Twenty-eight-day bed rest with hypercortisolemia induces peripheral insulin resistance and increases intramuscular triglycerides

Metabolism: Clinical and Experimental

Volumn 59, Issue 5, 2010, Pages 703-710

  Cree, Melanie G ^a   Paddon Jones, Douglas ^a   Newcomer, Bradley R ^b   Ronsen, Ola ^a,c   Aarsland, Asle ^a   Wolfe, Robert R ^a,d   Ferrando, Arny ^a,d  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Norwegian National Sports Center   (Norway)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BED REST; FEMORAL ARTERY; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPERCORTISOLISM; HYPERINSULINEMIA; INSULIN INFUSION; INSULIN RESISTANCE; MALE; MUSCLE CONTRACTION; MUSCLE LEVEL; MUSCLE METABOLISM; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SKELETAL MUSCLE; STRESS;

ADULT; BED REST; BLOOD GLUCOSE; BODY WEIGHT; CUSHING SYNDROME; FATTY ACIDS, NONESTERIFIED; GLUCOSE CLAMP TECHNIQUE; GLYCEROL; HUMANS; INSULIN; INSULIN RESISTANCE; LINEAR MODELS; MALE; MUSCLE, SKELETAL; TRIGLYCERIDES;

EID: 77950618361     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.09.014     Document Type: Article

References (57)

1. Strollo F., Riondino G., Harris B., Strollo G., Casarosa E., Mangrossa N., et al. The effect of microgravity on testicular androgen secretion. Aviat Space Environ Med 69 (1998) 133-136
2. Macho L., Koska J., Ksinantova L., Pacak K., Hoff T., Noskov V.B., et al. The response of endocrine system to stress loads during space flight in human subject. Adv Space Res 31 (2003) 1605-1610
3. Stein T.P., Schulter M.D., and Boden G. Development of insulin resistance by astronauts during spaceflight. Aviat Space Environ Med 65 (1994) 1091-1096
4. Stein T.P., and Schluter M.D. Excretion of IL-6 by astronauts during spaceflight. The Am J Physiol 266 (1994) E448-E452
5. Ferrando A.A., Stuart C.S., Sheffield-Moore M., and Wolfe R.R. Inactivity amplifies the catabolic response of skeletal muscle to cortisol. J Clin Endocrinol Metab 84 (1999) 3515-3521
6. Mikines K.J., Richter E.A., Dela F., and Galbo H. Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body. J Appl Physiol 70 (1991) 1245-1254
7. Shangraw R.E., Stuart C.A., Prince M.J., Peters E.J., and Wolfe R.R. Insulin responsiveness of protein metabolism in vivo following bed rest in humans. Am J Physiol 255 (1988) E548-558
8. Stuart C.A., Shangraw R.E., Prince M.J., Peters E.J., and Wolfe R.R. Bed-rest-induced insulin resistance occurs primarily in muscle. Metabolism 37 (1988) 802-806
9. Blanc S., Normand S., Pachiaudi C., Fortrat J.O., Laville M., and Gharib C. Fuel homeostasis during physical inactivity induced by bed rest. J Clin Endocrinol Metab 85 (2000) 2223-2233
10. Svanfeldt M., Thorell A., Brismar K., Nygren J., and Ljungqvist O. Effects of 3 days of "postoperative" low caloric feeding with or without bed rest on insulin sensitivity in healthy subjects. Clin Nutr 22 (2003) 31-38
11. van den Berghe G., Wouters P., Weekers F., Verwaest C., Bruyninckx F., Schetz M., et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 345 (2001) 1359-1367
12. Gelfand R.A., Matthews D.E., Bier D.M., and Sherwin R.S. Role of counterregulatory hormones in the catabolic response to stress. J Clin Invest 74 (1984) 2238-2248
13. Woolf P.D. Hormonal responses to trauma. Crit Care Med 20 (1992) 216-226
14. Khani S., and Tayek J.A. Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome. Clin Sci (Lond) 101 (2001) 739-747
15. Nielsen M.F., Caumo A., Chandramouli V., Schumann W.C., Cobelli C., Landau B.R., et al. Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects. Am J Physiol Endocrinol Metab 286 (2004) E102-110
16. Rizza R.A., Mandarino L.J., and Gerich J.E. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action. J Clin Endocrinol Metab 54 (1982) 131-138
17. Petersen K.F., and Shulman G.I. Etiology of insulin resistance. Am J Med 119 (2006) S10-16
18. Djurhuus C.B., Gravholt C.H., Nielsen S., Pedersen S.B., Moller N., and Schmitz O. Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans. Am J Physiol 286 (2004) E488-494
19. Paddon-Jones D., Sheffield-Moore M., Urban R.J., Aarsland A., Wolfe R.R., and Ferrando A.A. The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation. J Clin Endocrinol Metab 90 (2005) 1453-1459
20. Paddon-Jones D., Sheffield-Moore M., Urban R.J., Sanford A.P., Aarsland A., Wolfe R.R., et al. Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab 89 (2004) 4351-4358
21. Ferrando A.A., Lane H.W., Stuart C.A., and Wolfe R.R. Prolonged bed rest decreases skeletal muscle and whole-body protein synthesis. Am J Physiol (Endocrinol Metab) 270 (1996) E627-E633
22. Biolo G., Fleming D.Y., Maggi S., and Wolfe R.R. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol (Endocrinol Metab) 268 (1995) E75-E84
23. Jorfeld L., and Warhen J. Leg blood flow during exercise in man. Clin Sci 41 (1971) 459-473
24. Bergstrom J., Furst P., Noree L.O., and Vinnars E. Intracellular free amino acid concentration in human muscle tissue. J App Physiol 36 (1974) 693-697
25. Paddon-Jones D., Sheffield-Moore M., Creson D.L., Sanford A.P., Wolf S.E., Wolfe R.R., et al. Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids. Am J Physiol Endocrinol Metab 284 (2003) E946-953
26. Cree M.G., Newcomer B.R., Herndon D.N., Qian T., Sun D., Morio B., et al. PPAR-alpha agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial. Nutr Metab (Lond) 4 (2007) 9
27. Cree M.G., Newcomer B.R., Katsanos C.S., Sheffield-Moore M., Chinkes D., Aarsland A., et al. Intramuscular and liver triglycerides are increased in the elderly. J Clin Endocrinol Metab 89 (2004) 3864-3871
28. Perseghin G., Scifo P., De Cobelli F., Pagliato E., Battezzati A., Arcelloni C., et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48 (1999) 1600-1606
29. Klose U. In vivo proton spectroscopy in presence of eddy currents. Magnetic Resonance in Medicine 14 (1990) 26-30
30. van den Boogaart A. MRUI manual V.96.3. A user's guide to the magnetic resonance user interface software package (1997), Delft Technical University Press, Delft
31. van den Boogaart A., Van Hecke A., Van Huffel P., Graveron-Demilly S., van Ormondt D., and de Beer R. MRUI: a graphical user interface for accurate routine MRS data analysis. Proceedings of the ESMRMB 13th Annual Meeting, Prague (1996) 318
32. Vanhamme L., van den Boogaart A., and Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 129 (1997) 35-43
33. Cree M.G., Newcomer B.R., Read L.K., Sheffield-Moore M., Paddon-Jones D., Chinkes D., et al. Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment. Mech Ageing Dev 128 (2007) 558-565
34. Rico-Sanz J., Thomas E.L., Jenkinson G., Mierisova S., Iles R., and Bell J.D. Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS. J Appl Physiol 87 (1999) 2068-2072
35. Thyfault J.P., Cree M.G., Zheng D., Zwetsloot J.J., Tapscott E.B., Koves T.R., et al. Contraction of insulin resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. Am J Physiol Cell Physiol (2006)
36. Paddon-Jones D., Sheffield-Moore M., Cree M.G., Hewlings S.J., Aarsland A., Wolfe R.R., et al. Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab 91 (2006) 4836-4841
37. Astrakas L.G., Goljer I., Yasuhara S., Padfield K.E., Zhang Q., Gopalan S., et al. Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis. FASEB J 19 (2005) 1431-1440
38. Boden G., Chen X., Ruiz J., White J.V., and Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93 (1994) 2438-2446
39. Cree M.G., Aarsland A., Herndon D.N., and Wolfe R.R. Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance. Crit Care Med 35 (2007) S476-483
40. Cree M.G., Zwetsloot J.J., Herndon D.N., Qian T., Morio B., Fram R., et al. Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg 245 (2007) 214-221
41. Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothman D.L., et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300 (2003) 1140-1142
42. Hulver M.W., and Dohm G.L. The molecular mechanism linking muscle fat accumulation to insulin resistance. Proc Nutr Soc 63 (2004) 375-380
43. Cree M.G., Zwetsloot J.J., Herndon D.N., Newcomer B.R., Fram R.Y., Angel C., et al. Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. J Burn Care Res 29 (2008) 585-594
44. Dube J.J., Amati F., Stefanovic-Racic M., Toledo F.G., Sauers S.E., and Goodpaster B.H. Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am J Physiol 294 (2008) E882-E888
45. Wolfe R.R. Regulation of skeletal muscle protein metabolism in catabolic states. J Clin Nutr Metab 8 (2005) 61-65
46. Woolf P.D. Hormonal responses to trauma. J Clin Invest 74 (1984) 216-226
47. Wolfe R.R. Regulation of skeletal muscle protein metabolism in catabolic states. Ann Surg 8 (2005) 61-65
48. Woolf P.D. Hormonal responses to trauma. Am J Physiol 20 (1996) 216-226
49. Yanagibori R., Suzuki Y., Kawakubo K., Makita Y., and Gunji A. Carbohydrate and lipid metabolism after 20 days of bed rest. Acta Physiol Scand Suppl 616 (1994) 51-57
50. Nygren J., Thorell A., Efendic S., Nair K.S., and Ljungqvist O. Site of insulin resistance after surgery: the contribution of hypocaloric nutrition and bed rest. Clin Sci (Lond) 93 (1997) 137-146
51. Carter-Su C., and Okamoto K. Effect of insulin and glucocorticoids on glucose transporters in rat adipocytes. Am J Physiol 252 (1987) E441-453
52. Coderre L., Vallega G.A., Pilch P.F., and Chipkin S.R. In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution. Am J Physiol 271 (1996) E643-648
53. Holt H.B., Wild S.H., Postle A.D., Zhang J., Koster G., Umpleby M., et al. Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men. Diabetologia 50 (2007) 1024-1032
54. Tappy L., Randin D., Vollenweider P., Vollenweider L., Paquot N., Scherrer U., et al. Mechanisms of dexamethasone-induced insulin resistance in healthy humans. J Clin Endocrinol Metab 79 (1994) 1063-1069
55. Uchakin P.N., Stowe R., Paddon-Jones D., Tobin B.W., Ferrando A.A., and Wolfe R.R. Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Aviat Space Environ Med 78 (2007) 608-612
56. Ruzzin J., Wagman A.S., and Jensen J. Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor. Diabetologia 48 (2005) 2119-2130
57. Glass D.J. Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nat Cell Biol 5 (2003) 87-90