Hepadnaviral infection augments hepatocyte cytotoxicity mediated by both CD95 ligand and perforin pathways

Liver International

Volumn 30, Issue 3, 2010, Pages 396-405

  Guy, Clifford S ^a   Wang, Jinguo ^a   Michalak, Tomasz I ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

CD95 mediated cell killing; CD95L; Hepadnaviral infection; Hepatic innate immunity; Hepatocyte cytotoxicity; Perforin dependent cell killing

Indexed keywords

FAS LIGAND; GAMMA INTERFERON; PERFORIN;

ACUTE HEPATITIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CONTACT; CELL KILLING; CELL MEMBRANE POTENTIAL; CHRONIC HEPATITIS; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; FEMALE; GENETIC TRANSFECTION; HEPADNAVIRUS; HEPADNAVIRUS INFECTION; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; LIVER CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; VIRUS GENE; VIRUS HEPATITIS; VIRUS REPLICATION; WOODCHUCK; WOODCHUCK HEPATITIS; WOODCHUCK HEPATITIS VIRUS;

ANIMALS; ANTIGENS, CD3; ANTIGENS, CD95; CELL LINE, TUMOR; FAS LIGAND PROTEIN; GRANZYMES; HEPADNAVIRIDAE INFECTIONS; HEPATITIS ANTIBODIES; HEPATITIS ANTIGENS; HEPATITIS B VIRUS, WOODCHUCK; HEPATOCYTES; INTERFERON-GAMMA, RECOMBINANT; LIVER; MARMOTA; PERFORIN; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77950607059     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02168.x     Document Type: Article

References (37)

1. Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology 2006, 43:S54-62.
2. Crispe IN, Dao T, Klugewitz K. The liver as a site of T-cell apoptosis: graveyard, or killing field? Immunol Rev 2000, 174:47-62.
3. Diehl L, Schurich A, Grochtmann R. Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8(+) T cell tolerance. Hepatology 2008, 47:296-305.
4. Mehal WZ, Azzaroli F, Crispe IN. Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J Immunol 2001, 167:667-73.
5. Warren A, Le Couteur DG, Fraser R. T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology 2006, 44:1182-90.
6. Guy CS, Rankin SL, Wang J, Michalak TI. Hepatocytes can induce death of contacted cells via a perforin-dependent mechanism. Hepatology 2008, 47:1691-701.
7. Guy CS, Wang J, Michalak TI. Hepatocytes as cytotoxic effector cells can induce cell death by CD95 ligand-mediated pathway. Hepatology 2006, 43:1231-40.
8. Guidotti LG, Ishikawa T, Hobbs MV. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996, 4:25-36.
9. Kakimi K, Guidotti LG, Koezuka Y, Chisari FV. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med 2000, 192:921-30.
10. Hodgson PD, Michalak TI. Augmented hepatic interferon gamma expression and T-cell influx characterize acute hepatitis progressing to recovery and residual lifelong virus persistence in experimental adult woodchuck hepatitis virus infection. Hepatology 2001, 34:1049-59.
11. Hodgson PD, Grant MD, Michalak TI. Perforin and Fas/Fas ligand-mediated cytotoxicity in acute and chronic woodchuck viral hepatitis. Clin Exp Immunol 1999, 118:63-70.
12. Churchill ND, Michalak TI. Woodchuck hepatitis virus hepatocyte culture models. Methods Mol Med 2004, 96:175-87.
13. Wang J, Michalak TI. Inhibition by woodchuck hepatitis virus of class I major histocompatibility complex presentation on hepatocytes is mediated by virus envelope pre-S2 protein and can be reversed by treatment with gamma interferon. J Virol 2006, 80:8541-53.
14. Coffin CS, Pham TN, Mulrooney PM. Persistence of isolated antibodies to woodchuck hepatitis virus core antigen is indicative of occult infection. Hepatology 2004, 40:1053-61.
15. Michalak TI, Pardoe IU, Coffin CS. Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis. Hepatology 1999, 29:928-38.
16. Michalak TI, Mulrooney PM, Coffin CS. Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver. J Virol 2004, 78:1730-8.
17. Wang J, Michalak TI. Comparison of biological activity of recombinant woodchuck interferon gamma and tumor necrosis factor alpha produced in baculovirus and Escherichia coli expression systems. Cytokine 2005, 30:22-34.
18. Guy CS, Mulrooney-Cousins PM, Churchill ND, Michalak TI. Intrahepatic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus. J Virol 2008, 82:8579-91.
19. Wang J, Gujar SA, Cova L, Michalak TI. Bicistronic woodchuck hepatitis virus core and gamma interferon DNA vaccine can protect from hepatitis but does not elicit sterilizing antiviral immunity. J Virol 2007, 81:903-16.
20. Thimme R, Wieland S, Steiger C. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003, 77:68-76.
21. Sitia G, Isogawa M, Iannacone M. MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. J Clin Invest 2004, 113:1158-67.
22. Luo KX, Zhu YF, Zhang LX. In situ investigation of Fas/FasL expression in chronic hepatitis B infection and related liver diseases. J Viral Hepat 1997, 4:303-7.
23. Huang L, Soldevila G, Leeker M. The liver eliminate T cells undergoing antigen-triggered apoptosis in vivo. Immunity 1994, 1:741-9.
24. Samlowski WE, Spangrude GJ, Daynes RA. Studies on the liver sequestation of lymphocytes bearing membrane-associated galactose-terminal glycoconjugates: reversal with agents that effectively compete for the asialoglycoprotein receptor. Cell Immunol 1984, 88:309-22.
25. Signore A, Annovazzi A, Gradini R, Liddi R. Fas and Fas ligand-mediated apoptosis and its role in autoimmune diabetes. Diabetes Metab Rev 1998, 14:197-206.
26. Pearl-Yafe M, Yolcu ES, Yaniv I. The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation. Bioessays 2006, 28:211-22.
27. Matloubian M, Suresh M, Glass A. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol 1999, 73:2527-36.
28. Siegel RM, Chan FK, Chun HJ, Lenardo MJ. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol 2000, 1:469-74.
29. Suzuki I, Fink PJ. The dual functions of Fas ligand in the regulation of peripheral CD8+ and CD4+ T cells. Proc Natl Acad Sci USA 2000, 97:1707-12.
30. Desbarats J, Newell MK. Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 2000, 6:920-3.
31. Pham BN, Martinot-Peignoux M, Valla D. Differential expression of perforin and granzyme B in the liver of patients with chronic hepatitis C. Hum Pathol 2003, 34:770-7.
32. Salcedo TW, Azzoni L, Wolf SF, Perussia B. Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. J Immunol 1993, 151:2511-20.
33. Shresta S, Russell JH, Ley TJ. Mechanisms responsible for granzyme B-independent cytotoxicity. Blood 1997, 89:4085-91.
34. Iken K, Huang L, Bekele H, Schmidt EV, Koziel MJ. Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction. Virology 2006, 346:363-72.
35. Lee MO, Choi YH, Shin EC. Hepatitis B virus X protein induced expression of interleukin 18 (IL-18): a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection. J Hepatol 2002, 37:380-6.
36. Lara-Pezzi E, Majano PL, Gomez-Gonzalo M. The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes. Hepatology 1998, 28:1013-21.
37. Murakami S. Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol 2001, 36:651-60.