Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo

Kidney International

Volumn 70, Issue 8, 2006, Pages 1456-1462

  Menne, J ^a   Meier, M ^b   Park, J K ^b   Boehne, M ^b   Kirsch, T ^b   Lindschau, C ^b   Ociepka, R ^a   Leitges, M ^c   Rinta Valkama, J ^d   Holthofer, H ^d   Haller, H ^b  

^a Phenos GmbH   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Albuminuria; Diabetic nephropathy; Knockout; Nephrin; Protein kinase C

Indexed keywords

CD2 ASSOCIATED PROTEIN; MESSENGER RNA; NEPHRIN; PODOCIN; PROTEIN KINASE C ALPHA; TRANSCRIPTION FACTOR; WT1 PROTEIN;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; EXPERIMENTAL DIABETES MELLITUS; GENE DELETION; GLOMERULUS FILTRATION; HYPERGLYCEMIA; IN VIVO STUDY; MEMBRANE PERMEABILITY; MOUSE; NEPHROBLASTOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALBUMINURIA; ANIMALS; CYTOSKELETAL PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; GENE EXPRESSION REGULATION; HUMANS; HYPERGLYCEMIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY GLOMERULUS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROTEIN KINASE C-ALPHA; RNA, MESSENGER; SIGNAL TRANSDUCTION; WT1 PROTEINS;

EID: 33749515477     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5001830     Document Type: Article

References (38)

1. Nerlich A, Schleicher E. Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions. Am J Pathol 1991; 139: 889-899.
2. Cooper ME, Mundel P, Boner G. Role of nephrin in renal disease including diabetic nephropathy. Semin Nephrol 2002; 22: 393-398.
3. Meier M, King GL. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med 2000; 5: 173-185.
4. Menne J, Park JK, Boehne M et al. Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-\{alpha\} - deficient diabetic mice. Diabetes 2004; 53: 2101-2109.
5. Bonnet F, Cooper ME, Kawachi H et al. Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia 2001; 44: 874-877.
6. Kelly DJ, Aaltonen P, Cox AJ et al. Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies. Nephrol Dial Transplant 2002; 17: 1327-1332.
7. Davis BJ, Johnston CI, Burrell LM et al. Renoprotective effects of vasopeptidase inhibition in an experimental model of diabetic nephropathy. Diabetologia 2003; 46: 961-971.
8. Toyoda M, Suzuki D, Umezono T et al. Expression of human nephrin mRNA in diabetic nephropathy. Nephrol Dial Transplant 2004; 19: 380-385.
9. Benigni A, Gagliardini E, Tomasoni S et al. Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy. Kidney Int 2004; 65: 2193-2200.
10. Baelde HJ, Eikmans M, Doran PP et al. Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy. Am J Kidney Dis 2004; 43: 636-650.
11. Doublier S, Salvidio G, Lupia E et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes 2003; 52: 1023-1030.
12. Langham RG, Kelly DJ, Cox AJ et al. Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. Diabetologia 2002; 45: 1572-1576.
13. Wagner N, Wagner KD, Xing Y et al. The major podocyte protein nephrin is transcriptionally activated by the Wilms' Tumor Suppressor WT1. J Am Soc Nephrol 2004; 15: 3044-3051.
14. Guo G, Morrison DJ, Licht JD et al. WT1 activates a glomerular-specific enhancer identified from the human nephrin gene. J Am Soc Nephrol 2004; 15: 2851-2856.
15. Idris I, Gray S, Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia 2001; 44: 659-673.
16. Whiteside CI, Dlugosz JA. Mesangial cell protein kinase C isozyme activation in the diabetic milieu. Am J Physiol Renal Physiol 2002; 282: F975-980.
17. Haneda M, Koya D, Kikkawa R. Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway. Am J Kidney Dis 2001; 38(Suppl 1): S178-S181.
18. Kapor-Drezgic J, Zhou X, Babazono T et al. Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent. J Am Soc Nephrol 1999; 10: 1193-1203.
19. Ha H, Yu MR, Choi YJ et al. Activation of protein kinase C-delta and C-epsilon by oxidative stress in early diabetic rat kidney. Am J Kidney Dis 2001; 38(Suppl 1): S204-7.
20. Glogowski EA, Tsiani E, Zhou X et al. High glucose alters the response of mesangial cell protein kinase C isoforms to endothelin-1. Kidney Int 1999; 55: 486-499.
21. Haller H. Postprandial glucose and vascular disease. Diabet Med 1997; 14: S50-S56.
22. Babazono T, Kapor-Drezgic J, Dlugosz JA et al. Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells. Diabetes 1998; 47: 668-676.
23. Kang N, Alexander G, Park JK et al. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. Kidney Int 1999; 56: 1737-1750.
24. Dempsey EC, Newton AC, Mochly-Rosen D et al. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 2000; 279: L429-38.
25. Davis BJ, Forbes JM, Thomas MC et al. Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. Diabetologia 2004; 47: 89-97.
26. Davis BJ, Cao Z, de Gasparo M et al. Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin. J Hypertens 2003; 21: 209-216.
27. Osicka TM, Yu Y, Panagiotopoulos S et al. Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C. Diabetes 2000; 49: 87-93.
28. Thallas-Bonke V, Lindschau C, Rizkalla B et al. Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway. Diabetes 2004; 53: 2921-2930.
29. Tryggvason K, Wartiovaara J. Molecular basis of glomerular permselectivity. Curr Opin Nephrol Hypertens 2001; 10: 543-549.
30. Wang SX, Mene P, Holthofer H. Nephrin mRNA regulation by protein kinase C. J Nephrol 2001; 14: 98-103.
31. Wong MA, Cui S, Quaggin SE. Identification and characterization of a glomerular-specific promoter from the human nephrin gene. Am J Physiol Renal Physiol 2000; 279: F1027-F1032.
32. Moeller MJ, Kovari IA, Holzman LB. Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5′ flanking region drives LacZ expression in podocytes. J Am Soc Nephrol 2000; 11: 2306-2314.
33. Beltcheva O, Kontusaari S, Fetissov S et al. Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin. J Am Soc Nephrol 2003; 14: 352-358.
34. Schwarz K, Simons M, Reiser J et al. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 2002; 108: 1621-1629.
35. Shih NY, Li J, Cotran R et al. Congenital syndrome in mice lacking CD2-associated protein. Science 1999; 286: 312-315.
36. Shih NY, Li J, Cotran R et al. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol 2001; 159: 2303-2308.
37. Leitges M, Plomann M, Standaert ML et al. Knockout of PKC alpha enhances insulin signaling through PI3K. Mol Endocrinol 2002; 16: 847-858.
38. Ahola H, Wang SX, Luimula P et al. Cloning and expression of the rat nephrin homolog. Am J Pathol 1999; 155: 907-913.