Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs
    • Wagner JA, Williams SA, Webster CJ. Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs. Clin Pharmacol Ther 2007;81:104-7.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 104-107
    • Wagner, J.A.1    Williams, S.A.2    Webster, C.J.3
  • 5
    • 0036399255 scopus 로고    scopus 로고
    • Overview of biomarkers and surrogate endpoints in drug development
    • Wagner JA. Overview of biomarkers and surrogate endpoints in drug development. Dis Markers 2002;18:41-6.
    • (2002) Dis Markers , vol.18 , pp. 41-46
    • Wagner, J.A.1
  • 6
    • 33745712124 scopus 로고    scopus 로고
    • Joint National Cancer Institute-Food and Drug Administration workshop on research strategies, study designs, and statistical approaches to biomarker validation for cancer diagnosis and detection
    • Maruvada P, Srivastava S. Joint National Cancer Institute-Food and Drug Administration workshop on research strategies, study designs, and statistical approaches to biomarker validation for cancer diagnosis and detection. Cancer Epidemiol Biomarkers Prev 2006;15:1078-82.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1078-1082
    • Maruvada, P.1    Srivastava, S.2
  • 7
    • 28544446695 scopus 로고    scopus 로고
    • Biomarkers in cancer staging, prognosis and treatment selection
    • Ludwig JA, Weinstein JN. Biomarkers in cancer staging, prognosis and treatment selection. Nat Cancer Rev 2005;5:845-56.
    • (2005) Nat Cancer Rev , vol.5 , pp. 845-856
    • Ludwig, J.A.1    Weinstein, J.N.2
  • 8
    • 0035908491 scopus 로고    scopus 로고
    • Phases of biomarker development for early detection of cancer
    • Pepe MS, Etzioni R, Feng Z, et al. Phases of biomarker development for early detection of cancer. J Natl Cancer Inst 2001;93:1054-61.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1054-1061
    • Pepe, M.S.1    Etzioni, R.2    Feng, Z.3
  • 9
    • 33744502855 scopus 로고    scopus 로고
    • Cancer biomarkers - an invitation to the table
    • Dalton WS, Friend SH. Cancer biomarkers - an invitation to the table. Science 2006;312:1165-8.
    • (2006) Science , vol.312 , pp. 1165-1168
    • Dalton, W.S.1    Friend, S.H.2
  • 10
    • 24344491449 scopus 로고    scopus 로고
    • Translational crossroads for biomarkers
    • Bast RC, Jr., Lilja H, Urban N, et al. Translational crossroads for biomarkers. Clin Cancer Res 2005;11:6103-8.
    • (2005) Clin Cancer Res , vol.11 , pp. 6103-6108
    • Bast Jr., R.C.1    Lilja, H.2    Urban, N.3
  • 11
    • 33750515034 scopus 로고    scopus 로고
    • A cost-effectiveness approach to the qualification and acceptance of biomarkers
    • Williams SA, Slavin DE, Wagner JA, Webster CJ. A cost-effectiveness approach to the qualification and acceptance of biomarkers. Nat Rev Drug Discov 2006;5:897-902.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 897-902
    • Williams, S.A.1    Slavin, D.E.2    Wagner, J.A.3    Webster, C.J.4
  • 12
    • 33845293253 scopus 로고    scopus 로고
    • Pharmacodynamic biomarkers for molecular cancer therapeutics
    • Sarker D, Workman P. Pharmacodynamic biomarkers for molecular cancer therapeutics. Adv Cancer Res 2007;96:213-68.
    • (2007) Adv Cancer Res , vol.96 , pp. 213-268
    • Sarker, D.1    Workman, P.2
  • 13
    • 0036021196 scopus 로고    scopus 로고
    • A novel high-through-put assay for screening of pro-apoptotic drugs
    • Hagg M, Biven K, Ueno T, et al. A novel high-through-put assay for screening of pro-apoptotic drugs. Invest New Drugs 2002;20:253-9.
    • (2002) Invest New Drugs , vol.20 , pp. 253-259
    • Hagg, M.1    Biven, K.2    Ueno, T.3
  • 14
    • 12144290503 scopus 로고    scopus 로고
    • Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18
    • Kramer G, Erdal H, Mertens HJ, et al. Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res 2004;64:1751-6.
    • (2004) Cancer Res , vol.64 , pp. 1751-1756
    • Kramer, G.1    Erdal, H.2    Mertens, H.J.3
  • 15
    • 0345040854 scopus 로고    scopus 로고
    • Immunocytochemical detection and mappingof a cytokeratin 18 neo-epitope exposed during early apoptosis
    • Leers MP, Kolgen W, Bjorklund V, et al. Immunocytochemical detection and mappingof a cytokeratin 18 neo-epitope exposed during early apoptosis. J Pathol 1999;187:567-72.
    • (1999) J Pathol , vol.187 , pp. 567-572
    • Leers, M.P.1    Kolgen, W.2    Bjorklund, V.3
  • 16
    • 2942601770 scopus 로고    scopus 로고
    • Keratin 8/18 breakdown and reorganization during apoptosis
    • Schutte B, Henfling M, Kolgen W, et al. Keratin 8/18 breakdown and reorganization during apoptosis. Exp Cell Res 2004;297:11-26.
    • (2004) Exp Cell Res , vol.297 , pp. 11-26
    • Schutte, B.1    Henfling, M.2    Kolgen, W.3
  • 17
    • 33745529219 scopus 로고    scopus 로고
    • Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP
    • Cummings J, Ranson M, Lacasse E, et al. Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. Br J Cancer 2006;95:42-8.
    • (2006) Br J Cancer , vol.95 , pp. 42-48
    • Cummings, J.1    Ranson, M.2    Lacasse, E.3
  • 18
    • 15244345318 scopus 로고    scopus 로고
    • Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP
    • Cummings J, Ward TH, Lacasse E, et al. Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. Br J Cancer 2005;92:532-8.
    • (2005) Br J Cancer , vol.92 , pp. 532-538
    • Cummings, J.1    Ward, T.H.2    Lacasse, E.3
  • 19
    • 0346035003 scopus 로고    scopus 로고
    • Measurement of an apoptotic product in the sera of breast cancer patients
    • Ueno T, Toi M, Biven K, Bando H, Ogawa T, Linder S. Measurement of an apoptotic product in the sera of breast cancer patients. Eur J Cancer 2003;39:769-74.
    • (2003) Eur J Cancer , vol.39 , pp. 769-774
    • Ueno, T.1    Toi, M.2    Biven, K.3    Bando, H.4    Ogawa, T.5    Linder, S.6
  • 20
    • 33751538939 scopus 로고    scopus 로고
    • Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: A prospective pilot study
    • Demiray M, Ulukaya EE, Arslan M, et al. Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: a prospective pilot study. Cancer Invest 2006;24:669-76.
    • (2006) Cancer Invest , vol.24 , pp. 669-676
    • Demiray, M.1    Ulukaya, E.E.2    Arslan, M.3
  • 21
    • 34247642617 scopus 로고    scopus 로고
    • The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lungcancer and helpful to predict the survival
    • Ulukaya E, Yilmaztepe A, Akgoz S, Linder S, Karadag M. The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lungcancer and helpful to predict the survival. Lung Cancer 2007;56:399-404.
    • (2007) Lung Cancer , vol.56 , pp. 399-404
    • Ulukaya, E.1    Yilmaztepe, A.2    Akgoz, S.3    Linder, S.4    Karadag, M.5
  • 22
    • 34250643551 scopus 로고    scopus 로고
    • Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy
    • Olofsson MH, Ueno T, Pan Y, et al. Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy. Clin Cancer Res 2007;13:3198-206.
    • (2007) Clin Cancer Res , vol.13 , pp. 3198-3206
    • Olofsson, M.H.1    Ueno, T.2    Pan, Y.3
  • 23
    • 34250739960 scopus 로고    scopus 로고
    • AZD1152, a selective inhibitor of aurora B kinase, inhibits human tumor xenograft growth by inducingapop tosis
    • Wilkinson RW, Odedra R, Heaton SP, et al. AZD1152, a selective inhibitor of aurora B kinase, inhibits human tumor xenograft growth by inducingapop tosis. Clin Cancer Res 2007;13:3682-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 3682-3688
    • Wilkinson, R.W.1    Odedra, R.2    Heaton, S.P.3
  • 24
    • 34247603906 scopus 로고    scopus 로고
    • Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase
    • Mortlock AA, Foote KM, Heron NM, et al. Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J Med Chem 2007;50:2213-24.
    • (2007) J Med Chem , vol.50 , pp. 2213-2224
    • Mortlock, A.A.1    Foote, K.M.2    Heron, N.M.3
  • 25
    • 0033535347 scopus 로고    scopus 로고
    • Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
    • Griffiths GJ, Dubrez L, Morgan CP, et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol 1999;144:903-14.
    • (1999) J Cell Biol , vol.144 , pp. 903-914
    • Griffiths, G.J.1    Dubrez, L.2    Morgan, C.P.3
  • 26
    • 0028800947 scopus 로고
    • Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
    • Martin SJ, Reutelingsperger CP, McGahon AJ, et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995;182:1545-56.
    • (1995) J Exp Med , vol.182 , pp. 1545-1556
    • Martin, S.J.1    Reutelingsperger, C.P.2    McGahon, A.J.3
  • 27
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005;65:4389-400.
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 28
    • 0029029436 scopus 로고
    • Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen
    • Goldwasser F, Bae I, Valenti M, Torres K, Pommier Y. Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen. Cancer Res 1995;55:2116-21.
    • (1995) Cancer Res , vol.55 , pp. 2116-2121
    • Goldwasser, F.1    Bae, I.2    Valenti, M.3    Torres, K.4    Pommier, Y.5
  • 29
    • 33846523617 scopus 로고    scopus 로고
    • Targeted anti-mitotic therapies: Can we improve on tubulin agents?
    • Jackson JR, Patrick DR, Dar MM, Huang PS. Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer 2007;7:107-17.
    • (2007) Nat Rev Cancer , vol.7 , pp. 107-117
    • Jackson, J.R.1    Patrick, D.R.2    Dar, M.M.3    Huang, P.S.4
  • 30
    • 4344576754 scopus 로고    scopus 로고
    • Determining-tumor apoptosis and necrosis in patient serum usingcytok eratin 18 as a biomarker
    • Linder S, Havelka AM, Ueno T, Shoshan MC. Determining-tumor apoptosis and necrosis in patient serum usingcytok eratin 18 as a biomarker. Cancer Lett 2004;214:1-9.
    • (2004) Cancer Lett , vol.214 , pp. 1-9
    • Linder, S.1    Havelka, A.M.2    Ueno, T.3    Shoshan, M.C.4
  • 31
    • 33644534872 scopus 로고    scopus 로고
    • Detection of epithelial cell death in the body by cytokeratin 18 measurement
    • Ueno T, Toi M, Linder S. Detection of epithelial cell death in the body by cytokeratin 18 measurement. Biomed Pharmacother 2005;59 Suppl 2:S359-62.
    • (2005) Biomed Pharmacother , vol.59 , Issue.SUPPL. 2
    • Ueno, T.1    Toi, M.2    Linder, S.3
  • 32
    • 33745247388 scopus 로고    scopus 로고
    • Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles
    • Kramer G, Schwarz S, Hagg M, Havelka AM, Linder S. Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles. Br J Cancer 2006;94:1592-8.
    • (2006) Br J Cancer , vol.94 , pp. 1592-1598
    • Kramer, G.1    Schwarz, S.2    Hagg, M.3    Havelka, A.M.4    Linder, S.5
  • 33
    • 0021525316 scopus 로고
    • Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: Re-evaluation of a human tumor marker
    • Weber K, Osborn M, Moll R, Wiklund B, Luning B. Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: re-evaluation of a human tumor marker. EMBO J 1984;3:2707-14.
    • (1984) EMBO J , vol.3 , pp. 2707-2714
    • Weber, K.1    Osborn, M.2    Moll, R.3    Wiklund, B.4    Luning, B.5
  • 34
    • 0028939418 scopus 로고
    • A novel IRMA and ELISA for quantifying cytokeratin 8 and 18 fragments in the sera of healthy individuals and cancer patients
    • Silen A, Wiklund B, Andersson EL, Nilsson S. A novel IRMA and ELISA for quantifying cytokeratin 8 and 18 fragments in the sera of healthy individuals and cancer patients. Scand J Clin Lab Invest 1995;55:153-61.
    • (1995) Scand J Clin Lab Invest , vol.55 , pp. 153-161
    • Silen, A.1    Wiklund, B.2    Andersson, E.L.3    Nilsson, S.4
  • 37
    • 33644874982 scopus 로고    scopus 로고
    • Newly developed assay measuring cytokeratins 8, 18 and 19 in serum is correlated to survival and tumor volume in patients with esophageal carcinoma
    • Brattstrom D, Wagenius G, Sandstrom P, et al. Newly developed assay measuring cytokeratins 8, 18 and 19 in serum is correlated to survival and tumor volume in patients with esophageal carcinoma. Dis Esophagus 2005;18:298-303.
    • (2005) Dis Esophagus , vol.18 , pp. 298-303
    • Brattstrom, D.1    Wagenius, G.2    Sandstrom, P.3
  • 38
    • 0033500098 scopus 로고    scopus 로고
    • TPS: A cytokeratin serum tumour marker for effective therapy control of cancer patient with focus on breast cancer
    • Einarsson R, Barak V. TPS: a cytokeratin serum tumour marker for effective therapy control of cancer patient with focus on breast cancer. J Clin Ligand Assay 1997;22:348-51.
    • (1997) J Clin Ligand Assay , vol.22 , pp. 348-351
    • Einarsson, R.1    Barak, V.2
  • 39
    • 0035866040 scopus 로고    scopus 로고
    • The role of caspase 3 in producing cytokeratin 19 fragment (CYFRA21-1) in human lung cancer cell lines
    • Dohmoto K, Hojo S, Fujita J, et al. The role of caspase 3 in producing cytokeratin 19 fragment (CYFRA21-1) in human lung cancer cell lines. Int J Cancer 2001;91:468-73.
    • (2001) Int J Cancer , vol.91 , pp. 468-473
    • Dohmoto, K.1    Hojo, S.2    Fujita, J.3
  • 40
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001;411:342-8.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 41
    • 4544321561 scopus 로고    scopus 로고
    • Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoepitope M30 in critically ill patients
    • Roth GA, Krenn C, Brunner M, et al. Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoepitope M30 in critically ill patients. Shock 2004;22:218-20.
    • (2004) Shock , vol.22 , pp. 218-220
    • Roth, G.A.1    Krenn, C.2    Brunner, M.3
  • 43
    • 7044220856 scopus 로고    scopus 로고
    • Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury
    • Bantel H, Lugering A, Heidemann J, et al. Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 2004;40:1078-87.
    • (2004) Hepatology , vol.40 , pp. 1078-1087
    • Bantel, H.1    Lugering, A.2    Heidemann, J.3
  • 44
    • 33845654847 scopus 로고    scopus 로고
    • Clinical trial of the pancaspase inhibitor, IDN-6556, in human liver preservation injury
    • Baskin-Bey ES, Washburn K, Feng S, et al. Clinical trial of the pancaspase inhibitor, IDN-6556, in human liver preservation injury. Am J Transplant 2007;7:218-25.
    • (2007) Am J Transplant , vol.7 , pp. 218-225
    • Baskin-Bey, E.S.1    Washburn, K.2    Feng, S.3


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