Decreased Brainstem Function Following Cardiac Arrest and Resuscitation in Aged Rat

Brain Research

Volumn 1328, Issue , 2010, Pages 181-189

  Xu, Kui ^a,b   Puchowicz, Michelle A ^a   Sun, Xiaoyan ^b   LaManna, Joseph C ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidant treatment; Brain mitochondrial respiratory function; Hypoxic ventilatory response; Reperfusion injury; Transient global ischemia

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN FUNCTION; CELL COUNT; CELL FUNCTION; CONTROLLED STUDY; HEART ARREST; MALE; NONHUMAN; OVERALL SURVIVAL; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RESUSCITATION; TREATMENT OUTCOME;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN STEM; BRAIN STEM INFARCTIONS; CELL RESPIRATION; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; HEART ARREST; HIPPOCAMPUS; MALE; MITOCHONDRIA; NERVE DEGENERATION; OXIDATIVE STRESS; RATS; RATS, INBRED F344; RECOVERY OF FUNCTION; REPERFUSION INJURY; RESPIRATORY INSUFFICIENCY; RESUSCITATION; TREATMENT OUTCOME;

RATTUS; RATTUS NORVEGICUS;

EID: 77950594171     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.02.080     Document Type: Article

References (31)

1. Anderson M.F., and Sims N.R. Mitochondrial respiratory function and cell death in focal cerebral ischemia. J. Neurochem. 73 (1999) 1189-1199
2. Bianchi A.L., Denavit-Saubie M., and Champagnat J. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol. Rev. 75 (1995) 1-45
3. Cao X., and Phillis J.W. alpha-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Res. 644 (1994) 267-272
4. Chugh S.S., Jui J., Gunson K., Stecker E.C., John B.T., Thompson B., Ilias N., Vickers C., Dogra V., Daya M., Kron J., Zheng Z.J., Mensah G., and McAnulty J. Current burden of sudden cardiac death: multiple source surveillance versus retrospective death certificate-based review in a large U.S. community. J. Am. Coll. Cardiol. 44 (2004) 1268-1275
5. Finley J.C., and Katz D.M. The central organization of carotid body afferent projections to the brainstem of the rat. Brain Res. 572 (1992) 108-116
6. Floyd R.A. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc. Soc. Exp. Biol. Med. 222 (1999) 236-245
7. Floyd R.A., and Carney J.M. Age influence on oxidative events during brain ischemia/reperfusion. Arch. Gerontol. Geriatr. 12 (1991) 155-177
8. Folbergrova J., Zhao Q., Katsura K., and Siesjo B.K. N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 5057-5061
9. Hall E.D., Andrus P.K., Althaus J.S., and Von Voigtlander P.F. Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain. J. Neurosci. Res. 34 (1993) 107-112
10. Humphries K.M., and Szweda L.I. Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2- nonenal. Biochemical 37 (1998) 15835-15841
11. Kerner J., Turkaly P.J., Minkler P.E., and Hoppel C.L. Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content. Am. J. Physiol. Endocrinol. Metab. 281 (2001) E1054-E1062
12. Koshiya N., and Guyenet P.G. NTS neurons with carotid chemoreceptor inputs arborize in the rostral ventrolateral medulla. Am. J. Physiol. 270 (1996) R1273-R1278
13. LaManna J.C., Haxhiu M.A., Kutina-Nelson K.L., Pundik S., Erokwu B., Yeh E.R., Lust W.D., and Cherniack N.S. Decreased energy metabolism in brain stem during central respiratory depression in response to hypoxia. J. Appl. Physiol. 81 (1996) 1772-1777
14. Lesnefsky E.J., and Hoppel C.L. Oxidative phosphorylation and aging. Ageing Res. Rev. 5 (2006) 402-433
15. Lucas D.T., and Szweda L.I. Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 510-514
16. Nita D.A., Nita V., Spulber S., Moldovan M., Popa D.P., Zagrean A.M., and Zagrean L. Oxidative damage following cerebral ischemia depends on reperfusion - a biochemical study in rat. J. Cell. Mol. Med. 5 (2001) 163-170
17. Palkovits M., and Brownstein M.J. Maps and guide to microdissection of rat brain (1988), Elsevier, New York
18. Pazos A.J., Green E.J., Busto R., McCabe P.M., Baena R.C., Ginsberg M.D., Globus M.Y., Schneiderman N., and Dietrich W.D. Effects of combined postischemic hypothermia and delayed N-tert-butyl-alpha-pheylnitrone (PBN) administration on histopathologicaland behavioral deficits associated with transient global ischemia in rats. Brain Res. 846 (1999) 186-195
19. Phillis J.W., and Clough-Helfman C. Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN). Neurosci. Lett. 116 (1990) 315-319
20. Roberts Jr. E.L., and Chih C.P. Age-related alterations in energy metabolism contribute to the increased vulnerability of the aging brain to anoxic damage. Brain Res. 678 (1995) 83-90
21. Safar P. Cerebral resuscitation after cardiac arrest: research initiatives and future directions. Ann. Emerg. Med. 22 (1993) 324-349
22. Sastre J., Pallardo F.V., and Vina J. The role of mitochondrial oxidative stress in aging. Free Radic. Biol. Med. 35 (2003) 1-8
23. Schlenker E.H., and Goldman M. Ventilatory responses of aged male and female rats to hypercapnia and to hypoxia. Gerontology 31 (1985) 301-308
24. Sims N.R. Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat. J. Neurochem. 56 (1991) 1836-1844
25. Toescu E.C. Normal brain ageing: models and mechanisms. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360 (2005) 2347-2354
26. Vereczki V., Martin E., Rosenthal R.E., Hof P.R., Hoffman G.E., and Fiskum G. Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J. Cereb. Blood Flow Metab. 26 (2006) 821-835
27. Wenninger J.M., Olson Jr. E.B., Cotter C.J., Thomas C.F., and Behan M. Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats. J. Appl. Physiol. 106 (2009) 1522-1528
28. Xu K., and LaManna J.C. The loss of hypoxic ventilatory responses following resuscitation after cardiac arrest in rats is associated with failure of long-term survival. Brain Res. 1258 (2009) 59-64
29. Xu K., Puchowicz M.A., Lust W.D., and LaManna J.C. Adenosine treatment delays postischemic hippocampal CA1 loss after cardiac arrest and resuscitation in rats. Brain Res. 1071 (2006) 208-217
30. Xu K., Puchowicz M.A., Sun X., and LaManna J.C. Mitochondrial dysfunction in aging rat brain following transient global ischemia. Adv. Exp. Med. Biol. 614 (2008) 379-386
31. Zheng Z.J., Croft J.B., Giles W.H., and Mensah G.A. Sudden cardiac death in the United States, 1989 to 1998. Circulation 104 (2001) 2158-2163