D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model

NeuroImage

Volumn 50, Issue 4, 2010, Pages 1402-1407

  Skinbjerg, Mette ^a,b,c   Liow, Jeih San ^a   Seneca, Nicholas ^a   Hong, Jinsoo ^a   Lu, Shuiyu ^a   Thorsell, Annika ^d   Heilig, Markus ^d   Pike, Victor W ^a   Halldin, Christer ^b   Sibley, David R ^c   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

11C MNPA; 18F fallypride; Arrestin3; D2 receptor; Dopamine; Internalization; PET

Indexed keywords

AMPHETAMINE; BETA ARRESTIN; BETA ARRESTIN 3; CARBON 11; DOPAMINE 2 RECEPTOR; FLUORINE 18; RADIOLIGAND; UNCLASSIFIED DRUG; ARRESTIN3; CARBON; DOPAMINE RECEPTOR STIMULATING AGENT; FLUORINE; NAPROXEN; RADIOPHARMACEUTICAL AGENT; RETINA S ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; IN VIVO STUDY; INTERNALIZATION; KNOCKOUT MOUSE; LIGAND BINDING; MALE; MOUSE; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; RADIOACTIVITY; TRANSPORT KINETICS; WILD TYPE; ANIMAL; BRAIN; CELL MEMBRANE; CEREBELLUM; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; SCINTISCANNING; TIME;

AMPHETAMINE; ANIMALS; ARRESTINS; BRAIN; CARBON RADIOISOTOPES; CELL MEMBRANE; CEREBELLUM; CORPUS STRIATUM; DOPAMINE AGENTS; FEMALE; FLUORINE RADIOISOTOPES; MALE; MICE; MICE, KNOCKOUT; NAPROXEN; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE D2; TIME FACTORS;

EID: 77950595303     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2010.01.055     Document Type: Article

References (33)

1. Bjork K., Rimondini R., Hansson A.C., Terasmaa A., Hyytia P., Heilig M., and Sommer W.H. Modulation of voluntary ethanol consumption by beta-arrestin 2. FASEB J. 22 (2008) 2552-2560
2. Bjurling P., Reineck R., Westerburg G., Gee A.D., Sutcliffe J., and Långström B. Synthia, a compact radiochemistry system for automated production of radiopharmaceuticals. In: Link J.M., and Ruth T.J. (Eds). Proceedings-Sixth Workshop on Targetry and Target Chemistry (1995), TRIUMF, Vancouver 282-284
3. 11C]raclopride as measured by PET. Synapse 51 (2004) 27-31
4. 3H]propyl-norapomorphine to dopamine receptors in living mouse striatum: occupancy by endogenous dopamine and guanosine triphosphate-free G protein. J. Cereb. Blood Flow Metab. 22 (2002) 596-604
5. 11C]MNPA. Synapse 63 (2009) 378-389
6. Gao Y.G., Baldessarini R.J., Kula N.S., and Neumeyer J.L. Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. J. Med. Chem. 33 (1990) 1800-1805
7. 2 receptors in vivo using positron emission tomography. J. Neurochem. 97 (2006) 1089-1103
8. 11C]raclopride positron emission tomography study in cats. Biol. Psychiatry 55 (2004) 1188-1194
9. 11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J. Cereb. Blood Flow Metab. 23 (2003) 1096-1112
10. Innis R.B., Cunningham V.J., Delforge J., Fujita M., Gjedde A., Gunn R.N., Holden J., Houle S., Huang S.C., Ichise M., Iida H., Ito H., Kimura Y., Koeppe R.A., Knudsen G.M., Knuuti J., Lammertsma A.A., Laruelle M., Logan J., Maguire R.P., Mintun M.A., Morris E.D., Parsey R., Price J.C., Slifstein M., Sossi V., Suhara T., Votaw J.R., Wong D.F., and Carson R.E. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J. Cereb. Blood Flow Metab. 27 (2007) 1533-1539
11. Kim J.S., Lee J.S., Im K.C., Kim S.J., Kim S.Y., Lee D.S., and Moon D.H. Performance measurement of the microPET Focus 120 scanner. J. Nucl. Med. 48 (2007) 1527-1535
12. Kohout T.A., Lin F.S., Perry S.J., Conner D.A., and Lefkowitz R.J. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 1601-1606
13. Laruelle M. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J. Cereb. Blood Flow Metab. 20 (2000) 423-451
14. 2 PET radiotracers. NeuroImage 41 (2008) T36
15. Lazarova N., Siméon F.G., Musachio J.L., Lu S.Y., and Pike V.W. Integration of a microwave reactor with Synthia to provide a fully automated radiofluorination module. J. Label. Compd. Radiopharm. 50 (2007) 463-465
16. Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 308 (2005) 512-517
17. 18F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies. Curr. Radiopharm. 2 (2009) 49-55
18. 2 receptors: evidence for identical binding sites. Eur. J. Pharmacol. 303 (1996) 123-128
19. 2 receptor in vitro. Synapse 63 (2009) 998-1009
20. 2 agonists and antagonists ex vivo. Nucl. Med. Biol. 35 (2008) 11-17
21. 2 receptor tracer. Nucl. Med. Biol. 22 (1995) 283-296
22. 2 dopamine receptor. J. Biol. Chem. 284 (2009) 15038-15051
23. 11C]-raclopride. Synapse 52 (2004) 188-208
24. 11C]NPA) in an anesthetized nonhuman primate. Synapse 61 (2007) 106-109
25. 2 agonist. J. Med. Chem. 33 (1990) 3122-3124
26. Paxinos G., and Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates. 4th ed (2001), Academic Press, San Diego
27. Pierce K.L., and Lefkowitz R.J. Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nat. Rev. Neurosci. 2 (2001) 727-733
28. Seidel J., Vaquero J.J., and Green M.V. Resolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner: comparison to simulated LSO scanners without depth-of-interaction capability. IEEE Trans. Nucl. Sci. 50 (2003) 1347-1350
29. 11C]raclopride. Synapse 59 (2006) 260-269
30. 2 dopamine receptor internalization. Synapse 63 (2009) 621-624
31. 11C]MNPA. J. Label. Compd. Radiopharm. 52 (2009) 158-165
32. 3H]spiperone. Mol. Pharmacol. 63 (2003) 456-462
33. 2 high-affinity state with positron emission tomography. J. Med. Chem. 48 (2005) 4153-4160