A study of cytokine gene polymorphisms and protein secretion in renal transplantation

Transplant Immunology

Volumn 8, Issue 4, 2001, Pages 237-244

  Cartwright, N H ^a   Keen, L J ^b   Demaine, A G ^c   Hurlock, N J ^a   McGonigle, R J ^a   Rowe, P A ^a   Shaw, J F ^a   Szydlo, R M ^d   Kaminski, E R ^a  

^a DERRIFORD HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c PLYMOUTH UNIVERSITY PENINSULA SCHOOLS OF MEDICINE AND DENTISTRY   (United Kingdom)

^d IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Cytokine; Gene polymorphism; Mixed lymphocyte culture; Rejection; Renal transplantation

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHYTOHEMAGGLUTININ; PREDNISOLONE; TACROLIMUS;

ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HETERODUPLEX ANALYSIS; HUMAN; HUMAN CELL; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; MIXED LYMPHOCYTE CULTURE; PRIORITY JOURNAL; PROTEIN SECRETION;

ACUTE DISEASE; AMINO ACID SUBSTITUTION; COHORT STUDIES; CYTOKINES; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GRAFT REJECTION; HETERODUPLEX ANALYSIS; HISTOCOMPATIBILITY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKINS; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICROSATELLITE REPEATS; PHYTOHEMAGGLUTININS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035081678     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(01)00026-0     Document Type: Article

References (40)

1. Analysis of the polymorphism of the tumour necrosis factor (TNF) gene and promoter and of circulating TNF-alpha levels in heart transplant patients suffering or not suffering from severe rejection
2. Significance of tumour necrosis factor microsatellite polymorphism in renal transplantation
3. TNF-alpha in acute cardiac transplant rejection
4. The effect of polymorphisms in tumour necrosis factor-alpha, interleukin-10 and transforming growth factor-beta genes in acute hepatic allograft rejection
5. Cytokine gene polymorphism in human disease: On-line databases
6. A study of cytokine protein secretion, frequencies of cytokine expressing cells and IFN-G gene polymorphisms in normal individuals
7. Cytokine secretion in mixed lymphocyte culture: A prognostic indicator of renal allograft rejection in addition to HLA mismatching
8. Cytokines as mediator of organ graft rejection and tolerance
9. Interleukin-10 and cellular rejection following cardiac transplantation
10. Mapping of the human IL-10 gene and further characterisation of the 5′ flanking sequence
11. Interleukin-10 secretion in relation to human IL-10 locus haplotypes
12. Microsatellite alleles and single nucleotide polymorphisms (SNPs) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus
13. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and a association with systimic-onset jevenile chronic arthritits
14. Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation
15. Cytokine genotypes in allograft rejection: Guidelines for immunosuppression
16. Influence of cytokine genotypes on allograft rejection
17. A CA repeat polymorphism of the IFN-γ gene is associated with susceptibility to Type I diabetes
18. In vitro cytokine profiles and their relevance to rejection following renal transplantation
19. Cytokine genotyping in Caucasian and African American renal allograft recipients
20. Genetic polymorphism in the IL-10 promoter region in renal transplantation
21. Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients
22. High frequency of IL-10 secreting CD4 + graft-infiltrating T lymphocytes in promptly rejected kidney allografts
23. Genetic cytokine polymorphism in liver allograft recipients
24. Induced heteroduplex genotyping of TNF-α, IL-1β, IL-6 and IL-10 polymorphisms associated with transcriptional regulation
25. Identification of a novel polymorphism in the human IL-6 promoter region
26. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: A possible link to insulin-dependent diabetes mellitus
27. In vitro production of IFN-α correlates with CA repeat polymorphism in the human IFN-α gene
28. Dinucleotide repeat polymorphism in the interferon-gamma (IFNG) gene
29. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation
30. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation
31. Predicting the severity of graft vs. host-disease from interleukin-10 levels after bone marrow transplantation
32. Identification and initial characterisation of two polymorphisms in the human IL-10 promoter
33. A genetic marker of high TNF-alpha production in heart transplant recipients
34. Cytokine gene polymorphism and heart transplant rejection
35. An investigation of polymorphism in the interleukin-10 gene promoter
36. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy
37. Pre-transplant CD4 helper function and interleukin 10 response predict risk of acute kidney graft rejection
38. Genetic influence on cytokine production and fatal meningococcal disease
39. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8 and DR3 alleles
40. Cytokine polymorphism and renal allograft rejection in the mycophenolate mofetil era