Intragraft expression of the IL-10 gene is up-regulated in renal protocol biopsies with early interstitial fibrosis, tubular atrophy, and subclinical rejection

American Journal of Pathology

Volumn 176, Issue 4, 2010, Pages 1696-1704

  Hueso, Miguel ^a,b   Navarro, Estanis ^b   Moreso, Francesc ^a,d   O'Valle, Francisco ^c   Pérez Riba, Mercè ^b   Del Moral, Raimundo García ^c   Grinyó, Josep M ^a   Serón, Daniel ^a,d  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CD20 ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; CHLORDANE; CREATININE; CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 3; LYMPHOCYTE ANTIBODY; MESSENGER RNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DISEASE MARKER; FEMALE; GENE EXPRESSION; GRAFT DYSFUNCTION; HUMAN; HUMAN TISSUE; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY GRAFT REJECTION; LYMPHOCYTIC INFILTRATION; MALE; PRIORITY JOURNAL; PROTEINURIA;

EID: 77950591899     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090411     Document Type: Article

References (30)

1. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR: The natural history of chronic allograft nephropathy. N Engl J Med 2003, 349:2326-2333 (Pubitemid 37509740)
2. Nickerson P, Jeffery J, Gough J, McKenna R, Grimm P, Cheang M, Rush D: Identification of clinical and histopathologic risk factors for diminished renal function 2 years posttransplant. J Am Soc Nephrol 1998, 9:482-487 (Pubitemid 28122875)
3. Moreso F, Ibernon M, Goma M, Carrera M, Fulladosa X, Hueso M, Gil-Vernet S, Cruzado JM, Torras J, Grinyo JM, Seron D: Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss. Am J Transplant 2006, 6:747-752 (Pubitemid 43345012)
4. D'Elios MM, Josien R, Manghetti M, Amedei A, de Carli M, Cuturi MC, Blancho G, Buzelin F, del Prete G, Soulillou JP: Predominant Th1 cell infiltration in acute rejection episodes of human kidney grafts. Kidney Int 1997, 51:1876-1884 (Pubitemid 27252758)
5. Kirk AD, Jacobson LM, Heisey DM, Radke NF, Pirsch JD, Sollinger HW: Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function. Transplantation 1999, 68:1578-1582
6. Shirwan H: Chronic allograft rejection. Do the Th2 cells preferentially induced by indirect alloantigen recognition play a dominant role? Transplantation 1999, 68:715-726
7. Strehlau J, Pavlakis M, Lipman M, Shapiro M, Vasconcellos L, Harmon W, Strom TB: Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation, Proc Natl Acad Sci USA 1997, 94:695-700 (Pubitemid 27053696)
8. Goulter AB, Harmer DW, Clark KL: Evaluation of low density array technology for quantitative parallel measurement of multiple genes in human tissue. BMC Genomics 2006, 7:34
9. Seron D, Moreso F, Bover J, Condom E, Gil-Vernet S, Canas C, Fulladosa X, Torras J, Carrera M, Grinyo JM, Alsina J: Early protocol renal allograft biopsies and graft outcome. Kidney Int 1997, 51:310-316 (Pubitemid 27064552)
10. Solez K, Colvin RB, Racusen LC, Sis B, Halloran PF, Birk PE, Campbell PM, Cascalho M, Collins AB, Demetris AJ, Drachenberg CB, Gibson IW, Grimm PC, Haas M, Lerut E, Liapis H, Mannon RB, Marcus PB, Mengel M, Mihatsch MJ, Nankivell BJ, Nickeleit V, Papadimitriou JC, Platt JL, Randhawa P, Roberts I, Salinas-Madriga L, Salomon DR, Seron D, Sheaff M, Weening JJ: Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007, 7:518-526 (Pubitemid 46376465)
11. Moreso F, Seron D, O'Valle F, Ibernon M, Goma M, Hueso M, Cruzado JM, Bestard O, Duarte V, del Moral RG, Grinyo JM: Immunephenotype of glomerular and interstitial infiltrating cells in protocol renal allograft biopsies and histological diagnosis. Am J Transplant 2007, 7:2739-2747 (Pubitemid 350045787)
12. Hueso M, Beltran V, Moreso F, Ciriero E, Fulladosa X, Grinyo JM, Seron D, Navarro E: Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients. Biochim Biophys Acta 2004, 1689:58-65 (Pubitemid 38670503)
13. Muthukumar T, Dadhania D, Ding R, Snopkowski C, Naqvi R, Lee JB, Hartono C, Li B, Sharma VK, Seshan SV, Kapur S, Hancock WW, Schwartz JE, Suthanthiran M: Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005, 353:2342-2351 (Pubitemid 41713746)
14. Hoffmann SC, Hale DA, Kleiner DE, Mannon RB, Kampen RL, Jacobson LM, Cendales LC, Swanson SJ, Becker BN, Kirk AD: Functionally significant renal allograft rejection is defined by transcriptional criteria. Am J Transplant 2005, 5:573-581
15. Sarwal M, Chua MS, Kambham N, Hsieh SC, Satterwhite T, Masek M, Salvatierra O Jr: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling, N Engl J Med 2003, 349:125-138 (Pubitemid 36818782)
16. Zarkhin V, Li L, Sarwal M: "To B or not to B?" B-cells and graft rejection. Transplantation 2008, 85:1705-1714
17. Einecke G, Reeve J, Mengel M, Sis B, Bunnag S, Mueller TF, Halloran PF: Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts. Am J Transplant 2008, 8:1434-1443 (Pubitemid 351989485)
18. Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK: Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006, 212:28-50 (Pubitemid 44116698)
19. Edemir B, Kurian SM, Eisenacher M, Lang D, Muller-Tidow C, Gabriels G, Salomon DR, Schlatter E: Activation of counter-regulatory mechanisms in a rat renal acute rejection model. BMC Genomics 2008, 9:71 (Pubitemid 351344692)
20. Chen B, Kapturczak MH, Joseph R, George JF, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Tisher CC, Flotte TR, Agarwal A, Chen S: Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model. Am J Transplant 2007, 7:1112-1120 (Pubitemid 46643120)
21. Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH, Kastelein R, Moore KW, Banchereau J: Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes, Proc Natl Acad Sci USA 1992, 89:1890-1893
22. Sankaran D, Asderakis A, Ashraf S, Roberts IS, Short CD, Dyer PA, Sinnott PJ, Hutchinson IV: Cytokine gene polymorphisms predict acute graft rejection following renal transplantation. Kidney Int 1999, 56:281-288 (Pubitemid 29300546)
23. Tinckam K, Rush D, Hutchinson I, Dembinski I, Pravica V, Jeffery J, Nickerson P: The relative importance of cytokine gene polymorphisms in the development of early and late acute rejection and six-month renal allograft pathology. Transplantation 2005, 79:836-841 (Pubitemid 40546204)
24. Cartwright NH, Keen LJ, Demaine AG, Hurlock NJ, McGonigle RJ, Rowe PA, Shaw JF, Szydlo RM, Kaminski ER: A study of cytokine gene polymorphisms and protein secretion in renal transplantation. Transpl Immunol 2001, 8:237-244 (Pubitemid 32249011)
25. Weimer R, Zipperle S, Daniel V, Carl S, Staehler G, Opelz G: Pretransplant CD4 helper function and interleukin 10 response predict risk of acute kidney graft rejection. Transplantation 1996, 62:1606-1614 (Pubitemid 27009919)
26. Hribova P, Kotsch K, Brabcova I, Vitko S, Volk HD, Lacha J: Cytokines and chemokine gene expression in human kidney transplantation. Transplant Proc 2005, 37:760-763 (Pubitemid 40590692)
27. Hribova P, Lacha J, Kotsch K, Volk HD, Brabcova I, Skibova J, Vitko S, Viklicky O: Intrarenal cytokine and chemokine gene expression and kidney graft outcome. Kidney Blood Press Res 2007, 30:273-282 (Pubitemid 47482058)
28. Fitzgerald JT, Johnson JR, Perez RV: Pre-transplant elevations of interleukin-12 and interleukin-10 are associated with acute rejection after renal transplantation. Clin Transplant 2004, 18:434-439
29. Bohler T, Waiser J, Lichter S, Schumann B, Neumayer HH, Kamar N, Budde K: Pharmacodynamic effects of everolimus on anti-CD3 antibody-stimulated T-lymphocyte proliferation and interleukin-10 synthesis in stable kidney-transplant patients. Cytokine 2008, 42:306-311
30. Koch M, Mengel M, Poehnert D, Nashan B: Effects of everolimus on cellular and humoral immune processes leading to chronic allograft nephropathy in a rat model with sensitized recipients. Transplantation 2007, 83:498-505 (Pubitemid 46667854)