Alternative splicing attenuates transgenic expression directed by the apolipoprotein e promoter-enhancer based expression vector pLIV11

Journal of Lipid Research

Volumn 51, Issue 4, 2010, Pages 849-855

  Cheng, Dongmei ^a   MacArthur, Philip S ^a   Rong, Shunxing ^a   Parks, John S ^a   Shelness, Gregory S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Exon skipping; Liver specifi c transgenic expression; Microsomal triglyceride transfer protein; RNA processing; Transgenic mice

Indexed keywords

APOLIPOPROTEIN E; COMPLEMENTARY DNA; LIVER PROTEIN; MESSENGER RNA; PLASMID VECTOR; PROTEIN LIV11; UNCLASSIFIED DRUG; CARRIER PROTEIN; DROSOPHILA PROTEIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; ATTENUATION; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; DOWNSTREAM PROCESSING; EXON SKIPPING; EXPRESSION VECTOR; GENE DELETION; GENE INSERTION SEQUENCE; GENETIC ENGINEERING; HUMAN; HUMAN CELL; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSGENICS; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; DROSOPHILA; ENHANCER REGION; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; HEPG2 CELL LINE; LIVER; METABOLISM; PLASMID; PROCEDURES; SPECIES DIFFERENCE; TRANSGENE; TRANSGENIC MOUSE;

ALTERNATIVE SPLICING; ANIMALS; APOLIPOPROTEINS E; CARRIER PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETIC VECTORS; HEP G2 CELLS; HUMANS; LIVER; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; PLASMIDS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SPECIES SPECIFICITY; TRANSGENES;

EID: 77950614367     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.D002709     Document Type: Article

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